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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00777335 | Study of Panobinostat Monotherapy in Women With v-ERB-B2 Avian Erythroblastic Leukemia… | Phase 2 | terminated | Oct 22, 2008 | Translational Research in Oncology | Very low recruitement rate. | Enrollment / accrual |
| NCT00006126 | Peripheral Stem Cell Transplantation in Treating Patients With Melanoma or Small Cell… | Phase 1 | withdrawn | Mar 8, 2004 | Northwestern University | Unable to accrue subjects. | Enrollment / accrual |
| NCT00148720 | Capecitabine in Women With Operable Breast Cancer | Phase 2 | terminated | Sep 8, 2005 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT00891969 | Treatment Decision Making Between Oncologists and Women With Newly Diagnosed Breast… | — | terminated | May 1, 2009 | Rutgers, The State University of New Jersey | Slow accrual | Enrollment / accrual |
| NCT01542216 | Evaluation of Nutrition and Metabolism in Breast Cancer Patients | N/A | withdrawn | Mar 2, 2012 | University of Waterloo | Recruitment challenges | Enrollment / accrual |
| NCT00780000 | Clinical Trial of Intravenous Alvespimycin in Patients With Her2 Positive Breast Cancer | Phase 2 | terminated | Oct 24, 2008 | Bristol-Myers Squibb | not stated | Not stated |
| NCT01056757 | Treatment With Ribavirin for Patients With Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Jan 26, 2010 | Jewish General Hospital | Study closed because of new overlapping study with ribavirin. | Other (stated, no rule matched) |
| NCT02526719 | Nipple Delay Prior to Nipple Sparing Mastectomy: A Pilot RCT | N/A | withdrawn | Aug 18, 2015 | University Health Network, Toronto | Study design changed, no longer a randomized trial design | Other (stated, no rule matched) |
| NCT02073045 | Intensive Education in Increasing Understanding of Lymphedema in Patients With Breast… | N/A | terminated | Feb 27, 2014 | Case Comprehensive Cancer Center | research cancelled | Other (stated, no rule matched) |
| NCT01809171 | Placebo-controlled Trial With Vitamin D to Prevent Worsening/Relieve Aromatase… | Phase 2 / Phase 3 | terminated | Mar 12, 2013 | Universitaire Ziekenhuizen KU Leuven | Inclusion problems | Other (stated, no rule matched) |
| NCT02042456 | Automated Breast Ultrasound and Digital Breast Tomosynthesis Screening Compared to Full… | — | terminated | Jan 22, 2014 | GE Healthcare | Change in study staff at the site, change in Sponsor direction | Other (stated, no rule matched) |
| NCT02042885 | A Clinical Trial to Determine the Most Suitable Dose of OPB-111001 in Patients With… | Phase 1 / Phase 2 | terminated | Jan 23, 2014 | Otsuka Novel Products GmbH | not stated | Not stated |
| NCT00356681 | A Study of AMG 706 or Bevacizumab, in Combination With Paclitaxel Chemotherapy, as… | Phase 2 | terminated | Jul 26, 2006 | Amgen | Sponsor decision to close study | Sponsor / business decision |
| NCT02525913 | Feasibility Study of Cavity Radiofrequency Ablation in ex Vivo Mastectomy Breast Tissue | N/A | withdrawn | Aug 18, 2015 | University of Arkansas | Study was withdrawn from the IRB and never opened. No subjects were enrolled. | Enrollment / accrual |
| NCT01985841 | Bevacizumab in Combination With Chemotherapy in the Neo-adjuvant Setting for HER2 (-)… | Phase 2 | terminated | Nov 15, 2013 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT01047774 | The Effect of Soy Protein on Post- Breast Cancer Surgery Pain | Phase 2 | terminated | Jan 13, 2010 | Dr. Yoram Shir | Difficulty with recruitment - few eligible for enrolment. | Enrollment / accrual |
| NCT01120171 | Myocet Plus Endoxan for Older Patients With Breast Cancer | Phase 2 | terminated | May 10, 2010 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00075413 | Arsenic Trioxide in Treating Women With Locally Advanced or Metastatic Breast Cancer | Phase 2 | withdrawn | Jan 12, 2004 | The University of Texas Medical Branch, Galveston | Unable to identify qualified subjects willing to participate in this study | Other (stated, no rule matched) |
| NCT00530751 | Views on Sharing Family Medical History in Healthy Women Undergoing Mammograms or Breast… | — | withdrawn | Sep 17, 2007 | Case Comprehensive Cancer Center | PI left | Investigator |
| NCT00898573 | Lapatinib Resistance in Patients With Breast Cancer | — | withdrawn | May 12, 2009 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00909662 | Fatigue Caused by Chemotherapy in Women Who Have Undergone Surgery for Breast Cancer and… | — | terminated | May 28, 2009 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT01837563 | Monitoring of Neoadjuvant Therapy in Locally-Advanced Breast Cancer | — | terminated | Apr 23, 2013 | Dartmouth-Hitchcock Medical Center | not stated | Not stated |
| NCT00754702 | Vinorelbine Metronomic Plus Lapatinib for Overexpressing HER-2 Metastatic Breast Cancer | Phase 2 | terminated | Sep 18, 2008 | University Hospital of Crete | Poor accrual | Enrollment / accrual |
| NCT00377780 | Liposomal Doxorubicin, Trastuzumab, and Docetaxel in HER2 Positive Metastatic Breast…(MYOHERTAX) | Phase 2 | terminated | Sep 18, 2006 | Laurence J.C. van Warmerdam | wothdrawal of sponsor | Other (stated, no rule matched) |
| NCT00364975 | Development of Gourmet Healthy Cooking Workshop for Cancer Patients | N/A | withdrawn | Aug 16, 2006 | Hadassah Medical Organization | Was not funded | Funding |
| NCT01501604 | BKM120 in Cancers With PIK3CA Activating Mutations | Phase 2 | withdrawn | Dec 29, 2011 | Massachusetts General Hospital | The study has been closed due to lack of accrual | Enrollment / accrual |
| NCT02053597 | TRIal evalUating the Menstrual and Ovarian Function of Young Breast Cancer Patients…(TRIUMPH) | Phase 2 | withdrawn | Feb 3, 2014 | Jules Bordet Institute | due to evolving scientific knowledge in the field that would make the questions being addressed in… | Other (stated, no rule matched) |
| NCT01238133 | Gamma-Secretase/Notch Signalling Pathway Inhibitor RO4929097, Paclitaxel, and Carboplatin… | Phase 1 | terminated | Nov 10, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01281163 | Lapatinib Ditosylate and Akt Inhibitor MK2206 in Treating Women With Metastatic Breast… | Phase 1 | terminated | Jan 21, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02396433 | Combination of Carboplatin, Eribulin Mesylate, and E7449 in BRCA-Related Cancers | Phase 1 / Phase 2 | withdrawn | Mar 24, 2015 | The University of Texas Health Science Center at San Antonio | lack of funding. | Funding |
| NCT00704392 | Safety Study of XL647 and XL147 Administered in Combination Daily in Adults With Solid… | Phase 1 | withdrawn | Jun 24, 2008 | Exelixis | Study not initiated | Other (stated, no rule matched) |
| NCT01161368 | A Study Evaluating the Efficacy and Safety of Lapatinib + Vinorelbine in ErbB2 Positive… | Phase 2 | terminated | Jul 13, 2010 | Central European Cooperative Oncology Group | poor recruitment | Enrollment / accrual |
| NCT01548534 | A Randomised Study of Docosahexaenoic Acid (DHA) in Metastatic Breast Cancer(DHALYA) | Phase 3 | terminated | Mar 8, 2012 | University Hospital, Tours | Judicial liquidation of the society providing dietary supplementation. | Other (stated, no rule matched) |
| NCT01012440 | Role of Positron Emission Mammography (PEM) Flex Solo II Positron Emission Tomography… | N/A | terminated | Nov 13, 2009 | University of Chicago | Poor accrual | Enrollment / accrual |
| NCT00209001 | Efficacy of Acupuncture for Hot Flashes in Women Treated With Hormonal Therapy for Breast… | N/A | terminated | Sep 21, 2005 | Emory University | Principal investigator Peter Johnstone, MD relocated to another institution | Investigator |
| NCT00857714 | Lapatinib for Treatment of Ductal Carcinoma In Situ (DCIS) of the Breast | N/A | terminated | Mar 9, 2009 | Indiana University | Terminated due to low accrual | Enrollment / accrual |
| NCT01067989 | Low-Dose/Metronomic(LDM)Chemotherapy for Metastatic Breast Cancer | Phase 2 | terminated | Feb 12, 2010 | HaEmek Medical Center, Israel | No satisfactory acrual | Other (stated, no rule matched) |
| NCT01403168 | Comparative Evaluation of Osteopathy Treatment Efficacy in Pain Support After Breast…(OSTEOPATHIE) | N/A | terminated | Jul 27, 2011 | Centre Leon Berard | Recruitment difficulties | Enrollment / accrual |
| NCT01334099 | Safety Study of Radiation and CP-675,206 Infusion for Breast Cancer Patients | Phase 1 | terminated | Apr 12, 2011 | University Health Network, Toronto | Contract with drug supplier expired and was not renewed. | Other (stated, no rule matched) |
| NCT01375023 | Allogenic Haematopoietic Cell Transplantation for Patients With Refractory "Triple… | Phase 2 | terminated | Jun 17, 2011 | European Institute of Oncology | Very low accrual rate | Enrollment / accrual |
| NCT02111031 | Clinical Utility of CTC Test in Medicare-Eligible Metastatic Breast Cancer Patients | — | withdrawn | Apr 10, 2014 | Janssen Diagnostics, LLC | The company decided not to start the study. | Sponsor / business decision |
| NCT00581113 | Neural Stem Cell Preserving Brain Radiation Therapy & Stereotactic Radiosurgery in… | Phase 3 | terminated | Dec 27, 2007 | Virginia Commonwealth University | New research priorities | Other (stated, no rule matched) |
| NCT00694200 | Vinorelbine Metronomic Plus Bevacizumab as Salvage Therapy for Breast Cancer | Phase 2 | terminated | Jun 10, 2008 | Hellenic Oncology Research Group | Not reached the statistical hypothesis at the interim analysis | Efficacy / futility |
| NCT00899639 | Studying Tumor Tissue Samples From Patients With Early-Stage Breast Cancer | — | withdrawn | May 12, 2009 | Rutgers, The State University of New Jersey | not "applicable clinical trial" | Other (stated, no rule matched) |
| NCT02255240 | LEVEL UP: Video Games for Activity in Breast Cancer Survivors(LEVEL UP) | N/A | withdrawn | Oct 2, 2014 | The University of Texas Medical Branch, Galveston | Relinquished grant funding due to receipt of another incompatible grant | Funding |
| NCT01149356 | RO4929097 And Exemestane in Treating Pre- and Postmenopausal Patients With Advanced or… | Phase 1 | terminated | Jun 23, 2010 | National Cancer Institute (NCI) | Manufacturer discontinued drug development. | Drug supply |
| NCT01701466 | Neoviderm Skin Emulsion in the Prevention of Radiation Dermatitis | Phase 2 | terminated | Oct 5, 2012 | Sir Mortimer B. Davis - Jewish General Hospital | not stated | Not stated |
| NCT01750164 | Patient Derived Breast Cancer Xenografts | — | terminated | Dec 17, 2012 | Dartmouth-Hitchcock Medical Center | discontinued funding | Funding |
| NCT00022230 | Combination Chemotherapy Plus Biological Therapy in Treating Patients With Stage II or… | Phase 1 / Phase 2 | withdrawn | Jan 27, 2003 | Roger Williams Medical Center | PI left Institution | Investigator |
| NCT00678626 | Phase 2 Trial Of CP-751,871 And Docetaxel In Advanced Breast Cancer | Phase 2 | withdrawn | May 15, 2008 | Pfizer | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Nov 24, 2015source: clinicaltrials