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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,441 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,441 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT02029417 | Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With… | Phase 2 | terminated | Jan 7, 2014 | Roswell Park Cancer Institute | Major revisions needed in study | Other (stated, no rule matched) |
| NCT00579111 | Reduced Intensity Preparative Regimen Followed by Stem Cell Transplant (FAB) | Phase 1 / Phase 2 | terminated | Dec 21, 2007 | Baylor College of Medicine | slow accrual | Enrollment / accrual |
| NCT00578461 | T-Regulatory Cell Kinetics, Stem Cell Transplantation, REGKINE(REGKINE) | N/A | terminated | Dec 21, 2007 | Baylor College of Medicine | not stated | Not stated |
| NCT00578539 | T-Reg Cell Kinetics, Stem Cell Transplant, REGALE(REGALE) | N/A | terminated | Dec 21, 2007 | Baylor College of Medicine | not stated | Not stated |
| NCT02663648 | Cell Cycle Regulatory Gene Study in Patients With Myeloproliferative Disorders | — | withdrawn | Jan 26, 2016 | Shandong University | No eligible patient was enrolled. | Enrollment / accrual |
| NCT00510289 | Sorafenib in Myelodysplastic Syndrome | Phase 2 | terminated | Aug 1, 2007 | Duke University | Early closure of study due to poor response | Other (stated, no rule matched) |
| NCT01222819 | SubCutaneous (SC) Versus Intravenous (IV) Granulocyte Colony Stimulating Factors (G-CSF)…(G-CSF) | Phase 4 | terminated | Oct 18, 2010 | Rabin Medical Center | Physycians' refusal to continue the study | Other (stated, no rule matched) |
| NCT02221505 | Phase 1 Study of LOP628 in Adult Patients With cKit-positive Solid Tumors and Acute… | Phase 1 | terminated | Aug 20, 2014 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT00615589 | Stem Cell Transplantation To Treat High Risk Multiple Myeloma With Reduced Toxicity… | Phase 2 | terminated | Feb 14, 2008 | University of Michigan Rogel Cancer Center | Low accrual | Enrollment / accrual |
| NCT01573247 | Safety Study of AKN-028 in Patients With Acute Myelogenous Leukemia | Phase 1 / Phase 2 | terminated | Apr 9, 2012 | Akinion Pharmaceuticals AB | During the study two patients have experienced serious liver events related to AKN-028. The… | Other (stated, no rule matched) |
| NCT00002956 | Immunotherapy for Lymphoproliferative Diseases Associated With Epstein-Barr Virus in… | Phase 1 | withdrawn | Jul 19, 2004 | University of Alabama at Birmingham | not stated | Not stated |
| NCT01518153 | Planned Donor Lymphocyte Infusion (DLI) After Allogeneic Stem Cell Transplantation (SCT) | Phase 2 | terminated | Jan 25, 2012 | M.D. Anderson Cancer Center | Objectives not met. | Other (stated, no rule matched) |
| NCT01455025 | Study in Plerixafor and Granulocyte-colony Stimulating Factor Patients With Relapse Acute…(PRIMAL) | Phase 1 | terminated | Oct 19, 2011 | French Innovative Leukemia Organisation | no recruitment on time | Enrollment / accrual |
| NCT02556346 | Pharmacokinetics (PK), Pharmacodynamics (PD), Safety, Tolerability of Multiple Dose… | Phase 1 | withdrawn | Sep 22, 2015 | Molecular Templates, Inc. | The patient population (CLL \& SLL) was included in another ongoing study involving NHL patients. | Other (stated, no rule matched) |
| NCT00664677 | Phase 1 Study of Terameprocol (EM-1421) in Patients With Leukemia | Phase 1 | terminated | Apr 23, 2008 | Erimos Pharmaceuticals | Funding constraints | Funding |
| NCT00324077 | Phase I Study of Dasatinib (BMS-354825) and Imatinib in Subjects With Chronic Myeloid… | Phase 1 | withdrawn | May 10, 2006 | Bristol-Myers Squibb | Insufficient Enrollment | Enrollment / accrual |
| NCT00349518 | Study of Dasatinib in Imatinib Resistant or Intolerant Subjects With Chronic or Advanced… | Phase 2 / Phase 3 | withdrawn | Jul 7, 2006 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00732186 | Study of Ipilimumab and Dasatinib Combination Therapy in Patients With Chronic or… | Phase 1 | withdrawn | Aug 11, 2008 | Bristol-Myers Squibb | not stated | Not stated |
| NCT01604031 | Treatment of B-CLL With Autologous IL2 and CD40 Ligand-Expressing Tumor Cells +…(TAIL) | Phase 1 | terminated | May 23, 2012 | Baylor College of Medicine | not stated | Not stated |
| NCT00528450 | Tretinoin and Arsenic Trioxide With or Without Idarubicin in Treating Patients With Acute… | Phase 2 | terminated | Sep 12, 2007 | Memorial Sloan Kettering Cancer Center | Lack of accrual | Enrollment / accrual |
| NCT01510756 | Sorafenib for the Treatment of Chronic Lymphocytic Leukemia (CLL) | Phase 2 | terminated | Jan 16, 2012 | Thomas Kipps | slow enrollment | Enrollment / accrual |
| NCT00660036 | Phase I/II Study of Mitoxantrone, Etoposide and Gemtuzumab Ozogamicin for Acute Myeloid… | Phase 1 | terminated | Apr 17, 2008 | University of Pittsburgh | due to new safety information | Safety / toxicity |
| NCT00022490 | Imatinib Mesylate Plus Cytarabine in Treating Patients With Chronic Myelogenous Leukemia | Phase 2 | terminated | Jan 27, 2003 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00849524 | Study of Repeat Intranodal Injection of Memgen's Cancer Vaccine, Ad-ISF35, in Subjects… | Phase 2 | terminated | Feb 24, 2009 | Januario Castro, M.D. | drug supply became unavailable | Drug supply |
| NCT00942409 | Study of Repeat Intranodal Injections of Ad-ISF35 | Phase 2 | terminated | Jul 20, 2009 | Januario Castro, M.D. | drug supply was no longer available | Drug supply |
| NCT01067274 | ALFA-0703 Study in Older Patients With Acute Myeloblastic Leukemia (AML)(ALFA-0703) | Phase 3 | withdrawn | Feb 11, 2010 | Acute Leukemia French Association | Study abandoned | Other (stated, no rule matched) |
| NCT00866281 | A Study of the Safety and Preliminary Efficacy of Oral Midostaurin (PKC412) in Relapsed… | Phase 1 / Phase 2 | terminated | Mar 20, 2009 | Novartis Pharmaceuticals | Despite considerable efforts to boost recruitment during the final year of the study, no new… | Enrollment / accrual |
| NCT01010568 | Ofatumumab and Bendamustine for Previously Treated Chronic Lymphocytic Leukemia (CLL) | Phase 2 | terminated | Nov 10, 2009 | Georgetown University | Unable to accrue patients due to change in standard CLL therapy | Enrollment / accrual |
| NCT01411904 | A Novel Magnetic Needle Using Iron Oxide Nanoparticles for the Detection of Leukemia | N/A | withdrawn | Aug 8, 2011 | University of New Mexico | The NPs that we have been buying from a vendor show lot to lot variation. We are making our own… | Enrollment / accrual |
| NCT01049113 | Safety Study of ON 013105 in Lymphoma and Acute Lymphoid Leukemia | Phase 1 | terminated | Jan 14, 2010 | Traws Pharma, Inc. | Lack of available clinical drug supply | Drug supply |
| NCT01169753 | Nuvigil in Treatment of Cancer-Related Fatigue in Chronic Myeloid Leukemia Patients | N/A | terminated | Jul 26, 2010 | M.D. Anderson Cancer Center | Slow Enrollment | Enrollment / accrual |
| NCT01739491 | A Study of Safety and Effectiveness of Bendamustine Hydrochloride in Adult Filipino… | — | withdrawn | Dec 3, 2012 | Janssen Pharmaceutica | The study is cancelled. FDA Circular 2013-004 mandates that PMSs like this are not required | Other (stated, no rule matched) |
| NCT01624701 | Clinical Ex Vivo Expansion of Human Umbilical Cord Blood Stem and Progenitor Cells | Phase 1 / Phase 2 | terminated | Jun 21, 2012 | Singapore General Hospital | Funding expired | Funding |
| NCT02034227 | Safety, Tolerability Study of SG2000 in the Treatment of Advanced Chronic Lymphocytic… | Phase 1 / Phase 2 | terminated | Jan 13, 2014 | Spirogen | not stated | Not stated |
| NCT01050946 | Hematopoietic Stem Cell Transplantation (HSCT) Using CD34 Selected Mismatched Related…(Haplo/Cord) | Phase 2 | terminated | Jan 18, 2010 | Medical College of Wisconsin | Only one patient was enrolled. Due to low accrual study was terminated | Enrollment / accrual |
| NCT01076556 | Cyclophosphamide, Alvocidib, and Rituximab in Treating Patients With High Risk B-Cell… | Phase 1 | terminated | Feb 26, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01009931 | Phase II Study of TPA Plus Dexamethasone & CMT in Hematologic Malignancies | Phase 2 | terminated | Nov 9, 2009 | Rutgers, The State University of New Jersey | Study was terminated early due to lack of experimental medication (supply issues) | Drug supply |
| NCT01126502 | Alvespimycin Hydrochloride in Treating Patients With Relapsed Chronic Lymphocytic… | Phase 1 | terminated | May 19, 2010 | National Cancer Institute (NCI) | Administratively Complete. | Other (stated, no rule matched) |
| NCT01670084 | Nilotinib and Combination Chemotherapy in Treating Patients With Newly Diagnosed… | Phase 2 | withdrawn | Aug 21, 2012 | Mayo Clinic | No Accrual | Enrollment / accrual |
| NCT00924040 | Retreatment Protocol for BL22 Immunotherapy in Relapsed or Refractory Hairy Cell Leukemia | Phase 2 | terminated | Jun 18, 2009 | National Cancer Institute (NCI) | The supply of BL22 has expired and MedImmune the sponsor is not interested in producing any new… | Drug supply |
| NCT00670150 | New Retinoid Agent Combined With Arsenic Trioxide for Untreated Acute Promyelocytic… | Phase 2 | withdrawn | May 1, 2008 | University of Southern California | sponsor withdrew support | Other (stated, no rule matched) |
| NCT02258555 | Safety, Pharmacodynamics, Pharmacokinetics, and Efficacy of GS-9901 in Adults With… | Phase 1 | terminated | Oct 7, 2014 | Gilead Sciences | not stated | Not stated |
| NCT00587847 | Campath Maintenance in Chronic Lymphocytic Leukemia | N/A | terminated | Jan 8, 2008 | Northwell Health | Insufficient recruitment. | Enrollment / accrual |
| NCT00577694 | Clofarabine and Gemtuzumab in Treating Patients With Relapsed or Refractory Acute Myeloid… | Phase 1 | terminated | Dec 20, 2007 | UNC Lineberger Comprehensive Cancer Center | funding unavailable | Funding |
| NCT00918658 | Study of Natural Killer Cells in Bone Marrow and Blood Samples From Patients With and… | — | terminated | Jun 11, 2009 | Case Comprehensive Cancer Center | PI closed lab | Other (stated, no rule matched) |
| NCT00391066 | Lumiliximab With Fludarabine, Cyclophosphamide, and Rituximab (FCR) Versus FCR Alone in…(LUCID) | Phase 2 | terminated | Oct 23, 2006 | Biogen | not stated | Not stated |
| NCT00801060 | Evaluation of Safety and Efficacy of Fludarabine, Cyclophosphamide, and Rituximab (FCR)… | Phase 2 | terminated | Dec 3, 2008 | Biogen | not stated | Not stated |
| NCT00411281 | Low-Dose Cytarabine in Treating Infants With Down Syndrome and Transient… | Phase 3 | withdrawn | Dec 13, 2006 | Children's Oncology Group | Per Group Chair: This study will not move forward. | Other (stated, no rule matched) |
| NCT00860535 | Growth Factor Signature (GFS) Pilot Study (MK0000-098)(COMPLETED) | Phase 1 | terminated | Mar 12, 2009 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01625741 | Phase II Study of High-Dose Rituximab in High-Risk Chronic Lymphocytic Leukemia Patients…(HYDRIC) | Phase 2 | terminated | Jun 21, 2012 | Cliniques universitaires Saint-Luc- Université Catholique de Louvain | Stopped by Principal Investigator decision | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 9, 2016source: clinicaltrials