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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,441 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,441 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01621477 | T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell… | Phase 2 | terminated | Jun 18, 2012 | St. Jude Children's Research Hospital | Study was terminated in August 2016 due to replacement by a new study. | Other (stated, no rule matched) |
| NCT01843179 | Sulindac for Patients With AML | Phase 2 | withdrawn | Apr 30, 2013 | Massachusetts General Hospital | Lack of Funding | Funding |
| NCT00052598 | Therapeutic Allogeneic Lymphocytes and Aldesleukin in Treating Patients With High-Risk or… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT02167360 | Study of Efficacy and Safety of CTL019 in Adult ALL Patients | Phase 2 | withdrawn | Jun 19, 2014 | Abramson Cancer Center at Penn Medicine | Did not enroll | Enrollment / accrual |
| NCT00946283 | Lactobacillus in Preventing Infection in Patients Undergoing a Donor Stem Cell Transplant… | N/A | terminated | Jul 24, 2009 | Rutgers, The State University of New Jersey | slow accrual | Enrollment / accrual |
| NCT01650467 | Imatinib Response in Patients With Chronic Myeloid Leukemia (CML) in Function of Abl…(abl LMC) | — | withdrawn | Jul 26, 2012 | Centre Hospitalier Universitaire de Nīmes | Funding is late, unforseeable. | Funding |
| NCT02234037 | Physical Conditioning and Decitabine for Newly Diagnosed AML Patients Age ≥ 60 | Phase 1 | terminated | Sep 9, 2014 | Emory University | Slow accrual | Enrollment / accrual |
| NCT02722135 | A Study to Find a Safe Dose of Volasertib Given in Addition to Standard Salvage… | Phase 1 | withdrawn | Mar 29, 2016 | Boehringer Ingelheim | not stated | Not stated |
| NCT02129062 | Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic… | Phase 2 | terminated | May 2, 2014 | National Cancer Institute (NCI) | Slow accrual. | Enrollment / accrual |
| NCT01709396 | ED-TBI Followed By Allogeneic Stem Cell Transplantation For The Treatment Of Refractory…(ED-TBI) | Phase 2 | suspended | Oct 18, 2012 | Ottawa Hospital Research Institute | initial on hold due to space but now permanently suspended due to futility. | Efficacy / futility |
| NCT01176422 | Telomere and Telomerase | — | withdrawn | Aug 6, 2010 | University of Kansas Medical Center | lack of resources; no patient enrollment | Enrollment / accrual |
| NCT01520805 | Safety and Effectiveness Study of CPI-613 to Treat Refractory or Relapsed Leukemia and… | Phase 2 | withdrawn | Jan 30, 2012 | Cornerstone Pharmaceuticals | not stated | Not stated |
| NCT02086591 | A Phase II Study of Doxycycline in Relapsed NHL | Phase 2 | terminated | Mar 13, 2014 | University of Rochester | Lack of accrual | Enrollment / accrual |
| NCT01600053 | Revlimid® as Consolidation Treatment Chronic Lymphocytic Leukemia | Phase 2 | terminated | May 16, 2012 | Thomas Kipps | interim analysis showed that the trial will not meet the interim endpoint. | Efficacy / futility |
| NCT02861040 | Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or… | Phase 1 | withdrawn | Aug 10, 2016 | Northwestern University | not stated | Not stated |
| NCT02420938 | Urelumab (CD137 mAb) With Rituximab for Relapsed, Refractory or High-risk Untreated… | Phase 2 | withdrawn | Apr 20, 2015 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT01401322 | Single Agent Lenalidomide in Adult Patients With Relapsed/Refractory Acute Lymphoblastic… | Phase 2 | terminated | Jul 25, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT01073436 | Discontinuation of Imatinib Mesylate in Patients With Chronic-Phase Chronic Myeloid… | — | terminated | Feb 23, 2010 | University of Michigan Rogel Cancer Center | Closed prematurely due to low accrual. | Enrollment / accrual |
| NCT00255684 | Fludarabine, Cyclophosphamide, and Total-Body Irradiation Followed by Cyclosporine and… | N/A | terminated | Nov 21, 2005 | University of Rochester | low accrual | Enrollment / accrual |
| NCT00098371 | Flavopiridol in Treating Patients With Chronic Lymphocytic Leukemia or Prolymphocytic… | Phase 2 | terminated | Dec 8, 2004 | National Cancer Institute (NCI) | CTEP Initiated Action. | Other (stated, no rule matched) |
| NCT01517347 | Efficiency Study of Low Dose of IL-2 to Prevent Relapse in Standard Risk Leukemia After… | N/A | terminated | Jan 25, 2012 | Peking University People's Hospital | Because the conditional power was 0.083, the Data and Safety Monitoring Board recommended halting… | Safety / toxicity |
| NCT02147873 | Study of Azacitidine With or Without Birinapant in Subjects With MDS or CMMoL | Phase 2 | terminated | May 28, 2014 | TetraLogic Pharmaceuticals | Study terminated due to lack of efficacy | Efficacy / futility |
| NCT00278265 | Methotrexate Followed by Fludarabine in Patients With T-Cell Large Granular Lymphocytic… | Phase 2 | terminated | Jan 18, 2006 | German CLL Study Group | slow recruitment | Enrollment / accrual |
| NCT02047149 | Evaluating the Safety of Zileuton (Zyflo®) in Combination With Dasatinib (Sprycel®) in… | Phase 1 | terminated | Jan 28, 2014 | University of Massachusetts, Worcester | Low accrual | Enrollment / accrual |
| NCT01617473 | Randomized Trial of Mobilized Blood/Marrow Versus Blood Transplant | N/A | withdrawn | Jun 12, 2012 | Peking University People's Hospital | patients' reluctance | Other (stated, no rule matched) |
| NCT00281931 | Fludarabine, Cyclophosphamide, and Rituximab in Treating Patients With Prolymphocytic… | Phase 2 | terminated | Jan 25, 2006 | German CLL Study Group | not stated | Not stated |
| NCT00416910 | Combination Chemotherapy With or Without G-CSF in Treating Patients With Relapsed Chronic… | Phase 3 | terminated | Dec 28, 2006 | German CLL Study Group | low recruitment | Enrollment / accrual |
| NCT02528877 | Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host… | Phase 1 | withdrawn | Aug 19, 2015 | City of Hope Medical Center | The study design was revised so a new protocol will be opened. | Other (stated, no rule matched) |
| NCT02146846 | Population Pharmacokinetics of Imatinib in CML Patients in Iran | — | terminated | May 26, 2014 | Kerman University of Medical Sciences | not stated | Not stated |
| NCT02303782 | A Study Assessing tOTX015 in Combination With Azacitidine (AZA) or AZA Single Agent in… | Phase 1 / Phase 2 | withdrawn | Dec 1, 2014 | Oncoethix GmbH, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | not stated | Not stated |
| NCT00771056 | Hydroxychloroquine in Untreated B-CLL Patients | Phase 2 | terminated | Oct 10, 2008 | Northwell Health | study suspended while data is reviewed for safety and efficacy. | Safety / toxicity |
| NCT00814164 | Clofarabine and Daunorubicin in Treating Older Patients With Newly Diagnosed Acute… | Phase 2 | terminated | Dec 24, 2008 | Roswell Park Cancer Institute | Sponsor withdrew support | Other (stated, no rule matched) |
| NCT02115672 | Imatinib and BL-8040 (Novel Anti CXCR4 Antagonist) for Improving Molecular Response in… | Phase 1 / Phase 2 | withdrawn | Apr 16, 2014 | Sheba Medical Center | loss of support | Other (stated, no rule matched) |
| NCT02281279 | Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory… | Phase 1 / Phase 2 | withdrawn | Nov 3, 2014 | Mayo Clinic | not stated | Not stated |
| NCT01960387 | Phase II Clofarabine and Cytarabine for Newly Diagnosed Acute Myeloid Leukemia(UPCI 13-066) | Phase 2 | terminated | Oct 10, 2013 | University of Pittsburgh | lack of accrual | Enrollment / accrual |
| NCT02640833 | A Study of Duvelisib and Venetoclax in Subjects With Relapsed or Refractory Chronic… | Phase 1 | withdrawn | Dec 29, 2015 | AbbVie | Study Stopped | Other (stated, no rule matched) |
| NCT01652014 | Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With… | Phase 2 | withdrawn | Jul 27, 2012 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT01436084 | SB1518 for Patients With Myelodysplastic Syndrome (MDS) | Phase 2 | terminated | Sep 19, 2011 | M.D. Anderson Cancer Center | Colloborating sponsor decision. | Sponsor / business decision |
| NCT02046928 | Safety, Tolerability and Efficacy of A6 in Patients With Chronic Lymphocytic Leukemia… | Phase 2 | terminated | Jan 28, 2014 | Ångstrom Pharmaceuticals | Slow enrollment | Enrollment / accrual |
| NCT00004239 | 506U78 in Treating Patients With Hematologic Cancer and Kidney or Liver Impairment | Phase 1 | terminated | Jan 29, 2004 | Alliance for Clinical Trials in Oncology | poor accrual | Enrollment / accrual |
| NCT00004933 | Homoharringtonine Compared With Hydroxyurea for Chronic Myelogenous Leukemia That Has Not… | Phase 3 | terminated | Apr 28, 2004 | Alliance for Clinical Trials in Oncology | Poor accrual | Enrollment / accrual |
| NCT01649791 | Lenalidomide as Chemoprevention in Treating Patients With High-Risk, Early-Stage B-Cell… | N/A | terminated | Jul 25, 2012 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT01108497 | Genome, Proteome and Tissue Microarray in Childhood Acute Leukemia | — | terminated | Apr 22, 2010 | Stanford University | not stated | Not stated |
| NCT02273856 | Multicentre Registry of Treatments and Outcomes in Patients With Chronic Lymphocytic…(NADIR) | — | terminated | Oct 24, 2014 | Astellas Pharma International B.V. | The study was terminated due to insufficient subject enrollment and very slow enrollment. | Enrollment / accrual |
| NCT00185523 | Allogeneic Transplantation for Patients With Acute Leukemia or Chronic Myelogenous… | — | terminated | Sep 16, 2005 | Stanford University | not stated | Not stated |
| NCT00751296 | Study of Lenalidomide in Previously Untreated, Symptomatic Chronic Lymphocytic Leukemia…(Rev-CLL) | Phase 2 | terminated | Sep 11, 2008 | University Health Network, Toronto | Seven years of follow-up \& final analysis done in Dec 2012. | Other (stated, no rule matched) |
| NCT00313053 | Study of mAb 216 With Chemotherapy for Treatment of Pediatric Relapsed or Refractory… | Phase 1 | terminated | Apr 11, 2006 | Clare Twist | not stated | Not stated |
| NCT01658904 | Carfilzomib and Stem Cell Transplant for Plasma Cell Myeloma | Phase 1 / Phase 2 | terminated | Aug 7, 2012 | National Cancer Institute (NCI) | study closed prematurely because investigator left National Institutes of Health | Investigator |
| NCT00543114 | Dose Escalation Study of Revlimid With Fludarabine-Rituximab for CLL/SLL | Phase 1 | terminated | Oct 12, 2007 | Dana-Farber Cancer Institute | lack of efficacy and tolerability | Efficacy / futility |
| NCT00512460 | RTA 744 Injection in Patients With Leptomeningeal Disease | Phase 1 | terminated | Aug 7, 2007 | M.D. Anderson Cancer Center | Study was closed due to loss of industry sponsorship | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Feb 20, 2017source: clinicaltrials