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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,441 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,441 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00053014 | S0125, Chemotherapy, Total-Body Irradiation, and Peripheral Stem Cell Transplantation in… | Phase 2 | terminated | Jan 28, 2003 | SWOG Cancer Research Network | Poor accrual | Enrollment / accrual |
| NCT00068302 | Sirolimus in Treating Young Patients With Relapsed or Refractory Acute Leukemia or… | Phase 1 | terminated | Sep 11, 2003 | Children's Hospital of Philadelphia | Recruiting/enrolling participants halted prematurely but potentially will resume | Enrollment / accrual |
| NCT00002790 | Prevention of Graft-Versus-Host Disease in Patients With Hematologic Malignancies Who Are… | Phase 1 / Phase 2 | withdrawn | Sep 2, 2004 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT00833534 | Lenalidomide With or Without Rituximab in Treating Patients With Chronic Lymphocytic… | Phase 2 | withdrawn | Feb 2, 2009 | Fred Hutchinson Cancer Center | No patient enrolled on study. Did not get patients in timely fashion. All referrals for study when… | Enrollment / accrual |
| NCT00845104 | Fludarabine Phosphate, Rituximab, and Bevacizumab in Treating Patients With B-Cell… | Phase 2 | withdrawn | Feb 18, 2009 | Fred Hutchinson Cancer Research Center/University of Washington Cancer Consortium | No patients enrolled. | Enrollment / accrual |
| NCT00939328 | S0902 Bendamustine and Rituximab in Treating Patients With B-Cell Chronic Lymphocytic… | Phase 2 | withdrawn | Jul 15, 2009 | SWOG Cancer Research Network | question was no longer committee priority | Other (stated, no rule matched) |
| NCT00916045 | Pilot Study of Unrelated Cord Blood Transplantation | Phase 2 | terminated | Jun 8, 2009 | King's College Hospital NHS Trust | Recruitment issues | Enrollment / accrual |
| NCT01010373 | Safety and Efficacy Study of AS101 to Treat Elderly Acute Myeloid Leukemia (AML) and… | Phase 2 | suspended | Nov 10, 2009 | BioMAS Ltd | The sponsor is currently focusing on different indications | Other (stated, no rule matched) |
| NCT01643291 | Ultrasound Use for Difficult Lumbar Punctures in Pediatric Oncology Patients | N/A | terminated | Jul 18, 2012 | Nationwide Children's Hospital | We were unable to recruit subjects for this study. | Enrollment / accrual |
| NCT00798213 | SCH 727965 in Patients With Acute Myelogenous Leukemia and Acute Lymphoblastic Leukemia… | Phase 2 | terminated | Nov 26, 2008 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00500006 | A Phase I Dose Escalation Combination Study in Patients With Chronic Myelogenous Leukemia… | Phase 1 | terminated | Jul 12, 2007 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01486043 | Metformin and Transient Hyperglycemia | N/A | terminated | Dec 6, 2011 | Children's Hospital Los Angeles | The research project was terminated due to lower than projected patient recruitment within the… | Enrollment / accrual |
| NCT00405054 | A Phase II Study of MK0457 in Patients With T315I Mutant CML and Ph+All (0457-008) | Phase 2 | terminated | Nov 29, 2006 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01027923 | IV Plerixafor With Mitoxantrone Etoposide and Cytarabine for Acute Myeloid Leukemia (AML)(AML) | Phase 1 | terminated | Dec 9, 2009 | Washington University School of Medicine | Withdrawal of support from sponsor | Other (stated, no rule matched) |
| NCT00114959 | Homoharringtonine With Oral Gleevec in Chronic, Accelerated and Blast Phase Chronic… | Phase 2 | terminated | Jun 21, 2005 | ChemGenex Pharmaceuticals | Poor enrollment | Enrollment / accrual |
| NCT00509249 | Aflibercept in Treating Patients With Myelodysplastic Syndromes | Phase 2 | terminated | Jul 31, 2007 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT01035216 | A Phase I Study of GNKG168 in Patient With Relapsed or Refractory B-Cell Chronic… | Phase 1 | terminated | Dec 18, 2009 | SBI Biotech Co., Ltd. | This study has been terminated. | Other (stated, no rule matched) |
| NCT00624962 | Early Enteral Tube Feedings in Children Receiving Chemo for AML/MDS & High Risk Solid… | N/A | withdrawn | Feb 28, 2008 | Vanderbilt University | no participants enrolled | Enrollment / accrual |
| NCT01077440 | Presence of Donor-Derived DNA in Semen Samples From Cancer Survivors Who Underwent Donor… | — | terminated | Mar 1, 2010 | Vanderbilt University | PI leaving institution | Other (stated, no rule matched) |
| NCT00081055 | OTI-010 for Graft-Versus-Host Disease Prophylaxis in Treating Patients Who Are Undergoing… | Phase 2 | withdrawn | Apr 8, 2004 | Mesoblast International Sàrl | not stated | Not stated |
| NCT00907582 | ASCT for Relapsed APL After Molecular Remission | Phase 2 | terminated | May 22, 2009 | Shanghai Jiao Tong University School of Medicine | slow recruitment | Enrollment / accrual |
| NCT01230788 | Rituximab for Patients With Relapsed Acute Lymphoblastic Leukemia(Rituximab) | N/A | terminated | Oct 29, 2010 | Emory University | Lack of enrollment | Enrollment / accrual |
| NCT01650805 | Ponatinib in Newly Diagnosed Chronic Myeloid Leukemia (CML) (EPIC) | Phase 3 | terminated | Jul 26, 2012 | Ariad Pharmaceuticals | Study terminated based on evaluation of safety data. | Safety / toxicity |
| NCT02238522 | Phase 1 Study Evaluating ZEN003365 in Relapsed/Refractory Lymphoproliferative… | Phase 1 | withdrawn | Sep 12, 2014 | Zenith Epigenetics | not stated | Not stated |
| NCT01088763 | Gamma-Secretase Inhibitor RO4929097 in Treating Young Patients With Relapsed or… | Phase 1 | terminated | Mar 17, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01465230 | Maintenance Therapy: Lenalidomide Following Bendamustine and Rituximab Induction Therapy… | Phase 2 | terminated | Nov 4, 2011 | Yale University | This study was unsuccessful in enrolling the target number of subjects during the funding period. | Enrollment / accrual |
| NCT00288067 | Fenretinide and Rituximab in Treating Patients With B-Cell Non-Hodgkin Lymphoma | Phase 1 / Phase 2 | terminated | Feb 7, 2006 | National Cancer Institute (NCI) | NCI stopped supplying fenretinide in November of 2012. | Other (stated, no rule matched) |
| NCT00594308 | In-Vivo Activated T-Cell Depletion to Prevent GVHD | N/A | terminated | Jan 15, 2008 | Indiana University | Treatment ineffective | Other (stated, no rule matched) |
| NCT00967512 | Aezea® (Cenersen) and Chemotherapy for AML Subjects ≥ 55 Years of Age With No Response to… | Phase 2 | withdrawn | Aug 28, 2009 | Eleos, Inc. | Study Was Terminated due to lack of Funding. | Funding |
| NCT00593645 | Clofarabine, Cytarabine, and Thymoglobulin for Allogeneic Transplantation | Phase 2 | terminated | Jan 15, 2008 | Washington University School of Medicine | toxicities were worse than expected | Safety / toxicity |
| NCT00723203 | Panobinostat in Treating Patients With Relapsed or Refractory Acute Lymphoblastic… | Phase 2 | terminated | Jul 28, 2008 | City of Hope Medical Center | Terminated early due to a lack of efficacy | Efficacy / futility |
| NCT02117336 | Clinical Study of Relapsed/Refractory Chronic Lymphocytic Leukemia (CLL) | Phase 1 | suspended | Apr 17, 2014 | Piramal Enterprises Limited | Sponsor decision not related to patient safety | Safety / toxicity |
| NCT01688752 | Cardiometabolic Status in Childhood Acute Lymphoblastic Leukemia | — | withdrawn | Sep 20, 2012 | University of Minnesota | Funding unavailable | Funding |
| NCT01005979 | A Phase I Trial Using Cyclophosphamide, Rituximab and Revlimid (CR2) for the Treatment of… | Phase 1 | terminated | Nov 2, 2009 | Emory University | Slow Accrual | Enrollment / accrual |
| NCT00265915 | Rituximab and GM-CSF in Treating Patients With Chronic Lymphocytic Leukemia | Phase 2 | terminated | Dec 15, 2005 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | not stated | Not stated |
| NCT00458744 | Talotrexin in Treating Young Patients With Recurrent Solid Tumors or Leukemia That is… | Phase 1 | withdrawn | Apr 11, 2007 | Children's Oncology Group | Study withdrawn because of toxicity reported on the adult phase 1 trial. | Safety / toxicity |
| NCT00184054 | Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-Acute… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Competing studies | Other (stated, no rule matched) |
| NCT00756912 | A Study of Eritoran (E5564) Administered IV Over 14 Days Prior to and During Bone Marrow… | Phase 1 | terminated | Sep 22, 2008 | Eisai Inc. | This study was terminated in November 2008 due to "a business decision (resources)". | Sponsor / business decision |
| NCT00415909 | TALL-104 and Gleevec in Chronic Myelogenous Leukemia Patients | Phase 2 | terminated | Dec 25, 2006 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00076401 | A Study of Motexafin Gadolinium for the Treatment of Chronic Lymphocytic Leukemia (CLL) | Phase 2 | terminated | Jan 26, 2004 | Pharmacyclics LLC. | not stated | Not stated |
| NCT00947648 | Outpatient Neutropenic Diet Study | Phase 2 | terminated | Jul 28, 2009 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT00008216 | Blood Stem Cell Transplant in Treating Patients With Hematologic Cancer | — | terminated | Jan 27, 2003 | Columbia University | Poor enrollment | Enrollment / accrual |
| NCT00089076 | MDX-010 in Treating Patients With Recurrent or Refractory Lymphoma | Phase 1 / Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00387426 | Sunitinib in Treating Patients With Idiopathic Myelofibrosis | Phase 2 | terminated | Oct 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00100711 | Study of Motexafin Gadolinium (MGd) in Patients With Chronic Lymphocytic Leukemia or… | Phase 2 | terminated | Jan 5, 2005 | Pharmacyclics LLC. | not stated | Not stated |
| NCT00183950 | Study of Noscapine for Patients With Low Grade Non Hodgkin's Lymphoma or Chronic… | Phase 1 / Phase 2 | terminated | Sep 16, 2005 | University of Southern California | No funding | Funding |
| NCT00941928 | Haploidentical Natural Killer (NK) Cells With Epratuzumab for Relapsed Acute… | Phase 2 | terminated | Jul 20, 2009 | M.D. Anderson Cancer Center | Slow accrual | Enrollment / accrual |
| NCT00608517 | Treatment of Single or Double Umbilical Cord Trans + Graft-versus-host Disease (GVHD)… | N/A | terminated | Feb 6, 2008 | Vanderbilt-Ingram Cancer Center | slow accrual | Enrollment / accrual |
| NCT00303966 | Sorafenib in Treating Patients With Relapsed Chronic Lymphocytic Leukemia | Phase 2 | terminated | Mar 17, 2006 | National Cancer Institute (NCI) | Slow accrual | Enrollment / accrual |
| NCT00933985 | Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane… | Phase 1 | terminated | Jul 8, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 25, 2015source: clinicaltrials