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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00855114 | Everolimus in Treating Women With Breast Cancer That Can Be Removed by Surgery | Phase 2 | withdrawn | Mar 4, 2009 | Masonic Cancer Center, University of Minnesota | Withdrawn due to no accrual | Enrollment / accrual |
| NCT00005993 | Biological Therapies Following Peripheral Stem Cell Transplantation in Treating Patients… | Phase 1 | terminated | Jun 21, 2004 | Masonic Cancer Center, University of Minnesota | not stated | Not stated |
| NCT01724242 | Vaginal DHEA for Women After Breast Cancer | Phase 2 / Phase 3 | withdrawn | Nov 9, 2012 | Hadassah Medical Organization | Inability to recruit patients | Enrollment / accrual |
| NCT02752009 | Evaluation Of Lymph Nodes After Neoadjuvant Chemotherapy | N/A | withdrawn | Apr 26, 2016 | Dana-Farber Cancer Institute | The data that would be generated is no longer clinically novel. | Other (stated, no rule matched) |
| NCT01649258 | Fosaprepitant Dimeglumine and Granisetron Transdermal System in Preventing Nausea and… | Phase 1 | terminated | Jul 25, 2012 | University of Southern California | Lack of Efficacy | Efficacy / futility |
| NCT00622401 | Vaccination of Patients With Breast Cancer With Dendritic Cell/Tumor Fusions and IL-12 | Phase 1 / Phase 2 | terminated | Feb 25, 2008 | Beth Israel Deaconess Medical Center | not stated | Not stated |
| NCT02944721 | Genetic, Neurophysiological and Psychological Predictive Factors of Chronic Neuropathic…(DOLORISKSEIN) | N/A | withdrawn | Oct 26, 2016 | Hopital Foch | change of sponsor | Other (stated, no rule matched) |
| NCT01176838 | A 5 Year Follow-up on Newly Diagnosed Breast Cancer Patients | — | terminated | Aug 6, 2010 | Wake Forest University | not stated | Not stated |
| NCT01050075 | Acupuncture in Treating Nerve Pain in Patients With Stage I, Stage II, or Stage III… | N/A | terminated | Jan 15, 2010 | City of Hope Medical Center | Unable to recruit patients in the 6 month extension allowed. | Enrollment / accrual |
| NCT02250118 | Intrapleural Bevacizumab After Pleural Drainage in the Context of Breast Cancer(BEVAP) | Phase 1 | terminated | Sep 26, 2014 | Institut Curie | Insufficient Recruitment | Enrollment / accrual |
| NCT00581529 | Partial Breast Irradiation Using Accelerated Intensity Modulated Radiotherapy | Phase 2 | terminated | Dec 27, 2007 | University of Michigan Rogel Cancer Center | The trial was terminated early because fair/poor cosmesis developed in 7 of 32 women. | Other (stated, no rule matched) |
| NCT01187381 | An Observational Study of the Mean Duration of Trastuzumab (Herceptin) Treatment in…(HERODOT) | — | terminated | Aug 24, 2010 | Hoffmann-La Roche | Study was prematurely terminated because of missing data collection. | Other (stated, no rule matched) |
| NCT00722683 | Evaluate Breast Masses Using a New Method of Ultrasound Contrast to Detect Abnormal Blood… | N/A | withdrawn | Jul 25, 2008 | University of Michigan | not stated | Not stated |
| NCT01512199 | Phase 1b/2 Study of U3-1287 in Combination With Trastuzumab Plus Paclitaxel in Newly… | Phase 1 / Phase 2 | terminated | Jan 19, 2012 | Daiichi Sankyo | Improved, different standard of care caused business decision to terminate | Sponsor / business decision |
| NCT02017496 | Safety of Breast Conserving Treatment in Locally Advanced Breast Cancer Receiving…(NeoBCT) | — | terminated | Dec 20, 2013 | Oslo University Hospital | Too low inclusion rate | Other (stated, no rule matched) |
| NCT00813878 | Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants… | — | terminated | Dec 23, 2008 | City of Hope Medical Center | Closed due to low accrual | Enrollment / accrual |
| NCT01217489 | Study Into the Use of Electrical Impedance Mammography in the Diagnosis and…(Signascan) | — | terminated | Oct 8, 2010 | Oxford University Hospitals NHS Trust | not stated | Not stated |
| NCT00725946 | Pilot Study to Determine Radioiodide Accumulation and Dosimetry in Breast Cancers Using… | Early Phase 1 | terminated | Jul 31, 2008 | Stanford University | not stated | Not stated |
| NCT03032614 | Combination of Carboplatin, Eribulin and Veliparib in Stage IV Cancer Patients | Phase 2 | withdrawn | Jan 26, 2017 | The University of Texas Health Science Center at San Antonio | Lack of funding | Funding |
| NCT02863146 | Efficacy of the Use of Refrigerant Helmet to Prevent Alopecia in Patients Treated With… | — | terminated | Aug 11, 2016 | Centre Oscar Lambret | Lack of enrollment | Enrollment / accrual |
| NCT01939418 | Phase Ib/II Trials of RAD001 in Triple Negative Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Sep 11, 2013 | National Cancer Center, Korea | slow recruitment | Enrollment / accrual |
| NCT00003454 | Antineoplaston Therapy in Treating Women With Stage IV Breast Cancer | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT02768714 | Trial to Compare the Efficacy and Safety of Pegfilgrastim Biosimilar in Subjects With… | Phase 3 | withdrawn | May 11, 2016 | Eurofarma Laboratorios S.A. | Strategic changes regarding the product development | Sponsor / business decision |
| NCT00684216 | Second-line Endocrine Treatment Followed by Capecitabine Versus Capecitabine Followed by… | Phase 2 / Phase 3 | terminated | May 26, 2008 | The Netherlands Cancer Institute | acrual too slow | Other (stated, no rule matched) |
| NCT00754767 | L-Carnitine L-Tartrate in Preventing Peripheral Neuropathy Caused By Chemotherapy in… | Phase 4 | terminated | Sep 18, 2008 | HealthPartners Institute | unable to accrue study participants | Enrollment / accrual |
| NCT02712437 | Prospective Study Evaluating the Use of PROSPECT to Reduce Insomnia in Patients With… | N/A | terminated | Mar 18, 2016 | University of Michigan Rogel Cancer Center | The study was terminated because of low accrual. | Enrollment / accrual |
| NCT00832338 | Trial Using Docetaxel Cytoxan in Breast Cancers With High Recurrence Scores | Phase 2 | terminated | Jan 30, 2009 | Emory University | Funding withdrawn | Funding |
| NCT01319539 | MK2206 in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer | Phase 2 | terminated | Mar 21, 2011 | National Cancer Institute (NCI) | terminated early, due to toxicity | Safety / toxicity |
| NCT01351844 | The CEASE Study: Computer Based Educational Module for the Reduction of Arthralgia…(CEASE) | N/A | terminated | May 11, 2011 | George Washington University | Unable to recruit sufficient patients | Enrollment / accrual |
| NCT02360059 | Metformin for Reduction of Paclitaxel-Related Neuropathy in Patients With Breast Cancer | Phase 2 | terminated | Feb 10, 2015 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT02074878 | CRIZENT: Crizotinib and Sunitinib in Metastatic Breast Cancer(CRIZENT) | Phase 1 | terminated | Feb 28, 2014 | Mothaffar Rimawi | Poor accrual so the study was halted on May 16, 2017. | Enrollment / accrual |
| NCT01114256 | FNA Tumor Sampling for CD137 Modulation: A Pilot Study | — | terminated | May 3, 2010 | Stanford University | not stated | Not stated |
| NCT00206492 | Trial of ZD1839 (Iressa) and Tamoxifen in Breast Cancer Patients | Phase 2 | terminated | Sep 21, 2005 | Baylor Breast Care Center | halted by the PI only 3 of 45 subjects were accrued. | Enrollment / accrual |
| NCT00899197 | Tamoxifen Resistance in Women With Stage I, Stage II, Stage IIIA, or Stage IIIB Breast… | — | terminated | May 12, 2009 | Wake Forest University Health Sciences | not stated | Not stated |
| NCT01436604 | Early Detection of Cardiac Toxicity of Trastuzumab (Herceptin ®) in Patients Treated for…(MRTOX) | Phase 2 | terminated | Sep 19, 2011 | Centre Francois Baclesse | lack of recruitment | Enrollment / accrual |
| NCT02040493 | Intra-Operative Radiation Therapy Immediately Following Resection of Early Stage Breast… | N/A | terminated | Jan 20, 2014 | Xoft, Inc. | not stated | Not stated |
| NCT01847599 | Educational Intervention to Adherence of Patients Treated by Capecitabine +/- Lapatinib(ProMETheX) | N/A | terminated | May 7, 2013 | Centre Jean Perrin | interim analysis : discontinuation for efficacy of the intervention | Efficacy / futility |
| NCT00041470 | Navelbine, Taxol, Herceptin and Neupogen in Stage IV Breast Cancer: A Phase I - II Trial | Phase 1 / Phase 2 | terminated | Jul 10, 2002 | University of Washington | Sponsor withdrew the study | Other (stated, no rule matched) |
| NCT00899145 | Breast Cancer Risk in Women Who Are BRCA1/BRCA2 Mutation Carriers | — | withdrawn | May 12, 2009 | Gynecologic Oncology Group | not stated | Not stated |
| NCT00194792 | Hormone Therapy and Combination Chemotherapy Before and After Surgery in Treating… | Phase 2 | terminated | Sep 19, 2005 | University of Washington | not stated | Not stated |
| NCT02651610 | Taxane Therapy With or Without Bavituximab for the Treatment of HER2-Negative Metastatic… | Phase 2 / Phase 3 | withdrawn | Jan 11, 2016 | Peregrine Pharmaceuticals | not stated | Not stated |
| NCT01754519 | Radiation Therapy in Treating Post-Menopausal Women With Early Stage Breast Cancer… | Phase 2 | terminated | Dec 21, 2012 | Roswell Park Cancer Institute | IDE not submitted | Other (stated, no rule matched) |
| NCT01222416 | PET/CT Evaluation of Treatment Response in Breast Cancer | N/A | terminated | Oct 18, 2010 | Vanderbilt-Ingram Cancer Center | Slow accrual | Enrollment / accrual |
| NCT01386502 | CT-011 and p53 Genetic Vaccine for Advanced Solid Tumors | Phase 1 | withdrawn | Jul 1, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01918306 | GDC-0941 and Cisplatin in Treating Patients With Androgen Receptor-Negative Triple… | Phase 1 / Phase 2 | terminated | Aug 7, 2013 | Vanderbilt-Ingram Cancer Center | company stopped production of study drug due to excessive toxicities, lack of efficacy | Safety / toxicity |
| NCT01936961 | Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid…(I-CREST) | N/A | withdrawn | Sep 6, 2013 | Western Regional Medical Center | No patients enrolled | Enrollment / accrual |
| NCT01868503 | Lapatinib Ditosylate and Radiation Therapy in Treating Patients With Locally Advanced or… | Phase 2 | terminated | Jun 4, 2013 | Stanford University | Protocol modification | Other (stated, no rule matched) |
| NCT02915172 | Lenvatinib and Capecitabine in Patients With Advanced Malignancies | Phase 1 | withdrawn | Sep 26, 2016 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00088985 | Vaccine Therapy, Trastuzumab, and Vinorelbine in Treating Women With Locally Recurrent or… | Phase 2 | terminated | Aug 5, 2004 | UNC Lineberger Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT00932035 | Axillary Lymph Node Preservation Surgery in Reducing Lymphedema in Patients With Breast… | Phase 1 / Phase 2 | terminated | Jul 2, 2009 | City of Hope Medical Center | Loss of principal investigator | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Dec 2, 2017source: clinicaltrials