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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02048943 | Dovitinib Lactate, Gemcitabine Hydrochloride, and Paclitaxel Albumin-Stabilized… | Phase 1 | withdrawn | Jan 29, 2014 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT00511576 | Study to Evaluate Combination Treatment of MGCD0103 and Docetaxel (Taxotere®) for… | Phase 1 | terminated | Aug 6, 2007 | Mirati Therapeutics Inc. | Celgene terminated its collaboration agreement with MethylGene for the development of MGCD0103. All… | Other (stated, no rule matched) |
| NCT00683787 | Docetaxel With or Without Vandetanib in Treating Patients With Metastatic Stomach Cancer… | Phase 2 | terminated | May 23, 2008 | Roswell Park Cancer Institute | low accrual | Enrollment / accrual |
| NCT01927393 | Palliative Care in Improving Quality of Life and Symptoms in Patients With Stage III-IV… | N/A | withdrawn | Aug 22, 2013 | City of Hope Medical Center | Study was not funded | Funding |
| NCT01659424 | Phase II Trial of Preoperative High-dose-rate Endorectal Brachytherapy and FOLFOX…(HDRBT) | Phase 2 | withdrawn | Aug 7, 2012 | Beth Israel Medical Center | No participants were enrolled | Enrollment / accrual |
| NCT01694589 | A Pilot Study of a Hedgehog Pathway Inhibitor (LDE-225) in Surgically Resectable Pancreas… | Early Phase 1 | withdrawn | Sep 27, 2012 | Rutgers, The State University of New Jersey | Lack of accrual | Enrollment / accrual |
| NCT00624962 | Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid… | N/A | withdrawn | Feb 28, 2008 | Vanderbilt University | no participants enrolled | Enrollment / accrual |
| NCT01631539 | Chemoembolisation With CPT11 Loaded DC Bead With Cetuximab and 5FU/LV in First Line in… | N/A | withdrawn | Jun 29, 2012 | Universitaire Ziekenhuizen KU Leuven | No patients enrolled | Enrollment / accrual |
| NCT01544452 | Total Preoperative MR Diagnostic Evaluation Versus Standard Diagnostic Evaluation in… | N/A | terminated | Mar 6, 2012 | Herlev Hospital | Lack of MR scanning capacity | Other (stated, no rule matched) |
| NCT01889680 | Safety and Effectiveness Study of Chemotherapy and Ziv-aflibercept to Treat Metastatic… | Phase 2 | withdrawn | Jun 28, 2013 | NSABP Foundation Inc | not stated | Not stated |
| NCT02070419 | TACE With or Without Radiation Therapy in Treating Patients With Stage A-C Liver Cancer | Phase 2 | withdrawn | Feb 25, 2014 | Case Comprehensive Cancer Center | Principal Investigator left institution | Investigator |
| NCT01748851 | XELOX Versus FOLFOX for Advanced Gastric Cancer (AGC) | Phase 3 | terminated | Dec 13, 2012 | Dong-A University Hospital | Poor enrollment of patients | Enrollment / accrual |
| NCT00808145 | Study of Sorafenib, Gemcitabine, and Cisplatin in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | withdrawn | Dec 15, 2008 | Lahey Clinic | Lack of enrollment, many screen failures and non eligible study participants | Enrollment / accrual |
| NCT00881504 | A Study of FOLFOX6 With Bevacizumab for Biliary System Carcinoma | Phase 2 | terminated | Apr 15, 2009 | Georgetown University | It was not possible to get insurance companies to cover bevacizumab. | Other (stated, no rule matched) |
| NCT00482625 | Erlotinib Hydrochloride in Treating Patients With Pancreatic Cancer That Can Be Removed… | Phase 2 | terminated | Jun 5, 2007 | National Cancer Institute (NCI) | The protocol has been completed prematurely (e.g., due to poor accrual, insufficient drug supply,… | Drug supply |
| NCT00823810 | Treatment Monitoring of Advanced Colorectal Cancer With 18F-FDG PET/CT(RESCORE) | N/A | terminated | Jan 16, 2009 | Turku University Hospital | Recruitment promlems | Enrollment / accrual |
| NCT00390364 | Everolimus in Treating Patients With Advanced or Metastatic Colorectal Cancer That Did… | Phase 2 | terminated | Oct 19, 2006 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Withdrawn due to low accrual | Enrollment / accrual |
| NCT00660348 | Standard Pain Control or Intrathecal Therapy in Controlling Pain in Patients With Locally… | N/A | terminated | Apr 17, 2008 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low enrollment | Enrollment / accrual |
| NCT01149434 | Study of JI-101 in Patients With Advanced Low Grade Endocrine Tumors, Ovarian Cancers or… | Phase 1 / Phase 2 | terminated | Jun 23, 2010 | University of Utah | Lack of drug efficacy | Efficacy / futility |
| NCT00642746 | Erlotinib and Chemotherapy for 2nd Line Treatment (Tx) of Metastatic Colorectal Cancer… | Phase 2 | terminated | Mar 25, 2008 | OHSU Knight Cancer Institute | Terminated due to poor enrollment and grade 3 toxicities noted during an interim analysis. | Safety / toxicity |
| NCT01362582 | Comparing Parenteral Nutrition vs Best Supportive Nutritional Care in Patients With…(PANUSCO) | Phase 3 | terminated | May 30, 2011 | National Center for Tumor Diseases, Heidelberg | not stated | Not stated |
| NCT01859182 | Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced… | Phase 2 | withdrawn | May 21, 2013 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01872988 | Tenofovir Antiviral Therapy Following Transarterial Chemoembolization for HBV Related… | Phase 3 | terminated | Jun 7, 2013 | Taichung Veterans General Hospital | Difficult in patient enrollment | Enrollment / accrual |
| NCT02228785 | A Study of the Safety and Tolerance of Three Doses of G17DT in Metastatic Colorectal…(CC1C) | Phase 2 | terminated | Aug 29, 2014 | Cancer Advances Inc. | Poor local tolerance to injection. | Other (stated, no rule matched) |
| NCT00538291 | Cetuximab and Capecitabine in Treating Patients With Metastatic Colorectal Cancer That… | Phase 2 | terminated | Oct 2, 2007 | City of Hope Medical Center | Study was terminated early due to lack of efficacy. | Efficacy / futility |
| NCT01365910 | Linifanib in Treating Patients With Advanced, Refractory Colorectal Cancer | Phase 2 | terminated | Jun 3, 2011 | Vanderbilt-Ingram Cancer Center | Interim analysis determined the study did not meet criteria to proceed | Efficacy / futility |
| NCT01760694 | Multi-Modality Therapy for Untreated Patients With Resectable or Marginally Resectable… | N/A | terminated | Jan 4, 2013 | Southwestern Regional Medical Center | Lack of enrollment | Enrollment / accrual |
| NCT02005484 | A Study of Herceptin (Trastuzumab) in Patients With Metastatic or Advanced Gastric Cancer… | Phase 2 | terminated | Dec 9, 2013 | Hoffmann-La Roche | Study terminated due to slow patient recruitment. | Enrollment / accrual |
| NCT01574677 | Assessment of Septin9 Biomarker for Detection of Colorectal Cancer in Patients With… | — | withdrawn | Apr 10, 2012 | Epigenomics, Inc | not stated | Not stated |
| NCT02205463 | KD019 and Trastuzumab in Patients With Esophagus, Gastroesophageal Junction and Stomach… | Phase 1 | withdrawn | Jul 31, 2014 | NYU Langone Health | IND application withdrawn | Other (stated, no rule matched) |
| NCT00499369 | Irinotecan and Cetuximab With or Without Bevacizumab in Treating Patients With Metastatic… | Phase 3 | terminated | Jul 11, 2007 | National Cancer Institute (NCI) | Due to inadequate accrual, study was terminated and limited outcome data was reported. | Enrollment / accrual |
| NCT02204332 | Phase II-b Randomized Clinical Trial of Cabazitaxel in Metastatic Colorectal Cancer…(COMETA) | Phase 2 | terminated | Jul 30, 2014 | Hospital Clinico Universitario de Santiago | Interim analysis performed on the first 10 patients showed no efficacy of cabazitaxel | Efficacy / futility |
| NCT01627080 | Cardiac Biomarker Study in Esophageal Cancer Patients Treated With Chemotherapy and… | — | withdrawn | Jun 25, 2012 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01227018 | PhII Study STA-9090 as Second or Third-Line Therapy for Metastatic Pancreas Cancer | Phase 2 | terminated | Oct 22, 2010 | Vanderbilt-Ingram Cancer Center | interim analysis found the study drug to be ineffective | Efficacy / futility |
| NCT01722175 | Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or…(ALPPS) | Phase 2 | withdrawn | Nov 6, 2012 | Washington University School of Medicine | Safety concerns. | Safety / toxicity |
| NCT01864070 | Phase 1 TheraSphere + Everolimus With Neuroendocrine Tumors (NETs) + Liver Only or Liver… | Phase 1 | withdrawn | May 29, 2013 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01198548 | High-Dose Cholecalciferol in Treating Patients Receiving Combination Chemotherapy and… | Phase 2 | terminated | Sep 10, 2010 | Roswell Park Cancer Institute | Lack of funding | Funding |
| NCT01941173 | Short-Infusion Ziv-aflibercept in Treating Patients With Metastatic Colorectal Cancer… | N/A | withdrawn | Sep 13, 2013 | City of Hope Medical Center | Lack of accrual | Enrollment / accrual |
| NCT01669668 | Radiofrequency Ablation in Treating Patients With Liver Cancer (Hepatocellular Carcinoma) | Phase 2 | withdrawn | Aug 21, 2012 | Washington University School of Medicine | Lack of referrals. | Other (stated, no rule matched) |
| NCT01418742 | SKIP - A Double-blind Placebo-controlled Randomized Multicenter Trial of Skin Toxicity… | Phase 2 | terminated | Aug 17, 2011 | Gesellschaft fur Medizinische Innovation - Hamatologie und Onkologie mbH | Recruitement did not meet expectations. Prev. differentiation of RAS-wild-type and mutated RAS are… | Enrollment / accrual |
| NCT00107315 | Bevacizumab and Capecitabine as First-Line Therapy in Treating Older Patients With… | Phase 2 | terminated | Apr 6, 2005 | Roswell Park Cancer Institute | Terminated due to low accrual | Enrollment / accrual |
| NCT01432314 | Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat…(RTANDTACE) | Phase 2 | withdrawn | Sep 12, 2011 | Asan Medical Center | Another phase 2 randomized study has been started by other investigators. | Other (stated, no rule matched) |
| NCT00089076 | MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma | Phase 1 / Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT00835679 | Cetuximab and/or Dasatinib in Patients With Colorectal Cancer and Liver Metastases That… | Early Phase 1 | terminated | Feb 4, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00003085 | Laparoscopic Ultrasound in Diagnosing Patients With Pancreatic Cancer | Phase 2 | terminated | Jun 16, 2004 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00006037 | Chemotherapy Plus IM-862 in Treating Patients With Metastatic Colorectal Cancer | Phase 2 | terminated | Feb 26, 2004 | University of Southern California | Drug not available | Other (stated, no rule matched) |
| NCT00159471 | Genes as Predictors of Response to Gemcitabine, Docetaxel, and Capecitabine (GTX) in… | N/A | terminated | Sep 12, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00183807 | A Study of Irinotecan, Cisplatin and Celebrex in Patients With Metastatic or Unresectable… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT00323011 | FOLFIRI + Bevacizumab With or Without Dalteparin in First Line Treatment of Advanced… | Phase 2 | terminated | May 9, 2006 | University of Southern California | drug not available | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 9, 2015source: clinicaltrials