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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
820 stopped studies mapped to Malignant Colorectal Neoplasm and descendants · 90% state a reason
Over the 820 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00127036 | Trial for Microarray Analysis of Colon Cancer Outcome-A (MACCO-A) | Phase 2 | terminated | Aug 5, 2005 | H. Lee Moffitt Cancer Center and Research Institute | drug now on market | Other (stated, no rule matched) |
| NCT02301338 | Improving Health of Patients With Colon Cancer Following Surgery: A Trial of SA-ICAN Via… | — | terminated | Nov 25, 2014 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01032590 | Internet-Based Weight-Loss Program for Colorectal Cancer Survivors | N/A | withdrawn | Dec 15, 2009 | Rutgers, The State University of New Jersey | Trial was only opened at RCINJ for analysis of data, no patient enrollment took place here. | Enrollment / accrual |
| NCT00361244 | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage… | Phase 1 / Phase 2 | terminated | Aug 8, 2006 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT02423174 | Eval. of Safety and Effectiveness of the FMwand Ferromagnetic Surgical System During… | — | withdrawn | Apr 22, 2015 | Domain Surgical, Inc. | Funding | Funding |
| NCT00276861 | Gemcitabine and Oxaliplatin as Second-Line Therapy in Treating Patients With Metastatic… | Phase 2 | terminated | Jan 13, 2006 | University of Miami | Low Accrual | Enrollment / accrual |
| NCT01801085 | Nursing and Pharmacy Time for Delivering Xeloda® Versus 5-Fluoruracil Regimens | — | terminated | Feb 28, 2013 | Vivian Wing Yan Lee | Slow recruitment pace | Enrollment / accrual |
| NCT02965417 | Sym004 in Metastatic Colorectal Cancer and ECD-EGFR Patients | Phase 2 | withdrawn | Nov 16, 2016 | Symphogen A/S | Symphogen made a business decision to no longer perform the clinical study. | Sponsor / business decision |
| NCT01163526 | Perfusion CT as a Predictor of Treatment Response in Patients With Hepatic Malignancies | — | terminated | Jul 15, 2010 | Stanford University | accrual | Enrollment / accrual |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | Phase 2 | withdrawn | Jan 27, 2014 | Weill Medical College of Cornell University | Investigator terminated due to funding issues | Investigator |
| NCT01718808 | Cetuximab for Elderly Patients With mCRC | Phase 2 | terminated | Oct 31, 2012 | Swiss Cancer Institute | FU for 3 years from randomization as initially planned is stopped as we do not expect any changes… | Other (stated, no rule matched) |
| NCT02586610 | Trial of Chemoradiation and Pembrolizumab in Patients With Rectal Cancer | Phase 2 | withdrawn | Oct 26, 2015 | Osama Rahma, MD | Dr. Rahma decided to run the study through a different group | Other (stated, no rule matched) |
| NCT00072098 | Interleukin-12 Gene in Treating Patients With Liver Metastases Secondary to Colorectal… | Phase 1 | terminated | Nov 6, 2003 | Max Sung | limited funding | Funding |
| NCT02785068 | Evaluation of MM-151 + Nal-IRI + 5-FU + Leucovorin in RAS/RAF Wild-type Metastatic… | Phase 1 / Phase 2 | withdrawn | May 27, 2016 | Merrimack Pharmaceuticals | not stated | Not stated |
| NCT00537823 | Pre- and Post-operative FOLFOX Based Therapy for Patients With Colorectal Cancer With… | Phase 2 | terminated | Oct 1, 2007 | Washington University School of Medicine | Poor accrual. | Enrollment / accrual |
| NCT02511756 | Visualization of Anti-angiogenic Effects With Perfusion Computed Tomography (CTP)(AVA-CTP) | N/A | terminated | Jul 30, 2015 | Patrick Veit-Haibach | Slow accrual | Enrollment / accrual |
| NCT00081224 | Neoadjuvant Celecoxib and Capecitabine Combined With Pelvic Irradiation in Treating… | Phase 2 | terminated | Apr 8, 2004 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT02560740 | A Study of the Efficacy and Safety of PerOx Quench on the Prevention of Oxaliplatin… | N/A | terminated | Sep 25, 2015 | SMR Biotech Co., Ltd. | Subjects' not-well compliance due to diarrhea and softening stool after taking PerOx Quench 4… | Other (stated, no rule matched) |
| NCT02573220 | Irinotecan Hydrochloride With FOLFIRI and Cetuximab as First-Line Therapy in Treating… | Phase 1 | withdrawn | Oct 9, 2015 | University of Chicago | Study terminated by PI due to inability to accrue. | Enrollment / accrual |
| NCT01522677 | A Study of Neoadjuvant Photodynamic Immunomodulation for Colon Cancer | Phase 1 / Phase 2 | withdrawn | Jan 31, 2012 | Edward Nelson | Slow accrual | Enrollment / accrual |
| NCT02045030 | Study to Identify Biomarkers of Clinical Response to Aflibercept in Patients With… | Phase 2 | terminated | Jan 24, 2014 | CR-CSSS Champlain-Charles-Le Moyne | Drug (Aflibercept) no longuer available for the study | Other (stated, no rule matched) |
| NCT01276405 | An Observational Study of Xeloda (Capecitabine) Monotherapy in Patients With Colorectal… | — | terminated | Jan 13, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT01338558 | A Study of Avastin (Bevacizumab) in Combination With mFOLFOX6 in Treatment-Naïve Patients… | Phase 3 | withdrawn | Apr 19, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT01060423 | TACE With Irinotecan Drug-eluting Beads and Intravenous (IV) Cetuximab in Refractory…(DEBIRITUX) | Phase 2 | terminated | Feb 2, 2010 | Hans-Joachim Schmoll, MD | Terminated due to poor subject enrolment | Enrollment / accrual |
| NCT01085331 | MEK Inhibitor MSC1936369B Plus FOLFIRI in Second Line K-Ras Mutated Metastatic Colorectal… | Phase 1 / Phase 2 | terminated | Mar 11, 2010 | EMD Serono | Conduct the randomized Phase 2 part not recommended due to the achieved MTD for pimasertib… | Other (stated, no rule matched) |
| NCT00952016 | Methotrexate in Metastatic Colorectal Cancer With MSH2 Deficiency(MESH) | Phase 2 | terminated | Aug 4, 2009 | Royal Marsden NHS Foundation Trust | Lack of recruitment - only 2 patients recruited. | Enrollment / accrual |
| NCT02287727 | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have… | Phase 2 | withdrawn | Nov 11, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT02266849 | Loperamide vs. Placebo's Effect on Ileostomy Output: A Clinical Randomized Blinded… | Phase 3 | terminated | Oct 17, 2014 | Odense University Hospital | Insuficcient recruiting | Enrollment / accrual |
| NCT01815463 | Non-Invasive Prediction of Colorectal Neoplasia(NIPCON) | — | terminated | Mar 21, 2013 | Corporal Michael J. Crescenz VA Medical Center | Local PI did not submit annual renewal, still active in Detroit, not recruiting. | Enrollment / accrual |
| NCT00684229 | Regional Anesthesia in Colon Rectal Surgery | N/A | withdrawn | May 26, 2008 | The Cleveland Clinic | investigator could not identify any patients | Investigator |
| NCT01277120 | An Observational Study on The Correlation Between Time of Initiation of Avastin… | — | terminated | Jan 14, 2011 | Hoffmann-La Roche | Contract terminated with Site Management Organization | Other (stated, no rule matched) |
| NCT01969292 | Colometer - A Real Time Quality Improvement Feedback System for Screening Colonoscopy | N/A | terminated | Oct 25, 2013 | Christopher Andrews | Stage 1 Complete; Stage 2 and 3 not pursued | Other (stated, no rule matched) |
| NCT01457976 | A Survey on Attitudes on Financial Incentives | — | withdrawn | Oct 24, 2011 | University of Pennsylvania | protocol never approved by local IRB | Other (stated, no rule matched) |
| NCT01937715 | A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic… | Phase 1 / Phase 2 | terminated | Sep 9, 2013 | Pfizer | B2151007 was prematurely discontinued due to Pfizer's change in prioritization for the portfolio… | Safety / toxicity |
| NCT01322815 | A Pilot Trial of GI-4000 Plus Bevacizumab and Either FOLFOX or FOLFIRI | Phase 2 | terminated | Mar 25, 2011 | Georgetown University | Poor accrual rate | Enrollment / accrual |
| NCT01137162 | Clinical and Pathologic Studies of Patients Undergoing Treatment With EGFR Inhibitors | — | terminated | Jun 4, 2010 | Stanford University | Low Accrual | Enrollment / accrual |
| NCT01320683 | Combination Chemotherapy and Bevacizumab Before Surgery and Radiolabeled Monoclonal… | Phase 2 | terminated | Mar 22, 2011 | City of Hope Medical Center | Slow accrual. | Enrollment / accrual |
| NCT01888965 | Maintenance Dovitinib for Colorectal and Pancreas Cancer | Phase 2 | terminated | Jun 28, 2013 | Georgetown University | Adverse Event issues. | Safety / toxicity |
| NCT02112240 | Feasibility Study to Develop Sentinel Lymph Node Mapping in Rectal Cancer Patients | N/A | withdrawn | Apr 11, 2014 | University of Virginia | No accrual. New study opening with modified technique. | Enrollment / accrual |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT00571740 | Cetuximab and Bevacizumab as First-Line Therapy Followed By Combination Chemotherapy and… | Phase 2 | withdrawn | Dec 12, 2007 | Alliance for Clinical Trials in Oncology | The study was not activated | Other (stated, no rule matched) |
| NCT01339000 | Improving the Immune System With Human IL-7 Vaccine in Older Subjects Who Have Had… | Phase 2 | terminated | Apr 20, 2011 | National Cancer Institute (NCI) | Company supplying drug declared bankruptcy, thus there was no drug supply. | Drug supply |
| NCT00673322 | Trial of Second Generation Designer T Cells in Colorectal Carcinoma | Phase 1 | terminated | May 7, 2008 | Roger Williams Medical Center | This study will be incorporated into another study. | Other (stated, no rule matched) |
| NCT02202096 | A Pilot Randomized Trial of a Comprehensive Transitional Care Program for Colorectal… | N/A | withdrawn | Jul 28, 2014 | The University of Texas Health Science Center, Houston | Resources were not readily available to begin the study. | Other (stated, no rule matched) |
| NCT00216086 | Capecitabine + Irinotecan Followed by Combined Modality Capecitabine and Radiation in… | Phase 2 | terminated | Sep 22, 2005 | Gabi Chiorean, MD | Funding withdrawn | Funding |
| NCT01983371 | Diagnostic Accuracy of Ferumoxytol-Enhanced MRI for Detecting Lymph Node Metastases in… | N/A | withdrawn | Nov 14, 2013 | Scott Potenta, MD, PhD | not stated | Not stated |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT01233544 | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases(RAS01) | Phase 3 | terminated | Nov 3, 2010 | University of Aarhus | Insufficient recruitment | Enrollment / accrual |
| NCT01483638 | Axitinib as Maintenance Treatment in Patients With Metastatic CRC(TTD-11-01) | Phase 2 | terminated | Dec 1, 2011 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | The trial was prematurely closed due to lack of accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 4, 2017source: clinicaltrials