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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,575 stopped studies mapped to Malignant Breast Neoplasm and descendants · 90% state a reason
Over the 1,575 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00824538 | Sunitinib in Treating Patients With Stage I, Stage II, or Stage III Breast Cancer Who… | Phase 2 | terminated | Jan 16, 2009 | University of California, San Francisco | Closed prematurely due to emerging data on toxicity and competing trials. | Safety / toxicity |
| NCT01796444 | Axillary Lymph Node Dissection Versus no Dissection in Breast Cancer With Positive…(Z0011-China) | Phase 3 | withdrawn | Feb 21, 2013 | Shandong Cancer Hospital and Institute | not stated | Not stated |
| NCT02677857 | Developing a Healthy Lifestyle in Breast Cancer Survivors | N/A | terminated | Feb 9, 2016 | The University of Tennessee, Knoxville | Recruitment efforts were not effective. | Enrollment / accrual |
| NCT02708511 | Copper Cu 64-DOTA-B-Fab PET/CT in Imaging Patients With Ovarian and Breast Cancer | Phase 1 | terminated | Mar 15, 2016 | Sanjiv Sam Gambhir | not stated | Not stated |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
| NCT00504699 | Safety of Ovarian Stimulation With Letrozole and Gonadotropins in Breast Cancer Patients | N/A | terminated | Jul 20, 2007 | New York Medical College | The PI left the Institution. | Investigator |
| NCT02269696 | The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast… | Phase 3 | withdrawn | Oct 21, 2014 | Kuopio University Hospital | Withdrawn | Other (stated, no rule matched) |
| NCT00692692 | Use of Dermal Matrix in Breast Reconstruction | N/A | terminated | Jun 6, 2008 | Vanderbilt University | higher rate of post-operative infection in the Dermal Matrix arm of the study | Other (stated, no rule matched) |
| NCT03081234 | Adjuvant Ribociclib With Endocrine Therapy in Hormone Receptor+/HER2- Intermediate Risk…(EarLEE-2) | Phase 3 | withdrawn | Mar 16, 2017 | Novartis Pharmaceuticals | Withdrawn due to change in plan for this study and not due to safety reasons. | Safety / toxicity |
| NCT01010854 | Valproic Acid in Combination With FEC100 for Primary Therapy in Patients With Breast…(VPA-FEC100) | Phase 2 | terminated | Nov 10, 2009 | University of California, San Francisco | Premature closure for lack of efficacy. | Efficacy / futility |
| NCT00352872 | Pharmacogenetics as a Predictor of Toxicity in Pre-Menopausal Women Receiving Doxorubicin… | — | terminated | Jul 17, 2006 | Indiana University | This study has been difficult to recruit. | Enrollment / accrual |
| NCT02596867 | Neoadjuvant Propanolol in Breast Cancer(NPBC) | Phase 2 | terminated | Nov 4, 2015 | Texas Tech University Health Sciences Center, El Paso | poor accrual | Enrollment / accrual |
| NCT00722072 | Sorafenib and Fulvestrant in Treating Patients With Locally Advanced or Metastatic Breast… | Phase 2 | terminated | Jul 25, 2008 | OHSU Knight Cancer Institute | Sponsor pulled funding and low accrual | Enrollment / accrual |
| NCT01710293 | Intervention Protocol for Automated Point-of-Care Surveillance of Outpatient Delays in…(PACT CREATE 3) | N/A | withdrawn | Oct 19, 2012 | VA Office of Research and Development | Unable to obtain data needed to run the RCT; project never began recruitment | Enrollment / accrual |
| NCT03202446 | Randomized Clinical Trial Evaluating the Use of the Laser-Assisted Immunotherapy… | Phase 3 | terminated | Jun 28, 2017 | Eske Corporation S.A.C | not stated | Not stated |
| NCT00004261 | EF5 Prior to Surgery or Biopsy in Patients With Breast, Prostate, or Cervical Cancer or… | Phase 1 | terminated | Dec 11, 2003 | University Health Network, Toronto | Lack of patient accrual | Enrollment / accrual |
| NCT01698281 | Phase 2 Trial of AEZS-108 in Chemotherapy Refractory in Triple Negative Breast Cancer | Phase 2 | terminated | Oct 2, 2012 | AEterna Zentaris | Poor recruitment | Enrollment / accrual |
| NCT01887288 | Capecitabine With Digoxin for Metastatic Breast Cancer | Phase 2 | terminated | Jun 26, 2013 | Western Regional Medical Center | PI Leaving Site | Other (stated, no rule matched) |
| NCT02345772 | Neoadjuvant Hormonal Therapy Combined With Chemoimmunotherapy(Neohttp) | Phase 1 / Phase 2 | terminated | Jan 26, 2015 | Western Regional Medical Center | PI no longer at site. Data was not collected | Other (stated, no rule matched) |
| NCT00632541 | A Phase II Study of Bevacizumab + Sorafenib in Metastatic Breast Cancer | Phase 2 | terminated | Mar 10, 2008 | Hoosier Cancer Research Network | Significant Toxicities Experienced | Safety / toxicity |
| NCT02120417 | A Study of Ruxolitinib in Combination With Capecitabine in Subjects With Advanced or… | Phase 2 | terminated | Apr 22, 2014 | Incyte Corporation | The study was terminated as other related studies of ruxolitinib did not provide sufficient… | Efficacy / futility |
| NCT01484041 | Dovitinib Plus an Aromatase Inhibitor for Metastatic Breast Cancer | Phase 1 / Phase 2 | terminated | Dec 2, 2011 | Georgetown University | Decision by company to cease development of dovitinib | Sponsor / business decision |
| NCT01937507 | Hepatic Artery Infusion With FOLFOX in Liver Metastasis From Breast Cancer | Phase 2 | terminated | Sep 9, 2013 | Western Regional Medical Center | PI Decision | Other (stated, no rule matched) |
| NCT00095862 | Vaccine Therapy in Treating Patients With HER2/Neu Positive or Negative Stage IV Breast… | Phase 1 / Phase 2 | terminated | Nov 9, 2004 | Wiseman Research Initiatives LLC | not stated | Not stated |
| NCT02784730 | Iterative PICC Placement Versus Long Term Device(PICC One Day) | Phase 3 | withdrawn | May 27, 2016 | Centre Leon Berard | Changes of the standard adjuvant treatment which does not allow an iterative PICC placement | Other (stated, no rule matched) |
| NCT00610831 | Computed Radiography (CR) Data Collection for Mammography Computer Aided Detection (CAD) | N/A | withdrawn | Feb 8, 2008 | University of California, Irvine | Funding Issues | Funding |
| NCT02257775 | Evolution of Resistance to Systemic Therapies in Patients With Breast Cancer(EVOLUTION) | — | terminated | Oct 6, 2014 | Institute of Cancer Research, United Kingdom | Insufficient number of eligible and interested partients | Other (stated, no rule matched) |
| NCT03126487 | High Intensity Focused Ultrasound Guided by MRI as Thermic Destruction in Primitive Small…(MRHEATBREAST) | N/A | withdrawn | Apr 24, 2017 | Centre Antoine Lacassagne | study do not start due to concurrential trial | Other (stated, no rule matched) |
| NCT01817374 | Breast VCEUS to Evaluate Early Response to Neoadjuvant Chemotherapy | N/A | terminated | Mar 25, 2013 | University of Alabama at Birmingham | not stated | Not stated |
| NCT01972048 | Mobile Phone Multimedia Messaging Intervention for Breast Cancer Screening | N/A | withdrawn | Oct 30, 2013 | University of Minnesota | PI Left University | Investigator |
| NCT00873366 | Breath Test for Women Receiving Tamoxifen in the Prevention or Treatment of Breast Cancer | — | terminated | Apr 1, 2009 | Mayo Clinic | Funding issues | Funding |
| NCT01655992 | A Trial Comparing S1 Generic With Capecitabine in Metastatic Breast Cancer (MBC) | Phase 3 | terminated | Aug 2, 2012 | Fudan University | The sponsor decided to stop the study. | Sponsor / business decision |
| NCT01984892 | Treatment of Solid Tumors With Intratumoral Hiltonol® (Poly-ICLC)(Hiltonol) | Phase 2 | terminated | Nov 15, 2013 | Nina Bhardwaj | PI discretion, low enrollment | Enrollment / accrual |
| NCT02166658 | A Study of Cabazitaxel for Patients With Breast or Lung Cancer and Recurrent or…(CaBaMet) | Phase 2 | terminated | Jun 18, 2014 | AIO-Studien-gGmbH | After a recruitment of more than 2 years, only 8 patients have been registered. | Enrollment / accrual |
| NCT02348281 | Bicalutamide as A Treatment in AR-positive Metastatic Triple-Negative Breast Cancer… | Phase 2 | terminated | Jan 28, 2015 | Fudan University | it's too slow to enroll suitable patients into this study | Enrollment / accrual |
| NCT00864175 | Open Label Trial of INCB07839 to Determine Effect and Safety of INCB007839 Plus… | Phase 1 / Phase 2 | terminated | Mar 18, 2009 | Incyte Corporation | Incyte suspended development of the compound. | Other (stated, no rule matched) |
| NCT01929941 | An Open-Label Study of a Novel JAK-inhibitor, INCB047986, Given in Patients With Advanced… | Phase 1 | terminated | Aug 28, 2013 | Incyte Corporation | Business decision. | Sponsor / business decision |
| NCT01815346 | Acupuncture Chemotherapy-Induced Peripheral Neuropathy (CIPN) IRG | Phase 1 / Phase 2 | terminated | Mar 21, 2013 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00470548 | Abraxane and Alimta in Advanced Solid Tumors | Phase 1 / Phase 2 | terminated | May 7, 2007 | University of California, Davis | Practice patterns with pemetrexed have evolved. | Other (stated, no rule matched) |
| NCT03271853 | Thermalogical Analysis of a Cohort of Women and Men Undergoing Mammographic Analysis. | — | suspended | Sep 5, 2017 | First Sense Medical, LLC | Trial temporarily halted to conduct additional device testing to verify cooling data. This… | Safety / toxicity |
| NCT00516269 | Trial of a Sustained Release Methylphenidate in the Treatment of Fatigue in Cancer… | Phase 3 | terminated | Aug 15, 2007 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00290654 | Internal Radiation Therapy After Lumpectomy in Treating Women With Ductal Carcinoma in… | Phase 2 | terminated | Feb 13, 2006 | Masonic Cancer Center, University of Minnesota | Unable to recruit further patients. | Enrollment / accrual |
| NCT00376805 | Allogeneic Natural Killer (NK) Cells in Patients With Advanced Metastatic Breast Cancer | Phase 2 | terminated | Sep 15, 2006 | Masonic Cancer Center, University of Minnesota | Withdrawn due to toxicity | Safety / toxicity |
| NCT00379197 | Phase II of Naltrexone in Hormone-Refractory Metastatic Breast Cancer | Phase 2 | terminated | Sep 21, 2006 | Masonic Cancer Center, University of Minnesota | slow accrual | Enrollment / accrual |
| NCT00602446 | Deferasirox in Treating Patients With Iron Overload After Undergoing a Donor Stem Cell… | Phase 2 | terminated | Jan 28, 2008 | Masonic Cancer Center, University of Minnesota | Due to slow accrual of patients | Enrollment / accrual |
| NCT01012362 | Study of Pazopanib and Ixabepilone in Patients With Solid Tumors | Phase 1 | terminated | Nov 13, 2009 | Masonic Cancer Center, University of Minnesota | PI left institution. | Investigator |
| NCT01372618 | Breast Cancer Chemoprevention by SOM230, an IGF-I Action Inhibitor | Phase 1 / Phase 2 | terminated | Jun 14, 2011 | NYU Langone Health | PI has passed away. Requested by department to terminate study. | Other (stated, no rule matched) |
| NCT00769990 | Genistein in Treating Patients Undergoing External-Beam Radiation Therapy for Bone… | Phase 1 / Phase 2 | withdrawn | Oct 9, 2008 | Masonic Cancer Center, University of Minnesota | No patient accrual. | Enrollment / accrual |
| NCT00373152 | MRI in Predicting Tumor Reponse After Radiofrequency Ablation in Women With Invasive… | Phase 2 | withdrawn | Sep 7, 2006 | Masonic Cancer Center, University of Minnesota | No patient accrual | Enrollment / accrual |
| NCT01425294 | Collection of Efficacy and Safety Data of Chinese Patients Who Have Received Faslodex… | — | terminated | Aug 30, 2011 | AstraZeneca | The study has been decided to be early terminated for the FAS 500 mg has launched in 2015. The use… | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Apr 5, 2018source: clinicaltrials