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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
30 stopped studies mapped to Ewing Sarcoma and descendants · 93% state a reason
Over the 30 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT04890093 | Vincristine and Temozolomide in Combination With PEN-866 for Adolescents and Young Adults… | Phase 1 / Phase 2 | suspended | May 18, 2021 | National Cancer Institute (NCI) | Pending updated agreements in order to enroll additional participants. | Enrollment / accrual |
| NCT03514407 | A Study of INCB059872 in Relapsed or Refractory Ewing Sarcoma | Phase 1 | terminated | May 2, 2018 | Incyte Corporation | Strategic Business Decision | Sponsor / business decision |
| NCT05605522 | A Study of [225Ac]-FPI-2059 in Adult Participants With Solid Tumours | Phase 1 | terminated | Nov 4, 2022 | 3B Pharmaceuticals GmbH | Sponsor reprioritization of active trials. | Other (stated, no rule matched) |
| NCT02100891 | Phase 2 STIR Trial: Haploidentical Transplant and Donor Natural Killer Cells for Solid…(STIR) | Phase 2 | terminated | Apr 1, 2014 | Monica Thakar | 15 patients enrolled out of planned 20, terminated due to slow enrollment at end of study | Enrollment / accrual |
| NCT02657005 | TK216 in Patients With Relapsed or Refractory Ewing Sarcoma | Phase 1 / Phase 2 | terminated | Jan 15, 2016 | Oncternal Therapeutics, Inc | Sponsor Decision | Sponsor / business decision |
| NCT04791228 | A Pilot Study of Thermodox and MR-HIFU for Treatment of Relapsed Solid Tumors | Phase 2 | withdrawn | Mar 10, 2021 | Children's National Research Institute | Low enrollment. | Enrollment / accrual |
| NCT03604783 | Phase 1, First-in-human Study of Oral TP-1287 in Patients with Advanced Solid Tumors | Phase 1 | terminated | Jul 27, 2018 | Sumitomo Pharma America, Inc. | Sponsor's decision to terminate further development of the program. | Sponsor / business decision |
| NCT04129151 | Palbociclib + Ganitumab In Ewing Sarcoma | Phase 2 | terminated | Oct 16, 2019 | Dana-Farber Cancer Institute | The study closed early due to discontinuation of ganitumab supply. | Drug supply |
| NCT02624388 | Study of Genistein in Pediatric Oncology Patients (UVA-Gen001)(UVA-Gen001) | Phase 2 | terminated | Dec 8, 2015 | University of Virginia | Poor enrollment | Enrollment / accrual |
| NCT03458728 | Safety, Tolerability, Efficacy and Pharmacokinetics of Copanlisib in Pediatric Patients | Phase 1 / Phase 2 | terminated | Mar 8, 2018 | Bayer | no anticipated benefit over available standard therapies | Other (stated, no rule matched) |
| NCT02536183 | A Phase I Study of Lyso-thermosensitive Liposomal Doxorubicin and MR-HIFU for Pediatric… | Phase 1 | terminated | Aug 31, 2015 | AeRang Kim | low accrual | Enrollment / accrual |
| NCT03495921 | A Trial For Participants With Ewing's Sarcoma Treated With Vigil in Combination With…(VITA) | Phase 3 | terminated | Apr 12, 2018 | Gradalis, Inc. | Slow accrual and as a result, a strategic business decision was made to terminate enrollment. | Enrollment / accrual |
| NCT04730349 | A Study of Bempegaldesleukin (BEMPEG: NKTR-214) in Combination With Nivolumab in…(PIVOT IO 020) | Phase 1 / Phase 2 | terminated | Jan 29, 2021 | Bristol-Myers Squibb | Business objectives have changed | Sponsor / business decision |
| NCT05042934 | Lurbinectedin With or Without Irinotecan in Treating Patients With Relapsed or High Risk… | Phase 1 / Phase 2 | withdrawn | Sep 13, 2021 | M.D. Anderson Cancer Center | PI stated trial no longer fits the framework \& portfolio of work that is prioritized by the… | Enrollment / accrual |
| NCT05116800 | Phase 2 Study of 9-ING-41 With Chemotherapy in Sarcoma | Phase 2 | withdrawn | Nov 11, 2021 | Brown University | IND withdrawn | Other (stated, no rule matched) |
| NCT02581384 | Stereotactic Body Radiotherapy (SBRT) for Pulmonary Metastases in Ewing Sarcoma,… | Phase 1 / Phase 2 | terminated | Oct 21, 2015 | Dana-Farber Cancer Institute | The study closed primarily due to weak accrual, as well as study design limitations. | Enrollment / accrual |
| NCT03880123 | Selinexor in Combination With Ixazomib for the Treatment of Advanced Sarcoma | Phase 1 | withdrawn | Mar 19, 2019 | Matthew Ingham | Study will not proceed, no participants enrolled. | Enrollment / accrual |
| NCT00038142 | Vincristine, Doxorubicin, Cyclophosphamide and Dexrazoxane (VACdxr) in High Risk Ewing's… | Phase 2 | terminated | May 30, 2002 | M.D. Anderson Cancer Center | Low Accrual | Enrollment / accrual |
| NCT00428272 | HGS-ETR2 to Treat Children With Solid Tumors | Phase 1 | terminated | Jan 29, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT02689336 | Erlotinib in Combination With Temozolomide in Treating Relapsed/Recurrent/Refractory… | Phase 2 | withdrawn | Feb 23, 2016 | Washington University School of Medicine | Could not recruit any participants | Enrollment / accrual |
| NCT02557854 | HIFU Hyperthermia With Liposomal Doxorubicin (DOXIL) for Relapsed or Refractory Pediatric… | Phase 1 | withdrawn | Sep 23, 2015 | Theodore Laetsch | Lack of enrollment | Enrollment / accrual |
| NCT00617890 | A Study to Determine the Activity of Robatumumab (SCH 717454) in Participants With… | Phase 2 | terminated | Feb 18, 2008 | Merck Sharp & Dohme LLC | The study was prematurely terminated for strategic reasons, not for a safety concern. | Safety / toxicity |
| NCT01610570 | Mithramycin for Children and Adults With Solid Tumors or Ewing Sarcoma | Phase 1 / Phase 2 | terminated | Jun 4, 2012 | National Cancer Institute (NCI) | Study was closed to enrollment before dose level one was completed. | Enrollment / accrual |
| NCT01313884 | Cyclophosphamide, Doxorubicin, Vincristine w/ Irinotecan and Temozolomide in Ewings… | Phase 2 | terminated | Mar 14, 2011 | Stanford University | Study did not reach primary objective; study did not accrue enough patients. | Enrollment / accrual |
| NCT01969942 | A Phase I Study to Examine the Toxicity of Allogeneic Stem Cell Transplantation for…(ASCT) | Phase 1 | withdrawn | Oct 25, 2013 | University of Louisville | No subjects meeting study inclusion were enrolled. | Enrollment / accrual |
| NCT01882231 | Quantitative Imaging Biomarkers of Treatment Response in Osteosarcoma and Ewing Sarcoma | N/A | terminated | Jun 20, 2013 | Vanderbilt-Ingram Cancer Center | Slow accrual and lack of funding | Enrollment / accrual |
| NCT01734863 | Post-operative Radiotherapy in Poor Responders Ewing's Sarcoma Patients | Phase 3 | withdrawn | Nov 28, 2012 | Children's Cancer Hospital Egypt 57357 | not stated | Not stated |
| NCT01795430 | Whole-Body Radiation Therapy, Systemic Chemotherapy, and High-Dose Chemotherapy Followed… | N/A | withdrawn | Feb 20, 2013 | City of Hope Medical Center | No participants enrolled. | Enrollment / accrual |
| NCT01492569 | Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting | N/A | withdrawn | Dec 15, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT00568464 | Study on VCD/IE in the Patients With Ewing's Sarcoma Family of Tumors (ESFT) | Phase 2 | terminated | Dec 6, 2007 | Fudan University | The enrollment is slower than expected | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Mar 16, 2026source: clinicaltrials