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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00767936 | Viral & Host Factors Associated With Hepatitis B Virus-related Hepatocellular Carcinoma | — | terminated | Oct 7, 2008 | Stanford University | not stated | Not stated |
| NCT01473303 | Combination Chemotherapy With or Without Ganitumab in Treating Patients With Previously… | Phase 1 / Phase 2 | withdrawn | Nov 17, 2011 | Alliance for Clinical Trials in Oncology | CALGB 81003 closed about a week after it was activated because of withdrawal of support. No… | Other (stated, no rule matched) |
| NCT00800969 | Prospective Evaluation of the Preoperative Lymph Node Staging in Patients With Cancer of… | Phase 2 | withdrawn | Dec 3, 2008 | University of Zurich | not stated | Not stated |
| NCT01339000 | Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had… | Phase 2 | terminated | Apr 20, 2011 | National Cancer Institute (NCI) | Company supplying drug declared bankruptcy, thus there was no drug supply. | Drug supply |
| NCT00524186 | Sunitinib, Irinotecan, Fluorouracil, and Leucovorin In Treating Patients With Advanced… | Phase 1 | terminated | Sep 3, 2007 | Roswell Park Cancer Institute | PI left institute | Investigator |
| NCT00673322 | Trial of Second Generation Designer T Cells in Colorectal Carcinoma | Phase 1 | terminated | May 7, 2008 | Roger Williams Medical Center | This study will be incorporated into another study. | Other (stated, no rule matched) |
| NCT01980810 | First Line Chemotherapy for Advanced Cancer(GC-A-003) | Phase 2 | terminated | Nov 11, 2013 | Chinese Academy of Medical Sciences | recruit too slowly | Enrollment / accrual |
| NCT02202096 | A Pilot Randomized Trial of a Comprehensive Transitional Care Program for Colorectal… | N/A | withdrawn | Jul 28, 2014 | The University of Texas Health Science Center, Houston | Resources were not readily available to begin the study. | Other (stated, no rule matched) |
| NCT01094626 | Secretin-enhanced Magnetic Resonance Imaging (S-MRI) for Pancreatic Cancer Detection | N/A | withdrawn | Mar 29, 2010 | Elizabeth Hecht | Pharmaceutical company did not decide to renew contract | Sponsor / business decision |
| NCT01784081 | Integrating Palliative Care and Modern Palliative Care Tools Into the Care of Patients…(iPC3) | — | withdrawn | Feb 5, 2013 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | study was closed by PI due to no accrual | Enrollment / accrual |
| NCT02080416 | Nelfinavir for the Treatment of Gammaherpesvirus-Related Tumors | Early Phase 1 | terminated | Mar 6, 2014 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Very slow accrual; terminated to allow resources to be utilized more effectively on other studies.… | Enrollment / accrual |
| NCT01911416 | A Biomarker Study to Identify Predictive Signatures of Response to LDE225 (Hedgehog… | N/A | withdrawn | Jul 30, 2013 | University of Utah | No accrual | Enrollment / accrual |
| NCT01744639 | Analysis of Body Composition in Patients With Hepatocellular Carcinoma in Radioablation | N/A | withdrawn | Dec 7, 2012 | Instituto Nacional de Ciencias Medicas y Nutricion Salvador Zubiran | Unable to find patients | Other (stated, no rule matched) |
| NCT00216086 | Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in… | Phase 2 | terminated | Sep 22, 2005 | Gabi Chiorean, MD | Funding withdrawn | Funding |
| NCT01983371 | Diagnostic Accuracy of Ferumoxytol-Enhanced MRI for Detecting Lymph Node Metastases in… | N/A | withdrawn | Nov 14, 2013 | Scott Potenta, MD, PhD | not stated | Not stated |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT00766636 | Preoperative Chemotherapy (Gemcitabine and Erlotinib) With or Without Radiation Therapy | Phase 2 | terminated | Oct 6, 2008 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01843452 | Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine,… | Phase 2 | terminated | Apr 30, 2013 | Centre Hospitalier Universitaire Vaudois | Poor recruitment | Enrollment / accrual |
| NCT02689401 | MRI Iron Oxide Imaging for Lymph Node Staging in Esophageal Cancer | Phase 1 | withdrawn | Feb 24, 2016 | Dana-Farber Cancer Institute | Awaiting additional safety data | Safety / toxicity |
| NCT01233544 | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases(RAS01) | Phase 3 | terminated | Nov 3, 2010 | University of Aarhus | Insufficient recruitment | Enrollment / accrual |
| NCT01483638 | Axitinib as Maintenance Treatment in Patients With Metastatic CRC(TTD-11-01) | Phase 2 | terminated | Dec 1, 2011 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | The trial was prematurely closed due to lack of accrual | Enrollment / accrual |
| NCT00971126 | Study of Sorafenib With Combination of Thalidomide in Hepatocellular Carcinoma (HCC) | Phase 1 / Phase 2 | terminated | Sep 3, 2009 | National Health Research Institutes, Taiwan | Two patients in the first dose level be counted as reaching DLT. DSMB recommend terminated early… | Other (stated, no rule matched) |
| NCT01016028 | Chemotherapy-Induced Peripheral Neuropathy Survey | — | withdrawn | Nov 18, 2009 | M.D. Anderson Cancer Center | Study assessment tool development delayed. | Other (stated, no rule matched) |
| NCT01480817 | Sorafenib VS TACE in HCC Patients With Portal Vein Invasion | Phase 2 | terminated | Nov 29, 2011 | Seoul National University Hospital | Difficulty of participant enrollment. | Enrollment / accrual |
| NCT01857726 | Comparison of TACE Versus TACE/TACI Combination in Advanced Hepatocellular Carcinoma With… | N/A | withdrawn | May 20, 2013 | Seoul National University Hospital | No participants were enrolled | Enrollment / accrual |
| NCT01953406 | The Efficacy of 5-fluorouracil/Mitomycin for the Patients With Pulmonary Metastasis of… | Phase 2 | withdrawn | Oct 1, 2013 | Seoul National University Hospital | No participants were enrolled. Therefore, we stop this study, prematurely. | Enrollment / accrual |
| NCT02004210 | A Phase 3 Trial Comparing TACE and TARE in Unilobar Advanced Hepatocellular Carcinoma | Phase 3 | withdrawn | Dec 9, 2013 | Seoul National University Hospital | No participants were enrolled. | Enrollment / accrual |
| NCT01875549 | Comparison Between Unilateral Versus Bilateral Stenting for Malignant Hilar Biliary… | N/A | withdrawn | Jun 12, 2013 | Kwang Hyuck Lee | no enrollment | Enrollment / accrual |
| NCT01807156 | Phase II Trial of Tivozanib in Advanced Hepatocellular Cancer | Phase 2 | terminated | Mar 8, 2013 | Emory University | Primary endpoint not met | Other (stated, no rule matched) |
| NCT02598687 | Testing TH-302, in Combination With Preoperative Chemoradiotherapy, in Esophageal Cancer. | Phase 1 | withdrawn | Nov 6, 2015 | Maastricht Radiation Oncology | 2 Phase 3 trials didn't meet their primary endpoint, so further development and testing of TH-302… | Other (stated, no rule matched) |
| NCT00973193 | Preoperative Panitumumab and Radiotherapy in Rectal Cancer(PrePaRad) | Phase 2 | terminated | Sep 9, 2009 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | The intermediate analyses did not allowed to continue the clinical study. | Other (stated, no rule matched) |
| NCT00975039 | Study Using WST11 in Patients With Non-Resectable or Inoperable Cholangiocarcinoma | Phase 2 | terminated | Sep 11, 2009 | Steba Biotech S.A. | Early end of enrolment with regards to difficulty met to enrol patients . | Enrollment / accrual |
| NCT02317731 | Effect of Use of Straw on Tolerability and Quality of Split Dose 4l-PEG Preparation | N/A | terminated | Dec 16, 2014 | Yale University | PI relocated | Other (stated, no rule matched) |
| NCT01858662 | Study Comparing Pathological Responses Observed on Colorectal Cancer Metastases Resected… | Phase 2 | terminated | May 21, 2013 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | due to poor recrutment | Other (stated, no rule matched) |
| NCT01814631 | Endoscopic Ultrasound (EUS) Processor Comparison | — | withdrawn | Mar 20, 2013 | AdventHealth | Closed at PI discretion | Other (stated, no rule matched) |
| NCT02479178 | A Study of BIND-014 in Patients With Urothelial Carcinoma, Cholangiocarcinoma, Cervical…(iNSITE2) | Phase 2 | terminated | Jun 24, 2015 | BIND Therapeutics | not stated | Not stated |
| NCT02491372 | A Pilot Study of the Effectiveness of Acceptance and Commitment Therapy With a Post-Upper… | N/A | withdrawn | Jul 8, 2015 | Martin Dempster | Unable to recruit sufficient number of participants in the time available. | Enrollment / accrual |
| NCT02137343 | A Phase 3 Study of Rilotumumab (AMG 102) With Cisplatin and Capecitabine (CX) as…(RILOMET-2) | Phase 3 | terminated | May 13, 2014 | Amgen | All Amgen sponsored AMG102 clinical studies were terminated following a pre-planned Data Monitoring… | Safety / toxicity |
| NCT00865527 | Pilot Study of Colon Cancer Screening Tests | N/A | terminated | Mar 19, 2009 | Hamilton Health Sciences Corporation | Lack of ongoing funding | Funding |
| NCT02720926 | Study of TKI 258 in Combination With Xeloda and Oxaliplatin in Advanced Colorectal and… | Phase 1 | terminated | Mar 28, 2016 | National Cancer Centre, Singapore | Unafavourable toxicity profile | Safety / toxicity |
| NCT01962909 | Phase 0 Biodistribution of Novel Imaging for Resectable Pancreatic Cancer | Early Phase 1 | terminated | Oct 14, 2013 | University of Virginia | From preliminary imaging data, the study was stopped due to futility. | Efficacy / futility |
| NCT02323776 | Defining the Radiotherapy Dose and Volume Parameters Affecting Postoperative… | — | terminated | Dec 23, 2014 | Maastricht Radiation Oncology | not stated | Not stated |
| NCT00131586 | Cisplatin, Carboplatin, and Oxaliplatin Interactions With Plasma Proteins | — | terminated | Aug 19, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT01157039 | A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis… | Phase 2 | withdrawn | Jul 5, 2010 | AHS Cancer Control Alberta | abandoned | Other (stated, no rule matched) |
| NCT00414843 | Storage of Bile From Routine Procedures to Study Risk Factors | — | terminated | Dec 22, 2006 | Indiana University | Decreasing interest in using samples; department infrastructure waned | Other (stated, no rule matched) |
| NCT00582400 | A Phase II Protocol of Arsenic Trioxide (Trisenox) in Subjects With Advanced Primary… | Phase 2 | terminated | Dec 28, 2007 | The University of Texas Medical Branch, Galveston | recruiting or enrolling participants has halted prematurely and will not resume; participants are… | Enrollment / accrual |
| NCT00130936 | Study of Epirubicin (Pharmorubicin®), Carboplatin (Paraplatin®) and Capecitabine… | Phase 1 / Phase 2 | terminated | Aug 17, 2005 | AHS Cancer Control Alberta | not stated | Not stated |
| NCT00532441 | Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract… | Phase 2 | terminated | Sep 20, 2007 | Gabi Chiorean, MD | Terminated due to funding issues. | Funding |
| NCT01697072 | First-Line Treatment for Locally Advanced or Metastatic Mesenchymal Epithelial Transition…(RILOMET-1) | Phase 3 | terminated | Oct 2, 2012 | Amgen | All Amgen sponsored AMG102 clinical studies were terminated following a pre-planned Data Monitoring… | Safety / toxicity |
| NCT00580021 | Clinical Outcomes in Hereditary Cancer | — | withdrawn | Dec 24, 2007 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 29, 2016source: clinicaltrials