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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01959867 | SurgiMend in Two-stage Implant-based Breast Reconstruction in Patients With… | N/A | withdrawn | Oct 10, 2013 | Integra LifeSciences Corporation | not stated | Not stated |
| NCT02213744 | MM-302 Plus Trastuzumab vs. Chemotherapy of Physician's Choice Plus Trastuzumab in…(HERMIONE) | Phase 2 / Phase 3 | terminated | Aug 11, 2014 | Merrimack Pharmaceuticals | Felt not to show benefit over control per DMC and confirmed via futility analysis | Efficacy / futility |
| NCT01708798 | Study of the Effect of Eplerenone on Heart Function in Women Receiving Anthracycline… | Phase 2 / Phase 3 | terminated | Oct 17, 2012 | University of British Columbia | Futility | Efficacy / futility |
| NCT02661100 | A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously… | Phase 1 / Phase 2 | withdrawn | Jan 22, 2016 | Case Comprehensive Cancer Center | Drug unavailable | Other (stated, no rule matched) |
| NCT00450515 | Vinflunine and Capecitabine in Treating Patients With Previously Treated Metastatic… | Phase 2 | withdrawn | Mar 22, 2007 | Alliance for Clinical Trials in Oncology | Study was dropped prior to opening. | Other (stated, no rule matched) |
| NCT00752986 | ZACtima FASlodex Trial in Postmenopausal Advance Breast Cancer Patients Instead of…(ZACFAST) | Phase 2 | terminated | Sep 16, 2008 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT00912444 | Neoadjuvant Treatment of Docetaxel, Anthracycline and Cyclophosphamide (TAC) Versus…(NATT) | Phase 3 | terminated | Jun 3, 2009 | Shanghai Jiao Tong University School of Medicine | TAC treatment was associated with better survial outcome compared with TC treatment, we terminated… | Enrollment / accrual |
| NCT01875198 | Oncologic Impact of Splenectomy-omitting Radical Pancreatectomy in Well-selected… | N/A | terminated | Jun 11, 2013 | Yonsei University | because of difficulties of enrolling appropriate participants | Enrollment / accrual |
| NCT00977379 | A Study of Whole Brain Radiation Therapy and Capecitabine in Breast Cancer Participants…(XERAD) | Phase 2 | terminated | Sep 15, 2009 | Hoffmann-La Roche | Due to an insufficient number of participants enrolled. | Enrollment / accrual |
| NCT01246726 | Multiple Oncological Serial Scans Study(MOSS) | N/A | terminated | Nov 23, 2010 | University Hospitals Bristol and Weston NHS Foundation Trust | MRI scanner de-commissioned and there was no suitable alternative. | Other (stated, no rule matched) |
| NCT02058667 | Reirradiation With Concurrent Paclitaxel for Breast Cancer | Phase 1 | withdrawn | Feb 10, 2014 | University of Kentucky | Slow accrual | Enrollment / accrual |
| NCT02759549 | Fatigue in Breast Cancer Patients Undergoing Radiotherapy-eSMART-MH | N/A | withdrawn | May 3, 2016 | Emory University | not stated | Not stated |
| NCT02197949 | Preoperative and Intraoperative Quantification of Axillary Tumoral Load | — | terminated | Jul 23, 2014 | Parc de Salut Mar | Slow recuitment | Other (stated, no rule matched) |
| NCT00774241 | PRIMADOS Study:A Study of Avastin (Bevacizumab) Plus Docetaxel for First Line Treatment… | Phase 4 | withdrawn | Oct 17, 2008 | Hoffmann-La Roche | Study was put on hold then out of Medical Plan therefore cancelled | Other (stated, no rule matched) |
| NCT00845910 | A Study of Circulating Endothelial Cell as Marker for Avastin (Bevacizumab) in… | Phase 2 | terminated | Feb 18, 2009 | Hoffmann-La Roche | To be confirmed | Other (stated, no rule matched) |
| NCT00964704 | A Study of Herceptin (Trastuzumab) in Combination With Avastin (Bevacizumab) and… | Phase 2 | withdrawn | Aug 25, 2009 | Hoffmann-La Roche | No patients have been recruited therefore study has been cancelled | Enrollment / accrual |
| NCT01156961 | A Study of The Safety Profile of First-line Avastin (Bevacizumab) in Combination With… | Phase 4 | withdrawn | Jul 5, 2010 | Hoffmann-La Roche | Absence of patient's recruitment in the study due to administrative reasons | Enrollment / accrual |
| NCT01277133 | An Observational Study on The Correlation Between Time of Initiation of Avastin… | — | terminated | Jan 14, 2011 | Hoffmann-La Roche | not stated | Not stated |
| NCT00066807 | Premenopausal Endocrine Responsive Chemotherapy Trial(PERCHE) | Phase 3 | terminated | Aug 7, 2003 | ETOP IBCSG Partners Foundation | Poor accrual, patients were followed until completion of 5 yrs treatment | Enrollment / accrual |
| NCT01943240 | Pectoral Nerve Blockade in Mastectomy | Phase 4 | withdrawn | Sep 16, 2013 | Timothy R Petersen | Insufficient population of eligible patients; none enrolled | Enrollment / accrual |
| NCT02380209 | An Early Phase Clinical Trial to Evaluate the Feasibility of CEST MRI in Patients With… | Early Phase 1 | terminated | Mar 5, 2015 | University of Arizona | PI has terminated study as the sequencing on patients and volunteers didn't yield the results… | Other (stated, no rule matched) |
| NCT01479179 | Trastuzumab in Combination With AMG 479 in HER-2 Overexpressing MBC Progressing on… | Phase 1 / Phase 2 | withdrawn | Nov 24, 2011 | M.D. Anderson Cancer Center | Drug sponsor decision to discontinue study. | Sponsor / business decision |
| NCT01756092 | Treatment of Benign Breast Deformities and Post-Segmental Mastectomy Breast Deformities… | N/A | withdrawn | Dec 24, 2012 | University of Pittsburgh | Because funding was not secured, the study was never initiated. 0 subjects enrolled | Enrollment / accrual |
| NCT02645175 | Evaluate the Safety Profile and Ability of TW1025 Oral Solution to Decrease Fatigue | Phase 2 | terminated | Jan 1, 2016 | Meriyana Bio Inc. | Business Decision | Sponsor / business decision |
| NCT01194869 | Preoperative Trial of Sorafenib in Combination With Cisplatin Followed by Paclitaxel for… | Phase 2 | terminated | Sep 3, 2010 | Emory University | Slow accrual, availability of other clinical options | Enrollment / accrual |
| NCT01188915 | Personalised Program for Women Treated for Hodgkin Disease(PROPER) | N/A | terminated | Aug 26, 2010 | Institut Paoli-Calmettes | Sponsor decision | Sponsor / business decision |
| NCT02610621 | Safety and Efficacy of Sentinel Node Biopsy Omission for Breast Cancer Patients Who Plan… | Phase 2 | withdrawn | Nov 20, 2015 | Cedars-Sinai Medical Center | Study may not be clinically relevant at this time. | Other (stated, no rule matched) |
| NCT01910844 | Phase II Pilot Study Assessing Efficacy of a Cisplatin - Métronomic Cyclophosphamide…(META2) | Phase 2 | terminated | Jul 30, 2013 | Centre Jean Perrin | Because of difficulties in recruting | Other (stated, no rule matched) |
| NCT01498588 | Trial of Eribulin Followed by Doxorubicin & Cyclophosphamide for Her2-negative, Locally… | Phase 2 | terminated | Dec 23, 2011 | Emory University | Slow accrual | Enrollment / accrual |
| NCT01032447 | Overcoming Obstacles to Clinical Trials Enrollment Through a Navigator Program | — | terminated | Dec 15, 2009 | Stanford University | not stated | Not stated |
| NCT01723124 | Low-dose Molecular Breast Imaging: Comparison of Breast Cancer Detection Rate at Initial… | N/A | terminated | Nov 7, 2012 | Mayo Clinic | Dose specified in protocol was not adequate to achieve optimal resolution. | Other (stated, no rule matched) |
| NCT02725541 | Trial of Neoadjuvant Trastuzumab Emtansine in Patients With HER2-Equivocal Breast Cancer(NATURE) | Phase 2 | withdrawn | Apr 1, 2016 | Jenny C. Chang, MD | loss of funding support | Funding |
| NCT02102438 | Chemotherapy for Elderly Patients Diagnosed With Localized HER2 Positive Breast Cancer | N/A | withdrawn | Apr 3, 2014 | Instituto do Cancer do Estado de São Paulo | No financial support aproved | Funding |
| NCT00603408 | Effect of Chemotherapy and Radiation Prior to Surgery for Triple Negative Breast Cancer | Phase 2 | terminated | Jan 29, 2008 | Washington University School of Medicine | Study was discontinued due to lack of accrual. | Enrollment / accrual |
| NCT01132664 | Phase 1b/2 Study of BKM120 Plus Trastuzumab in Patients With HER2-positive Breast Cancer | Phase 1 / Phase 2 | terminated | May 28, 2010 | Novartis Pharmaceuticals | Due to the rare patient population and challenges to enroll patients. | Enrollment / accrual |
| NCT01653366 | Effect of a Goal Setting Intervention on Exercise in Women With Metastatic Breast Cancer:… | N/A | terminated | Jul 31, 2012 | Dartmouth-Hitchcock Medical Center | primary goal not achievable | Other (stated, no rule matched) |
| NCT01836640 | Developing Plasma DNA as a Surrogate for Tumor Biopsy to Identify Tumor Genetic… | — | terminated | Apr 22, 2013 | Dartmouth-Hitchcock Medical Center | Primary goal not achievable | Other (stated, no rule matched) |
| NCT00692458 | A Study to Assess the Effects of MK0822 in Reducing the Risk of Bone Metastasis in Women… | Phase 3 | withdrawn | Jun 6, 2008 | Merck Sharp & Dohme LLC | Withdrawn for administrative reasons | Other (stated, no rule matched) |
| NCT02183597 | Whole-body MRI for the Detection of Metastasis(WBMRI) | — | withdrawn | Jul 8, 2014 | Norwegian University of Science and Technology | not stated | Not stated |
| NCT02539017 | The Clinical Significance of Cellular Immune Adjuvant Therapy of Triple Negative Breast… | Phase 2 | withdrawn | Sep 2, 2015 | First Affiliated Hospital Xi'an Jiaotong University | because of safety problem, this trial was stopped in the hospital | Safety / toxicity |
| NCT00805597 | Clinical Trial of Postmastectomy Radiotherapy in Breast Cancer With One to Three Positive… | Phase 3 | terminated | Dec 9, 2008 | Chinese Academy of Medical Sciences | The recuiting was to slow to complete the study | Other (stated, no rule matched) |
| NCT01938651 | Ultra High Field MRI and MRS Techniques in Diagnosing Breast Cancer | N/A | terminated | Sep 10, 2013 | Vanderbilt-Ingram Cancer Center | funding ceased | Funding |
| NCT02639611 | Effectiveness of Acupuncture in Post-Mastectomy Patients With Tissue Expanders | N/A | withdrawn | Dec 24, 2015 | NYU Langone Health | not stated | Not stated |
| NCT01568346 | Breast MRI for Newly Diagnosed Breast Cancer:Impact on Re-excision Lumpectomy | Phase 3 | terminated | Apr 2, 2012 | Dana-Farber Cancer Institute | Slow Accural | Other (stated, no rule matched) |
| NCT00427427 | Delayed Adjuvant Herceptin® Treatment in Patients With HER-2 Positive Breast Cancer | Phase 2 | terminated | Jan 29, 2007 | Jonsson Comprehensive Cancer Center | lack of accrual | Enrollment / accrual |
| NCT02429544 | Effects of a Group Residential Retreat on Cancer Outcomes | N/A | withdrawn | Apr 29, 2015 | M.D. Anderson Cancer Center | Study is unfunded and lack of resources | Other (stated, no rule matched) |
| NCT02627430 | Talazoparib and HSP90 Inhibitor AT13387 in Treating Patients With Metastatic Advanced… | Phase 1 | withdrawn | Dec 11, 2015 | National Cancer Institute (NCI) | Other - Protocol moved to Withdrawn | Other (stated, no rule matched) |
| NCT01360177 | Radioactive Iodide (131I) Treatment of 124I PET/CT Detected Breast Cancers | N/A | withdrawn | May 25, 2011 | Stanford University | not stated | Not stated |
| NCT00041171 | Docetaxel and St. John's Wort in Treating Patients With Solid Tumors That Cannot Be… | Phase 3 | withdrawn | Jan 27, 2003 | Alliance for Clinical Trials in Oncology | The study was not activated. | Other (stated, no rule matched) |
| NCT00053339 | Trastuzumab With or Without Tamoxifen in Treating Women With Progressive Stage IV Breast… | Phase 3 | withdrawn | Jan 28, 2003 | Alliance for Clinical Trials in Oncology | The study was not activated. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jan 10, 2017source: clinicaltrials