A Study of Duvelisib and Venetoclax in Subjects With Relapsed or Refractory Chronic Lymphocytic Leukemia, Small Lymphocytic Lymphoma, or Indolent or Aggressive Non-Hodgkin Lymphoma, Who Have Not Previously Received a Bcl-2 or PI3K Inhibitor

Inclusion Criteria: -

Subject must have either • Relapsed or refractory Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma (for Waves 2 or 3)

* Subject has evaluable disease and requires treatment in the opinion of the investigator.
* Subject must have relapsed following or be refractory to ≥ 1 standard treatments such as fludarabine based regimens (F, FC, FR, FCR), alkylator (chlorambucil, bendamustine) based regimens, or Bruton's Tyrosine Kinase inhibitor (Ibrutinib).

Or

• Relapsed or refractory indolent Non-Hodgkin Lymphoma or aggressive Non-Hodgkin Lymphoma (for Waves 1, 2, or 3, unless otherwise indicated)

* Subject must have histologically documented diagnosis of a Follicular Lymphoma or Marginal Zone Lymphoma.
* Subject must have histologically documented diagnosis of a Diffuse Large B-cell Lymphoma (excluding Richter's Transformation), Non-cutaneous T-Cell Lymphoma, or Mantle Cell Lymphoma (MCL) (MCL Wave 3 only)
* Subject has evaluable disease and requires treatment in the opinion of the investigator.
* Subject must have relapsed following or be refractory to ≥ 1 standard treatments such as R-CHOP, R-CVP, bendamustine, lenalidomide-rituximab, or fludarabine-based regimens.

  * Subject has an Eastern Cooperative Oncology Group (ECOG) performance score of less than or equal to 2.
  * Subject must have adequate bone marrow independent of growth factor support per local laboratory reference range at Screening.
  * Subject must have adequate coagulation, renal, and hepatic function, per laboratory reference range at Screening.
  * NHL subjects who have a history of an autologous stem cell transplant (e.g., bone marrow) must be \> 6 months post-transplant (prior to the first dose of study drug) and must not require any growth factor support.

Exclusion Criteria:

* Subject has been previously treated with a Bcl-2 or PI3K inhibitor.
* Subject is a candidate to receive another second-line therapy approved for usage by the local Health Authority.
* Subject is appropriate for a stem cell transplant or has undergone an allogeneic stem cell transplant.
* Subject has received any of the following within 14 days or 5 drug half-lives (whichever is shortest) prior to the first dose of duvelisib or venetoclax, or has not recovered to less than Grade 2 clinically significant adverse effect(s)/toxicity(s) of the previous therapy:

  * Any anti-cancer therapy including chemotherapy or radiotherapy;
  * Investigational therapy, including targeted small molecule agents.
* Subject has received biologic agents (e.g., monoclonal antibodies) for anti-neoplastic treatment within 30 days prior to first dose of duvelisib or venetoclax.
* Subject has received live or live attenuated vaccines within 6 weeks prior to first dose of duvelisib or venetoclax.
* Subject has received the following within 7 days prior to the first dose of duvelisib or venetoclax:

  * Steroid therapy for anti-neoplastic treatment;
  * Strong and Moderate CYP3A inhibitors;
  * Strong and Moderate CYP3A inducers;
  * Chronic immunosuppressants, other than corticosteroids given at daily dose \< 20 mg prednisone equivalent for ITP or AIHA.