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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00584753 | Molecular Imaging of Breast Cancer With Breast PET/CT | Phase 1 | terminated | Jan 2, 2008 | University of California, Davis | Low enrollment | Enrollment / accrual |
| NCT00914043 | Studying Biological Markers of Fatigue in Women With Residual Invasive Breast Cancer… | — | withdrawn | Jun 4, 2009 | NSABP Foundation Inc | Withdrawn as NCI rescinded approval for parent study NSABP-B-45 | Other (stated, no rule matched) |
| NCT00960154 | PEAK PlasmaBlade™ 4.0 Versus Traditional Electrosurgery in Lumpectomy(PRECISE) | N/A | terminated | Aug 17, 2009 | Medtronic Surgical Technologies | Termination due to acquisition of PEAK Surgical by Medtronic | Other (stated, no rule matched) |
| NCT00217659 | S0511, Goserelin and Anastrozole in Treating Men With Recurrent or Metastatic Breast… | Phase 2 | withdrawn | Sep 22, 2005 | SWOG Cancer Research Network | poor accrual | Enrollment / accrual |
| NCT01301911 | Study of Cipatinib in Patients With HER2 Positive or Uncertain Advanced Breast Cancer | Phase 1 | terminated | Feb 23, 2011 | Jiangsu HengRui Medicine Co., Ltd. | not stated | Not stated |
| NCT00288444 | Interaction of Docetaxel and Lonafarnib in Patients With Advanced Cancer | Phase 1 | terminated | Feb 8, 2006 | Emory University | not stated | Not stated |
| NCT01055678 | To Evaluate the Characteristics of a Breast Cancer | Early Phase 1 | withdrawn | Jan 26, 2010 | Mark Dewhirst | PI left Duke | Investigator |
| NCT00006032 | Combination Chemotherapy Followed by Peripheral Stem Cell Transplantation in Treating… | Phase 2 | terminated | Apr 2, 2004 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT00227656 | Capecitabine and Pegylated Interferon Alfa-2a in Treating Patients With Recurrent or… | Phase 2 | terminated | Sep 28, 2005 | M.D. Anderson Cancer Center | Study slow to accrue. | Enrollment / accrual |
| NCT00817362 | Efficacy and Safety of IPI-504 With Trastuzumab Pretreated, Locally Advanced or… | Phase 2 | terminated | Jan 6, 2009 | Infinity Pharmaceuticals, Inc. | Limited efficacy response observed during interim analysis. | Efficacy / futility |
| NCT01277926 | Patterns of Care in Hormone-receptor Positive, Advanced Breast Cancer | — | terminated | Jan 17, 2011 | AstraZeneca | not stated | Not stated |
| NCT00506064 | Melatonin Postoperative Sleep Study in Breast Cancer Patients | Phase 1 | terminated | Jul 25, 2007 | M.D. Anderson Cancer Center | Terminated due to low accrual. | Enrollment / accrual |
| NCT00324714 | Risedronate in Improving Bone Mineral Density and Bone Health in Postmenopausal Women… | Phase 3 | withdrawn | May 11, 2006 | ETOP IBCSG Partners Foundation | not stated | Not stated |
| NCT01297231 | Prospective Analysis of Changes in Background Parenchymal Enhancement (BPE) and Amount of… | — | withdrawn | Feb 16, 2011 | Memorial Sloan Kettering Cancer Center | Lack of funding | Funding |
| NCT00793546 | Study Evaluating Bosutinib-Exemestane Combination Vs Exemestane Alone in Post Menopausal… | Phase 2 | terminated | Nov 19, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01163929 | A Study to Look at the Combination of Chemotherapy, Trastuzumab and RAD001 in HER2… | Phase 2 | withdrawn | Jul 16, 2010 | University of Kansas | Study closed by Protocol Review Monitoring Committee because of lack of accrual | Enrollment / accrual |
| NCT01006785 | Efficacy and Safety of DLBS1425 in Subjects With Advanced/Metastatic Breast Cancer | Phase 2 | terminated | Nov 3, 2009 | Dexa Medica Group | The study was terminated due to difficulty of find eligible subjects | Other (stated, no rule matched) |
| NCT01007890 | Prediction of Response to Neoadjuvant Chemotherapy in Women With Operable Breast Cancer(PT-304) | — | terminated | Nov 5, 2009 | Precision Therapeutics | not stated | Not stated |
| NCT00005614 | Management of Metastatic Breast Cancer in Frail Patients | Phase 2 | withdrawn | Jul 26, 2004 | H. Lee Moffitt Cancer Center and Research Institute | no accrual | Enrollment / accrual |
| NCT00036686 | Isoflavones in Treating Women Who Have Breast Cancer and Are Planning to Undergo… | N/A | terminated | Jan 27, 2003 | H. Lee Moffitt Cancer Center and Research Institute | low accrual | Enrollment / accrual |
| NCT01473680 | Neuropsychologic and Electrophysiological Features of Cancer-Related Cognitive Side… | — | terminated | Nov 17, 2011 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01436591 | Comparison of Diagnostic Performance of an Algorithm and a High Definition Classical…(TEP-Sein) | — | terminated | Sep 19, 2011 | Centre Francois Baclesse | not stated | Not stated |
| NCT00817531 | Efficacy Study of Dasatinib in Locally Advanced Triple-Negative Breast Cancer Patients | Phase 2 | terminated | Jan 6, 2009 | Baylor Breast Care Center | terminated due to futility after interim analysis | Efficacy / futility |
| NCT00555841 | Safety and Efficacy of ALC in Breast Cancer in Subjects With Fatigue | Phase 2 | terminated | Nov 9, 2007 | Sigma-Tau Research, Inc. | Sponsor decision | Sponsor / business decision |
| NCT00499681 | PhII Neo-Adjuvant Letrozole & Lapatinib in Pts w/HER2+ & Hormone Receptor+ Operable… | Phase 2 | terminated | Jul 11, 2007 | Vanderbilt-Ingram Cancer Center | slow accrual | Enrollment / accrual |
| NCT00611715 | Ph II Letrozole + OSI-774 (Tarceva) in Post-menopausal, w/ ER and/or PR-positive Met… | Phase 2 | terminated | Feb 11, 2008 | Vanderbilt-Ingram Cancer Center | low accrual | Enrollment / accrual |
| NCT01597921 | A DB Randomized Study of R1 and R2 WaterJel / AloeVera Jell in Prevention of Radiation… | — | terminated | May 14, 2012 | Water-Jel | The study was stopped due to unbalanced side effects | Other (stated, no rule matched) |
| NCT01081106 | Low Level Laser Therapy for Hair Preservation With Chemotherapy for Breast Cancer | N/A | withdrawn | Mar 5, 2010 | Northwestern University | not stated | Not stated |
| NCT01159236 | Molecular Triaging of Newly Diagnosed Breast Cancer | N/A | withdrawn | Jul 9, 2010 | M.D. Anderson Cancer Center | Recent developments lead to re-evaluation of study. | Other (stated, no rule matched) |
| NCT00434031 | CETRA: Neoadjuvant Caelyx and Trastuzumab in Her-2 Positive Breast Cancer(CETRA) | Phase 2 | withdrawn | Feb 12, 2007 | National Cancer Institute, Naples | lack of enrollment | Enrollment / accrual |
| NCT00899288 | Fingernails in Evaluating Bone Health in Postmenopausal Women With Breast Cancer… | Phase 3 | terminated | May 12, 2009 | ETOP IBCSG Partners Foundation | Insufficient accrual | Enrollment / accrual |
| NCT00006121 | Oxaliplatin in Treating Women With Advanced or Metastatic Breast Cancer That Has Not… | Phase 2 | terminated | Oct 8, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00516542 | Dehydroepiandrosterone (DHEA) and Letrozole in Treating Patients With Metastatic Breast… | Phase 1 | terminated | Aug 15, 2007 | OHSU Knight Cancer Institute | Study was terminated due to lack of accrual | Enrollment / accrual |
| NCT00010153 | ICI 182780 in Treating Women With Stage I or Stage II Primary Breast Cancer | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00028704 | Breast-Conserving Therapy Compared With Mastectomy Followed By Radiation Therapy in… | Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT00049660 | Capecitabine Compared With Vinorelbine in Treating Women With Metastatic Breast Cancer | Phase 2 / Phase 3 | terminated | Jan 27, 2003 | European Organisation for Research and Treatment of Cancer - EORTC | low accrual | Enrollment / accrual |
| NCT01005641 | ELBA: Exemestane and Lapatinib in Advanced Breast Cancer(ELBA) | Phase 2 | withdrawn | Nov 2, 2009 | National Cancer Institute, Naples | Study not started for administrative reasons | Other (stated, no rule matched) |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00054470 | Tipifarnib Plus Trastuzumab in Treating Patients With Metastatic Breast Cancer | Phase 2 | withdrawn | Feb 6, 2003 | The University of Texas Health Science Center at San Antonio | not stated | Not stated |
| NCT01333423 | Maximum Tolerated Dose (MTD) of Liposomal Doxorubicin in Combination With Seliciclib for… | Phase 1 | withdrawn | Apr 12, 2011 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00057993 | Trastuzumab and Exemestane in Treating Postmenopausal Women With Metastatic or Locally… | Phase 2 | withdrawn | Apr 9, 2003 | Northwestern University | Unable to accrue subjects to the study after 2 years - closed per request by Data Monitoring… | Enrollment / accrual |
| NCT00131924 | High-Dose Esterified Estrogens in Treating Postmenopausal Women With Metastatic Breast… | Phase 2 | terminated | Aug 19, 2005 | Northwestern University | Data Monitoring Committee recommended closure due to poor accrual. | Enrollment / accrual |
| NCT00276822 | Improving Communication With Patients With Breast Cancer | N/A | terminated | Jan 13, 2006 | Northwestern University | Preliminary findings did not support purpose. | Other (stated, no rule matched) |
| NCT01288092 | BEZ235 Trial in Patients With HER2-(Human Epidermal Growth Factor Receptor 2 Negative)… | Phase 2 | withdrawn | Feb 2, 2011 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00005608 | Fluorouracil-Uracil and Leucovorin in Treating Women With Metastatic Breast Cancer | Phase 2 | terminated | Apr 19, 2004 | Northwestern University | Drug was pulled from the market. | Other (stated, no rule matched) |
| NCT00479856 | Lapatinib In Combination With Chemotherapy In Subjects With Relapsed Breast Cancer | Phase 2 | terminated | May 28, 2007 | GlaxoSmithKline | Study was terminated due to difficulty in identifying eligible subjects | Other (stated, no rule matched) |
| NCT00403182 | Chemotherapy and Hormone Therapy as First-Line Therapy in Treating Postmenopausal Women… | Phase 3 | withdrawn | Nov 23, 2006 | Technical University of Munich | study halted prematurely, prior to enrollment of first participant | Enrollment / accrual |
| NCT00935558 | Dendritic Cell Based Therapy for Breast Cancer Patients | Phase 2 | withdrawn | Jul 9, 2009 | Inge Marie Svane | no patients enrolled | Enrollment / accrual |
| NCT00473005 | Phase I Oral mTOR Inhibitor RAD001 in Combo w/ Capecitabine for Metastatic Breast | Phase 1 | terminated | May 14, 2007 | Stanford University | Principal Investigator (Dr. Guardino) left Stanford | Investigator |
| NCT01362712 | Exploratory, Phase I,Open Label,Non-randomized Study of [F18]CP-18 PET in Normal and… | Phase 1 | terminated | May 30, 2011 | Siemens Molecular Imaging | Unable to enroll breast cancer patients with current I/E criteria. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 14, 2013source: clinicaltrials