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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,263 stopped studies mapped to Lung Carcinoma and descendants · 91% state a reason
Over the 1,263 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00791336 | Study to Evaluate Using Nelfinavir With Chemoradiation for Non-small Cell Lung Cancer | Phase 2 | terminated | Nov 14, 2008 | University of Iowa | Poor enrollment. | Enrollment / accrual |
| NCT01575782 | Chloroquine as an Anti-autophagic Radiosensitizing Drug in Stage I-III Small Cell Lung…(Chloroquine) | Phase 1 | terminated | Apr 11, 2012 | Maastricht Radiation Oncology | Poor accrual | Enrollment / accrual |
| NCT00454324 | Study of Abraxane and Carboplatin to Treat Small Cell Lung Cancer(NRR) | Phase 2 | terminated | Mar 30, 2007 | UNC Lineberger Comprehensive Cancer Center | slow accrual | Enrollment / accrual |
| NCT03042013 | A Study for Subjects Who Are Participating in an Astellas-sponsored ASP8273 Study | Phase 2 | withdrawn | Feb 3, 2017 | Astellas Pharma Global Development, Inc. | Following recommendation by SOLAR Study IDMC, Astellas closed enrollment in ASP8273 studies. | Enrollment / accrual |
| NCT01936961 | Study of Immunochemotherapy +/- Hypofractionated Radiation for Complete Response in Solid…(I-CREST) | N/A | withdrawn | Sep 6, 2013 | Western Regional Medical Center | No patients enrolled | Enrollment / accrual |
| NCT00958022 | Carboplatin and Etoposide Plus LBH589 for Small Cell Lung Cancer | Phase 1 | terminated | Aug 13, 2009 | Ahmad Tarhini | Based on the tolerabilty challenges of the combination | Other (stated, no rule matched) |
| NCT02495636 | Phase 2 Study of MPDL3280A Combined With CDX-1401 in NY-ESO 1 (+) IIIB, IV or Recurrent… | Phase 2 | withdrawn | Jul 13, 2015 | Yale University | Study closed due to lack of enrollment | Enrollment / accrual |
| NCT00662311 | Vorinostat, Paclitaxel, and Radiation Therapy in Treating Patients Unable to Tolerate… | Phase 1 / Phase 2 | terminated | Apr 21, 2008 | University of Washington | not stated | Not stated |
| NCT00266812 | Safety and Tolerability of Low-Dose Temozolomide During Whole Brain Radiation in Patients… | Phase 2 | terminated | Dec 19, 2005 | Merck Sharp & Dohme LLC | Patient target could not be reached within the planned timeframe. | Other (stated, no rule matched) |
| NCT00423150 | Phase 2 Study of Temozolomide in Pre-Selected Advanced Aerodigestive Tract Cancers (Study… | Phase 2 | terminated | Jan 18, 2007 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00632203 | Study of Maintenance Temozolomide Versus Observation in Stable or Responding Stage III/IV… | Phase 2 | terminated | Mar 10, 2008 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00592007 | Study Evaluating the Addition of Fulvestrant to Erlotinib in Stage IIIB/IV Non-Small Cell… | Phase 2 | terminated | Jan 11, 2008 | Lyudmila Bazhenova, M.D. | Study was terminated due to slow subject accrual | Enrollment / accrual |
| NCT02570958 | ENB Robotic ICG Guided Surgery: A Novel Technique for Targeting Small Lung Tumors(ENB-RIGGS) | Phase 1 | withdrawn | Oct 7, 2015 | St. Joseph's Healthcare Hamilton | Funding was not received | Funding |
| NCT00034697 | Study of Temozolomide in the Treatment of Brain Metastasis From Non-small-cell Lung… | Phase 2 | terminated | May 2, 2002 | Merck Sharp & Dohme LLC | Slow Enrollment | Enrollment / accrual |
| NCT02735850 | Combination of SABR and L19-IL2 in Patients With Stage IV Lung Cancer (ImmunoSABR)(ImmunoSABR) | Phase 2 | withdrawn | Apr 13, 2016 | Maastricht Radiation Oncology | Not yet submitted, unclear timelines | Other (stated, no rule matched) |
| NCT00801801 | Study of Low Dose Chemotherapy Plus Sorafenib as Initial Therapy for Patients With… | Phase 2 | terminated | Dec 4, 2008 | Francisco Robert,MD | Sponsors withdrew funding; preliminary efficacy data was not encouraging. | Efficacy / futility |
| NCT00455572 | Cancer Immunotherapy GSK1572932A as Adjuvant Therapy for Patients With… | Phase 1 | terminated | Apr 3, 2007 | GlaxoSmithKline | Study early termination was due to slow recruitment and difficulties at achieving the required… | Enrollment / accrual |
| NCT02276560 | Cisplatin and Nab-paclitaxel for (N2) Defined NSCLC(LCCC1407) | Phase 2 | terminated | Oct 28, 2014 | UNC Lineberger Comprehensive Cancer Center | This study was terminated due to lack of funding. | Funding |
| NCT02567396 | Talazoparib in Treating Patients With Advanced or Metastatic Solid Tumors That Cannot Be… | Phase 1 | withdrawn | Oct 5, 2015 | National Cancer Institute (NCI) | Other- Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT01719861 | Phase 2a Desipramine in Small Cell Lung Cancer and Other High-Grade Neuroendocrine Tumors | Phase 2 | terminated | Nov 1, 2012 | Joel Neal | Lack of efficacy | Efficacy / futility |
| NCT02844140 | DE-CT in Lung Cancer Proton Therapy(DE-CT) | N/A | withdrawn | Jul 26, 2016 | Maastricht Radiation Oncology | not stated | Not stated |
| NCT02017925 | Pulmonary Rehabilitation in Improving Lung Function in Patients With Locally Advanced… | N/A | withdrawn | Dec 23, 2013 | Ohio State University Comprehensive Cancer Center | not stated | Not stated |
| NCT00126451 | A Clinical Trial of Oral Suberoylanilide Hydroxamic Acid (SAHA) in Patients With Relapsed… | Phase 2 | terminated | Aug 4, 2005 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT02087241 | Ph II Trial of Carboplatin and Pemetrexed With or Without AZD1775 for Untreated Lung… | Phase 2 | terminated | Mar 14, 2014 | AstraZeneca | The sponsor decided to terminate the study. | Sponsor / business decision |
| NCT00526643 | CAPPA-2: Cisplatin Added to Gemcitabine in Poor Performance Advanced NSCLC Patients(CAPPA-2) | Phase 3 | terminated | Sep 10, 2007 | National Cancer Institute, Naples | scarce enrolment and presentation of positive results of similar study in June 2012. | Enrollment / accrual |
| NCT00351039 | Phase I/II Trial of Bevacizumab, Pemetrexed and Erlotinib in Elderly Patients With… | Phase 1 / Phase 2 | terminated | Jul 12, 2006 | H. Lee Moffitt Cancer Center and Research Institute | slow accrual | Enrollment / accrual |
| NCT01319669 | Clinical Trial on the Prevention of Thrombocytopenia After First-line Chemotherapy | Phase 2 / Phase 3 | terminated | Mar 22, 2011 | Chinese Society of Lung Cancer | recruiting too slowly | Enrollment / accrual |
| NCT02095782 | Chemotherapy and Erlotinib for Lung Cancer With Low Abundance Epidermal Growth Factor…(INNOVATE) | Phase 2 | terminated | Mar 26, 2014 | Guangdong Association of Clinical Trials | Because of the very slow enrollment, this study was stopped. | Enrollment / accrual |
| NCT00073008 | A Study Of Oral GW572016 In Advanced Or Metastatic Non-Small Cell Lung Cancer | Phase 2 | terminated | Nov 17, 2003 | GlaxoSmithKline | Based on interim analysis at the end of Stage 1, and predefined stopping rules for futility,… | Efficacy / futility |
| NCT01731587 | Anti-cancer MUC1-specific Immunotherapy for Unresectable Stage III Non-small Cell Lung…(FINGERPRINT) | Phase 1 | withdrawn | Nov 22, 2012 | Merck KGaA, Darmstadt, Germany | The objectives of this trial are no longer deemed appropriate for the clinical development of… | Other (stated, no rule matched) |
| NCT01640847 | MRI Guided High Intensity Focused Ultrasound (HIFU) and ThermoDox for Palliation of… | Phase 2 | withdrawn | Jul 16, 2012 | Imunon | not stated | Not stated |
| NCT02319889 | Feasibility Study of SBRT Plus Chemotherapy for Non-Small Cell Lung Carcinoma | Early Phase 1 | terminated | Dec 18, 2014 | Case Comprehensive Cancer Center | Funding unavailable | Funding |
| NCT01026844 | Hydroxychloroquine With or Without Erlotinib in Advanced Non-small Cell Lung Cancer… | Phase 1 | terminated | Dec 4, 2009 | Massachusetts General Hospital | slow enrollment | Enrollment / accrual |
| NCT01383148 | Phase IIB/III Of TG4010 Immunotherapy In Patients With Stage IV Non-Small Cell Lung Cancer(TIME) | Phase 2 / Phase 3 | terminated | Jun 28, 2011 | Transgene | not stated | Not stated |
| NCT02795884 | Adjuvant Erlotinib Intercalating Chemotherapy or Adjuvant Chemotherapy Alone in NSCLC… | Phase 3 | withdrawn | Jun 10, 2016 | Yonsei University | Because of reconsideration of using erlotinib(EGFR Tyrosine kinase inhibitor) as adjuvant aim | Other (stated, no rule matched) |
| NCT02059889 | Diffusion-weighted MRI for Individualized Radiation Therapy Planning of Lung Cancer | N/A | withdrawn | Feb 11, 2014 | Virginia Commonwealth University | slow accrual | Enrollment / accrual |
| NCT00921310 | Temsirolimus and Pemetrexed for Recurrent or Refractory Non-Small Cell Lung Cancer | Phase 1 / Phase 2 | terminated | Jun 16, 2009 | Washington University School of Medicine | Withdrawal of funding from sponsor | Funding |
| NCT00352690 | A Phase II Study of Radiation Therapy, Paclitaxel Poliglumex, and Carboplatin in Stage… | Phase 2 | terminated | Jul 17, 2006 | Washington University School of Medicine | Safety of patients | Safety / toxicity |
| NCT01377376 | A Phase 3, Randomized, Double-Blinded, Placebo-Controlled Study of ARQ 197 Plus Erlotinib…(ATTENTION) | Phase 3 | terminated | Jun 21, 2011 | Kyowa Kirin Co., Ltd. | not stated | Not stated |
| NCT02661100 | A Trial of CDX-1401 in Combination With Poly-ICLC and Pembrolizumab, in Previously… | Phase 1 / Phase 2 | withdrawn | Jan 22, 2016 | Case Comprehensive Cancer Center | Drug unavailable | Other (stated, no rule matched) |
| NCT00565227 | Phase I Study of Vorinostat in Combination With Docetaxel in Patients With Advanced and… | Phase 1 | terminated | Nov 29, 2007 | University of Michigan Rogel Cancer Center | closed due to toxicity | Safety / toxicity |
| NCT01886573 | Azacitidine and Entinostat in Treating Patients With Newly Diagnosed Stage IA-IIIA… | Phase 1 | terminated | Jun 26, 2013 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01702714 | A Study of RO5083945 in Combination With Cisplatin and Gemcitabine or Carboplatin and… | Phase 1 | withdrawn | Oct 8, 2012 | Hoffmann-La Roche | Project Team decision | Other (stated, no rule matched) |
| NCT00642824 | A Genetic Substudy Associated With the Avastin (Bevacizumab) Study MO19390 in Patients… | Phase 2 | terminated | Mar 25, 2008 | Hoffmann-La Roche | Terminated due to low enrollment. No statistical analyses were performed. | Enrollment / accrual |
| NCT01015443 | Cancer Vaccine Study for Stage III, Unresectable, Non-small Cell Lung Cancer (NSCLC) in…(INSPIRE) | Phase 3 | terminated | Nov 18, 2009 | Merck KGaA, Darmstadt, Germany | The study is terminated prematurely as the sponsor decided to discontinue program with Tecemotide… | Sponsor / business decision |
| NCT02083679 | Sym004 in Subjects With Stage IV Non-small Cell Lung Cancer | Phase 1 | terminated | Mar 11, 2014 | EMD Serono | Sponsor the return rights of the compound to the collaboration partner for further clinical… | Other (stated, no rule matched) |
| NCT01179269 | Pazopanib and Paclitaxel for Non-Small Cell Lung Cancer | Phase 2 | withdrawn | Aug 11, 2010 | Loyola University | The study was stopped because the research team was unable to enroll any participants | Enrollment / accrual |
| NCT01423760 | Common Safety Follow-up Trial of Tecemotide (L-BLP25) | N/A | terminated | Aug 26, 2011 | Merck KGaA, Darmstadt, Germany | The study is terminated prematurely as the sponsor decided to discontinue program with Tecemotide… | Sponsor / business decision |
| NCT01997775 | Metformin in Stage IV Lung Adenocarcinoma | Phase 2 | terminated | Nov 28, 2013 | National Cheng-Kung University Hospital | Difficult enrollment | Enrollment / accrual |
| NCT01829971 | A Multicenter Phase I Study of MRX34, MicroRNA miR-RX34 Liposomal Injection | Phase 1 | terminated | Apr 11, 2013 | Mirna Therapeutics, Inc. | Five immune related serious adverse events | Safety / toxicity |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Jul 28, 2017source: clinicaltrials