Loading clinical trials…
Loading clinical trials…
Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
2,226 stopped studies mapped to Malignant Digestive System Neoplasm and descendants · 91% state a reason
Over the 2,226 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT05310565 | The Effects of Chiropractic in Adults With Colon Cancer(CCX) | N/A | withdrawn | Apr 5, 2022 | Life University | Low recruitment rate | Enrollment / accrual |
| NCT05687617 | Near-infrared Imaging With Indocyanine Green for Detection of Peritoneal Metastases for… | Phase 2 | terminated | Jan 18, 2023 | Laval University | Recruitment lower than expected and negative results. | Enrollment / accrual |
| NCT06341725 | EUS Role in Non-metastatic Pancreatic Adenocarcinoma Lymph Nodes Staging | — | terminated | Apr 2, 2024 | Paolo Giorgio Arcidiacono, MD | no patients with inclusion criteria | Other (stated, no rule matched) |
| NCT03958669 | Fingerprint Characterization Tyrosine Kinase Inhibitors in Advanced HCC(e:Med-HCC-2) | — | terminated | May 22, 2019 | University Hospital Tuebingen | Slow recruitment due to COVID-19 pandemic and several newly approved treatment options | COVID-19 / pandemic |
| NCT01904968 | Impact of Methylation Alterations in Colon Cancer: Epidemiology and Prognosis | — | withdrawn | Jul 22, 2013 | Centre Hospitalier Universitaire Dijon | not stated | Not stated |
| NCT04300114 | A Study of Maintenance Treatment With Fluzoparib in gBRCA/PALB2 Mutated Pancreatic Cancer… | Phase 3 | terminated | Mar 9, 2020 | Jiangsu HengRui Medicine Co., Ltd. | Sponsor R \& D Strategy Adjustment | Sponsor / business decision |
| NCT03377660 | Resection of the Esophagus and Subsequent Weight Loss(REWARD) | — | terminated | Dec 19, 2017 | Imperial College London | Funding stopped. | Funding |
| NCT03108885 | Measuring Cell Free DNA During the Course of Treatment for Esophageal Cancer as a Marker… | — | terminated | Apr 11, 2017 | Mayo Clinic | Study's Principal Investigator no longer at the institution. | Investigator |
| NCT03733197 | #CuttingCRC: Barbershop-Based Trial & Colorectal Cancer | N/A | withdrawn | Nov 7, 2018 | Medical College of Wisconsin | PI no longer employed at institutuion | Other (stated, no rule matched) |
| NCT04682431 | A Phase 1a/1b FIH Study of PY159 and in Combination With Pembrolizumab in Subjects With… | Phase 1 | terminated | Dec 23, 2020 | Ikena Oncology | Sponsor business decision. | Sponsor / business decision |
| NCT04691375 | A Study of PY314 in Subjects With Advanced Solid Tumors | Phase 1 | terminated | Dec 31, 2020 | Ikena Oncology | Sponsor business decision. | Sponsor / business decision |
| NCT06317272 | BReath Hold TecHniquEs for Radiotherapy of Esophageal Carcinoma(BROTHER) | N/A | terminated | Mar 19, 2024 | University Medical Center Groningen | Poor inclusion | Other (stated, no rule matched) |
| NCT02293811 | Decoding of the Expression of Tumor Suppressor P2RX7 in Inflammatory and Malignant…(P2RX7) | N/A | terminated | Nov 18, 2014 | Centre Hospitalier Universitaire de Nice | the tissue mass of each biopsy sample was not sufficient to perform an exploratory analysis to… | Other (stated, no rule matched) |
| NCT03724435 | Focused Ultrasound for the Treatment of Pancreatic Cancer - an International Registry(ARRAY) | — | terminated | Oct 30, 2018 | Focused Ultrasound Foundation | Competing trial will publish similar results | Other (stated, no rule matched) |
| NCT03519308 | A Pilot Study of Perioperative Nivolumab and Paricalcitol to Target the Microenvironment… | Early Phase 1 | terminated | May 8, 2018 | Abramson Cancer Center at Penn Medicine | The accrual goal could not be met and the drug manufacturer pulled support | Drug supply |
| NCT04172597 | A Study of Poziotinib in Patients With Epidermal Growth Factor Receptor (EGFR) or Human… | Phase 2 | terminated | Nov 21, 2019 | Spectrum Pharmaceuticals, Inc | Strategic business decision (unrelated to safety) | Safety / toxicity |
| NCT04276909 | Feasibility Study of LUM Imaging System for Pancreatic Cancer | N/A | withdrawn | Feb 19, 2020 | Lumicell, Inc. | Study not initiated. | Other (stated, no rule matched) |
| NCT02762266 | Transarterial Chemoembolization Compared With Stereotactic Body Radiation Therapy or… | Phase 3 | terminated | May 4, 2016 | Stanford University | Business decision - funding | Funding |
| NCT04718402 | A Study of Mitoxantrone Hydrochloride Liposome Injection in the Treatment of Advanced… | Phase 1 | terminated | Jan 22, 2021 | CSPC ZhongQi Pharmaceutical Technology Co., Ltd. | The sponsor has adjusted its R\&D strategy. | Sponsor / business decision |
| NCT05101616 | A Pilot Study of Neoadjuvant Chemotherapy With or Without Camrelizumab for Locally… | Phase 1 / Phase 2 | suspended | Nov 1, 2021 | Shanghai Minimally Invasive Surgery Center | difficult in enrolling participants | Enrollment / accrual |
| NCT03878524 | Serial Measurements of Molecular and Architectural Responses to Therapy (SMMART) PRIME… | Phase 1 | terminated | Mar 18, 2019 | OHSU Knight Cancer Institute | Low accrual | Enrollment / accrual |
| NCT05703555 | INTRUSION: Unraveling the INTRatUmoral PK/PD relatION for SAR408701(INTRUSION) | Phase 2 | withdrawn | Jan 30, 2023 | Erasmus Medical Center | Due to the decision to discontinue the global clinical development program of tusamitamab ravtansine | Other (stated, no rule matched) |
| NCT04518449 | Medial Border of Laparoscopic D3 Lymphadenectomy for Right Colon Cancer | — | withdrawn | Aug 19, 2020 | Shanghai Minimally Invasive Surgery Center | no funds | Funding |
| NCT05292443 | Therapeutic ResistAnce and Clonal Evolution Assessed With Liquid Biopsy in ICIs Treated… | — | withdrawn | Mar 23, 2022 | Geneplus-Beijing Co. Ltd. | No participants were enrolled | Enrollment / accrual |
| NCT03812562 | Nivolumab and Yttrium-90 in Treating Patients With Liver Cancer Undergoing Surgical… | Early Phase 1 | terminated | Jan 23, 2019 | Northwestern University | Lack of funding | Funding |
| NCT04274790 | Impact of 5-Fluorouracil (5-FU) on Cancer Cells From Liver Metastases of Colon Cancer(FLUORIB) | — | withdrawn | Feb 18, 2020 | Centre Leon Berard | Lack of funding | Funding |
| NCT04812743 | Colorectal Health Research Champions | N/A | terminated | Mar 24, 2021 | Virginia Commonwealth University | End of grant funding | Funding |
| NCT05233007 | Upper GI Serial Tumour Biopsies | — | suspended | Feb 10, 2022 | The Christie NHS Foundation Trust | To explore alternative funding streams | Funding |
| NCT00322712 | INST 0603C Patients With Unresectable/Metastatic Pancreatic Cancer Treated in the UNM… | — | terminated | May 8, 2006 | University of New Mexico | This is only a chart review. This is not a clinical trial and was inadvertently entered in the… | Other (stated, no rule matched) |
| NCT03376659 | Durvalumab Plus CV301 With Maintenance Chemotherapy in Metastatic Colorectal or… | Phase 1 / Phase 2 | terminated | Dec 18, 2017 | Georgetown University | Study closed due to lack of enrollment. | Enrollment / accrual |
| NCT01913275 | Comparison Between Endoscopic Stenting and Cholecystojejunostomy for PreoperativeDrainage… | N/A | withdrawn | Aug 1, 2013 | All India Institute of Medical Sciences | Lack of interest | Other (stated, no rule matched) |
| NCT01605318 | Study of Labetuzumab Govitecan in Participants With Metastatic Colorectal Cancer | Phase 1 / Phase 2 | terminated | May 24, 2012 | Gilead Sciences | not stated | Not stated |
| NCT01769222 | Ipilimumab and Local Radiation for Selected Solid Tumors | Phase 1 | terminated | Jan 16, 2013 | Stanford University | Planned Future Study | Other (stated, no rule matched) |
| NCT04025216 | A Study of CART-TnMUC1 in Patients With TnMUC1-Positive Advanced Cancers | Phase 1 | terminated | Jul 18, 2019 | Kite, A Gilead Company | The sponsor finds the risk/benefit analysis unfavorable and has terminated the study. | Other (stated, no rule matched) |
| NCT05238831 | SMMART Adaptive Clinical Treatment (ACT) Trial | Early Phase 1 | withdrawn | Feb 14, 2022 | OHSU Knight Cancer Institute | Withdrawn due to a change in therapeutic interventions. | Other (stated, no rule matched) |
| NCT03500874 | Adjuvant Systemic Chemotherapy With or Without HAI-FUDR in Patients With Resected CRLM | Phase 3 | terminated | Apr 18, 2018 | Sun Yat-sen University | The study was terminated prematurely due to FUDR production halt in China | Other (stated, no rule matched) |
| NCT02722616 | Ultrasound Monitoring of Abdominal Soft Tissue | N/A | terminated | Mar 30, 2016 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Ultrasound vendor cannot support the study | Other (stated, no rule matched) |
| NCT03397342 | MRI Only Radiation Therapy With CPAP | N/A | terminated | Jan 12, 2018 | Albert Einstein College of Medicine | Study terminated prematurely well short of enrollment target. Only 5 health participants were… | Enrollment / accrual |
| NCT03291899 | Trial of Infusional FOLFIRINOX in First Line Treatment of Advanced Biliary Tract Cancers(FBI-TRAC) | Phase 2 | terminated | Sep 25, 2017 | King Faisal Specialist Hospital & Research Center | poor accrual | Enrollment / accrual |
| NCT03422679 | Study of CB-103 in Adult Patients With Advanced or Metastatic Solid Tumours and… | Phase 1 / Phase 2 | terminated | Feb 6, 2018 | Cellestia Biotech AG | business reason | Sponsor / business decision |
| NCT00320918 | Chart Review: Unresectable/Metastatic Cholangiocarcinoma Treated With Irinotecan,… | — | terminated | May 3, 2006 | University of New Mexico | This was a Chart Review only and was entered in the system in error. | Other (stated, no rule matched) |
| NCT04589884 | Intraoperative EXamination Using MAChine-learning-based HYperspectral for diagNosis &…(iEXMachyna3) | — | terminated | Oct 19, 2020 | IHU Strasbourg | Data acquisition not possible anymore | Other (stated, no rule matched) |
| NCT03806244 | Feasibility of Stereotactic Navigation in Laparoscopic Surgery for Colorectal Cancer(PELVINAV) | N/A | terminated | Jan 16, 2019 | IHU Strasbourg | Departure of the two main investigators | Other (stated, no rule matched) |
| NCT03753789 | Ablation Confirmation Study | N/A | terminated | Nov 27, 2018 | Ethicon, Inc. | Combined study endpoints with ongoing registry (NOLA/NEU\_2017\_04) | Other (stated, no rule matched) |
| NCT04046887 | Study of Lonsurf in Combination With Gemcitabine and Nab-Paclitaxel in Patients With… | Phase 1 | terminated | Aug 6, 2019 | Patrick Joseph Loehrer Sr. | Unable to proceed due to Neulasta difficulties and other complications. | Other (stated, no rule matched) |
| NCT04379830 | Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients | N/A | withdrawn | May 8, 2020 | McMaster University | There were no patients recruited during the trial period. This was a result of: 1) COVID-19… | COVID-19 / pandemic |
| NCT04592861 | Carbon Ion RT for Locally Advanced Pancreatic Cancer | Phase 3 | terminated | Oct 19, 2020 | Albert Einstein College of Medicine | Study administratively closed out by the Einstein IRB. NO US enrolling sites. | Enrollment / accrual |
| NCT03135652 | Consolidative Radiotherapy for Colorectal Cancer Liver Metastases Receiving Surgery or… | Phase 2 | withdrawn | May 1, 2017 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT03193814 | Safety and Efficacy Study of Chemotherapy Plus Apatinib as Second-line Therapy in…(XHZL) | Phase 2 | withdrawn | Jun 21, 2017 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT04558684 | Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer | Phase 1 / Phase 2 | suspended | Sep 22, 2020 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 3, 2024source: clinicaltrials