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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
464 stopped studies mapped to Malignant Central Nervous System Neoplasm and descendants · 90% state a reason
Over the 464 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01100658 | Effects of Methylphenidate on Attention Deficits in Childhood Cancer Survivors | N/A | terminated | Apr 9, 2010 | University of Minnesota | Due to slow accrual | Enrollment / accrual |
| NCT01225510 | A Trial Of PF-04856884 In Patients With Recurrent Glioblastoma | Phase 2 | withdrawn | Oct 21, 2010 | Pfizer | not stated | Not stated |
| NCT00432445 | Proton Beam Radiation Therapy for Intraocular and Periocular Retinoblastoma | Phase 2 | terminated | Feb 7, 2007 | M.D. Anderson Cancer Center | Low accrual. | Enrollment / accrual |
| NCT02128373 | A Computer-Based Intervention for Distance Caregivers of Parents With Advanced Cancer | N/A | terminated | May 1, 2014 | Case Comprehensive Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01795430 | Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed… | N/A | withdrawn | Feb 20, 2013 | City of Hope Medical Center | No participants enrolled. | Enrollment / accrual |
| NCT01378481 | High-Dose Vorinostat and Fractionated Stereotactic Body Radiation Therapy in Treating… | Phase 1 | terminated | Jun 22, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00761280 | Efficacy and Safety of AP 12009 in Patients With Recurrent or Refractory Anaplastic…(SAPPHIRE) | Phase 3 | terminated | Sep 29, 2008 | Isarna Therapeutics GmbH | Unable to recruit the projected patient number. All analyses are descriptive, only. | Enrollment / accrual |
| NCT00378235 | Phase I/II Trial of Intracerebral IL13-PE38QQR Infusions in Pediatric Patients With… | Phase 1 / Phase 2 | withdrawn | Sep 19, 2006 | INSYS Therapeutics Inc | There was a change of sponsor. The new sponsor company did not wish to conduct the study after all. | Sponsor / business decision |
| NCT01088763 | Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or… | Phase 1 | terminated | Mar 17, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01320787 | 18-F-Fluoroacetate as PET Imaging Agent | Phase 1 | withdrawn | Mar 22, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01952886 | Patient Satisfaction, Efficacy and Compliance of Antiemetic Patch vs Pill in Malignant… | Phase 2 | withdrawn | Sep 30, 2013 | Duke University | Lack of approval and funding from company | Funding |
| NCT00589095 | Early Detection of Glioblastoma Multiforme (GBM) Treatment Responses Using Multiple… | — | terminated | Jan 9, 2008 | Yale University | not stated | Not stated |
| NCT02055196 | Genetically Modified Stem Cells and Irinotecan Hydrochloride in Treating Patients With… | Phase 1 | withdrawn | Feb 5, 2014 | City of Hope Medical Center | New study written | Other (stated, no rule matched) |
| NCT00387426 | Sunitinib in Treating Patients With Idiopathic Myelofibrosis | Phase 2 | terminated | Oct 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01515085 | MRI-Guided Laser Induced Thermal Therapy(LITT) | — | terminated | Jan 23, 2012 | Rutgers, The State University of New Jersey | PI elected to close study | Other (stated, no rule matched) |
| NCT01169415 | Effects of Steroid Tapering on Functional Capacity and Neurocognition | N/A | withdrawn | Jul 26, 2010 | Duke University | Funding not obtained | Funding |
| NCT01403285 | Peptide-based Glioma Vaccine IMA950 in Patients With Glioblastoma | Phase 1 | terminated | Jul 27, 2011 | Immatics Biotechnologies GmbH | Due to poor accrual. This decision was taken without any safety reasons. Since beginning of the… | Safety / toxicity |
| NCT00636805 | Aloxi for Prevention of Chemotherapy Induced Nausea and Vomiting in Malignant Glioma… | Phase 2 | terminated | Mar 14, 2008 | Duke University | Study was halted early after 63 subjects were enrolled due to slow accrual. | Enrollment / accrual |
| NCT01854099 | Peptide Vaccine for Glioblastoma Against Cytomegalovirus Antigens(PERFORMANCE) | Phase 1 | withdrawn | May 15, 2013 | University of Florida | Investigator decided not to open study. | Investigator |
| NCT01400958 | Nuvigil or Placebo in Newly Diagnosed Malignant Glioma | Phase 2 | terminated | Jul 25, 2011 | H. Lee Moffitt Cancer Center and Research Institute | Slow Accrual, Initiating Principal Investigator (PI) left Moffitt | Investigator |
| NCT00003292 | S9624 Ifosfamide in Treating Patients With Meningeal Tumors | Phase 2 | terminated | Jan 27, 2003 | SWOG Cancer Research Network | lack of accrual | Enrollment / accrual |
| NCT01652768 | PRESENCE Project: An Early Palliative Care Intervention in Brain Tumors | N/A | terminated | Jul 30, 2012 | Case Comprehensive Cancer Center | Research Cancelled | Other (stated, no rule matched) |
| NCT01697514 | A Study of LY2940680 in Pediatric Medulloblastoma or Rhabdomyosarcoma | Phase 1 | withdrawn | Oct 2, 2012 | Eli Lilly and Company | Trial stopped early for poor accrual. | Enrollment / accrual |
| NCT01205334 | Administration of CMV-Specific Cytotoxic T Cells in Patients With Glioblastoma Multiforme(COGLI) | Phase 1 / Phase 2 | terminated | Sep 20, 2010 | Baylor College of Medicine | poor accrual | Enrollment / accrual |
| NCT00003505 | Antineoplaston Therapy in Treating Patients With Primary Central Nervous System Lymphoma | Phase 2 | withdrawn | Jan 27, 2003 | Burzynski Research Institute | not stated | Not stated |
| NCT01115036 | A Panobinostat Presurgery(CLBH589C) | Phase 2 | withdrawn | May 3, 2010 | Duke University | No subjects were enrolled on this study, so study was closed and IND withdrawn. | Enrollment / accrual |
| NCT01095094 | Ritonavir and Lopinavir in Treating Patients With Progressive or Recurrent High-Grade… | Phase 2 | terminated | Mar 29, 2010 | Case Comprehensive Cancer Center | Study did not meet its primary objective | Other (stated, no rule matched) |
| NCT00005812 | Temozolomide in Treating Patients With Leptomeningeal Metastases From a Solid Tumor or… | Phase 2 | terminated | Jan 27, 2003 | Dartmouth-Hitchcock Medical Center | No objective response documented, protocol terminated after 12 patients. | Other (stated, no rule matched) |
| NCT01011231 | Study of Gamma-Knife Radiosurgery Using Magnetic Resonance Imaging (MRI) Spectroscopy for…(GKS) | Phase 2 | terminated | Nov 11, 2009 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00650949 | Efficacy Study of CYT997 in Combination With Carboplatin in Glioblastoma | Phase 1 / Phase 2 | terminated | Apr 2, 2008 | Gilead Sciences | Strategic | Sponsor / business decision |
| NCT00959946 | Study Of Bosutinib With Capecitabine In Solid Tumors And Locally Advanced Or Metastatic… | Phase 1 / Phase 2 | terminated | Aug 17, 2009 | Pfizer | not stated | Not stated |
| NCT00735436 | A Study of Gliadel Followed by Avastin + Irinotecan for Glioblastoma Multiforme (GBM) | Phase 2 | terminated | Aug 15, 2008 | Duke University | Study enrollment was halted due to slow accrual. | Enrollment / accrual |
| NCT01269411 | RO4929097 in Treating Patients With Recurrent Invasive Gliomas | Phase 1 | terminated | Jan 4, 2011 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00005856 | Oxaliplatin in Treating Patients With Newly Diagnosed Glioblastoma Multiforme | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00006773 | Bortezomib in Treating Patients With Recurrent Glioma | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00075491 | Neoadjuvant and Adjuvant Fenretinide Compared With Adjuvant Fenretinide Alone in Treating… | Phase 2 | terminated | Jan 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00036855 | Radiolabeled Monoclonal Antibody With or Without Peripheral Stem Cell Transplantation in… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00110032 | Positron Emission Tomography Using Fluorine F 18 EF5 to Find Oxygen in Tumor Cells of… | Phase 1 | terminated | May 4, 2005 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00430079 | Use of EF5 to Measure the Oxygen Level in Tumor Cells of Patients Undergoing Surgery or… | N/A | terminated | Feb 1, 2007 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00797940 | Convection Enhanced Localized Administration of PRX321 With Real-time Imaging for Therapy…(CLARITY-1) | Phase 2 | withdrawn | Nov 25, 2008 | Sophiris Bio Corp | No funding for study | Funding |
| NCT00734864 | Ph. I Dasatinib/Protracted Temozolomide in Recurrent Malignant Glioma | Phase 1 | withdrawn | Aug 14, 2008 | Annick Desjardins | Study drug supplier withdrew support for the study. Study was withdrawn from the Duke IRB. | Other (stated, no rule matched) |
| NCT01438021 | Continuous Intraventricular Methotrexate in Treating Patients With Leptomeningeal Disease | N/A | withdrawn | Sep 21, 2011 | City of Hope Medical Center | Lack of funding | Funding |
| NCT00948389 | Study of CCNU (Lomustine) Plus Dasatinib in Recurrent Glioblastoma (GBM) | Phase 1 / Phase 2 | terminated | Jul 29, 2009 | Bristol-Myers Squibb | Inability to meet protocol objectives | Other (stated, no rule matched) |
| NCT00272870 | Treatment of Newly Diagnosed Brain Tumors With Chemotherapy and Radiation Using Cells… | Phase 1 | terminated | Jan 9, 2006 | Children's Hospital Medical Center, Cincinnati | Slow accrual; drug availability | Drug supply |
| NCT01151748 | Intra-arterial Chemotherapy for Advanced Intraocular Retinoblastoma | Phase 2 | withdrawn | Jun 28, 2010 | Stanford University | Study abandoned; Could not obtain final SRC approval due to IND disagreements | Other (stated, no rule matched) |
| NCT01044225 | Effect of Radiation Therapy Plus Temozolomide Combined With Cilengitide or Cetuximab on… | Phase 2 | terminated | Jan 7, 2010 | Bart Neyns | Results of the phase III RTOG0525 trial made the manufacturer of cilengitide decide to end their… | Drug supply |
| NCT01189513 | SCH-900105 in Recurrent Glioblastoma | Phase 1 | withdrawn | Aug 26, 2010 | M.D. Anderson Cancer Center | Sponsor decision. | Sponsor / business decision |
| NCT00508456 | Dietary Methionine Restriction Plus Temozolomide for Recurrent GBM | Phase 1 | terminated | Jul 30, 2007 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT01105988 | Evaluating Tumor Pseudoprogression With FLT-PET and MRI | Early Phase 1 | terminated | Apr 19, 2010 | Massachusetts General Hospital | Funding ended | Funding |
| NCT01441388 | A Study Of Crizotinib Plus VEGF Inhibitor Combinations In Patients With Advanced Solid… | Phase 1 | withdrawn | Sep 27, 2011 | Pfizer | Business/Operational issues | Sponsor / business decision |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 27, 2015source: clinicaltrials