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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,441 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,441 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01542684 | Study of Azacytidine Followed by GM-CSF in Patients With Myelodysplastic Syndrome (MDS) | Phase 2 | terminated | Mar 2, 2012 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01193400 | Clofarabine and Low-dose Cytarabine Followed by Consolidation Therapy in AML Patients Age… | Phase 2 | terminated | Sep 1, 2010 | PETHEMA Foundation | not stated | Not stated |
| NCT01198054 | LENA-LMA-5:Lenalidomide in Acute Myeloid Leukemia (AML) | Phase 4 | terminated | Sep 9, 2010 | PETHEMA Foundation | not stated | Not stated |
| NCT01655875 | AMD3100 for Sensitizing in Allogeneic Blood or Marrow Transplant for Chemotherapy…(BMTAMD3100) | Phase 1 | terminated | Aug 2, 2012 | Emory University | lack of patient enrollment | Enrollment / accrual |
| NCT00949117 | Cyproheptadine Hydrochloride and Nutritional Supplementation in Treating Young Patients… | Phase 2 | terminated | Jul 30, 2009 | University of South Florida | study not feasible with low accrual. DSMB recommended closure | Enrollment / accrual |
| NCT01426334 | Dasatinib and Cyclosporine in Treating Patients With Chronic Myelogenous Leukemia… | Phase 1 | terminated | Aug 31, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01001390 | The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute… | N/A | terminated | Oct 26, 2009 | St. Jude Children's Research Hospital | The study closed due to poor accrual and difficulty with participant compliance. | Enrollment / accrual |
| NCT01326078 | Use of Lipid Emulsion or Nanoemulsion of Propofol on Children Undergoing Ambulatory… | Phase 2 / Phase 3 | withdrawn | Mar 30, 2011 | Cristália Produtos Químicos Farmacêuticos Ltda. | The Sponsor has no interest in continuing the study. | Other (stated, no rule matched) |
| NCT00469820 | Vaccine Therapy With or Without Donor Lymphocyte Infusion in Treating Patients With Acute… | Phase 1 | terminated | May 7, 2007 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | low accrual | Enrollment / accrual |
| NCT00866346 | PR1-Specific Cytotoxic T-Lymphocyte Infusion With Recurrent Chronic Myelogenous Leukemia… | Phase 1 | withdrawn | Mar 20, 2009 | M.D. Anderson Cancer Center | Study failed to accrue any patients due to regulatory issues with PR1 vaccine and T cell production. | Enrollment / accrual |
| NCT00101205 | Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00396968 | AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant… | Phase 1 / Phase 2 | withdrawn | Nov 8, 2006 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT00499239 | A Trial of GS-9219 in Chronic Lymphocytic Leukemia (CLL), Non-Hodgkin's Lymphoma (NHL) or… | Phase 1 / Phase 2 | terminated | Jul 11, 2007 | Gilead Sciences | Unacceptable safety profile | Safety / toxicity |
| NCT01251250 | Azadirachta Indica in Treating Patients With Chronic Lymphocytic Leukemia | Phase 1 | withdrawn | Dec 1, 2010 | Roswell Park Cancer Institute | lost sponsor support | Other (stated, no rule matched) |
| NCT02028039 | IPI-145 in Relapsed Refractory Acute Lymphoblastic Leukemia (ALL) | Phase 2 | withdrawn | Jan 6, 2014 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01478074 | ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia | Phase 1 | withdrawn | Nov 23, 2011 | Altor BioScience | The treatment planned was determined to be of low feasibility as no subject was found eligible and… | Enrollment / accrual |
| NCT00818961 | Donor Stem Cell Transplant in Treating Patients With High-Risk Hematologic Cancer | Phase 2 | terminated | Jan 8, 2009 | Northside Hospital, Inc. | terminated early due to meeting end point with fewer patients than anticipated | Other (stated, no rule matched) |
| NCT00923234 | Combination of 5-azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute…(AZALE) | Phase 1 | terminated | Jun 18, 2009 | Technische Universität Dresden | The primary objective has already been answered with the number of recruited patients. | Enrollment / accrual |
| NCT00899353 | Prevention of Disease Progression in Early Stage Indolent B Cell Malignancies. (SMM) | Phase 2 | terminated | May 12, 2009 | Marshall University | Original Principal Investigator left the institution. | Investigator |
| NCT00672152 | A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following…(WT-1) | Phase 1 | terminated | May 6, 2008 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT00129558 | A Study to Evaluate PT-523 in Patients With Refractory Leukemia | Phase 1 / Phase 2 | withdrawn | Aug 12, 2005 | Spectrum Pharmaceuticals, Inc | not stated | Not stated |
| NCT00836043 | Safety, Effectiveness and Patient Acceptance of the Treatment With MabCampath in Chronic… | — | terminated | Feb 4, 2009 | Genzyme, a Sanofi Company | Study terminated due to low enrollment. | Enrollment / accrual |
| NCT00957320 | Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL) | Phase 1 | withdrawn | Aug 12, 2009 | Emory University | no patients enrolled, decided not to pursue study | Enrollment / accrual |
| NCT00967525 | Intraosseous Infusion of Unrelated Cord Blood Grafts | N/A | terminated | Aug 28, 2009 | Emory University | poor enrollment | Enrollment / accrual |
| NCT00814983 | Myeloablative Allogeneic Stem Cell Transplantation Using a Naive T-Cell Depleted… | Phase 1 / Phase 2 | terminated | Dec 29, 2008 | Duke University | IND approval for naive T-cell depletion not obtained | Other (stated, no rule matched) |
| NCT01500161 | Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing… | Phase 2 | terminated | Dec 28, 2011 | Texas Oncology Cancer Center | Insufficient accruals | Enrollment / accrual |
| NCT00156299 | Gene Expression During Chemotherapy in Patients With Newly Diagnosed Acute Myeloid… | Phase 1 | terminated | Sep 12, 2005 | Rutgers, The State University of New Jersey | Replaced by another study | Other (stated, no rule matched) |
| NCT00297921 | A Phase 2 Study of Tandutinib in Patients With Newly Diagnosed Acute Myelogenous Leukemia… | Phase 1 / Phase 2 | withdrawn | Mar 1, 2006 | Millennium Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00320190 | Study of Dasatinib in Patients With Chronic Phase Chronic Myeloid Leukemia and a… | Phase 2 | terminated | May 3, 2006 | Bristol-Myers Squibb | Terminated due to slow participant accrual | Enrollment / accrual |
| NCT00985530 | Tamibarotene and Arsenic Trioxide for Relapsed Acute Promyelocytic Leukemia | Phase 1 | terminated | Sep 28, 2009 | Northwestern University | Supporting agency withdrew funding for study. | Funding |
| NCT00002961 | Chemotherapy With or Without Total-Body Irradiation Prior to Bone Marrow Transplantation… | Phase 3 | terminated | May 19, 2004 | Children's Hospital of Philadelphia | poor accrual | Enrollment / accrual |
| NCT00058461 | Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or… | Phase 2 | terminated | Apr 9, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00724360 | Trastuzumab for HER2 Positive Relapsed/Refractory B-Acute Lymphoblastic Leukemia (B-ALL) | Phase 2 | terminated | Jul 29, 2008 | Nantes University Hospital | Difficulties of recruitment | Enrollment / accrual |
| NCT00049582 | Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00301769 | SJG-136 in Treating Patients With Relapsed or Refractory Acute Leukemia, Myelodysplastic… | Phase 1 | terminated | Mar 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00612612 | Obatoclax, Fludarabine, and Rituximab in Treating Patients With Previously Treated… | Phase 1 | terminated | Feb 11, 2008 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00720850 | Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or…(LENAMAINT) | Phase 2 | terminated | Jul 23, 2008 | Technische Universität Dresden | Low recruitment, scientific rationale not applicable anymore to all patients and possible induction… | Enrollment / accrual |
| NCT01159301 | Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid… | Phase 1 | terminated | Jul 9, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00176475 | Irradiated Donor Lymphocytes and Rituximab in Treating Patients With Relapsed or… | Phase 1 | terminated | Sep 15, 2005 | University of Medicine and Dentistry of New Jersey | slow accrual | Enrollment / accrual |
| NCT00996359 | Partially HLA-Matched Irradiated Allogeneic Cellular Therapy After Reduced Intensity… | Phase 1 | terminated | Oct 16, 2009 | University of Medicine and Dentistry of New Jersey | Slow accrual | Enrollment / accrual |
| NCT01701375 | A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults… | Phase 1 | terminated | Oct 5, 2012 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Material sponsor withdrew support | Other (stated, no rule matched) |
| NCT00943709 | Intensive Glycemic Control on Infectious Morbidity In Patients With Acute Leukemia | Phase 3 | withdrawn | Jul 22, 2009 | University of Medicine and Dentistry of New Jersey | lack of accrual | Enrollment / accrual |
| NCT00947388 | Bendamustine Plus Alemtuzumab for Refractory Chronic Lymphocytic Leukemia (CLL) | Phase 1 | terminated | Jul 28, 2009 | Case Comprehensive Cancer Center | No more eligible patients | Other (stated, no rule matched) |
| NCT00514722 | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced… | N/A | terminated | Aug 10, 2007 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00513318 | Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients… | — | terminated | Aug 8, 2007 | University of California, San Francisco | Insufficient enrollment to justify keeping open. | Enrollment / accrual |
| NCT00872976 | Study of Dasatinib and Bendamustine in Chronic Lymphocytic Leukemia | Phase 1 | withdrawn | Apr 1, 2009 | Bristol-Myers Squibb | Business Objectives Changed | Sponsor / business decision |
| NCT00301860 | Donor Stem Cell Transplant Followed By Donor White Blood Cell Infusions in Treating Young… | N/A | terminated | Mar 13, 2006 | University of California, San Francisco | lack of efficacy | Efficacy / futility |
| NCT00377104 | Alvocidib in Treating Patients With B-Cell Chronic Lymphocytic Leukemia or Small… | Phase 1 | terminated | Sep 15, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00150878 | Standard vs. Reduced-Intensity Conditioning in Patients With Acute Myeloid Leukemia in… | Phase 3 | terminated | Sep 8, 2005 | University Hospital Carl Gustav Carus | Insurance coverage reached | Other (stated, no rule matched) |
| NCT01492569 | Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting | N/A | withdrawn | Dec 15, 2011 | Stanford University | low accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 30, 2014source: clinicaltrials