Clinical trial · Observational
MRI-Guided Laser Induced Thermal Therapy
MRI-Guided Laser-Induced Thermal Therapy for Cytoreduction of Inoperable Grade III/IV GLiomas Prior to Chemotherapy and Radiation
NCT01515085CI-TRIAL-00014642LITTterminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): PI elected to close study
Summary
Brief summary (as posted)
Does MR-guided laser interstitial thermal therapy (MRgLITT) prior to chemotherapy and/or radiation give patients a beneficial increase in overall survival? Laser induced thermal therapy (LITT) is a minimally invasive procedure for destroying tissue through generation of heat.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Malignant Glioma | Malignant Glioma | ONTOLOGY_EXACT | 0.98 |
Interventions
Interventions (1)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| laser interstitial thermal therapy | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (1)
- label
- biopsy proven glioma, no prior treatment
- interventionNames
- Procedure: laser interstitial thermal therapy
Primary outcomes (1)
- measure
- Progression free survival
- timeFrame
- three years
Secondary outcomes (1)
- measure
- Overall survival
- timeFrame
- three years
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
Show eligibility criteria text
Inclusion Criteria: * Subjects that have/will undergo MRgLITT for inoperable brain tumor. * Tumor size \< 3cm in transverse diameter for each planned applicator placement. * Tumor size \< 4 cm in largest dimension. * Lesion(s) are clearly defined on pre-therapy contrast enhanced MRI scans as determined by the treating surgeon. * Karnofsky Performance Scale score \> 70. * ECOG performance status of 2 or better. * Biopsy proven histologic diagnosis of malignant glioma. Exclusion Criteria: * Patients with co-existing medical conditions with life expectancy \< 1 year. * Patients having received pre-ablation chemotherapy and/or radiation to lesion.
References
Publications (0)
Data not yet available
No reference posted for this study.