Clinical trial · Interventional
The Effect of Metoprolol on Anaesthesia, the Need for Analgesics, and Pain in Breast Cancer Patients
NCT02269696CI-TRIAL-00032202withdrawnPhase 3ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Why stopped (as posted): Withdrawn
Summary
Brief summary (as posted)
The purpose of the study is to test the effects of metoprolol on anaesthesia and the need for perioperative analgesics in patients undergoing breast surgery. With 12 months follow-up the incidence of pain and life satisfaction will be evaluated.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Breast Cancer | Malignant Breast Neoplasm | CURATED_EXACT | 0.92 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Metoprolol | Drug | — | UNRESOLVED |
| Normal saline | Drug | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Metoprolol
- description
- Metoprolol infusion
- interventionNames
- Drug: Metoprolol
- type
- PLACEBO_COMPARATOR
- label
- Normal saline
- description
- Equal volume of saline.
- interventionNames
- Drug: Normal saline
Primary outcomes (7)
- measure
- Anaesthesia
- timeFrame
- Intraoperative
- description
- Total consumption of desflurane
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 18 Years
- Maximum age
- 65 Years
Show eligibility criteria text
Inclusion Criteria: * Elective breast surgery due to breast cancer * Voluntary * BMI ≥ 18 and ≤ 35 kg/m2 * ASA 1-3 * No regular use of beta-blockers or during the last 72 hours * No contraindications to beta-blockers Exclusion Criteria: * Pregnancy or breast feeding * AV-block, degree II or III * Untreated cardiac insufficiency * Sinus bradycardia, heart rate \< 45 / min or symptoms * Sick sinus syndrome * Cardiogenic shock * Severe peripheral vascular disorder * Systolic blood pressure \< 100 mmHg * Long PQ-time, \> 0,24 seconds * Known hypersensitivity to beta-blockers or the ingredients of the drug
References
Publications (0)
Data not yet available
No reference posted for this study.