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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
200 stopped studies mapped to Malignant Anorectal Neoplasm and descendants · 93% state a reason
Over the 200 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01769222 | Ipilimumab and Local Radiation for Selected Solid Tumors | Phase 1 | terminated | Jan 16, 2013 | Stanford University | Planned Future Study | Other (stated, no rule matched) |
| NCT04379830 | Preoperative Very Low Energy Diet for Obese Rectal Cancer Patients | N/A | withdrawn | May 8, 2020 | McMaster University | There were no patients recruited during the trial period. This was a result of: 1) COVID-19… | COVID-19 / pandemic |
| NCT04558684 | Radiotherapy With Neoadjuvant Chemotherapy and Immunotherapy in Rectal Cancer | Phase 1 / Phase 2 | suspended | Sep 22, 2020 | Union Hospital, Tongji Medical College, Huazhong University of Science and Technology | Inadequate patient enrollment | Enrollment / accrual |
| NCT03592641 | Savolitinib in Treating Patients With MET Amplified Metastatic or Unresectable Colorectal… | Phase 2 | terminated | Jul 19, 2018 | National Cancer Institute (NCI) | Inadequate accrual rate | Enrollment / accrual |
| NCT00745134 | Radiation Therapy and Capecitabine With or Without Curcumin Before Surgery in Treating… | Phase 2 | terminated | Sep 3, 2008 | M.D. Anderson Cancer Center | The trial was stopped early because there was only one patient with pCR among the first 15 patients… | Other (stated, no rule matched) |
| NCT04066894 | Sacral Nerve Stimulation in Treating Low Anterior Resection Syndrome or Fecal… | Phase 2 | terminated | Aug 26, 2019 | M.D. Anderson Cancer Center | Due to Issues Enrolling Patients | Enrollment / accrual |
| NCT04139967 | Study of Short Course Radiation Therapy for Elderly Patients With Rectal Cancer | N/A | terminated | Oct 25, 2019 | University of Rochester | recruitment rates were too low | Enrollment / accrual |
| NCT00303628 | Postoperative Chemotherapy With or Without Bevacizumab for Patients With Stage II or III… | Phase 3 | terminated | Mar 17, 2006 | ECOG-ACRIN Cancer Research Group | The study was terminated before reaching its accrual goal due to slow accrual. | Enrollment / accrual |
| NCT01347645 | Irinotecan Plus E7820 Versus FOLFIRI in Second-Line Therapy in Patients With Locally… | Phase 1 / Phase 2 | terminated | May 4, 2011 | Eisai Inc. | The study was terminated by the Sponsor due to E7820 plus irinotecan being potentially inferior to… | Other (stated, no rule matched) |
| NCT05582031 | Regorafenib With Tislelizumab in Patients With Selected Mismatch…(REFIT-MSS) | Phase 2 | withdrawn | Oct 17, 2022 | Translational Research in Oncology | Study never started/ will not proceed. | Other (stated, no rule matched) |
| NCT02682485 | Serial Endoscopic Surveillance & Direct Topical Antibiotics to Define the Role of…(SES-DTA) | Phase 2 | withdrawn | Feb 15, 2016 | University of Chicago | Lack of funding | Funding |
| NCT01160926 | Dual REctcal Angiogenesis or MEK Inhibition radioTHERAPY Trial(DREAMtherapy) | Phase 1 | terminated | Jul 13, 2010 | The Christie NHS Foundation Trust | 2 DLTs had been reported from first 4 patients on lowest possible dose cohort. | Other (stated, no rule matched) |
| NCT04177602 | Evaluating Trifluridine/Tipiracil Based Chemoradiation in Locally Advanced Rectal Cancer… | Phase 1 / Phase 2 | terminated | Nov 26, 2019 | Universitätsklinikum Hamburg-Eppendorf | Due to the amended therapy strategies for rectal cancer recently, it was decided not to transfer… | Sponsor / business decision |
| NCT04150705 | PET/MR for Rectal Cancer Treatment Monitoring and Surveillance | N/A | terminated | Nov 5, 2019 | Washington University School of Medicine | It was determined that the trial could stop early due to surpassing the feasibility rate. | Other (stated, no rule matched) |
| NCT02910843 | Neoadjuvant Treatment With Regorafenib and Capecitabine Combined With Radiotherapy in…(RECAP) | Phase 1 | terminated | Sep 22, 2016 | Swiss Cancer Institute | due to structural financial deficit of SAKK | Funding |
| NCT04044430 | Encorafenib, Binimetinib, and Nivolumab in Treating Microsatellite Stable BRAF V600E… | Phase 1 | terminated | Aug 5, 2019 | University of California, San Francisco | Sponsor funding | Funding |
| NCT04672980 | RTX-321 Monotherapy in Patients With HPV 16+ Tumors | Phase 1 | terminated | Dec 17, 2020 | Rubius Therapeutics | The Sponsor terminated study after dosing 3 dose groups (9 pts) and closed trial on 11/30/22.… | Other (stated, no rule matched) |
| NCT03693846 | Nivolumab and Ipilimumab in Mucinous Colorectal and Appendiceal Tumors | Phase 2 | terminated | Oct 3, 2018 | Abramson Cancer Center at Penn Medicine | Terminated due to slow enrollment and lack of efficacy | Efficacy / futility |
| NCT03781778 | Pilot Trial of Resistant Starch in Stage I-III Colorectal Cancer Survivors | Phase 2 | terminated | Dec 20, 2018 | Fred Hutchinson Cancer Center | Terminated due to expiration of funding | Funding |
| NCT04372992 | The Stoma Closure Before or After Adjuvant Therapy Trial(STOMAD) | N/A | terminated | May 4, 2020 | Ospedale Umberto I di Torino | Low accrual - no restart after pandemic suspension | COVID-19 / pandemic |
| NCT05018325 | Assessing Effect of Withdrawal Time on Adenoma Detection Rate for Screening Colonoscopy | N/A | terminated | Aug 24, 2021 | Washington University School of Medicine | Futility | Efficacy / futility |
| NCT04670588 | Response Assessment by Circulating Tumor DNA in Patients With Locally Advanced Rectal… | — | withdrawn | Dec 17, 2020 | Medical College of Wisconsin | No accrual. | Enrollment / accrual |
| NCT04596033 | TiTAN-1: Safety, Proliferation and Persistence of GEN-011 Autologous Cell Therapy | Phase 1 | terminated | Oct 22, 2020 | Genocea Biosciences, Inc. | Business reasons | Sponsor / business decision |
| NCT02445456 | Feasibility of Sentinel Lymph Node Biopsy in Rectal Cancer(SentiRect) | N/A | terminated | May 15, 2015 | Oxford University Hospitals NHS Trust | Logistical difficulties in recruiting patients led to slower than expected recruitment. Recruitment… | COVID-19 / pandemic |
| NCT02503111 | The HPV-SAVE Study Team: HPV Screening and Vaccine Evaluation in Men Who Have Sex With Men(HPV-SAVE) | N/A | terminated | Jul 20, 2015 | University Health Network, Toronto | Results from ANCHOR study showed benefit of Treatment over Surveillance in preventing anal… | Other (stated, no rule matched) |
| NCT02933944 | Exploratory Study of TG02-treatment as Monotherapy or in Combination With Pembrolizumab… | Phase 1 | terminated | Oct 14, 2016 | Targovax ASA | Changing priorities | Other (stated, no rule matched) |
| NCT02465593 | A Study of PEP503(Radio-enhancer) With Radiotherapy and Chemotherapy for Patients With… | Phase 1 / Phase 2 | terminated | Jun 8, 2015 | PharmaEngine | not stated | Not stated |
| NCT01285102 | Chemoembolization Using Irinotecan in Treating Patients With Liver Metastases From… | Phase 1 | terminated | Jan 27, 2011 | Fox Chase Cancer Center | This study was closed early by the DSMB due to increased toxicity. | Safety / toxicity |
| NCT01995396 | Hartmanns Procedure or Abdominoperineal Excision With Intersphincteric Dissection in…(HAPIrect) | N/A | terminated | Nov 26, 2013 | Region Västmanland | Decision after interims analysis | Other (stated, no rule matched) |
| NCT01324141 | Topical MTS-01 for Dermatitis During Radiation and Chemotherapy for Anal Cancer | Phase 1 | terminated | Mar 28, 2011 | National Cancer Institute (NCI) | Slow, insufficient accrual and failure to meet endpoints. | Enrollment / accrual |
| NCT04499352 | A Study to Test BI 754091 Alone or in Combination With BI 836880 in People Who Have… | Phase 2 | withdrawn | Aug 5, 2020 | Boehringer Ingelheim | Not due to safety reasons (sponsor decision). | Safety / toxicity |
| NCT04418895 | Neoadjuvant Therapy for Localized Rectal Adenocarcinoma | Phase 2 | withdrawn | Jun 5, 2020 | UNC Lineberger Comprehensive Cancer Center | lack of resources | Other (stated, no rule matched) |
| NCT02319304 | Pelvic Radiotherapy With Concurrent Neoadjuvant FOLFOX for Patients With Newly Diagnosed…(GCC 1314) | Phase 2 | terminated | Dec 18, 2014 | University of Maryland, Baltimore | Slow accrual, PI left instituion | Investigator |
| NCT03699410 | Observational Study on Rectal Cancer to Verify if Response After Chemo-radiotherapy Can…(LiBReCa) | — | terminated | Oct 9, 2018 | Dimitri Christoforidis | failure to identify complete responders since ctDNA disappears after radiotherapy in most patients. | Other (stated, no rule matched) |
| NCT02163785 | Abdominoperineal Extra-Elevators Rectal Resection for Cancer: Prone Position vs. Supine…(APPRO) | N/A | terminated | Jun 16, 2014 | Hospital Universitario La Fe | insufficient recruitment rate | Enrollment / accrual |
| NCT04620473 | Anlotinib Hydrochloride Combined With Capeox in the Neoadjuvant Treatment of Locally… | Phase 2 | withdrawn | Nov 9, 2020 | Shanghai Minimally Invasive Surgery Center | No approval from ethical committee | Other (stated, no rule matched) |
| NCT03280277 | Ferumoxytol-Enhanced MRI in Imaging Lymph Nodes in Patients With Locally Advanced Rectal… | Early Phase 1 | terminated | Sep 12, 2017 | OHSU Knight Cancer Institute | low accrual | Enrollment / accrual |
| NCT03633539 | Single-incision Versus Conventional Laparoscopic Surgery for Colorectal Cancer(mSILSC) | N/A | withdrawn | Aug 16, 2018 | Ruijin Hospital | No research funds were raised | Funding |
| NCT03942900 | Immunomonitoring and Biomarker Research in Patients With Squamous Cell Anal Carcinoma(LAND) | — | withdrawn | May 8, 2019 | Centre Hospitalier Universitaire de Besancon | Study not submitted to regulatory authorities | Other (stated, no rule matched) |
| NCT02550743 | BrUOG 302:BYL719, Capecitabine and Radiation for Rectal Cancer: A Brown University… | Phase 1 | terminated | Sep 15, 2015 | howard safran | lack of accural | Other (stated, no rule matched) |
| NCT02614157 | Lateral Lymph Node Dissection After Neoadjuvant Chemo-radiation in Advanced Low Rectal… | N/A | terminated | Nov 25, 2015 | West China Hospital | The enrollment was too low | Enrollment / accrual |
| NCT03170115 | Induction Chemotherapy Plus Chemoradiotherapy With or Without Aspirin in High Risk Rectal…(ICAR) | Phase 2 | terminated | May 30, 2017 | Instituto Nacional de Cancer, Brazil | Aspirin added to chemoradiotherapy was safe but did not improve response to total neoadjuvant… | Other (stated, no rule matched) |
| NCT03257332 | Determining Early Development of Faecal Incontinence and Anorectal Muscle Function After…(EDFI-Cohort) | — | withdrawn | Aug 22, 2017 | Slagelse Hospital | Not possible to include participants | Other (stated, no rule matched) |
| NCT01097239 | Examining the Role of Transrectal High Intensity Focused Ultrasound (HIFU) in Rectal… | Phase 1 / Phase 2 | withdrawn | Apr 1, 2010 | Imperial College London | Failure to recruit. | Enrollment / accrual |
| NCT02010567 | Neoadjuvant Chemoradiotherapy With CRLX-101 and Capecitabine for Rectal Cancer | Phase 1 / Phase 2 | terminated | Dec 12, 2013 | UNC Lineberger Comprehensive Cancer Center | The study was halted prematurely at the funding partner's request. | Funding |
| NCT00671645 | Preoperative Combined RadioChemo-Molecular Target Therapy With Capecitabine, Bevacizumab,… | Phase 2 | terminated | May 5, 2008 | Austrian Breast & Colorectal Cancer Study Group | reaching of step 1 (recruitment of 8 patients) per protocol -\> risk assessment -\> termination… | Safety / toxicity |
| NCT01302613 | Altered Chemotherapy Sequencing During Neoadjuvant Therapy for Patients With Stage II or… | Phase 1 / Phase 2 | withdrawn | Feb 24, 2011 | University of Texas Southwestern Medical Center | Drug shortage | Other (stated, no rule matched) |
| NCT01249443 | Paclitaxel and Carboplatin in Treating Patients With Metastatic or Recurrent Solid Tumors… | Phase 1 | terminated | Nov 29, 2010 | AIDS Malignancy Consortium | Inadequate accrual rate | Enrollment / accrual |
| NCT00568425 | QOL & Functional Outcomes After Combined Modality Tx for Anal CA: Comparison of… | — | terminated | Dec 6, 2007 | Stanford University | Inadequate response to Scientific Review Committee. | Other (stated, no rule matched) |
| NCT02205307 | A Study Assessing Perfusion Outcomes With PINPOINT® Near Infrared Fluorescence Imaging in…(PILLAR III) | N/A | terminated | Jul 31, 2014 | Novadaq Technologies ULC, now a part of Stryker | Slow recruitment | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 24, 2024source: clinicaltrials