Clinical trial · Observational
Nipple Secretion Samples in Detecting Breast Cancer in Patients and Healthy Participants Undergoing Breast Cancer Screening, Breast Diagnostic Studies, or Treatment for Benign Breast Disease
Optical Biosensor for the Early Detection of Breast Cancer
NCT00813878CI-TRIAL-00029911terminatedClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Closed due to low accrual
Summary
Brief summary (as posted)
RATIONALE: Diagnostic procedures that measure biomarker levels in nipple section and blood samples, may help in the early detection of breast cancer. PURPOSE: This clinical trial is studying nipple secretion samples in detecting breast cancer in patients and healthy participants undergoing breast cancer screening, breast diagnostic studies, or treatment for benign breast disease.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (10)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| diagnostic laboratory biomarker analysis | Other | — | UNRESOLVED |
| fine-needle aspiration | Procedure | — | UNRESOLVED |
| immunohistochemistry staining method | Other | — | UNRESOLVED |
| liquid chromatography | Other | — | UNRESOLVED |
| mass spectrometry | Other | — | UNRESOLVED |
| needle biopsy | Procedure | — | UNRESOLVED |
| protein analysis | Genetic | — | UNRESOLVED |
| protein expression analysis | Genetic | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- label
- Normal participants
- interventionNames
- Genetic: protein analysis
- Genetic: protein expression analysis
- Genetic: proteomic profiling
- Other: diagnostic laboratory biomarker analysis
- Other: immunohistochemistry staining method
- Other: liquid chromatography
- Other: mass spectrometry
- Procedure: fine-needle aspiration
- Procedure: needle biopsy
- Procedure: radiomammography
- label
- Breast Cancer Patients
- interventionNames
- Genetic: protein analysis
- Genetic: protein expression analysis
- Genetic: proteomic profiling
- Other: diagnostic laboratory biomarker analysis
- Other: immunohistochemistry staining method
- Other: liquid chromatography
- Other: mass spectrometry
- Procedure: fine-needle aspiration
- Procedure: needle biopsy
- Procedure: radiomammography
Primary outcomes (4)
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 120 Years
Show eligibility criteria text
DISEASE CHARACTERISTICS: * Referred to the Women's Health Center at the City of Hope National Medical Center for breast cancer screening, breast diagnostic studies, or treatment of breast disease * Meets 1 of the following criteria: * Asymptomatic and undergoing screening mammography (normal controls) * Symptomatic and undergoing diagnostic mammography * History of an abnormal mammogram and undergoing stereotactic or ultrasound-guided fine-needle aspiration or core needle biopsy * Recently diagnosed biopsy-proven unilateral breast cancer prior to initiation of surgical or systemic therapy * No prior breast surgery or surgical biopsy that removed the current breast pathology * No prior breast reconstruction or breast reduction surgery that altered the ductal drainage pattern in the affected breast PATIENT CHARACTERISTICS: * No other cancer within the past 5 years except skin cancer * Not pregnant or nursing PRIOR CONCURRENT THERAPY: * See Disease Characteristics
References
Publications (0)
Data not yet available
No reference posted for this study.