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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,261 stopped studies mapped to Lung Carcinoma and descendants · 91% state a reason
Over the 1,261 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00596830 | Carboplatin And Paclitaxel With Or Without CP-751, 871 (An IGF-1R Inhibitor) For Advanced… | Phase 3 | terminated | Jan 17, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01871480 | CIK Cell Transfusion Plus Gefitinib As Second Or Third-Line Treatment for Advanced… | Phase 2 | terminated | Jun 6, 2013 | Kunming Medical University | not stated | Not stated |
| NCT00558636 | A Trial Comparing Safety and Efficacy of Carboplatin and Paclitaxel Plus or Minus… | Phase 3 | terminated | Nov 15, 2007 | Bayer | Terminated early when the results from Study NCT00300885 showed an overall lack of efficacy in… | Efficacy / futility |
| NCT01836341 | Afatinib In Combination With Cisplatin Or Carboplatin + Pemetrexed In Patients With… | Phase 1 | withdrawn | Apr 19, 2013 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT01533727 | CIK Cell Transfusion Plus Chemotherapy as Adjuvant Therapy for Stage IB-IIIA Non-Small… | Phase 2 | withdrawn | Feb 15, 2012 | Sun Yat-sen University | Few patients would like to participate ,since CIK cell transfusion was a new treatment and its… | Efficacy / futility |
| NCT00887315 | The Synergistic Metastases Annihilation With Radiotherapy and Docetaxel (Taxotere)…(SMART) | Phase 2 | terminated | Apr 23, 2009 | University of Chicago | Slow accrual and loss of sponsor | Enrollment / accrual |
| NCT00701870 | Study of Telintra for Treatment of Chemotherapy Induced Neutropenia in Patients With… | Phase 2 | terminated | Jun 19, 2008 | Telik | Study TLK199.2102 was terminated for lack of enrollment. | Enrollment / accrual |
| NCT01504542 | Immune Response and Safety of HS110 Vaccine in Combination With Erlotinib in Patients… | Phase 2 | withdrawn | Jan 5, 2012 | Heat Biologics | Lack of enrollment | Enrollment / accrual |
| NCT00365183 | Trial of Motexafin Gadolinium and Pemetrexed (Alimta®) for Second Line Treatment in… | Phase 2 | terminated | Aug 17, 2006 | Pharmacyclics LLC. | not stated | Not stated |
| NCT01060514 | Pazopanib + Vinorelbine in Non Small Cell Lung Cancer (NSCLC) and Breast Cancer | Phase 1 | terminated | Feb 2, 2010 | Northwestern University | Lack of timely accrual. | Enrollment / accrual |
| NCT01674738 | TS Stratified Chemotherapy and VEGF Inhibition in Non-Squamous Non-Small Cell Lung Cancer…(SELECT-A) | Phase 2 | withdrawn | Aug 29, 2012 | Aktion Bronchialkarzinom e.V. | Decision of the Sponsor, as the funding of the study was no longer guaranteed. | Funding |
| NCT00536107 | Study to Assess Safety/Tolerability/Efficacy of Gefitinib Versus Docetaxel in Locally… | Phase 4 | terminated | Sep 27, 2007 | AstraZeneca | not stated | Not stated |
| NCT01210131 | Hypoxia-guided Radiotherapy With Cisplatin-etoposide in Stage I-III : Small Cell Lung…(HX4 in SCLC) | N/A | withdrawn | Sep 28, 2010 | Maastricht Radiation Oncology | not stated | Not stated |
| NCT01728181 | A Phase I/II Study of Tivozanib and Erlotinib as Initial Treatment for Metastatic… | Phase 1 / Phase 2 | withdrawn | Nov 16, 2012 | University of Utah | Stopped before approval due to ineffective drug | Other (stated, no rule matched) |
| NCT00673049 | Trial Of CP-751, 871 And Erlotinib In Refractory Lung Cancer(NSCLC) | Phase 3 | terminated | May 7, 2008 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01006226 | 64CuATSM and Hypoxia in Stage IV Non-small Cell Lung Cancer With Carboplatin, Paclitaxel,… | N/A | withdrawn | Nov 2, 2009 | Washington University School of Medicine | Withdrawn due to funding issues | Funding |
| NCT01282333 | Veliparib, Cisplatin, and Gemcitabine Hydrochloride in Treating Patients With Advanced… | Phase 1 | terminated | Jan 25, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01337154 | First Line Study of Tamibarotene in Combination for Advanced Non-Small Cell Lung Cancer | Phase 2 | terminated | Apr 18, 2011 | CytRx | Interim analysis showed that the primary endpoint would not be met. | Efficacy / futility |
| NCT00773383 | A Study of the Effect of R1507 in Combination With Tarceva (Erlotinib) on… | Phase 2 | terminated | Oct 16, 2008 | Hoffmann-La Roche | not stated | Not stated |
| NCT00087269 | Erlotinib in Treating Patients With Stage I-IIIA Non-Small Cell Lung Cancer Undergoing… | Phase 2 | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00697476 | Study of Oral Vorinostat in Combination With Topotecan in Patients With Chemosensitive… | Phase 1 / Phase 2 | terminated | Jun 13, 2008 | Armando Santoro, MD | insufficient enrollment | Enrollment / accrual |
| NCT00758134 | Trastuzumab Therapy in Non-Small Cell Lung Cancer Patients | Phase 2 | terminated | Sep 23, 2008 | Armando Santoro, MD | Insufficient accrual | Enrollment / accrual |
| NCT00916669 | A Randomized Study to Evaluate the Effect of Two Different Doses of Enoxaparin Sodium in… | Phase 2 | withdrawn | Jun 9, 2009 | Massachusetts General Hospital | sponsor withdrew funding prior to patient enrollment | Enrollment / accrual |
| NCT00268255 | Gefitinib and Radiation Therapy in Treating Patients With Inoperable Stage I or Stage II… | Phase 1 / Phase 2 | withdrawn | Dec 22, 2005 | Barbara Ann Karmanos Cancer Institute | Study never moved forward with accrual. | Enrollment / accrual |
| NCT01088620 | Panitumumab Plus Pemetrexed and Cisplatin (PemCisP) Versus PemCis in the First-line… | Phase 2 | suspended | Mar 17, 2010 | WiSP Wissenschaftlicher Service Pharma GmbH | the DSMB stopped the trial due to unacceptable side effects in the experimental arm which has not… | Other (stated, no rule matched) |
| NCT00937482 | Cediranib Maleate and Whole Brain Radiation Therapy in Patients With Brain Metastases… | Phase 1 | terminated | Jul 13, 2009 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00977561 | A Study Of Cisplatin (Or Carboplatin) And Etoposide With Or Without Figitumumab… | Phase 2 | terminated | Sep 15, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01500824 | A Clinical Study Testing The Safety And Efficacy Of Crizotinib In East Asian Patients… | Phase 2 | withdrawn | Dec 28, 2011 | Pfizer | not stated | Not stated |
| NCT00705549 | Individualized Therapy Based of Tumoral mRNA Levels of ERCC1, RRM1 and BRCA1 in Advanced… | Phase 2 | terminated | Jun 26, 2008 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00042835 | Erlotinib and Radiation Therapy Plus Combination Chemotherapy in Treating Patients With… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00090675 | Maintenance ZD1839 (IRESSA®) Following Completion of Front Line, Platinum-Based, Double…(IMAC/Herbst) | Phase 3 | withdrawn | Sep 3, 2004 | AstraZeneca | No patients randomised | Other (stated, no rule matched) |
| NCT00776295 | Autologous SCT Followed by Dendritic Cell p53 Vaccination in Patients With Limited Stage… | Phase 2 | terminated | Oct 21, 2008 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT00040768 | Bortezomib in Treating Patients With Advanced Non-small Cell Lung Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00087191 | EF5 and Motexafin Lutetium in Detecting Tumor Cells in Patients With Abdominal or… | N/A | terminated | Jul 12, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00862134 | Randomized, Multi-center, Open-label, Study of PR104 Versus PR104/Docetaxel in Non-Small… | Phase 2 | terminated | Mar 16, 2009 | Proacta, Incorporated | Interim analysis indicated low probability of clinically significant result | Efficacy / futility |
| NCT01071434 | Feasibility of Using Real-time Cine-MRI for Treating Moving & Deforming Tumors | — | terminated | Feb 19, 2010 | Stanford University | PI left | Investigator |
| NCT01004510 | Zometa Adjuvant Treatment of Malignant Pleural Effusion Due To Non-Small Cell Lung Cancer(ZAP) | Phase 2 | terminated | Oct 30, 2009 | Peter Bushunow MD | failure to accrue projected number of patients | Enrollment / accrual |
| NCT01124812 | 131I-L19SIP Radioimmunotherapy Combined With Radiochemotherapy in Patients With… | Phase 1 | terminated | May 17, 2010 | Philogen S.p.A. | not stated | Not stated |
| NCT00694603 | Cetuximab as Therapy for Recurrent Non-Small Cell Lung Cancer Patients Who Have Received… | Phase 2 | terminated | Jun 10, 2008 | Lecia V. Sequist | Slow accrual | Enrollment / accrual |
| NCT00093132 | Satraplatin for Locally Advanced Non-Small Cell Lung Cancer With Simultaneous Radiotherapy | Phase 1 / Phase 2 | terminated | Oct 4, 2004 | Agennix | Sponsor decided to discontinue study drug development. | Sponsor / business decision |
| NCT01563601 | Efficacy and Safety of Obatoclax Mesylate in Combination With Carboplatin and Etoposide… | Phase 3 | withdrawn | Mar 27, 2012 | Cephalon | Business Decision | Sponsor / business decision |
| NCT00386555 | A Phase 2 Study in Patients With Advanced Non-Small Cell Lung Cancer Using New Agents… | Phase 2 | withdrawn | Oct 11, 2006 | Arog Pharmaceuticals, Inc. | Study was cancelled before patient enrollment | Enrollment / accrual |
| NCT00048087 | Iressa/Docetaxel in Non-Small-Cell Lung Cancer | Phase 2 | withdrawn | Oct 25, 2002 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT01373463 | Cisplatin and Pemetrexed With Radiation Followed by Lobectomy(CisPemXetSrg) | Phase 1 | terminated | Jun 15, 2011 | Medical University of South Carolina | Investigator left site | Investigator |
| NCT01314677 | Fludeoxyglucose F 18 PET/CT Scans in Predicting Therapy Response in Patients With Stage… | N/A | withdrawn | Mar 14, 2011 | City of Hope Medical Center | No subjects have been accrued to this trial. The PI will no longer be at COH and requests a study… | Enrollment / accrual |
| NCT00522938 | Clinical Trial of the Safety and Effectiveness of CHR-2797 With Erlotinib in Patients… | Phase 1 / Phase 2 | terminated | Aug 30, 2007 | Chroma Therapeutics | Very poor recruitment of patients to the study | Enrollment / accrual |
| NCT00442026 | Randomized Trial of Docetaxel and Gemcitabine Versus Gemcitabine in Elderly Patients With… | Phase 3 | terminated | Mar 1, 2007 | Hellenic Oncology Research Group | Due to poor accrual | Enrollment / accrual |
| NCT00971191 | A Study In Patients Who Will Undergo Surgical Removal Of Non-Small Cell Lung Cancer To… | Phase 1 | terminated | Sep 3, 2009 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT00042302 | A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of… | Phase 3 | terminated | Aug 1, 2002 | QLT Inc. | not stated | Not stated |
| NCT00042315 | A Double-Blind, Randomized, Placebo-Controlled, Multicenter, Phase III Study of… | Phase 3 | terminated | Aug 1, 2002 | QLT Inc. | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jan 13, 2014source: clinicaltrials