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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,739 stopped studies mapped to Lymphoma and descendants · 89% state a reason
Over the 1,739 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00128921 | Study of Velcade® and Bone Formation in Patients With Relapsed/Refractory Multiple Myeloma | Phase 2 | terminated | Aug 10, 2005 | University of Arkansas | study terminated due to low accrual | Enrollment / accrual |
| NCT00704691 | Lenalidomide Therapy for Patients With Relapsed and/or Refractory, Peripheral T-Cell… | Early Phase 1 | terminated | Jun 25, 2008 | University of Alabama at Birmingham | Closed due to futility with only 1 patient accrued | Efficacy / futility |
| NCT00171925 | Therapy With Zoledronic Acid in Patients With Multiple Myeloma Stage I | Phase 3 | terminated | Sep 15, 2005 | Novartis Pharmaceuticals | Recruitment in study could not be reached after 8 yrs of recruiting | Enrollment / accrual |
| NCT00366106 | Alternative Schedule of Velcade/Dexamethasone Plus Doxil for Patients With Multiple… | Phase 2 | terminated | Aug 18, 2006 | Accelerated Community Oncology Research Network | Study was closed to enrollment when it became clear that enrollment was too slow to complete full… | Enrollment / accrual |
| NCT00121186 | S0501 Fludarabine, Melphalan, and Donor Stem Cell Transplant Followed By Tacrolimus and… | Phase 2 | terminated | Jul 21, 2005 | SWOG Cancer Research Network | poor accrual | Enrollment / accrual |
| NCT00827099 | Umbilical Cord Blood (UCB) Transplant, Fludarabine, Melphalan, and Anti-thymocyte… | Phase 2 | terminated | Jan 22, 2009 | Northside Hospital, Inc. | Unacceptable morbidity \& mortality | Other (stated, no rule matched) |
| NCT00003929 | Chemotherapy, Filgrastim, and Radiation Therapy in Treating Patients With Primary Central… | Phase 2 | withdrawn | Jul 26, 2004 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00402935 | Ovarian Damage in Young Premenopausal Women Undergoing Chemotherapy for Cancer | — | withdrawn | Nov 23, 2006 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00389506 | Fludarabine and Cyclophosphamide Followed By LMB-2 Immunotoxin in Treating Patients With… | N/A | withdrawn | Oct 19, 2006 | National Institutes of Health Clinical Center (CC) | not stated | Not stated |
| NCT00488553 | Molecular Epidemiology of Lymphoma Patients | — | withdrawn | Jun 20, 2007 | M.D. Anderson Cancer Center | No participants recruited, study discontinued. | Enrollment / accrual |
| NCT01452334 | Safety Study of Anti-Programmed Death-Ligand 1 in Hematologic Malignancy | Phase 1 | withdrawn | Oct 14, 2011 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00005969 | Liposomal Tretinoin in Treating Patients With Recurrent or Refractory Hodgkin's Disease | Phase 2 | withdrawn | Apr 28, 2004 | M.D. Anderson Cancer Center | Study withdrawn. | Other (stated, no rule matched) |
| NCT00475332 | Study to Treat Relapsed Follicular Non-Hodgkin's Lymphoma With Radiation and Bexxar | Phase 2 | terminated | May 21, 2007 | University of Florida | PI left our institution | Investigator |
| NCT00419081 | Study of Forodesine Hydrochloride in Patients With Relapsed/Refractory Precursor… | Phase 2 | terminated | Jan 8, 2007 | BioCryst Pharmaceuticals | Issues with Manufacturing | Drug supply |
| NCT01175278 | Vertebral Augmentation With Kyphoplasty vs Nonsurgical Mgmt for Vertebral Body… | N/A | withdrawn | Aug 4, 2010 | H. Lee Moffitt Cancer Center and Research Institute | No enrollment | Enrollment / accrual |
| NCT00432419 | Therapeutic Intensification of HIV-associated Non-Hodgkin's Lymphoma by Peripheral Blood… | Phase 1 / Phase 2 | terminated | Feb 7, 2007 | French National Agency for Research on AIDS and Viral Hepatitis | only one patient enrolled | Enrollment / accrual |
| NCT00473551 | Anti-Third Party T Lymphocytes With Nonmyeloablative Stem Cell Transplantation for… | Phase 1 | terminated | May 15, 2007 | M.D. Anderson Cancer Center | Terminated due to slow accrual. | Enrollment / accrual |
| NCT00400764 | A Study of Dulanermin in Combination With Rituximab in Subjects With Follicular and Other… | Phase 1 / Phase 2 | terminated | Nov 17, 2006 | Genentech, Inc. | not stated | Not stated |
| NCT00587015 | A Phase I, Multicenter, Dose Escalation Study of CAT-8015 in Patients With Non-Hodgkin's… | Phase 1 | terminated | Jan 7, 2008 | MedImmune LLC | Due to a lack of IP supply and then terminated because they were combined into one new study with… | Drug supply |
| NCT00505921 | Autologous and Allogenic Transplantation With Campath-1H for T-Cell Lymphoma | Phase 2 | terminated | Jul 25, 2007 | M.D. Anderson Cancer Center | Slow Accrual. | Enrollment / accrual |
| NCT00712062 | Study of Pemetrexed to Treat Recurrent or Progressive Primary Central Nervous System… | Phase 2 | withdrawn | Jul 9, 2008 | University of Florida | Lack of accrual | Enrollment / accrual |
| NCT00107614 | DT PACE, Tandem Autologous Transplant, Maintenance Therapy for Waldenstrom's… | Phase 2 | terminated | Apr 6, 2005 | University of Arkansas | Terminated due to poor accrual. | Enrollment / accrual |
| NCT00023790 | Photodynamic Therapy in Treating Patients With Skin Cancer or Solid Tumors Metastatic to… | Phase 1 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00573391 | Study of Multiple Myeloma Patients Relapsing or Progressing After Autologous… | Phase 3 | terminated | Dec 14, 2007 | University of Arkansas | low accrual | Enrollment / accrual |
| NCT00880867 | Intratumoral Poly-ICLC Plus Low Dose Local Radiation in Low Grade Recurrent B and T Cell… | Phase 1 | terminated | Apr 14, 2009 | Nevada Cancer Institute | Low enrollment | Enrollment / accrual |
| NCT00112619 | Topotecan in Treating Young Patients With Neoplastic Meningitis Due to Leukemia,… | Phase 1 | terminated | Jun 3, 2005 | Pediatric Brain Tumor Consortium | Slow accrual and company withdrawing support to supply the drug | Drug supply |
| NCT01116128 | Dasatinib in Combination With Melphalan and Prednisone to Treat Relapsed and Refractory…(D-MP) | Phase 2 | terminated | May 4, 2010 | Fondazione EMN Italy Onlus | difficulty in enrolling patients | Enrollment / accrual |
| NCT01194193 | Preliminary Anti-tumour Activity of mTor Kinase Inhibitor in Advanced Tumours | Phase 1 | withdrawn | Sep 2, 2010 | AstraZeneca | Amendment to study compound development programme | Other (stated, no rule matched) |
| NCT00577668 | A Pilot Study of the Combination of Melphalan, Bortezomib, Thalidomide and Dexamethasone… | Phase 2 | withdrawn | Dec 20, 2007 | University of Arkansas | Poor accrual | Enrollment / accrual |
| NCT00216151 | Zoledronic Acid in the Management of Patients With Asymptomatic/Early Stage Multiple… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | Study terminated due to low patient enrollment. | Enrollment / accrual |
| NCT01170052 | Bendamustine and Temsirolimus in Patients With Relapsed or Refractory Mantle Cell… | Phase 1 / Phase 2 | withdrawn | Jul 27, 2010 | Charite University, Berlin, Germany | insufficient enrollment | Enrollment / accrual |
| NCT00813501 | Immunologic Diagnostic Blood Test in Predicting Side-Effects in Patients Undergoing a… | — | terminated | Dec 23, 2008 | City of Hope Medical Center | Terminated at the request of the study sponsor | Other (stated, no rule matched) |
| NCT00050687 | Safety and Pharmacokinetics of Orally Administered Gallium Maltolate in Various… | Phase 1 / Phase 2 | terminated | Dec 19, 2002 | Titan Pharmaceuticals | not stated | Not stated |
| NCT00460460 | Phase I, Open-label, Dose Escalation of AZD4877 in Hematologic Malignancies | Phase 1 | terminated | Apr 16, 2007 | AstraZeneca | Study was terminated due to low enrollment | Enrollment / accrual |
| NCT00003113 | Oral Combination Chemotherapy in Treating Elderly Patients With Intermediate or… | Phase 2 | terminated | Sep 24, 2003 | Case Comprehensive Cancer Center | not stated | Not stated |
| NCT00651443 | Mechanism of Action of Galiximab in Subjects With Previously Untreated Follicular… | Phase 1 | terminated | Apr 2, 2008 | Biogen | A company's strategic decision to focus on areas whereit believes it can be competitive and decided… | Sponsor / business decision |
| NCT01116154 | Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin… | Phase 1 | terminated | May 4, 2010 | City of Hope Medical Center | Sponsor withdrew support for the study | Other (stated, no rule matched) |
| NCT00386321 | Yt90 Zevalin and Combination Chemotherapy (Z-CHOP)in Treating Patients With Stage II,… | Phase 2 | terminated | Oct 11, 2006 | Chulalongkorn University | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00162500 | A Novel Vaccine for the Treatment of MUC1-expressing Tumor Malignancies | Phase 2 | withdrawn | Sep 13, 2005 | Hadassah Medical Organization | not stated | Not stated |
| NCT00136591 | A Phase 2 Study of Velcade™ in Subjects With Relapsed or Refractory Follicular B-Cell… | Phase 2 | terminated | Aug 29, 2005 | Lymphoma Study Association | An arm closed due to lack of efficacy | Efficacy / futility |
| NCT00775957 | Assessment of Hematopoietic Recovery Following Chemotherapy for Non-Hodgkin's Lymphoma | — | terminated | Oct 20, 2008 | University of Oklahoma | Terminated by institutional review board | Other (stated, no rule matched) |
| NCT00003567 | Gene Therapy and Chemotherapy in Treating Patients With Advanced Solid Tumors or… | Phase 1 | terminated | Jan 27, 2003 | Case Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT00110006 | Positron Emission Tomography Using Fludeoxyglucose F 18 in Predicting Response to… | N/A | withdrawn | May 4, 2005 | Case Comprehensive Cancer Center | No accrual | Enrollment / accrual |
| NCT00275262 | A Study to Evaluate the Ability of Lupron Depot to Enhance Immune Function Following Bone… | Phase 2 | terminated | Jan 11, 2006 | Abbott | not stated | Not stated |
| NCT00298467 | MDX-060 in Patients With Relapsed or Refractory Classic Systemic or Primary Cutaneous… | Phase 2 | withdrawn | Mar 2, 2006 | Bristol-Myers Squibb | sponsor decision | Sponsor / business decision |
| NCT00304590 | Study of XL999 in Patients With Multiple Myeloma | Phase 2 | terminated | Mar 20, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00004058 | 12-O-Tetradecanoylphorbol-13-acetate in Treating Patients With Hematologic Cancer or Bone… | Phase 1 | terminated | Jan 27, 2003 | University of Medicine and Dentistry of New Jersey | At this time it is felt that we will not gain further information from an additional patients. | Other (stated, no rule matched) |
| NCT00161239 | LAMPP Trial for Peripheral and Cutaneous T-Cell Lymphoma | N/A | terminated | Sep 12, 2005 | University of Medicine and Dentistry of New Jersey | toxicity | Safety / toxicity |
| NCT00243763 | TKI258 in Subjects With Refractory or Relapsed Multiple Myeloma | Phase 1 | terminated | Oct 25, 2005 | Novartis | not stated | Not stated |
| NCT00471367 | Phase I, Open-label, Dose-escalation, Safety and PK Study of AZD4877 | Phase 1 | terminated | May 9, 2007 | AstraZeneca | Part B of the study was terminated early due to a lack of enrollment. | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 26, 2012source: clinicaltrials