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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00677326 | Histocompatibility Leukocyte Antigen (HLA)-A*0201 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 14, 2008 | Tokyo University | Difficulty in recruiting | Enrollment / accrual |
| NCT00678509 | Histocompatibility Leukocyte Antigen (HLA)-A*2402 Restricted Peptide Vaccine Therapy in… | Phase 1 / Phase 2 | terminated | May 15, 2008 | Tokyo University | Lack of financial support | Funding |
| NCT00434356 | A Study of Sunitinib in Combination With Bevacizumab and Paclitaxel in Previously… | Phase 2 | terminated | Feb 13, 2007 | Genentech, Inc. | Based on data collected, the combination appeared to be poorly tolearated. | Other (stated, no rule matched) |
| NCT00712621 | Determining Quality of Life in Breast Cancer Patient After Completing… | Phase 2 | withdrawn | Jul 10, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00770354 | Phase II Study of AS1402 Combined With Letrozole to Treat Breast Cancer | Phase 2 | terminated | Oct 10, 2008 | Antisoma Research | not stated | Not stated |
| NCT00465673 | Liposomal Doxorubicin (Lipo-Dox) in Patients With Brain Metastasis From Breast Cancer | Phase 2 | terminated | Apr 25, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Low recruitment | Enrollment / accrual |
| NCT00354900 | Phase I Study of Aprotinin in Advanced Breast Cancer | Phase 1 | terminated | Jul 20, 2006 | Dartmouth-Hitchcock Medical Center | The FDA changed the labeling for this agent, and we felt we could not offer it to patients on a… | Other (stated, no rule matched) |
| NCT00452140 | Phase II Study With the Trifunctional Antibody Ertumaxomab to Treat Metastatic Breast… | Phase 2 | terminated | Mar 27, 2007 | Neovii Biotech | company focus on other projects | Sponsor / business decision |
| NCT00241462 | Faslodex Observations During Regular Use by Advanced Mammacarcinoma Patients(FORUM) | — | terminated | Oct 19, 2005 | AstraZeneca | Due to poor patient enrollment | Enrollment / accrual |
| NCT00637364 | High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain(HIFU Pancreas) | Phase 1 / Phase 2 | suspended | Mar 18, 2008 | CMED HIFU Development Corporation | Sponsor is not proceeding with USA human trial at this time | Other (stated, no rule matched) |
| NCT00810706 | Adjuvant Post-Tamoxifen Exemestane Trial(ATENA) | Phase 3 | terminated | Dec 18, 2008 | Hellenic Breast Surgeons Society | Publication of MA17 results (similar trial in the extented adjuvant setting with letrozole) | Other (stated, no rule matched) |
| NCT00303615 | Androgen Therapy for Management of Estrogen/Progesterone Receptor Negative ER(-)PR(-)… | Phase 2 | terminated | Mar 17, 2006 | Legacy Health System | Low accrural | Enrollment / accrual |
| NCT00156260 | Feasibility Study of Evaluating Breast Cancer Patients With Ductal Lavage | — | terminated | Sep 12, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00380835 | Study of Amrubicin With or Without Herceptin in Patients With Metastatic Breast Cancer | Phase 2 | withdrawn | Sep 27, 2006 | Celgene Corporation | Study Never Initiated | Other (stated, no rule matched) |
| NCT00162812 | Topoisomerase II Alpha Gene Amplification and Protein Overexpression Predicting Efficacy…(TOP) | Phase 2 | terminated | Sep 13, 2005 | Jules Bordet Institute | Low accrual rate | Enrollment / accrual |
| NCT00461344 | Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer | Phase 2 | terminated | Apr 18, 2007 | Sanofi | due to slow recruitment of patients | Enrollment / accrual |
| NCT00146029 | Companion Pharmacogenetic Study to UMCC 9900/9901 | — | terminated | Sep 5, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00197925 | Dendritic Cell Based Therapy of Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Sep 20, 2005 | Herlev Hospital | all patients recruited | Enrollment / accrual |
| NCT00165581 | High Dose Rate Intracavitary Brachytherapy as the Sole Method of Radiation Therapy for… | N/A | terminated | Sep 14, 2005 | Dana-Farber Cancer Institute | Due to continuing review | Other (stated, no rule matched) |
| NCT00215748 | Reduced Dexamethasone Pre-Medication Dose in Elderly Patients Receiving Weekly Docetaxel | Phase 2 | terminated | Sep 22, 2005 | Geriatric Oncology Consortium | slow accrual | Enrollment / accrual |
| NCT00225056 | Phase II Study of Capecitabine and Weekly Docetaxel Followed by Capecitabine Maintenance… | Phase 2 | terminated | Sep 23, 2005 | Oncology Specialties, Alabama | Terminated due to lack of accrual | Enrollment / accrual |
| NCT00099281 | DPPE in Combination With Epirubicin and Cyclophosphamide in the Treatment of Breast Cancer | Phase 3 | terminated | Dec 10, 2004 | YM BioSciences | not stated | Not stated |
| NCT00287482 | Essiac (ESIAK) Versus Placebo to Improve Quality of Life in Transition in Women With… | N/A | terminated | Feb 6, 2006 | Women and Infants Hospital of Rhode Island | not stated | Not stated |
| NCT00123877 | Study of GPX-100 in the Treatment of Metastatic Breast Cancer | Phase 2 | terminated | Jul 26, 2005 | Gem Pharmaceuticals | not stated | Not stated |
| NCT00395655 | Hydralazine and Valproate Added to Chemotherapy for Breast Cancer | Phase 2 | terminated | Nov 3, 2006 | National Institute of Cancerología | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 29, 2009source: clinicaltrials