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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02843750 | Study of Inspiratory Muscle Training for Patients Undergoing Esophageal Surgery | N/A | withdrawn | Jul 26, 2016 | Mayo Clinic | Difficulty recruiting patients | Enrollment / accrual |
| NCT02560740 | A Study of the Efficacy and Safety of PerOx Quench on the Prevention of Oxaliplatin… | N/A | terminated | Sep 25, 2015 | SMR Biotech Co., Ltd. | Subjects' not-well compliance due to diarrhea and softening stool after taking PerOx Quench 4… | Other (stated, no rule matched) |
| NCT02573220 | Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating… | Phase 1 | withdrawn | Oct 9, 2015 | University of Chicago | Study terminated by PI due to inability to accrue. | Enrollment / accrual |
| NCT01522677 | A Study of Neoadjuvant Photodynamic Immunomodulation for Colon Cancer | Phase 1 / Phase 2 | withdrawn | Jan 31, 2012 | Edward Nelson | Slow accrual | Enrollment / accrual |
| NCT01450696 | A Study of Herceptin (Trastuzumab) in Combination With Cisplatin/Capecitabine…(HELOISE) | Phase 3 | terminated | Oct 12, 2011 | Hoffmann-La Roche | futility following planned interim analysis | Efficacy / futility |
| NCT01342653 | Clinical Trial at Neoadjuvant Peritoneal and Systemic Chemotherapy Plus HIPEC in Gastric…(HIPEC) | Phase 2 | suspended | Apr 27, 2011 | Hospital General Universitario Gregorio Marañon | unable to reach planned recruitment | Enrollment / accrual |
| NCT02045030 | Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With… | Phase 2 | terminated | Jan 24, 2014 | CR-CSSS Champlain-Charles-Le Moyne | Drug (Aflibercept) no longuer available for the study | Other (stated, no rule matched) |
| NCT01335074 | Temsirolimus + Sorafenib in Advanced Hepatocellular Carcinoma (HCC) | Phase 1 / Phase 2 | withdrawn | Apr 13, 2011 | Philipps University Marburg | not stated | Not stated |
| NCT01260194 | A Study of Herceptin (Trastuzumab) in Combination With Standard Chemotherapy in Patients… | Phase 4 | terminated | Dec 15, 2010 | Hoffmann-La Roche | not stated | Not stated |
| NCT01276405 | An Observational Study of Xeloda (Capecitabine) Monotherapy in Patients With Colorectal… | — | terminated | Jan 13, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT01338558 | A Study of Avastin (Bevacizumab) in Combination With mFOLFOX6 in Treatment-Naïve Patients… | Phase 3 | withdrawn | Apr 19, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT00427973 | AZD2171 in Treating Patients With Locally Advanced Unresectable or Metastatic Liver Cancer | Phase 2 | terminated | Jan 29, 2007 | National Cancer Institute (NCI) | The study was stopped prior to 2nd stage. | Other (stated, no rule matched) |
| NCT01060423 | TACE With Irinotecan Drug-eluting Beads and Intravenous (IV) Cetuximab in Refractory…(DEBIRITUX) | Phase 2 | terminated | Feb 2, 2010 | Hans-Joachim Schmoll, MD | Terminated due to poor subject enrolment | Enrollment / accrual |
| NCT01085331 | MEK Inhibitor MSC1936369B Plus FOLFIRI in Second Line K-Ras Mutated Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Mar 11, 2010 | EMD Serono | Conduct the randomized Phase 2 part not recommended due to the achieved MTD for pimasertib… | Other (stated, no rule matched) |
| NCT00952016 | Methotrexate in Metastatic Colorectal Cancer With MSH2 Deficiency(MESH) | Phase 2 | terminated | Aug 4, 2009 | Royal Marsden NHS Foundation Trust | Lack of recruitment - only 2 patients recruited. | Enrollment / accrual |
| NCT01050426 | A Clinical Study of UFT/Leucovorin, Radiotherapy With or Without Cetuximab Following…(PERU) | Phase 2 | terminated | Jan 15, 2010 | Royal Marsden NHS Foundation Trust | Data from other trials failed to demonstrate meaningful survival advantage | Other (stated, no rule matched) |
| NCT01123473 | Epirubicin Hydrochloride, Cisplatin, and Fluorouracil or Capecitabine With or Without… | Phase 2 | terminated | May 14, 2010 | European Organisation for Research and Treatment of Cancer - EORTC | company withdrew interest | Sponsor / business decision |
| NCT02287727 | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have… | Phase 2 | withdrawn | Nov 11, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT02266849 | Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded… | Phase 3 | terminated | Oct 17, 2014 | Odense University Hospital | Insuficcient recruiting | Enrollment / accrual |
| NCT02851381 | Compassionate Single Subject Use of FG-3019 (FibroGen) in Locally Advanced, Unresectable… | N/A | withdrawn | Aug 1, 2016 | Jonsson Comprehensive Cancer Center | The patient passed before treatment could be started | Other (stated, no rule matched) |
| NCT00726037 | A Pilot Study, Evaluating the Efficacy of Regulatory T-cell Suppression by Ontak in… | Phase 2 | terminated | Jul 31, 2008 | Loyola University | Collaborator withdrew support due to a drug supply interruption. | Drug supply |
| NCT01188109 | Gemcitabine/Cisplatin for Resected Pancreas Cancer: Establishing the Role of ERCC1 in… | Phase 2 | terminated | Aug 25, 2010 | Emory University | Slow accrual | Enrollment / accrual |
| NCT01815463 | Non-Invasive Prediction of Colorectal Neoplasia(NIPCON) | — | terminated | Mar 21, 2013 | Corporal Michael J. Crescenz VA Medical Center | Local PI did not submit annual renewal, still active in Detroit, not recruiting. | Enrollment / accrual |
| NCT01829971 | A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | Phase 1 | terminated | Apr 11, 2013 | Mirna Therapeutics, Inc. | Five immune related serious adverse events | Safety / toxicity |
| NCT00336700 | A Phase II Study of Gemcitabine and Erlotinib As Adjuvant Therapy In Patients With… | Phase 2 | terminated | Jun 14, 2006 | Herbert J. Zeh, III MD, FACS | Study published November 2010 and no further work will be done | Other (stated, no rule matched) |
| NCT00684229 | Regional Anesthesia in Colon Rectal Surgery | N/A | withdrawn | May 26, 2008 | The Cleveland Clinic | investigator could not identify any patients | Investigator |
| NCT01104116 | Use of PET Imaging to Distinguish Malignant From Benign IPMN | N/A | terminated | Apr 15, 2010 | Columbia University | Poor enrollment; PI left the institution | Investigator |
| NCT01277120 | An Observational Study on The Correlation Between Time of Initiation of Avastin… | — | terminated | Jan 14, 2011 | Hoffmann-La Roche | Contract terminated with Site Management Organization | Other (stated, no rule matched) |
| NCT01964235 | Study of Efficacy and Safety INC280 in Patients With Advanced Hepatocellular Carcinoma | Phase 2 | withdrawn | Oct 17, 2013 | Novartis Pharmaceuticals | Study was cancelled by Sponsor. | Other (stated, no rule matched) |
| NCT00642733 | A Study of First Line Treatment With Tarceva (Erlotinib) in Combination With Gemcitabine… | Phase 4 | terminated | Mar 25, 2008 | Hoffmann-La Roche | poor recruitment | Enrollment / accrual |
| NCT01946061 | A Phase II Trial of Adjuvant Chemotherapy With S-1 Plus Oxaliplatin for Locally Advanced… | Phase 2 | terminated | Sep 19, 2013 | Yonsei University | This study was stopped because of difficulties of supplying the drug. | Other (stated, no rule matched) |
| NCT01969292 | Colometer - A Real Time Quality Improvement Feedback System for Screening Colonoscopy | N/A | terminated | Oct 25, 2013 | Christopher Andrews | Stage 1 Complete; Stage 2 and 3 not pursued | Other (stated, no rule matched) |
| NCT01457976 | A Survey on Attitudes on Financial Incentives | — | withdrawn | Oct 24, 2011 | University of Pennsylvania | protocol never approved by local IRB | Other (stated, no rule matched) |
| NCT01937715 | A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic… | Phase 1 / Phase 2 | terminated | Sep 9, 2013 | Pfizer | B2151007 was prematurely discontinued due to Pfizer's change in prioritization for the portfolio… | Safety / toxicity |
| NCT00837135 | GI-4000 With Adoptive Transfer in Pancreatic Cancer | Phase 1 | withdrawn | Feb 5, 2009 | University of Pennsylvania | Withdrawn due to transfer of Investigator | Investigator |
| NCT01322815 | A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI | Phase 2 | terminated | Mar 25, 2011 | Georgetown University | Poor accrual rate | Enrollment / accrual |
| NCT02281279 | Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory… | Phase 1 / Phase 2 | withdrawn | Nov 3, 2014 | Mayo Clinic | not stated | Not stated |
| NCT01151761 | Phase II SBRT & Chemo for Unresectable Cholangiocarcinoma Followed by Liver… | Phase 2 | terminated | Jun 28, 2010 | Stanford University | Poor accrual | Enrollment / accrual |
| NCT01020812 | Combination SBRT With TACE for Unresectable Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Nov 26, 2009 | Stanford University | enrollment was too low | Enrollment / accrual |
| NCT01137162 | Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors | — | terminated | Jun 4, 2010 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT01320683 | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal… | Phase 2 | terminated | Mar 22, 2011 | City of Hope Medical Center | Slow accrual. | Enrollment / accrual |
| NCT01888965 | Maintenance Dovitinib for Colorectal and Pancreas Cancer | Phase 2 | terminated | Jun 28, 2013 | Georgetown University | Adverse Event issues. | Safety / toxicity |
| NCT02112240 | Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients | N/A | withdrawn | Apr 11, 2014 | University of Virginia | No accrual. New study opening with modified technique. | Enrollment / accrual |
| NCT01652014 | Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With… | Phase 2 | withdrawn | Jul 27, 2012 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT00767234 | Permission to Collect Blood Over Time for Research | — | terminated | Oct 7, 2008 | Stanford University | Accrual issues - Low Accrual | Enrollment / accrual |
| NCT00003381 | Quality of Life Assessment of Patients Receiving Treatment for Esophageal Cancer… | — | terminated | Jun 16, 2004 | Alliance for Clinical Trials in Oncology | companion study to CALGB-9781 which closed administratively due to poor accrual | Enrollment / accrual |
| NCT00268437 | Radiation Therapy, Pemetrexed Disodium, and Carboplatin in Treating Patients With Locally… | Phase 2 | terminated | Dec 22, 2005 | Alliance for Clinical Trials in Oncology | Trial closed early because, during an interim analysis, the primary endpoint fell short. | Efficacy / futility |
| NCT00571740 | Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and… | Phase 2 | withdrawn | Dec 12, 2007 | Alliance for Clinical Trials in Oncology | The study was not activated | Other (stated, no rule matched) |
| NCT01326364 | Prognostic Value of Baseline Computed Tomography (CT) Perfusion Parameters of Pancreatic… | — | terminated | Mar 30, 2011 | Stanford University | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 15, 2016source: clinicaltrials