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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
847 stopped studies mapped to Malignant Bone Marrow Neoplasm and descendants · 88% state a reason
Over the 847 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT05279859 | A Study of Anti-Cancer Therapies Targeting the MAPK Pathway in Patients With Hematologic…(HERKULES-4) | Phase 1 / Phase 2 | withdrawn | Mar 15, 2022 | Erasca, Inc. | Sponsor decision. | Sponsor / business decision |
| NCT04655391 | Glasdegib-Based Treatment Combinations for the Treatment of Patients With Relapsed Acute… | Phase 1 | withdrawn | Dec 7, 2020 | City of Hope Medical Center | Drug availability | Drug supply |
| NCT02452983 | Sertraline in Treatment of Low-Risk Myelodysplastic Syndrome(SS1) | Phase 1 | terminated | May 25, 2015 | Gustavo Rivero | This protocol is closed to further enrollment due to lack of study progress. | Enrollment / accrual |
| NCT03063203 | Single Agent Decitabine in TP53 Mutated Relapsed/Refractory Acute Myeloid Leukemia | Phase 2 | terminated | Feb 24, 2017 | Washington University School of Medicine | Futility | Efficacy / futility |
| NCT04676243 | Daunorubicin or Idarubicin With Cytarabine Plus Quizartinib vs Physician's Choice in…(Q-SOC) | Phase 3 | withdrawn | Dec 19, 2020 | University Hospital Heidelberg | Study turned out no longer feasible | Other (stated, no rule matched) |
| NCT02999854 | Safety and Efficacy of ATIR101 as Adjunctive Treatment to Blood Stem Cell Transplantation…(HATCY) | Phase 3 | terminated | Dec 21, 2016 | Kiadis Pharma | Insufficient efficacy, terminated by Sponsor | Efficacy / futility |
| NCT03552029 | Milademetan Plus Quizartinib Combination Study in FLT3-ITD Mutant Acute Myeloid Leukemia… | Phase 1 | terminated | Jun 11, 2018 | Daiichi Sankyo | This study was terminated based on a business decision by the Sponsor. | Sponsor / business decision |
| NCT04264806 | A Study of Cusatuzumab in Combination With Azacitidine Compared With Azacitidine Alone in… | Phase 2 | withdrawn | Feb 11, 2020 | Janssen Research & Development, LLC | The cusatuzumab MDS strategy is under revision | Sponsor / business decision |
| NCT03303950 | Allogeneic Stem Cell Transplantation for Multiple Myeloma and Myelofibrosis | Phase 2 | terminated | Oct 6, 2017 | University of Utah | Slow accrual | Enrollment / accrual |
| NCT00968864 | T-cell Depleted Alternative Donor Transplantation | Phase 2 | terminated | Aug 31, 2009 | Wake Forest University Health Sciences | Sponsor/ PI leaving institution, no plans to continue this research at this time | Other (stated, no rule matched) |
| NCT02927938 | Leukemia Stem Cell Detection in Acute Myeloid Leukemia | Phase 3 | terminated | Oct 7, 2016 | Wake Forest University Health Sciences | Study terminated 7/23/2019 due to limited participation and testing challenges. | Other (stated, no rule matched) |
| NCT03600909 | A Study of the Effect of Blood Stem Cell Transplant After Chemotherapy Alone in Patients… | Phase 2 | terminated | Jul 26, 2018 | Memorial Sloan Kettering Cancer Center | Accrual has been slow | Enrollment / accrual |
| NCT04858594 | Study of Periodontitis and Blood Stream Infection in AML Patients Receiving Chemotherapy | — | terminated | Apr 26, 2021 | Masonic Cancer Center, University of Minnesota | PI left and research was stopped | Investigator |
| NCT03217838 | Safety, Tolerability, Pharmacokinetics, and Efficacy of AZD2811 Nanoparticles as… | Phase 1 | terminated | Jul 14, 2017 | AstraZeneca | strategic decision | Sponsor / business decision |
| NCT01187810 | Fenretinide in Children With Recurrent/Resistant ALL, AML, and NHL | Phase 1 | terminated | Aug 24, 2010 | South Plains Oncology Consortium | drug supply | Drug supply |
| NCT01876953 | Dasatinib, Cytarabine, and Idarubicin in Treating Patients With High-Risk Acute Myeloid… | Phase 1 / Phase 2 | terminated | Jun 13, 2013 | City of Hope Medical Center | Due to the budget issues, the study discontinued at Phase II. | Funding |
| NCT04893915 | Cytokine-induced Memory-like NK Cells in Relapsed/Refractory AML and MDS | Phase 2 | withdrawn | May 20, 2021 | Washington University School of Medicine | No funding support | Funding |
| NCT03151408 | An Efficacy and Safety Study Of Pracinostat In Combination With Azacitidine In Adults… | Phase 3 | terminated | May 12, 2017 | Helsinn Healthcare SA | The IDMC recommended to stop the study prematurely due to a lack of efficacy. | Efficacy / futility |
| NCT03696537 | IMRT-TMI With Fludarabine as Myeloablative Conditioning for Allogeneic HSCT | Phase 1 | terminated | Oct 4, 2018 | Naoyuki G. Saito, M.D., Ph.D. | Extreme toxicity | Safety / toxicity |
| NCT04331483 | A Study to Assess a Physical Activity Program in Children, Adolescents and Young Adults…(EVAADE) | N/A | withdrawn | Apr 2, 2020 | Centre Leon Berard | modification of the intervention before patient's enrollment, new protocol submitted | Enrollment / accrual |
| NCT03922477 | A Study Evaluating the Safety and Pharmacokinetics of Atezolizumab Administered in… | Phase 1 | terminated | Apr 22, 2019 | Hoffmann-La Roche | The Sponsor decided to discontinue the development of atezolizumab in combination with magrolimab… | Sponsor / business decision |
| NCT03761069 | Study of PTC299 (Emvododstat) in Relapsed/Refractory Acute Leukemias | Phase 1 | terminated | Dec 3, 2018 | PTC Therapeutics | Sponsor terminated the study. | Other (stated, no rule matched) |
| NCT03951961 | Midostaurin in MRD (Minimal Residual Disease) Positive Acute Myeloid Leukemia After… | Phase 2 | terminated | May 16, 2019 | University of Jena | Insufficient Recruitment | Enrollment / accrual |
| NCT04044209 | A Study of the IDH1 Inhibitor AG-120 in Combination With the Checkpoint Blockade… | Phase 2 | withdrawn | Aug 5, 2019 | Yale University | No patients were able to be screened nor enrolled. | Enrollment / accrual |
| NCT04097301 | Study of CAR T-cell Therapy in Acute Myeloid Leukemia and Multiple Myeloma | Phase 1 / Phase 2 | terminated | Sep 20, 2019 | AGC Biologics S.p.A. | Inability to close the study in a clinically relevant time frame | Other (stated, no rule matched) |
| NCT00740181 | Decitabine, Cytarabine, GCSF for Refractory AML/MDS | Phase 2 | terminated | Aug 22, 2008 | Brown University | Lack of efficacy | Efficacy / futility |
| NCT02228382 | Safety And Efficacy Study Of Bosutinib In Patients With Philadelphia Chromosome Positive… | Phase 4 | terminated | Aug 29, 2014 | Pfizer | not stated | Not stated |
| NCT03287245 | A Study to Evaluate the Efficacy, Safety, Pharmacokinetics and Pharmacodynamics of… | Phase 2 | terminated | Sep 19, 2017 | Hoffmann-La Roche | The Sponsor decided to discontinue the development of idasanutlin in the polycythemia vera… | Sponsor / business decision |
| NCT03797261 | A Study of Venetoclax and AMG 176 in Patients With Relapsed/Refractory Hematologic… | Phase 1 | terminated | Jan 9, 2019 | AbbVie | Safety | Safety / toxicity |
| NCT03557970 | JNJ-40346527 in Treating Participants With Relapsed or Refractory Acute Myeloid Leukemia | Phase 2 | terminated | Jun 15, 2018 | OHSU Knight Cancer Institute | Not enough enrollment to determine efficacy | Efficacy / futility |
| NCT04973618 | Study of APVO436 in Elderly or Unfit Patients With Newly Diagnosed AML | Phase 1 | withdrawn | Jul 22, 2021 | Aptevo Therapeutics | Change of strategy | Sponsor / business decision |
| NCT03519984 | EphB4-HSA Fusion Protein and Cytarabine /or Liposomal Vincristine in Patients With… | Phase 1 | terminated | May 9, 2018 | University of Southern California | Study drug supply issue | Drug supply |
| NCT02627677 | A Study Comparing Ponatinib and Nilotinib in Participants With Chronic Myeloid Leukemia(OPTIC-2L) | Phase 3 | terminated | Dec 11, 2015 | Ariad Pharmaceuticals | The study was stopped due to operational feasibility and not due to any safety concerns | Safety / toxicity |
| NCT02795520 | Pharmacological Study of Intravenous OTS167 in Patients With Refractory or Relapsed Acute… | Phase 1 / Phase 2 | terminated | Jun 10, 2016 | OncoTherapy Science, Inc. | slow patient accrual | Enrollment / accrual |
| NCT03123588 | Phase 2 Study of Ruxolitinib Versus Anagrelide in Subjects With Essential Thrombocythemia… | Phase 2 | terminated | Apr 21, 2017 | Incyte Corporation | Enrollment issues | Enrollment / accrual |
| NCT02055781 | Pacritinib Versus Best Available Therapy to Treat Patients With Myelofibrosis and…(PAC326) | Phase 3 | terminated | Feb 5, 2014 | CTI BioPharma | not stated | Not stated |
| NCT02078960 | A Study to Evaluate the Pharmacokinetics, Safety,and Efficacy of Omacetaxine Given… | Phase 1 / Phase 2 | terminated | Mar 5, 2014 | Teva Branded Pharmaceutical Products R&D, Inc. | Inability to accrue additional sites and enroll an adequate number of subjects. | Enrollment / accrual |
| NCT00210119 | Imatinib Mesylate and Zoledronic Acid in Patients With Chronic Myeloid Leukaemia in…(AFR22) | Phase 2 | terminated | Sep 21, 2005 | Institut Bergonié | not stated | Not stated |
| NCT01620216 | Targeted Therapy in Treating Patients With Relapsed or Refractory Acute Lymphoblastic… | Phase 2 | terminated | Jun 15, 2012 | OHSU Knight Cancer Institute | Unable to recruit enough eligible subjects | Enrollment / accrual |
| NCT02770820 | Laboratory-Treated (Central Memory/Naive) CD8+ T Cells in Treating Patients With Newly… | Phase 1 / Phase 2 | terminated | May 12, 2016 | Fred Hutchinson Cancer Center | Terminated due to funding difficulties | Funding |
| NCT04051996 | GLAD-AML - Glasdegib (Pf-04449913) With Two Standard Decitabine Regimens for Older… | Phase 2 | terminated | Aug 9, 2019 | Yale University | Unable to accrue patients following COVID-19 study pause. | COVID-19 / pandemic |
| NCT00766779 | HCT Versus CT in Elderly AML | Phase 3 | terminated | Oct 6, 2008 | European Society for Blood and Marrow Transplantation | Recommendation of DMC | Other (stated, no rule matched) |
| NCT02319369 | Safety, Tolerability and Pharmacokinetics of Milademetan Alone and With 5-Azacitidine… | Phase 1 | terminated | Dec 18, 2014 | Daiichi Sankyo | This study was terminated based on a business decision by the Sponsor. | Sponsor / business decision |
| NCT03588936 | Nivolumab and Tocilizumab for Relapsed Hematological Malignancy Post-allogeneic Transplant | Phase 1 | terminated | Jul 17, 2018 | Medical College of Wisconsin | Poor accrual and loss of funding. | Enrollment / accrual |
| NCT04464889 | HA-1H TCR T Cell for Relapsed/Persistent Hematologic Malignancies After Allogeneic Stem… | Phase 1 | withdrawn | Jul 9, 2020 | Medigene AG | Medigene transfered all rights to a new Sponsor | Other (stated, no rule matched) |
| NCT02298166 | Study of Crenolanib in Combination With Chemotherapy in Patients With Relapsed or… | Phase 3 | terminated | Nov 21, 2014 | University of Ulm | The manufacturer Arog Pharmaceuticals Inc has terminated the Agreement Concerning the Support of an… | Drug supply |
| NCT00900120 | Collecting and Storing Blood Samples From Patients With Cancer | — | withdrawn | May 12, 2009 | University of Medicine and Dentistry of New Jersey | Will be replaced by honest broker program | Other (stated, no rule matched) |
| NCT03473457 | CAR-T Cells Therapy in Relapsed/Refractory Acute Myeloid Leukemia(AML) | N/A | terminated | Mar 22, 2018 | Zhujiang Hospital | The therapeutic effect was not as expected | Other (stated, no rule matched) |
| NCT01045382 | MSC and HSC Coinfusion in Mismatched Minitransplants | Phase 2 | terminated | Jan 11, 2010 | University of Liege | recruitment too slow | Enrollment / accrual |
| NCT02105116 | AML Therapy With Irradiated Allogeneic Cells | N/A | terminated | Apr 7, 2014 | Rutgers, The State University of New Jersey | No patients were eligible to receive the experimental component of the protocol therapy. | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jun 15, 2022source: clinicaltrials