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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
975 stopped studies mapped to Digestive System Carcinoma and descendants · 93% state a reason
Over the 975 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00225290 | Phase III Trial of Oral Thalidomide in Advanced Hepatocellular Carcinoma With Poor Liver… | Phase 3 | terminated | Sep 23, 2005 | TTY Biopharm | slowly recruitment rate | Enrollment / accrual |
| NCT00732745 | Vandetanib, Oxaliplatin, and Docetaxel in Advanced Cancer of the Esophagus or… | Phase 1 | terminated | Aug 12, 2008 | Case Comprehensive Cancer Center | Lost funding for Phase II portion of study | Funding |
| NCT00725400 | Comparative Study of Cetuximab and Radiation Vs Surgery Before or After Radiation in… | Phase 2 | withdrawn | Jul 30, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT01126866 | Curative Resectability of Not Optimally Resectable Liver and/or Lung Metastases From…(APRIORI) | Phase 2 | terminated | May 20, 2010 | National Center for Tumor Diseases, Heidelberg | recruiting inadequate | Enrollment / accrual |
| NCT00568308 | Phase III Study of PI-88 in Post-resection Hepatocellular Carcinoma(PATHWAY) | Phase 3 | terminated | Dec 6, 2007 | Progen Pharmaceuticals | Commercial decision to discontinue the study | Other (stated, no rule matched) |
| NCT00470340 | Chemotherapy or Not, Following Complete Treatment of Hepatic Cancer in Cirrhotic Patients(GEMOXIAL) | Phase 3 | terminated | May 7, 2007 | Assistance Publique - Hôpitaux de Paris | during the study | Other (stated, no rule matched) |
| NCT01330823 | L-CARnitine in the Palliative Treatment of Advanced PANcreatic Cancer (CARPAN)(CARPAN) | Phase 3 | suspended | Apr 7, 2011 | University Medicine Greifswald | after interims analysis standard errors for inflammatory and nutritional markers varied widely,… | Other (stated, no rule matched) |
| NCT00428597 | A Study Of Sunitinib Compared To Placebo For Patients With Advanced Pancreatic Islet Cell… | Phase 3 | terminated | Jan 30, 2007 | Pfizer | Refer to Detailed Description. | Other (stated, no rule matched) |
| NCT00791544 | Dose Finding Study of AVE1642 in Patients With Advanced or Metastatic Liver Carcinoma | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | Sanofi | Company decision to discontinue the AVE1642 development program, not due to any safety or efficacy… | Safety / toxicity |
| NCT00280007 | Transarterial Chemoembolisation Plus Bevacizumab for Treatment of Hepatocellular Carcinoma | Phase 2 | terminated | Jan 20, 2006 | Medical University of Vienna | Safety concerns in the treatment arm | Safety / toxicity |
| NCT00909558 | Safety and Effectiveness Study of Autologous Natural Killer and Natural Killer T Cells on… | Phase 1 | suspended | May 28, 2009 | Envita Medical Center, Inc. | not stated | Not stated |
| NCT00540735 | Efficiency Evaluation of Photodynamic Therapy With Photofrin® on Unresectable Type III or…(CK/PDT) | Phase 3 | terminated | Oct 8, 2007 | University Hospital, Angers | Big difficulties to enroll patients | Enrollment / accrual |
| NCT00307723 | Study of Bevacizumab in Combination With 5-FU, Oxaliplatin and External Beam Radiation… | Phase 1 / Phase 2 | terminated | Mar 28, 2006 | Massachusetts General Hospital | poor accrual | Enrollment / accrual |
| NCT00585845 | Study of Safety and Tolerability of Intravenous CRS-207 in Adults With Selected Advanced… | Phase 1 | terminated | Jan 3, 2008 | Anza Therapeutics, Inc. | not stated | Not stated |
| NCT00637364 | High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain(HIFU Pancreas) | Phase 1 / Phase 2 | suspended | Mar 18, 2008 | CMED HIFU Development Corporation | Sponsor is not proceeding with USA human trial at this time | Other (stated, no rule matched) |
| NCT00319683 | A Study of ADH300004 and 5-Fluorouracil in Locally Advanced, Recurrent, or Metastatic… | Phase 1 / Phase 2 | terminated | Apr 27, 2006 | Adherex Technologies, Inc. | Lack of funds | Funding |
| NCT00165633 | A Phase II/III Clinical Study on Inhibitory Effects of E0167 on Recurrence of… | Phase 2 / Phase 3 | terminated | Sep 14, 2005 | Eisai Limited | not stated | Not stated |
| NCT00415155 | A Study of LY2181308 in Patients With Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | withdrawn | Dec 22, 2006 | Eli Lilly and Company | Trial cancelled | Other (stated, no rule matched) |
| NCT00351195 | Etoposide, Oxaliplatin and Capecitabine in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | terminated | Jul 12, 2006 | Rigshospitalet, Denmark | Did not meet the criteria for continuation to second stage | Other (stated, no rule matched) |
| NCT00239200 | Lapatinib (GW572016) for Metastatic or Recurrent Squamous Cell Carcinoma Esophagus | Phase 2 | terminated | Oct 14, 2005 | University of Michigan Rogel Cancer Center | notification from sponsor | Other (stated, no rule matched) |
| NCT00440934 | A Study of Electromagnetic Waves in the Treatment of the Advanced Hepatocarcinoma(THBC002) | Phase 2 | terminated | Feb 27, 2007 | Pasche, Boris, M.D. | Poor patient accrual | Enrollment / accrual |
| NCT00514332 | Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A… | N/A | terminated | Aug 9, 2007 | University Hospital, Montpellier | enrolling participants stopped | Enrollment / accrual |
| NCT00355212 | Comparison Between Radiofrequency Versus Ethanol Injection for the Treatment of… | Phase 3 | terminated | Jul 21, 2006 | Azienda Ospedaliera San Giovanni Battista | not stated | Not stated |
| NCT00034333 | Safety and Efficacy of Doxorubicin Adsorbed to Magnetic Beads Vs. IV Doxorubicin in… | Phase 2 / Phase 3 | terminated | Apr 26, 2002 | FeRx | not stated | Not stated |
| NCT00057382 | T138067 Versus Doxorubicin in Chemotherapy-Naive, Unresectable, Hepatocellular Carcinoma… | Phase 2 / Phase 3 | terminated | Apr 2, 2003 | Tularik | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Oct 12, 2011source: clinicaltrials