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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02283359 | Selinexor in Combination With Irinotecan in Adenocarcinoma of Stomach and Distal Esophagus | Phase 1 | terminated | Nov 5, 2014 | H. Lee Moffitt Cancer Center and Research Institute | Principal Investigator left the institution | Investigator |
| NCT00305643 | Celecoxib in Preventing Hand/Foot Syndrome Caused By Capecitabine With Metastatic Breast… | Phase 3 | terminated | Mar 22, 2006 | M.D. Anderson Cancer Center | Terminated due to low accrual. No data analyzed. | Enrollment / accrual |
| NCT00746655 | SBRT + TACE for Primary Hepatocellular Carcinoma | N/A | withdrawn | Sep 4, 2008 | University of Pittsburgh | Unable to recruit | Enrollment / accrual |
| NCT00843830 | A Pilot Study Assessing Intra-Metastasis Administration of Autologous KLH-pulsed… | Phase 1 | terminated | Feb 13, 2009 | University of Michigan Rogel Cancer Center | Study closed early secondary to inability to obtain grant funding to conduct. | Funding |
| NCT00864513 | Study of Pemetrexed for Second-Line Pancreas Cancer | Phase 2 | terminated | Mar 18, 2009 | Georgetown University | At interim analysis the study did not meet the response criteria to continue | Efficacy / futility |
| NCT00271011 | A Study of Mitomycin C, Irinotecan, and Cetuximab | Phase 2 | terminated | Dec 29, 2005 | University of Michigan Rogel Cancer Center | The study was discontinued due to the death of a co-investigator and a second co-investigator… | Investigator |
| NCT00669136 | Immunization With AFP + GM CSF Plasmid Prime and AFP Adenoviral Vector Boost in Patients… | Phase 1 | terminated | Apr 29, 2008 | Lisa H. Butterfield, Ph.D. | Poor accrual and limited target patient population for future accrual. Did not complete the Phase 1… | Enrollment / accrual |
| NCT01116791 | Cytoreductive Surgery(CRS) Plus Hyperthermic Intraoperative Peritoneal Chemotherapy(HIPC)… | Phase 2 | terminated | May 5, 2010 | Baki Topal | Insufficient enrollment in Pancreatic \& Biliary arm | Enrollment / accrual |
| NCT02304445 | Chemoembolization With or Without Stereotactic Body Radiosurgery for Liver Cancer(TACE-SBRT) | N/A | withdrawn | Dec 2, 2014 | Juan Sanabria, MD | Necessary equipment could not be obtained. | Other (stated, no rule matched) |
| NCT01998347 | Paclitaxel Liposome and Cisplatin as First-line Chemotherapy in Patients With Metastatic… | Phase 3 | withdrawn | Nov 28, 2013 | Shantou University Medical College | slow enrollment | Enrollment / accrual |
| NCT00109850 | S0414 Cetuximab, Combo Chemo, and RT in Locally Advanced Esophageal Cancer | Phase 2 | terminated | May 4, 2005 | SWOG Cancer Research Network | Closed due to poor accrual | Enrollment / accrual |
| NCT01186705 | Clinical And Translational Study Of MK-2206 In Patients With Metastatic KRAS-Wild-Type,… | Phase 2 | terminated | Aug 23, 2010 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01816659 | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to… | Phase 1 | terminated | Mar 22, 2013 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01521780 | Characterization of Baseline Biomarker Variability in Participants With Hepatocellular… | Phase 1 | terminated | Jan 31, 2012 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00019747 | Surgery With or Without Thalidomide in Treating Patients With Recurrent or Metastatic… | Phase 2 | terminated | Jan 27, 2003 | National Institutes of Health Clinical Center (CC) | DSMB recommended closure of the protocol due to slow accrual. | Enrollment / accrual |
| NCT01911273 | A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A… | Phase 2 | terminated | Jul 30, 2013 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01693276 | Gemcitabine/Abraxane Chemotherapy and Dose Escalated Radiotherapy for Locally Advanced,… | Phase 1 / Phase 2 | terminated | Sep 26, 2012 | Olugbenga Olowokure | Slow accrual | Enrollment / accrual |
| NCT01856322 | Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal Cancer | Phase 2 | terminated | May 17, 2013 | National Cancer Institute (NCI) | The trial was prematurely closed due to lack of accrual. | Enrollment / accrual |
| NCT01042028 | A Randomised Trial With Irinotecan, Cetuximab and Everolimus (ICE)Compared to… | Phase 1 / Phase 2 | terminated | Jan 5, 2010 | Per Pfeiffer | Emergence of FOLFIRINOX and slow recruitment | Enrollment / accrual |
| NCT01004159 | Cetuximab Plus Irinotecan in Colorectal Cancer Patients Who Progressed After Failure With… | Phase 2 | terminated | Oct 29, 2009 | Roswell Park Cancer Institute | former PI left institute | Investigator |
| NCT00031837 | Gemcitabine With or Without Dalteparin in Treating Patients With Unresectable or… | Phase 3 | terminated | Jan 27, 2003 | Gary Morrow | not stated | Not stated |
| NCT01108705 | Comparison of Brivanib and Best Supportive Care (BSC) With Placebo and BSC for Treatment…(BRISK-APS) | Phase 3 | terminated | Apr 22, 2010 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00227773 | Vatalanib and Octreotide in Treating Patients With Progressive Neuroendocrine Tumors | Phase 2 | withdrawn | Sep 28, 2005 | Eastern Cooperative Oncology Group | not stated | Not stated |
| NCT01716546 | Trial of Panitumumab Cisplatin, Fluourouracil and Docetaxel in Locally Advanced or… | Phase 1 / Phase 2 | terminated | Oct 30, 2012 | Hellenic Oncology Research Group | Not reached the primary endpoint target according to the statistical design | Other (stated, no rule matched) |
| NCT00717990 | Irinotecan, Capecitabine and Avastin for Metastatic Colorectal Cancer as Salvage Treatment | Phase 2 | terminated | Jul 18, 2008 | University Hospital of Crete | Poor Accrual | Enrollment / accrual |
| NCT00755118 | Lohp, 5-Fu/Lv and Bevacizumab, Alternative With Cpt-11, 5-Fu/Lv and Cetuximab In… | Phase 2 | terminated | Sep 18, 2008 | University Hospital of Crete | Due to poor Accrual | Enrollment / accrual |
| NCT00093652 | Oxaliplatin, Gefitinib, and Radiation Therapy in Treating Patients With Locally Advanced… | Phase 1 / Phase 2 | terminated | Oct 8, 2004 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT00544908 | Dasatinib in Treating Patients With Stage IV Pancreatic Cancer | Phase 2 | terminated | Oct 16, 2007 | City of Hope Medical Center | Toxicity | Safety / toxicity |
| NCT01239355 | MK2206 in Treating Patients With Advanced Liver Cancer That Did Not Respond to Previous… | Phase 2 | terminated | Nov 11, 2010 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT00899132 | Studying a Tumor Marker for Testicular Cancer, Skin Cancer, Small Intestine Cancer, and… | — | terminated | May 12, 2009 | Case Comprehensive Cancer Center | Study due for continuing review | Other (stated, no rule matched) |
| NCT01598584 | Mirtazapine Plus Gemcitabine Versus Gemcitabine in Metastasis Pancreatic Cancer | Phase 2 / Phase 3 | withdrawn | May 15, 2012 | Tianjin Medical University Cancer Institute and Hospital | Gemcitabine is not the first choice for most pancreatic cancer patients nowdays | Other (stated, no rule matched) |
| NCT02334332 | Educational Brochure in Preparing Patients With Gastric Cancer and Their Caregivers for… | N/A | withdrawn | Jan 8, 2015 | City of Hope Medical Center | No accrual | Enrollment / accrual |
| NCT01968629 | 24hr Imaging Of HCC After EOVIST | Early Phase 1 | withdrawn | Oct 24, 2013 | Massachusetts General Hospital | No eligible subject enrolled | Enrollment / accrual |
| NCT01501604 | BKM120 in Cancers With PIK3CA Activating Mutations | Phase 2 | withdrawn | Dec 29, 2011 | Massachusetts General Hospital | The study has been closed due to lack of accrual | Enrollment / accrual |
| NCT00630890 | Cyberknife Radiosurgery Boost for Hilar Cholangiocarcinoma (Klatskin Tumor) | Phase 1 | terminated | Mar 7, 2008 | University of California, San Francisco | investigator left UCSF and study was closed prematurely in 2008. No results to report. | Investigator |
| NCT00598091 | A Phase I/Expansion Study of Dasatinib(Gem/Dsat) | Phase 1 | terminated | Jan 18, 2008 | Duke University | Low accrual, unable to meet endpoint in timely manner | Enrollment / accrual |
| NCT00250835 | Combination of Oxaliplatin, Capecitabine, and Celecoxib With Concurrent Radiation for… | Phase 2 | terminated | Nov 8, 2005 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT01348503 | Lenalidomide in Combination With a Fixed Dose of Sorafenib for the Treatment of… | Phase 1 | terminated | May 5, 2011 | Indiana University | Treatment was ineffective | Other (stated, no rule matched) |
| NCT00244348 | Hepatic Artery Infusion With Oxaliplatin | Phase 1 / Phase 2 | withdrawn | Oct 26, 2005 | Medical College of Wisconsin | Investigator has left institution | Investigator |
| NCT02109224 | Ibrutinib in Treating Relapsed or Refractory B-Cell Non-Hodgkin Lymphoma in Patients With… | Phase 1 | terminated | Apr 9, 2014 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT02527577 | Analgesia by Transversus Abdominis Plane Nerve Block in Patients Undergoing Liver…(BLOC-TAP) | N/A | terminated | Aug 19, 2015 | Centre Hospitalier Universitaire de Saint Etienne | difficulties to recruit patients | Enrollment / accrual |
| NCT01754623 | GTX-RT in Borderline Resectable Pancreatic Cancer | Phase 2 | terminated | Dec 21, 2012 | H. Lee Moffitt Cancer Center and Research Institute | Lack of pre-treatment tissue to make the study plan feasible. | Other (stated, no rule matched) |
| NCT01539018 | Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for… | Phase 2 | terminated | Feb 27, 2012 | Egyptian Society of Liver Cancer | After interim results data showed no evidence of a difference between both groups | Other (stated, no rule matched) |
| NCT01062919 | Local Anesthetic Wound Infusion and Functional Recovery After Colon Surgery | N/A | terminated | Feb 4, 2010 | Franco Carli | Low recruitment rate - \>70% of colorectal procedures are done laparoscopically | Enrollment / accrual |
| NCT01419002 | Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in…(Net-Pac) | Phase 3 | terminated | Aug 17, 2011 | CHIR-Net | lack of recruitment | Enrollment / accrual |
| NCT01050283 | A Study to Evaluate [18F]-FDG PET (Fluorodeoxyglucose-positron) in Patients With… | Phase 1 | terminated | Jan 15, 2010 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01954732 | Metformin Hydrochloride in Treating Patients With Pancreatic Cancer That Can be Removed… | Phase 1 | withdrawn | Oct 7, 2013 | Case Comprehensive Cancer Center | Slow accrual | Enrollment / accrual |
| NCT01300858 | A Study of the Safety and Biological Activity of Intraperitoneal (IP) EGEN-001… | Phase 1 / Phase 2 | terminated | Feb 23, 2011 | EGEN, Inc. | Sites could not enroll patients. | Enrollment / accrual |
| NCT01009801 | Transarterial Chemoembolization With Doxorubicin With or Without Everolimus in Treating… | Phase 1 / Phase 2 | terminated | Nov 9, 2009 | Swiss Cancer Institute | due to slow patient recruitement. | Enrollment / accrual |
| NCT01030757 | Study of Stereotactic Body Radiation Therapy Using Tomotherapy for Metastatic Tumors to… | Phase 2 | terminated | Dec 11, 2009 | New Mexico Cancer Research Alliance | Low accrual rate | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 15, 2016source: clinicaltrials