Resection in Pancreatic Cancer With Minimal Metastatic Disease or Venous Infiltration Trial at Technische Universität München

Inclusion Criteria:

* suspicion of cancer of the pancreas and an intraoperative histologically proven diagnosis of pancreatic adenocarcinoma.
* intraoperative assessment of tumor as potentially locally resectable
* COHORT 1: Minimal metastatic disease
* COHORT 2: Venous infiltration
* ability to sign the informed consent.
* Karnofsky performance status \> 70.
* Life-expectancy of more than 3 months.
* able to attend follow-up.
* no previous or concurrent malignancy diagnoses, except non-melanoma skin cancer and in situ carcinoma of the cervix.
* no serious medical, psychological, familial, sociological or geographical conditions potentially hampering compliance with the study protocol and follow-up.
* patients older than 18 years.
* no pregnant or lactating women.
* preoperative evaluation by thin-sliced CT scans with:
* No evidence of substantial extra-pancreatic disease, i.e. no evidence of malignant ascites, extended liver metastasis (\>5 metastatic lesions), spread to other distant abdominal organs, peritoneal metastasis, spread to extra-abdominal organs.
* No evidence of extension of the tumor into the celiac axis or superior mesenteric artery (T4 disease).
* intraoperative findings with:
* tumor assessed as potentially locally resectable.
* no signs of peritoneal metastasis or tumor manifestations outside of the pancreas and the liver.
* frozen section: adenocarcinoma

Exclusion Criteria:

* extrapancreatic disease (except minimal metastatic disease of the liver, see above)
* concomitant venous infiltration and minimal metastatic disease
* extension of the tumor into the celiac axis or superior mesenteric artery
* life expectancy of less than 3 months
* previous or concurrent malignancy diagnosis, except non-melanoma skin cancer and in situ carcinoma of the cervix
* conditions potentially hampering compliance (also inclusion criteria)