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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01686880 | Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular…(TRYPHON) | Phase 2 | terminated | Sep 18, 2012 | Jules Bordet Institute | poor recruitment and an unexpected low treatment rate | Enrollment / accrual |
| NCT02482909 | A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular… | N/A | terminated | Jun 26, 2015 | Seoul National University Hospital | The post-treatment recurrence rate was expected to be different between two treatment groups. | Other (stated, no rule matched) |
| NCT00624182 | Gemcitabine With Peptide Vaccine Therapy in Treating Patients With Bile Duct Cancer | Phase 1 | suspended | Feb 26, 2008 | Akita University Hospital | not stated | Not stated |
| NCT01103128 | Validation of a Mouse Model of Pancreatic Carcinogenesis | — | terminated | Apr 14, 2010 | Columbia University | not stated | Not stated |
| NCT00099346 | MK0457 (an Aurora Kinase Inhibitor) Study in Patients With Advanced Colorectal Cancer and… | Phase 1 | terminated | Dec 13, 2004 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00396487 | Tailored Treatment in Metastatic Colorectal Cancer | Phase 3 | terminated | Nov 7, 2006 | Vejle Hospital | Only one patient included as per Feb. 4, 2008. | Other (stated, no rule matched) |
| NCT01080248 | Gemcitabine and Pazopanib in Metastatic Pancreatic Cancer | Phase 2 | terminated | Mar 4, 2010 | Washington University School of Medicine | Closed due to delay by GSK | Other (stated, no rule matched) |
| NCT01775280 | Response of Hepatic Tumors to Radioembolization(RESRAD) | Phase 2 | withdrawn | Jan 24, 2013 | University of Zurich | Lack of enrollment | Enrollment / accrual |
| NCT01375816 | Liposome-encapsulated Irinotecan Hydrochloride PEP02 or Irinotecan Hydrochloride,…(PEPCOL) | Phase 2 | terminated | Jun 17, 2011 | GERCOR - Multidisciplinary Oncology Cooperative Group | efficacy interim analysis as per protocol | Efficacy / futility |
| NCT00907413 | Photodynamic Therapy (PDT) Trial for Palliation of Cholangiocarcinoma(PDT) | Phase 3 | terminated | May 22, 2009 | Weill Medical College of Cornell University | PI relocated and reopened trial in new university | Other (stated, no rule matched) |
| NCT01301495 | Prospective Evaluation of a New Covered Metal Stent for Malignant Lesions of the Esophagus | Phase 2 | withdrawn | Feb 23, 2011 | Weill Medical College of Cornell University | No participants enrolled for more than 1 year. | Enrollment / accrual |
| NCT01439685 | Comparison of Biliary Stenting Alone vs. Stenting With Photodynamic Therapy (PDT) During…(PDT) | — | withdrawn | Sep 23, 2011 | Weill Medical College of Cornell University | A single cohort, alternative trial was started. | Other (stated, no rule matched) |
| NCT02162641 | Study to Determine the Feasibility of Sentinel Node Biopsy in Patients With Anal Cancer(R-SeNSAR) | — | withdrawn | Jun 13, 2014 | The Christie NHS Foundation Trust | The study was terminated early as it failed to recruit. | Enrollment / accrual |
| NCT01238965 | Panobinostat and Fluorouracil Followed By Leucovorin Calcium in Treating Patients With… | Phase 1 | terminated | Nov 11, 2010 | University of Southern California | Adverse Events | Safety / toxicity |
| NCT00735241 | FOLFOX6 Plus Sir-Spheres Microspheres Plus Avastin in Patients With Nonresectable Liver…(FAST) | Phase 2 / Phase 3 | withdrawn | Aug 14, 2008 | Sirtex Medical | Withdrawn by the study sponsor. | Other (stated, no rule matched) |
| NCT00176735 | Capecitabine and Radiation Therapy in Advanced Pancreatic Cancer | N/A | terminated | Sep 15, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT01198535 | Phase I Study of Cetuximab With RO4929097 in Metastatic Colorectal Cancer | Phase 1 | terminated | Sep 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01769911 | Genetically Modified Peripheral Blood Stem Cell Transplant in Treating Patients With… | N/A | withdrawn | Jan 17, 2013 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT02235324 | Ziv-Aflibercept Followed by Ziv-Aflibercept, Fluorouracil, and Leucovorin Calcium in… | Phase 2 | withdrawn | Sep 9, 2014 | University of Southern California | Lack of funding | Funding |
| NCT01434459 | Study of Gemcitabine With TheraSphere® (Yttrium-90)in Patients With Hepatic Tumors of… | Phase 1 | terminated | Sep 15, 2011 | Emory University | PI moved to different institution | Other (stated, no rule matched) |
| NCT02132403 | (PM-01) IMPRIME PGG® With BTH1704 and Gemcitabine for Advanced Pancreatic Cancer(PM-01) | Phase 1 | terminated | May 7, 2014 | University of Illinois at Chicago | Drug Recall | Other (stated, no rule matched) |
| NCT00459901 | Study of the Antitumor Activity of Capecitabine in Combination With Erlotinib in Patients… | Phase 2 | terminated | Apr 13, 2007 | Peter Kozuch | Study halted by drug manufacturer | Drug supply |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00253526 | Gemcitabine Hydrochloride With or Without Bevacizumab in Treating Patients Who Are… | Phase 2 | withdrawn | Nov 15, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02159248 | Tolfenamic Acid, Gemcitabine and Radiation for Locally Advanced or Metastatic Pancreatic… | Phase 1 | withdrawn | Jun 9, 2014 | Orlando Health, Inc. | The study closed prior to enrolling any participants. | Enrollment / accrual |
| NCT01167738 | Combination Chemotherapy With or Without Metformin Hydrochloride in Treating Patients…(PACT-17) | Phase 2 | terminated | Jul 22, 2010 | IRCCS San Raffaele | concern of detrimental effect | Other (stated, no rule matched) |
| NCT01029418 | AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Dec 10, 2009 | National Cancer Centre, Singapore | The phase II portion was not conducted due to funding issue. | Funding |
| NCT01801163 | A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With… | Phase 1 | withdrawn | Feb 28, 2013 | Indiana University | Trial had no patients accrued while open | Enrollment / accrual |
| NCT00826800 | Neoadjuvant FOLFOX Plus Bevacizumab Chemotherapy in Patients With Locally Advanced Colon… | N/A | terminated | Jan 22, 2009 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01882972 | Strength for Health | N/A | withdrawn | Jun 21, 2013 | Loyola University | investigator left Loyola | Investigator |
| NCT00081900 | A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible… | Phase 1 / Phase 2 | terminated | Apr 28, 2004 | Genzyme, a Sanofi Company | This study was terminated early by Genzyme because there were insufficient data to support clinical… | Other (stated, no rule matched) |
| NCT02023541 | Proton Beam Therapy to Treat Esophageal Cancer | Phase 1 | terminated | Dec 30, 2013 | Washington University School of Medicine | Lack of insurance coverage for proton beam treatment | Other (stated, no rule matched) |
| NCT01094535 | Secretin-enhanced Magnetic Resonance Cholangiopancreatography (S-MRCP) and Pancreatic… | N/A | withdrawn | Mar 29, 2010 | Columbia University | Poor enrollment | Enrollment / accrual |
| NCT02310971 | Cvac as Maintenance Treatment Patients With Resected Stage I or Stage II Adenocarcinoma… | Phase 2 | withdrawn | Dec 8, 2014 | Prima BioMed Ltd | The trial has been terminated per Sponsor direction due to longer than expected clinical and… | Other (stated, no rule matched) |
| NCT01440127 | Impact of Pretreatment With Metformin on Colorectal Cancer Stem Cells (CCSC) and Related… | Phase 1 | terminated | Sep 26, 2011 | Tufts Medical Center | Unable to accrue all planned subjects in a timely fashion, but data collected will still be… | Enrollment / accrual |
| NCT00873600 | Outpatient Health Care Program for Older Patients Receiving Chemotherapy for Newly… | — | withdrawn | Apr 1, 2009 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT01706822 | Radial Reload Laparoscopic LAR Case Series | Phase 4 | terminated | Oct 15, 2012 | Medtronic - MITG | Slow recruitment | Enrollment / accrual |
| NCT01130701 | A Pilot Study to Evaluate the Efficacy and Safety of Neoadjuvant Chemoradiotherapy With…(PMABIIS) | Phase 2 | withdrawn | May 26, 2010 | University of Massachusetts, Worcester | Study never went beyond FDA application for an IND #. FDAA required institutional DSMC which this… | Other (stated, no rule matched) |
| NCT00720512 | Second-Line Combination Chemotherapy With or Without Bevacizumab in Treating Patients…(BEBYP) | Phase 3 | terminated | Jul 22, 2008 | Gruppo Oncologico del Nord-Ovest | not stated | Not stated |
| NCT00735345 | Chemotherapy Induction and Chemoradiotherapy in Patients With Esophageal Carcinoma | Phase 2 | terminated | Aug 14, 2008 | Arbeitsgemeinschaft medikamentoese Tumortherapie | because of safety concerns the study was terminated prematurely | Safety / toxicity |
| NCT00023634 | S0114 Vaccine Therapy in Treating Patients With Gastric, Prostate, or Ovarian Cancer | Phase 1 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | lack of accrual | Enrollment / accrual |
| NCT02033538 | Neoadjuvant Chemotherapy of Nanoparticle Albumin-bound Paclitaxel in Squamous Cell… | Phase 2 | withdrawn | Jan 10, 2014 | Zhejiang University | This clinical trial was closed due to slow recruitment of patients. | Enrollment / accrual |
| NCT02034968 | Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced… | Phase 2 | withdrawn | Jan 14, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT02041819 | Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of… | Phase 2 | withdrawn | Jan 22, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT00575640 | Hydralazine as a Demethylating Agent in Rectal Cancer | Phase 1 / Phase 2 | withdrawn | Dec 18, 2007 | University of Arkansas | No enrollment | Enrollment / accrual |
| NCT01717014 | Radial Reload Open LAR Case Series | N/A | terminated | Oct 30, 2012 | Medtronic - MITG | not stated | Not stated |
| NCT00003843 | Irinotecan in Treating Patients With Colorectal Cancer | — | terminated | Jan 27, 2003 | California Cancer Consortium | Study terminated due to poor accrual | Enrollment / accrual |
| NCT02011594 | Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma | Phase 2 | withdrawn | Dec 13, 2013 | Zhejiang University | There was no participants enrolled in this clinical trial. | Enrollment / accrual |
| NCT00539968 | A Study to Evaluate the Safety, Tolerability, and Activity of Lonafarnib and Docetaxel… | Phase 1 / Phase 2 | terminated | Oct 5, 2007 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01989858 | ITACA-S2 (Intergroup Trial in Adjuvant Chemotherapy for Adenocarcinoma of the Stomach)(ITACA-S2) | Phase 3 | terminated | Nov 21, 2013 | Mario Negri Institute for Pharmacological Research | lack of clinical cases | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jul 1, 2015source: clinicaltrials