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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,441 stopped studies mapped to Leukemia and descendants · 87% state a reason
Over the 1,441 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00496132 | A Trial of the Safety of Escalating Doses of PRO131921 in Patients With Relapsed or… | Phase 1 / Phase 2 | terminated | Jul 4, 2007 | Genentech, Inc. | not stated | Not stated |
| NCT01342887 | Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating… | Phase 1 / Phase 2 | terminated | Apr 27, 2011 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT01076270 | Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A… | N/A | terminated | Feb 26, 2010 | Fred Hutchinson Cancer Center | Funding withdrawal | Funding |
| NCT00020670 | Vaccine Therapy in Treating Patients With Acute Lymphoblastic Leukemia | Early Phase 1 | terminated | Jan 27, 2003 | Dana-Farber Cancer Institute | Slow accrual | Enrollment / accrual |
| NCT00719849 | Donor Umbilical Cord Blood Transplant in Treating Patients With Advanced Hematological… | Phase 2 | terminated | Jul 22, 2008 | Fred Hutchinson Cancer Center | A new protocol was developed to replace this protocol in 2008, with removal of ATG and extension of… | Other (stated, no rule matched) |
| NCT02194374 | Autologous ROR1R-CAR-T Cells for Chronic Lymphocytic Leukemia (CLL) | Phase 1 | withdrawn | Jul 18, 2014 | M.D. Anderson Cancer Center | Study closed with no enrollment due to unavailability of reagent. | Enrollment / accrual |
| NCT02276651 | Observational Trial of a Therapeutic Platelet Transfusion Regimen | — | terminated | Oct 28, 2014 | Klinikum Nürnberg | Insufficient recruitment | Enrollment / accrual |
| NCT01220297 | Sirolimus & Mycophenolate Mofetil as GvHD Prophylaxis in Myeloablative, Matched Related… | Phase 2 | terminated | Oct 13, 2010 | Stanford University | Low accrual | Enrollment / accrual |
| NCT02647190 | Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed… | Phase 1 | withdrawn | Jan 6, 2016 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT02829840 | Dose-Escalation Study of Ponatinib, a FLT3 Inhibitor, With and Without Combination of… | Phase 1 / Phase 2 | withdrawn | Jul 12, 2016 | M.D. Anderson Cancer Center | not stated | Not stated |
| NCT00673153 | Vorinostat and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated… | Phase 2 | terminated | May 7, 2008 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT00676806 | A Phase II Study of Umbilical Cord Blood Transplantation | Phase 2 | terminated | May 13, 2008 | Tufts Medical Center | Slow accrual | Enrollment / accrual |
| NCT00708721 | Low-dose Oral Clofarabine for the Treatment of IPSS INT-1, INT-2 or HIGH Myelodysplastic… | Phase 1 / Phase 2 | terminated | Jul 2, 2008 | University of Utah | Data analysis revealed sufficient data for safety and efficacy | Safety / toxicity |
| NCT00589602 | T-Cell Depletion, Donor Hematopoietic Stem Cell Transplant (HSCT), and T-Cell Infusions… | Phase 2 | terminated | Jan 9, 2008 | The Cleveland Clinic | slow accrual | Enrollment / accrual |
| NCT02259348 | Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following… | Phase 2 | terminated | Oct 8, 2014 | St. Jude Children's Research Hospital | Investigator's decision. | Investigator |
| NCT00450983 | Donor Peripheral Stem Cell Transplant and Donor Natural Killer Cell Transplant After… | Phase 2 | terminated | Mar 22, 2007 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT00555048 | Alemtuzumab, Busulfan, and Cyclophosphamide Followed By a Donor Stem Cell Transplant in… | Phase 1 / Phase 2 | terminated | Nov 7, 2007 | Fred Hutchinson Cancer Center | Low accrual | Enrollment / accrual |
| NCT00863434 | Clofarabine and Cytarabine in Treating Patients With Acute Myeloid Leukemia With Minimal… | Phase 2 | terminated | Mar 18, 2009 | University of Washington | not stated | Not stated |
| NCT00997243 | Azacitidine and Lintuzumab in Treating Patients With Previously Untreated Myelodysplastic… | Phase 2 | terminated | Oct 19, 2009 | Alison Walker | Drug no longer being supplied by sponsor | Other (stated, no rule matched) |
| NCT01625455 | Effect of Neurokinin-1 Receptor (NK1R) Antagonism on Pruritus in Patients With Sezary… | Phase 4 | terminated | Jun 21, 2012 | Vanderbilt University Medical Center | Difficulty recruiting. | Enrollment / accrual |
| NCT00324324 | Moxifloxacin in Preventing Bacterial Infections in Patients Who Have Undergone Donor Stem… | Phase 3 | terminated | May 11, 2006 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT00900068 | Blood Samples From Patients on a Clinical Trial to CINV During HSCT | — | terminated | May 12, 2009 | OHSU Knight Cancer Institute | not stated | Not stated |
| NCT01191749 | Alemtuzumab in Myelodysplastic Syndrome (MDS), Aplastic Anemia, and T-Cell Large Granular… | Phase 2 | terminated | Aug 31, 2010 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT01483274 | Decitabine and Vaccine Therapy for Patients With Relapsed AML Following Allogeneic Stem…(AML) | Phase 1 | withdrawn | Dec 1, 2011 | University of Louisville | Adult patient population barriers. | Other (stated, no rule matched) |
| NCT01610999 | Pilot Study of Lymphoid Tumor Microenvironmental Dysruption Prior to Autologous Stem Cell… | Phase 1 | terminated | Jun 4, 2012 | Tufts Medical Center | Unavailability of study article | Other (stated, no rule matched) |
| NCT02564536 | Pacritinib in Combination With Low Dose Decitabine in Intermediate-High Risk… | Phase 1 | withdrawn | Sep 30, 2015 | Washington University School of Medicine | Lack of funding following full FDA clinical hold | Funding |
| NCT02791919 | Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children,… | Phase 1 | withdrawn | Jun 7, 2016 | National Cancer Institute (NCI) | Other - Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT02371577 | Evaluation of the Immune Restoration Potential Of Lenalidomide(Revlimid) | Phase 2 | withdrawn | Feb 25, 2015 | University of California, San Diego | withdrawn | Other (stated, no rule matched) |
| NCT01605981 | Trial Evaluating Nilotinib as Treatment for Newly Diagnosed CML Patients in Accelerated…(MACS1881) | Phase 4 | withdrawn | May 25, 2012 | Novartis Pharmaceuticals | not stated | Not stated |
| NCT02520102 | Open Label Study of Sargramostim Among Patients Receiving Myelosuppressive Induction… | Phase 2 | withdrawn | Aug 11, 2015 | Sanofi | Company has fulfilled post-marketing requirements | Sponsor / business decision |
| NCT01173679 | Dasatinib With Fludarabine and Rituximab in Relapsed and Refractory CLL and SLL | Phase 2 | terminated | Aug 2, 2010 | Massachusetts General Hospital | Slow accrual | Enrollment / accrual |
| NCT00596336 | Study of Immune Responses to Influenza Vaccination With or Without Imiquimod Application…(CLLIFVAC) | Phase 2 | terminated | Jan 17, 2008 | The Royal Bournemouth Hospital | Recruitment issues | Enrollment / accrual |
| NCT02973191 | A Study to Determine Safety, Feasibility and Efficacy of JCAR015 in Adult Subjects With…(ORBIT) | Phase 1 / Phase 2 | withdrawn | Nov 25, 2016 | Celgene | Development of JCAR015 has been discontinued. No subjects were enrolled/treated under protocol… | Enrollment / accrual |
| NCT02200380 | A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell… | Phase 2 | terminated | Jul 25, 2014 | Celldex Therapeutics | not stated | Not stated |
| NCT02227108 | Study in Pediatrics With Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia… | Phase 2 | terminated | Aug 27, 2014 | MedImmune LLC | The study was terminated prior to a planned interim analysis based on lack of required efficacy in… | Efficacy / futility |
| NCT00360776 | Tipifarnib in Treating Patients With Anemia or Neutropenia and Large Granular Lymphocyte… | Phase 2 | terminated | Aug 7, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02285244 | Sotrastaurin Acetate in Treating Patients With Relapsed or Refractory Chronic Lymphocytic… | Phase 2 | withdrawn | Nov 6, 2014 | James Blachly | Decision made by the Principal Investigator | Investigator |
| NCT02527174 | A Study of Volasertib Plus Induction Chemotherapy for Acute Myeloid Leukemia(VIAC) | Phase 1 | withdrawn | Aug 18, 2015 | University of Alberta | Volasertib no longer available | Other (stated, no rule matched) |
| NCT01465386 | Bortezomib in Treating Patients With High-Risk Acute Myeloid Leukemia in Remission | Phase 2 | terminated | Nov 4, 2011 | Fred Hutchinson Cancer Center | Closed early due to slow enrollment | Enrollment / accrual |
| NCT02067637 | Delayed Effects of Treatment in Cancer Survivors (DETECS)(DETECS) | — | withdrawn | Feb 20, 2014 | University of Colorado, Denver | Low accrual | Enrollment / accrual |
| NCT02257684 | A Dose Confirmation and Pharmacokinetic Study of Pegcrisantaspase Administered as… | Phase 2 | terminated | Oct 6, 2014 | Jazz Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT00698685 | Pentostatin and Alemtuzumab as a Preparative Regimen for Allogeneic Peripheral Blood Stem… | Phase 2 | terminated | Jun 17, 2008 | University of Arizona | Pentostatin/alemtuzumab regimen had greater risk of graft failure. | Other (stated, no rule matched) |
| NCT01607645 | Decitabine Followed by Idarubicin and Cytarabine in Treating Patients With Relapsed or… | Phase 2 | terminated | May 30, 2012 | Fred Hutchinson Cancer Center | The study was terminated early because there were other competing protocols. | Other (stated, no rule matched) |
| NCT01118013 | Donor Stem Cell Transplant in Treating Patients With Relapsed Hematologic Malignancies or… | Phase 2 | terminated | May 6, 2010 | Alliance for Clinical Trials in Oncology | not stated | Not stated |
| NCT00363467 | Busulfan Monotherapy as Conditioning for Autologous Hematopoietic Progenitor Cell… | N/A | terminated | Aug 15, 2006 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT01357655 | Phase 2 Dasatinib Combo With Smoothened (SMO) Antagonist (BMS-833923) | Phase 2 | terminated | May 23, 2011 | Bristol-Myers Squibb | No participants enrolled in this trial could receive the SMO antagonist as a recommended phase 2… | Enrollment / accrual |
| NCT01944943 | Phase II Study of Vismodegib in Patients With Refractory or Relapsed B-cell Lymphoma or…(VISMOLY) | Phase 2 | terminated | Sep 18, 2013 | The Lymphoma Academic Research Organisation | lack of efficacy | Efficacy / futility |
| NCT02473523 | Yoga to Alleviate Fatigue, Anxiety and Pain in Adolescents During Treatment for Lymphoma… | N/A | terminated | Jun 16, 2015 | St. Jude Children's Research Hospital | The principal investigator left the institution. | Investigator |
| NCT02086487 | Efficacy and Safety Assessment of NIlotinib in CML Patients With Suboptimal Response on…(NISRI) | Phase 4 | terminated | Mar 13, 2014 | King Abdullah International Medical Research Center | Because of many unseen obstacles resulted in poor accrual, study is terminated. | Enrollment / accrual |
| NCT01749111 | Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin…(CICLODECH) | Phase 3 | terminated | Dec 13, 2012 | Hospital Israelita Albert Einstein | Lack of accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Jul 2, 2017source: clinicaltrials