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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
709 stopped studies mapped to Hepatopancreatobiliary Carcinoma and descendants · 93% state a reason
Over the 709 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01807156 | Phase II Trial of Tivozanib in Advanced Hepatocellular Cancer | Phase 2 | terminated | Mar 8, 2013 | Emory University | Primary endpoint not met | Other (stated, no rule matched) |
| NCT00975039 | Study Using WST11 in Patients With Non-Resectable or Inoperable Cholangiocarcinoma | Phase 2 | terminated | Sep 11, 2009 | Steba Biotech S.A. | Early end of enrolment with regards to difficulty met to enrol patients . | Enrollment / accrual |
| NCT01814631 | Endoscopic Ultrasound (EUS) Processor Comparison | — | withdrawn | Mar 20, 2013 | AdventHealth | Closed at PI discretion | Other (stated, no rule matched) |
| NCT02479178 | A Study of BIND-014 in Patients With Urothelial Carcinoma, Cholangiocarcinoma, Cervical…(iNSITE2) | Phase 2 | terminated | Jun 24, 2015 | BIND Therapeutics | not stated | Not stated |
| NCT01962909 | Phase 0 Biodistribution of Novel Imaging for Resectable Pancreatic Cancer | Early Phase 1 | terminated | Oct 14, 2013 | University of Virginia | From preliminary imaging data, the study was stopped due to futility. | Efficacy / futility |
| NCT00414843 | Storage of Bile From Routine Procedures to Study Risk Factors | — | terminated | Dec 22, 2006 | Indiana University | Decreasing interest in using samples; department infrastructure waned | Other (stated, no rule matched) |
| NCT00582400 | A Phase II Protocol of Arsenic Trioxide (Trisenox) in Subjects With Advanced Primary… | Phase 2 | terminated | Dec 28, 2007 | The University of Texas Medical Branch, Galveston | recruiting or enrolling participants has halted prematurely and will not resume; participants are… | Enrollment / accrual |
| NCT00532441 | Erlotinib in Combination With Docetaxel in Advanced Hepatocellular and Biliary Tract… | Phase 2 | terminated | Sep 20, 2007 | Gabi Chiorean, MD | Terminated due to funding issues. | Funding |
| NCT00746655 | SBRT + TACE for Primary Hepatocellular Carcinoma | N/A | withdrawn | Sep 4, 2008 | University of Pittsburgh | Unable to recruit | Enrollment / accrual |
| NCT00843830 | A Pilot Study Assessing Intra-Metastasis Administration of Autologous KLH-pulsed… | Phase 1 | terminated | Feb 13, 2009 | University of Michigan Rogel Cancer Center | Study closed early secondary to inability to obtain grant funding to conduct. | Funding |
| NCT00864513 | Study of Pemetrexed for Second-Line Pancreas Cancer | Phase 2 | terminated | Mar 18, 2009 | Georgetown University | At interim analysis the study did not meet the response criteria to continue | Efficacy / futility |
| NCT00669136 | Immunization With AFP + GM CSF Plasmid Prime and AFP Adenoviral Vector Boost in Patients… | Phase 1 | terminated | Apr 29, 2008 | Lisa H. Butterfield, Ph.D. | Poor accrual and limited target patient population for future accrual. Did not complete the Phase 1… | Enrollment / accrual |
| NCT02304445 | Chemoembolization With or Without Stereotactic Body Radiosurgery for Liver Cancer(TACE-SBRT) | N/A | withdrawn | Dec 2, 2014 | Juan Sanabria, MD | Necessary equipment could not be obtained. | Other (stated, no rule matched) |
| NCT01521780 | Characterization of Baseline Biomarker Variability in Participants With Hepatocellular… | Phase 1 | terminated | Jan 31, 2012 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01911273 | A Study To Evaluate The Efficacy And Safety of The Investigational Drug PF-03446962 (A… | Phase 2 | terminated | Jul 30, 2013 | Pfizer | See termination reason in detailed description. | Other (stated, no rule matched) |
| NCT01108705 | Comparison of Brivanib and Best Supportive Care (BSC) With Placebo and BSC for Treatment…(BRISK-APS) | Phase 3 | terminated | Apr 22, 2010 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00227773 | Vatalanib and Octreotide in Treating Patients With Progressive Neuroendocrine Tumors | Phase 2 | withdrawn | Sep 28, 2005 | Eastern Cooperative Oncology Group | not stated | Not stated |
| NCT01239355 | MK2206 in Treating Patients With Advanced Liver Cancer That Did Not Respond to Previous… | Phase 2 | terminated | Nov 11, 2010 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT01968629 | 24hr Imaging Of HCC After EOVIST | Early Phase 1 | withdrawn | Oct 24, 2013 | Massachusetts General Hospital | No eligible subject enrolled | Enrollment / accrual |
| NCT01501604 | BKM120 in Cancers With PIK3CA Activating Mutations | Phase 2 | withdrawn | Dec 29, 2011 | Massachusetts General Hospital | The study has been closed due to lack of accrual | Enrollment / accrual |
| NCT00630890 | Cyberknife Radiosurgery Boost for Hilar Cholangiocarcinoma (Klatskin Tumor) | Phase 1 | terminated | Mar 7, 2008 | University of California, San Francisco | investigator left UCSF and study was closed prematurely in 2008. No results to report. | Investigator |
| NCT00598091 | A Phase I/Expansion Study of Dasatinib(Gem/Dsat) | Phase 1 | terminated | Jan 18, 2008 | Duke University | Low accrual, unable to meet endpoint in timely manner | Enrollment / accrual |
| NCT01348503 | Lenalidomide in Combination With a Fixed Dose of Sorafenib for the Treatment of… | Phase 1 | terminated | May 5, 2011 | Indiana University | Treatment was ineffective | Other (stated, no rule matched) |
| NCT01539018 | Sorafenib Plus Tegafur-uracil (UFT) Versus Sorafenib as First Line Systemic Treatment for… | Phase 2 | terminated | Feb 27, 2012 | Egyptian Society of Liver Cancer | After interim results data showed no evidence of a difference between both groups | Other (stated, no rule matched) |
| NCT01419002 | Study to Evaluate if Neoadjuvant Radiotherapy Improves Recurrence Free Survival in…(Net-Pac) | Phase 3 | terminated | Aug 17, 2011 | CHIR-Net | lack of recruitment | Enrollment / accrual |
| NCT01050283 | A Study to Evaluate [18F]-FDG PET (Fluorodeoxyglucose-positron) in Patients With… | Phase 1 | terminated | Jan 15, 2010 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01686880 | Y90 Radioembolization Prior to Surgical Resection or Radiofrequency for Hepatocellular…(TRYPHON) | Phase 2 | terminated | Sep 18, 2012 | Jules Bordet Institute | poor recruitment and an unexpected low treatment rate | Enrollment / accrual |
| NCT02482909 | A Study Comparing Radiofrequency Ablation and Hepatic Resection for Hepatocellular… | N/A | terminated | Jun 26, 2015 | Seoul National University Hospital | The post-treatment recurrence rate was expected to be different between two treatment groups. | Other (stated, no rule matched) |
| NCT01775280 | Response of Hepatic Tumors to Radioembolization(RESRAD) | Phase 2 | withdrawn | Jan 24, 2013 | University of Zurich | Lack of enrollment | Enrollment / accrual |
| NCT00907413 | Photodynamic Therapy (PDT) Trial for Palliation of Cholangiocarcinoma(PDT) | Phase 3 | terminated | May 22, 2009 | Weill Medical College of Cornell University | PI relocated and reopened trial in new university | Other (stated, no rule matched) |
| NCT01439685 | Comparison of Biliary Stenting Alone vs. Stenting With Photodynamic Therapy (PDT) During…(PDT) | — | withdrawn | Sep 23, 2011 | Weill Medical College of Cornell University | A single cohort, alternative trial was started. | Other (stated, no rule matched) |
| NCT01434459 | Study of Gemcitabine With TheraSphere® (Yttrium-90)in Patients With Hepatic Tumors of… | Phase 1 | terminated | Sep 15, 2011 | Emory University | PI moved to different institution | Other (stated, no rule matched) |
| NCT01507740 | Profile of Soluble and Cellular Biomarkers and of Functional Imaging During… | — | terminated | Jan 11, 2012 | Medical University Innsbruck | Study was stopped 04.10.2014 prematurly after recruitment of HCC and RCC patients. NSCLC (2 of 10… | Enrollment / accrual |
| NCT00253526 | Gemcitabine Hydrochloride With or Without Bevacizumab in Treating Patients Who Are… | Phase 2 | withdrawn | Nov 15, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01029418 | AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Dec 10, 2009 | National Cancer Centre, Singapore | The phase II portion was not conducted due to funding issue. | Funding |
| NCT01801163 | A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With… | Phase 1 | withdrawn | Feb 28, 2013 | Indiana University | Trial had no patients accrued while open | Enrollment / accrual |
| NCT00081900 | A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible… | Phase 1 / Phase 2 | terminated | Apr 28, 2004 | Genzyme, a Sanofi Company | This study was terminated early by Genzyme because there were insufficient data to support clinical… | Other (stated, no rule matched) |
| NCT02310971 | Cvac as Maintenance Treatment Patients With Resected Stage I or Stage II Adenocarcinoma… | Phase 2 | withdrawn | Dec 8, 2014 | Prima BioMed Ltd | The trial has been terminated per Sponsor direction due to longer than expected clinical and… | Other (stated, no rule matched) |
| NCT02070419 | TACE With or Without Radiation Therapy in Treating Patients With Stage A-C Liver Cancer | Phase 2 | withdrawn | Feb 25, 2014 | Case Comprehensive Cancer Center | Principal Investigator left institution | Investigator |
| NCT00808145 | Study of Sorafenib, Gemcitabine, and Cisplatin in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | withdrawn | Dec 15, 2008 | Lahey Clinic | Lack of enrollment, many screen failures and non eligible study participants | Enrollment / accrual |
| NCT01859182 | Selumetinib and Akt Inhibitor MK-2206 in Treating Patients With Refractory or Advanced… | Phase 2 | withdrawn | May 21, 2013 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01872988 | Tenofovir Antiviral Therapy Following Transarterial Chemoembolization for HBV Related… | Phase 3 | terminated | Jun 7, 2013 | Taichung Veterans General Hospital | Difficult in patient enrollment | Enrollment / accrual |
| NCT01227018 | PhII Study STA-9090 as Second or Third-Line Therapy for Metastatic Pancreas Cancer | Phase 2 | terminated | Oct 22, 2010 | Vanderbilt-Ingram Cancer Center | interim analysis found the study drug to be ineffective | Efficacy / futility |
| NCT01722175 | Associating Liver Partition With Portal Vein Ligation For Staged Hepatectomy (ALPPS) or…(ALPPS) | Phase 2 | withdrawn | Nov 6, 2012 | Washington University School of Medicine | Safety concerns. | Safety / toxicity |
| NCT01669668 | Radiofrequency Ablation in Treating Patients With Liver Cancer (Hepatocellular Carcinoma) | Phase 2 | withdrawn | Aug 21, 2012 | Washington University School of Medicine | Lack of referrals. | Other (stated, no rule matched) |
| NCT01432314 | Efficacy of Radiation Therapy and Transarterial Chemoembolization (TACE) to Treat…(RTANDTACE) | Phase 2 | withdrawn | Sep 12, 2011 | Asan Medical Center | Another phase 2 randomized study has been started by other investigators. | Other (stated, no rule matched) |
| NCT01741597 | Dynamic Contrast Enhanced MRI in Patients With Advanced Breast or Pancreatic Cancer With… | Phase 1 | withdrawn | Dec 5, 2012 | City of Hope Medical Center | PI chose to close the study | Other (stated, no rule matched) |
| NCT01963949 | Prospective, Observational Study of Biomarkers in Liver Cancer - Identification of… | — | withdrawn | Oct 17, 2013 | University of Texas Southwestern Medical Center | not stated | Not stated |
| NCT00493428 | Treatment of Non-Metastatic Hepatocellular Carcinoma in Humans by Increasing Gabaergic… | Phase 2 | withdrawn | Jun 28, 2007 | University of Manitoba | The study have been stoped because the protocol is going to be modify. | Other (stated, no rule matched) |
| NCT00023946 | BMS-247550 in Treating Patients With Liver or Gallbladder Cancer | Phase 2 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Apr 22, 2016source: clinicaltrials