Evaluation of the Immune Restoration Potential Of Lenalidomide

Main Inclusion Criteria:

1. Clinical and phenotypic verification of B cell CLL/ SLL/ or MBL and measurable disease.
2. Subjects must have total serum IgG \< 500 mg/dL
3. Disease Status/ Prior Therapy: There is not any requirement nor restriction for prior therapy.
4. Recovered from the toxic effects of prior therapy to their clinical baseline.
5. Both men and women of all races and ethnic groups are eligible for this trial.
6. Women of childbearing potential (not postmenopausal for at least one year or not surgically incapable of bearing children) must agree not to become pregnant for the duration of the study. Both men and women must agree to use a barrier method of contraception for the duration of the study and until 8 weeks after the final dose of lenalidomide.
7. ECOG performance status of 0-2.
8. Adequate hematologic function:

   8.1. Platelet count ≥ 50,000/µL; AND 8.2. Hemoglobin ≥ 8.0 g/dL 8.3. Absolute neutrophil count \> 1000 /uL
9. Adequate renal function:

   9.1. Serum creatinine \<1.5 times upper limit of normal; OR 9.2. Calculated Creatinine clearance (CrCl) ≥ 50 mL/min
10. Adequate hepatic function:

    12.1. Total bilirubin ≤ 2.5 times upper limit of normal; AND 12.2. ALT ≤ 2.5 times upper limit of normal.
11. Able to take aspirin (81mg or 325mg) daily, warfarin, low molecular weight heparin, or equivalent anticoagulation as prophylactic medication.
12. All study participants must be registered into the mandatory Revlimid REMS® program, and be willing and able to comply with the requirements of REMS®.
13. Females of childbearing potential must have a negative serum or urine pregnancy test with a sensitivity of at least 50 mIU/mL within 10 - 14 days prior to and again within 24 hours prior to starting Revlimid® and must either commit to continued abstinence from heterosexual intercourse or begin TWO acceptable methods of birth control, one highly effective method and one additional effective method AT THE SAME TIME, at least 28 days before she starts taking Revlimid®. Men must agree to use a latex condom during sexual contact with a FCBP even if they have had a successful vasectomy.
14. Females of reproductive potential must adhere to the scheduled pregnancy testing as required in the Revlimid REMS® program.

Exclusion Criteria:

1. Progressive CLL requiring therapy based on 2008 international working group guidelines (iwCLL 2008, Hallek et al, Blood 2008).
2. Pregnant or breast-feeding women will not be entered on this study due to risks of fetal and teratogenic adverse events as seen in animal/human studies.
3. Known hypersensitivity to thalidomide or lenalidomide.
4. Prior lenalidomide-associated deep vein thrombosis
5. Deep vein thrombosis or superficial thrombophlebitis of any cause on current anticoagulation therapy at the time of screening.
6. Patients who are currently receiving another investigational agent are excluded.
7. Patients who have had chemotherapy (e.g., purine analogues, alkylating agents), radiation therapy, tyrosine kinase inhibitor therapy, or participation in any investigational drug treatment within 4 weeks of initiation of lenalidomide or at any time during the study.
8. Patients who have had prior (within 8 weeks of initiation of lenalidomide) or concurrent antibody therapy directed against CLL.
9. Current infection requiring parenteral antibiotics.
10. Known seropositive for or active viral infection with human immunodeficiency virus (HIV); or known active infection with hepatitis B virus (HBV) or hepatitis C virus (HCV) based on detectable viral load. Patients who are seropositive because of hepatitis B virus vaccine are eligible.
11. Active malignancy within the previous 2 years (other than completely resected non-melanoma skin cancer or carcinoma in situ).
12. Known history of IgA or IgG monoclonal gammopathy of undetermined significance (MGUS)
13. Known central nervous system (CNS) involvement by malignancy.
14. Untreated autoimmunity such as autoimmune hemolytic anemia, or immune thrombocytopenia.