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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02483871 | Dose Optimization of Rosuvastatin in Early Stage and Metastatic Estrogen Receptor… | Phase 1 | withdrawn | Jun 29, 2015 | Duke University | Enrollment did not meet anticipated goals. Eligibility was a challenge. | Enrollment / accrual |
| NCT00959985 | Early Detection and Intervention for Mild and Moderate Lymphedema in Patients Treated for… | N/A | terminated | Aug 17, 2009 | Massachusetts General Hospital | low accrual | Enrollment / accrual |
| NCT02322853 | A Multicenter Trial Assessing the Efficacy and Safety of tamOxifen Plus LY2228820 in…(OLYMPE) | Phase 2 | terminated | Dec 23, 2014 | Centre Francois Baclesse | lack of recruitment | Enrollment / accrual |
| NCT00324324 | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem… | Phase 3 | terminated | May 11, 2006 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00900068 | Blood Samples From Patients on a Clinical Trial to CINV During HSCT | — | terminated | May 12, 2009 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT01361945 | AUY922 With Lapatinib and Letrozole for ER+ HER2+ Advanced Breast Cancer | Phase 1 / Phase 2 | withdrawn | May 27, 2011 | Texas Tech University Health Sciences Center, El Paso | Closed due to no enrollment | Enrollment / accrual |
| NCT01784042 | Dietary Energy Restriction and Omega-3 Fatty Acids on Mammary Tissue | Early Phase 1 | withdrawn | Feb 5, 2013 | Milton S. Hershey Medical Center | No funding | Funding |
| NCT02621099 | Hybrid Gamma Camera in Breast Surgery(HICAM) | — | withdrawn | Dec 3, 2015 | University of Nottingham | The study was withdrawn due to the CE mark of the device was not yet granted during the specified… | Other (stated, no rule matched) |
| NCT01227408 | Neoadjuvant Doxorubicin, Polyglutamate Paclitaxel, Capecitabine and Metronomic… | Phase 2 | withdrawn | Oct 25, 2010 | University of Southern California | Sponsor withdrew due to funding issues | Funding |
| NCT01029977 | Imaging Modality Effects on the Multi-dimensional InfraRed Analysis (MIRA) Technology | — | withdrawn | Dec 10, 2009 | Real Imaging Ltd. | Re-definition of MIRA technology goals. | Other (stated, no rule matched) |
| NCT00937417 | S0716 Vandetanib and Docetaxel in Treating Patients With Advanced Solid Tumors | Phase 1 | withdrawn | Jul 13, 2009 | SWOG Cancer Research Network | Withdrawn because SWOG no longer pursuing this study at this time | Other (stated, no rule matched) |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT00397501 | BBBD Followed By Methotrexate and Carboplatin With or Without Trastuzumab in Treating… | Phase 1 / Phase 2 | withdrawn | Nov 9, 2006 | OHSU Knight Cancer Institute | after original approval, IRB closed enrollment; major revisions required to re-open. | Enrollment / accrual |
| NCT02483377 | Patient Navigation and Tailored Treatment Planning in Latina Patients With Breast Cancer | — | terminated | Jun 26, 2015 | University of Southern California | Principal Investigator left | Investigator |
| NCT02217033 | Effects of 'R' (Electro-kinetic Beverage) on Insomnia, Fatigue, and Depression in Breast… | N/A | terminated | Aug 15, 2014 | South Sound Care Foundation | After an interim analysis the Company providing the product decided not to continue with the study | Efficacy / futility |
| NCT01681901 | Ultrasound in Detecting Lymph Node Metastasis in Older Patients Undergoing Breast… | — | withdrawn | Sep 10, 2012 | Ohio State University Comprehensive Cancer Center | no patient accrual | Enrollment / accrual |
| NCT01729832 | Stereotactic Image-Guided Navigation During Breast Reconstruction in Patients With Breast… | N/A | withdrawn | Nov 20, 2012 | Ohio State University Comprehensive Cancer Center | not stated | Not stated |
| NCT02370264 | Questionnaires in Identifying Upper Extremity Function and Quality of Life After… | N/A | terminated | Feb 24, 2015 | University of Southern California | Study not progressing toward scientific goals | Other (stated, no rule matched) |
| NCT00661531 | Estrogen in Postmenopausal Women With ER Positive Metastatic Breast Cancer After Failure… | Phase 2 | terminated | Apr 18, 2008 | Georgetown University | Poor accrual | Enrollment / accrual |
| NCT01151449 | Gamma-secretase/Notch Signalling Pathway Inhibitor RO4929097 in Treating Patients With… | Phase 2 | terminated | Jun 28, 2010 | National Cancer Institute (NCI) | Administratively Complete | Other (stated, no rule matched) |
| NCT01729884 | Vaccine Therapy in Treating Patients With Stage IV Hormone Receptor Positive Breast Cancer | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Study ended early due to slow enrollment | Enrollment / accrual |
| NCT00126451 | A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed… | Phase 2 | terminated | Aug 4, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT02067637 | Delayed Effects of Treatment in Cancer Survivors (DETECS)(DETECS) | — | withdrawn | Feb 20, 2014 | University of Colorado, Denver | Low accrual | Enrollment / accrual |
| NCT00176488 | Epirubicin and Vinorelbine in Treating Patients With Stage II, Stage III, or Stage IV… | Phase 2 | terminated | Sep 15, 2005 | University of Medicine and Dentistry of New Jersey | Competing studies | Other (stated, no rule matched) |
| NCT00549822 | Intermittent Letrozole Therapy in Postmenopausal Women With Metastatic Breast Cancer | Phase 2 | terminated | Oct 26, 2007 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT00496366 | Capecitabine (Xeloda) and Lapatinib (Tykerb) as First-line Therapy in HER2/Neu-positive… | Phase 2 | terminated | Jul 4, 2007 | Rutgers, The State University of New Jersey | not stated | Not stated |
| NCT00993642 | ERB-B4 After Treatment With HDAC Inhibitor in ER+ Tamoxifen Refractory Breast Cancer | Early Phase 1 | withdrawn | Oct 12, 2009 | Tulane University Health Sciences Center | Lack of accrual | Enrollment / accrual |
| NCT00285857 | Phase 2 Study of Lovastatin as Breast Cancer Chemoprevention | Phase 2 | terminated | Feb 2, 2006 | Stanford University | Slow accrual | Enrollment / accrual |
| NCT02685306 | A Study of Neoadjuvant Paclitaxel in Combination With Bavituximab in Early- Stage Triple-… | Phase 2 | withdrawn | Feb 18, 2016 | Peregrine Pharmaceuticals | not stated | Not stated |
| NCT02144012 | A Study to Evaluate the Efficacy and Safety of Trastuzumab Emtansine Versus the… | Phase 3 | terminated | May 21, 2014 | Hoffmann-La Roche | not stated | Not stated |
| NCT01120158 | Paclitaxel Plus Bevacizumab for Older Patients With Breast Cancer | Phase 2 | terminated | May 10, 2010 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT01302821 | C11 AMT Positron Emission Tomography (PET) Imaging in Patients With Metastatic Invasive… | N/A | withdrawn | Feb 24, 2011 | H. Lee Moffitt Cancer Center and Research Institute | not stated | Not stated |
| NCT01562873 | Ruxolitinib in Patients With Breast Cancer | Phase 2 | terminated | Mar 26, 2012 | Dana-Farber Cancer Institute | Not enough responses to continue treatment. | Other (stated, no rule matched) |
| NCT02616224 | A Study To Observe Treatment Patterns and Outcomes in Patients With HER2-Positive… | — | withdrawn | Nov 26, 2015 | Hoffmann-La Roche | Resource constraints | Other (stated, no rule matched) |
| NCT00904423 | Ph I/II of Vitamin D on Bone Mineral Density & Markers of Bone Resorption | Phase 1 / Phase 2 | terminated | May 19, 2009 | Mark Pegram | Low accrual | Enrollment / accrual |
| NCT00133796 | Neoadjuvant Herceptin in Patients With Breast Cancer | Phase 2 | terminated | Aug 24, 2005 | Mothaffar Rimawi | Closed to accrual 4/19/2006 / Study doesn't qualify for reporting. | Enrollment / accrual |
| NCT00481845 | Phase 2 Anastrozole and Vandetanib (ZD6474) in Neoadjuvant Treatment of Postmenopausal… | Phase 2 | terminated | Jun 4, 2007 | Stanford University | Low accrual | Enrollment / accrual |
| NCT01640847 | MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of… | Phase 2 | withdrawn | Jul 16, 2012 | Imunon | not stated | Not stated |
| NCT01856036 | Anti-Tumor Immunity Induced by Cryoablation of Invasive Breast Cancers | N/A | terminated | May 17, 2013 | Saint John's Cancer Institute | PI left institute and contacted IRB to close study. | Investigator |
| NCT00087620 | A Study of Capecitabine In Combination With Docetaxel vs Capecitabine Followed by… | Phase 4 | terminated | Jul 14, 2004 | Hoffmann-La Roche | not stated | Not stated |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT02273752 | Pharmacokinetically Guided Everolimus in Patients With Breast Cancer, Pancreatic… | Phase 2 | terminated | Oct 24, 2014 | Emory University | Slow accrual | Enrollment / accrual |
| NCT00301106 | Biological Therapy in Treating Women With Breast Cancer That Has Spread to the Liver | Phase 1 | terminated | Mar 10, 2006 | Max Sung | protocol underwent significant revisions, decision made to terminate study and open as new study… | Other (stated, no rule matched) |
| NCT00695916 | MRI in Women With Newly Diagnosed Breast Cancer Prior to Breast Conserving Surgery | Phase 3 | withdrawn | Jun 12, 2008 | Stanford University | PI | Other (stated, no rule matched) |
| NCT01780532 | Photoacoustic Imaging (PAI) of Suspicious Breast Cancers - A Clinical Feasibility Study | N/A | withdrawn | Jan 31, 2013 | Stanford University | Insufficient resources | Other (stated, no rule matched) |
| NCT01699672 | Group-based or Individual Information About Disease and Treatment Plan | N/A | terminated | Oct 4, 2012 | Norwegian University of Science and Technology | Problems recruiting patients (not willing, travel time, no respons) | Enrollment / accrual |
| NCT00537173 | Predicting Response and Toxicity in Patients Receiving Paclitaxel and Avastin for Breast… | — | terminated | Sep 28, 2007 | Hoosier Cancer Research Network | Lack of Accrual | Enrollment / accrual |
| NCT00282529 | Identification of a Screening Tool and Treatment of Lymphedema Secondary to the… | N/A | terminated | Jan 26, 2006 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | not stated | Not stated |
| NCT00096109 | Tanespimycin in Treating Women With Refractory Locally Advanced or Metastatic Breast… | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Closed to accrual before all 12 planned patients were enrolled. | Enrollment / accrual |
| NCT00045591 | Celecoxib in Treating Women With Metastatic or Recurrent Breast Cancer | Phase 2 | terminated | Jan 27, 2003 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jun 5, 2017source: clinicaltrials