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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
174 stopped studies mapped to Intestinal Carcinoma and descendants · 93% state a reason
Over the 174 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT03029988 | An Evaluation of Tilmanocept by IV Injection Using SPECT/CT vs PET Imaging in Subjects… | Phase 1 | terminated | Jan 24, 2017 | Navidea Biopharmaceuticals | Lack of effect in Cohort 1 | Other (stated, no rule matched) |
| NCT01367275 | Irinotecan Plus Brivanib in Metastatic Colorectal Cancer (CRC) Enriched for Elevated… | Phase 2 | terminated | Jun 7, 2011 | M.D. Anderson Cancer Center | Sponsor closed study | Other (stated, no rule matched) |
| NCT02652702 | Study Comparing Circular Stapler-assisted Colostomy vs Hand-stitching Colostomy of…(STAPLER) | Phase 2 | terminated | Jan 12, 2016 | Zhejiang University | Not enough patients recruited | Enrollment / accrual |
| NCT03300609 | 5-FU Based Maintenance Therapy in RAS Wild Type Metastatic Colorectal Cancer After… | Phase 3 | terminated | Oct 3, 2017 | University of Southern California | Insufficient Accrual | Enrollment / accrual |
| NCT02797405 | Tumour and HEalthy Tissues DOse-response and Radiosensitivity Assay(THEODORA) | N/A | terminated | Jun 13, 2016 | Centre Leon Berard | Withdrawal of analysis study Partner. | Other (stated, no rule matched) |
| NCT02425683 | Study of Colorectal Cancer Patients (Stage IIIC) With Either Regorafenib or Standard of… | Phase 2 | terminated | Apr 24, 2015 | US Oncology Research | insufficient accrual | Enrollment / accrual |
| NCT03408561 | Social Media Listening in Improving Clinical Trial Recruitment in Patients With Cancer | N/A | withdrawn | Jan 24, 2018 | University of Southern California | No accrual | Enrollment / accrual |
| NCT00397878 | AZD0530 (NSC 735464) in Treating Patients With Previously Treated Metastatic Colon Cancer… | Phase 2 | terminated | Nov 10, 2006 | National Cancer Institute (NCI) | The study was terminated after all enrolled participants progressed. | Enrollment / accrual |
| NCT02233595 | Evaluation of Rectal Cancer Treatment Response Using PET/MRI(Rectal PET/MRI) | — | terminated | Sep 8, 2014 | University of California, San Francisco | Low Accrual | Enrollment / accrual |
| NCT00621036 | Vaccine Therapy and GM-CSF in Treating Patients With CNS Lymphoma | Phase 2 | withdrawn | Feb 22, 2008 | University of Texas Southwestern Medical Center | MyVax did not meet its primary endpoints | Other (stated, no rule matched) |
| NCT02669914 | MEDI4736 (Durvalumab) in Patients With Brain Metastasis From Epithelial-derived Tumors | Phase 2 | terminated | Feb 1, 2016 | Washington University School of Medicine | Low accrual, funding withdrawn by AstraZeneca, and change in clinical practice | Enrollment / accrual |
| NCT03527784 | Prestoma-Trial for Parastomal Hernia Prevention | N/A | terminated | May 17, 2018 | University of Oulu | Parastomal Parietex withdrawn from market by the manufacturer. | Drug supply |
| NCT02650635 | TLR8 Agonist VTX-2337 and Cyclophosphamide in Treating Patients With Metastatic,… | Phase 1 | terminated | Jan 8, 2016 | Mayo Clinic | permanently closed per sponsor's request | Other (stated, no rule matched) |
| NCT03096899 | A Study to Estimate Overall Survival in Patients Receiving Best Supportive Care for… | — | withdrawn | Mar 30, 2017 | The Rogosin Institute | The investigator conducting the study determined that the entry criteria for the proposed subjects… | Investigator |
| NCT02216149 | Effects of S-1 and Capecitabine on Coronary Artery Blood Flow(FluoHeart) | Phase 2 | terminated | Aug 13, 2014 | Heikki Joensuu | Slow accrual | Enrollment / accrual |
| NCT02508077 | FOLFIRI and Panitumumab in Treating Patients With RAS and BRAF Wild-Type Metastatic… | Phase 2 | terminated | Jul 24, 2015 | City of Hope Medical Center | Poor Accrual | Enrollment / accrual |
| NCT01197664 | Paricalcitol, Fluorouracil, and Radiation Therapy in Treating Patients With Rectal Cancer… | Phase 1 | terminated | Sep 9, 2010 | Wake Forest University Health Sciences | Study terminated due to funding issues | Funding |
| NCT02423954 | Study of Nivolumab Plus Chemotherapy in Patients With Advanced Cancer (NivoPlus)(NivoPlus) | Phase 1 / Phase 2 | terminated | Apr 22, 2015 | Western Regional Medical Center | Investigator no longer at site to enroll patients or write up data | Investigator |
| NCT00832637 | Gemcitabine, Oxaliplatin, Tarceva &/or Cisplatin in HCC & Biliary Tree Cancers(Gem-ox) | Phase 2 | terminated | Jan 30, 2009 | New Mexico Cancer Research Alliance | Low accrual | Enrollment / accrual |
| NCT01887509 | Evaluation of Rectal Tumor Margin Using Confocal Endomicroscopy and Comparison to…(TRaMA) | N/A | terminated | Jun 27, 2013 | IHU Strasbourg | Difficulties with patients recruitment, study acceptance and protocol implementation. | Enrollment / accrual |
| NCT02577588 | Trial of Adoptive T Cell Therapy With Activated P53 Specific T Cells for Treatment of…(ATACC) | Phase 1 | terminated | Oct 16, 2015 | National Center for Tumor Diseases, Heidelberg | not feasible | Other (stated, no rule matched) |
| NCT02638909 | Study of Oral Ceritinib in Patients With ALK and ROS1 Activated Gastrointestinal… | Phase 2 | terminated | Dec 23, 2015 | Criterium, Inc. | Lack of Enrollment | Enrollment / accrual |
| NCT02365662 | A Study Evaluating Safety and Pharmacokinetics of ABBV-221 in Subjects With Advanced… | Phase 1 | terminated | Feb 19, 2015 | AbbVie | Safety | Safety / toxicity |
| NCT02110953 | Irinotecan-Eluting Beads in Treating Patients With Refractory Metastatic Colon or Rectal… | Phase 1 | terminated | Apr 10, 2014 | Fox Chase Cancer Center | IRB study closure by investigator due to low enrollment | Investigator |
| NCT02119676 | Study of Ruxolitinib in Colorectal Cancer Patients | Phase 2 | terminated | Apr 22, 2014 | Incyte Corporation | Substudy 1 was terminated for futility at interim analysis and Substudy 2 was terminated per… | Efficacy / futility |
| NCT01934179 | Telomere Length in Predicting Toxicity in Older Patients With Stage III-IV Colorectal… | — | terminated | Sep 4, 2013 | Fox Chase Cancer Center | Low Accrual Rate | Enrollment / accrual |
| NCT02407561 | Prospective Validation Study for the Proprietary Rectal and Anal Cancer Protein… | — | terminated | Apr 3, 2015 | Castle Biosciences Incorporated | Futility - unable to secure sites and samples for participation | Efficacy / futility |
| NCT01729923 | A Trial of Maintenance ADAPT Therapy With Capecitabine and Celecoxib in Patients With…(ADAPT) | Phase 2 | terminated | Nov 20, 2012 | University of Washington | Funding ended | Funding |
| NCT00903396 | Palonosetron Hydrochloride in Preventing Nausea and Vomiting Caused by Radiation Therapy… | Phase 2 | terminated | May 18, 2009 | Alliance for Clinical Trials in Oncology | Slow accrual | Enrollment / accrual |
| NCT01606124 | Polyphenon E in Treating Patients With High-Risk of Colorectal Cancer | Phase 2 | terminated | May 25, 2012 | Mayo Clinic | pending expiration of the supply of study agent. | Drug supply |
| NCT00003522 | Antineoplaston Therapy in Treating Patients With Cancer of the Small Intestine | Phase 2 | terminated | Jan 27, 2003 | Burzynski Research Institute | slow accrual | Enrollment / accrual |
| NCT01114256 | FNA Tumor Sampling for CD137 Modulation: A Pilot Study | — | terminated | May 3, 2010 | Stanford University | not stated | Not stated |
| NCT01095523 | Prospective Randomized Trial Evaluating Mandatory Second Look Surgery With HIPEC and CRS… | Phase 2 | withdrawn | Mar 30, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01646554 | Efficacy of FOLFOX Versus FOLFOX Plus Aflibercept in K-ras Mutant Patients With…(BOS3) | Phase 2 / Phase 3 | withdrawn | Jul 20, 2012 | European Organisation for Research and Treatment of Cancer - EORTC | not stated | Not stated |
| NCT02413853 | Combination Chemotherapy and Bevacizumab With or Without PRI-724 in Treating Patients…(PRIMIER) | Phase 2 | withdrawn | Apr 10, 2015 | University of Southern California | Study drug supply issues | Drug supply |
| NCT01270438 | Combination Chemotherapy and Bevacizumab With or Without RO4929097 in Treating Patients… | Phase 2 | withdrawn | Jan 5, 2011 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01229111 | Cediranib Maleate and Combination Chemotherapy in Treating Patients With Advanced Biliary… | Phase 2 | terminated | Oct 27, 2010 | National Cancer Institute (NCI) | Lack of Drug Supply | Drug supply |
| NCT00361244 | SU011248 in Combination With Irinotecan and Cetuximab as a Second Line Regimen for Stage… | Phase 1 / Phase 2 | terminated | Aug 8, 2006 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT02046538 | Phase II Study of Zaltrap and Chemotherapy for Advanced Resectable Colorectal Cancer | Phase 2 | withdrawn | Jan 27, 2014 | Weill Medical College of Cornell University | Investigator terminated due to funding issues | Investigator |
| NCT02287727 | Regorafenib in Reducing Recurrence in Patients With Non-metastatic Rectal Cancer Who Have… | Phase 2 | withdrawn | Nov 11, 2014 | Roswell Park Cancer Institute | not stated | Not stated |
| NCT01937715 | A Study Of PF-05212384 Plus FOLFIRI Versus Bevacizumab Plus FOLFIRI In Metastatic… | Phase 1 / Phase 2 | terminated | Sep 9, 2013 | Pfizer | B2151007 was prematurely discontinued due to Pfizer's change in prioritization for the portfolio… | Safety / toxicity |
| NCT01111292 | Inositol in Preventing Colorectal Cancer in Patients With Colitis-Associated Dysplasia | Phase 1 / Phase 2 | terminated | Apr 27, 2010 | National Cancer Institute (NCI) | The study was closed prematurely due to poor accrual. | Enrollment / accrual |
| NCT02575508 | Pan FGFR Kinase Inhibitor BGJ398 and Combination Chemotherapy in Treating Patients With… | Phase 1 / Phase 2 | withdrawn | Oct 14, 2015 | Roswell Park Cancer Institute | drug supply issues | Drug supply |
| NCT01843452 | Phase II Study of Concomitant Intensity-modulated Radiotherapy Combined to Capecitabine,… | Phase 2 | terminated | Apr 30, 2013 | Centre Hospitalier Universitaire Vaudois | Poor recruitment | Enrollment / accrual |
| NCT01233544 | Radiofrequency Ablation Versus Stereotactic Radiotherapy in Colorectal Liver Metastases(RAS01) | Phase 3 | terminated | Nov 3, 2010 | University of Aarhus | Insufficient recruitment | Enrollment / accrual |
| NCT01483638 | Axitinib as Maintenance Treatment in Patients With Metastatic CRC(TTD-11-01) | Phase 2 | terminated | Dec 1, 2011 | Spanish Cooperative Group for the Treatment of Digestive Tumours (TTD) | The trial was prematurely closed due to lack of accrual | Enrollment / accrual |
| NCT01157039 | A Trial of Glutamine to Prevent Oxaliplatin Neurotoxicity and a Pharmacokinetic Analysis… | Phase 2 | withdrawn | Jul 5, 2010 | AHS Cancer Control Alberta | abandoned | Other (stated, no rule matched) |
| NCT01816659 | An Open-Labeled Pilot Study of Biomarker Response Following Short-Term Exposure to… | Phase 1 | terminated | Mar 22, 2013 | M.D. Anderson Cancer Center | Slow Accrual | Enrollment / accrual |
| NCT01856322 | Surgery Plus Sulindac or Surgery Alone for Advanced Colorectal Cancer | Phase 2 | terminated | May 17, 2013 | National Cancer Institute (NCI) | The trial was prematurely closed due to lack of accrual. | Enrollment / accrual |
| NCT00899132 | Studying a Tumor Marker for Testicular Cancer, Skin Cancer, Small Intestine Cancer, and… | — | terminated | May 12, 2009 | Case Comprehensive Cancer Center | Study due for continuing review | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Sep 10, 2020source: clinicaltrials