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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
3,703 stopped studies mapped to Carcinoma and descendants · 91% state a reason
Over the 3,703 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00712621 | Determining Quality of Life in Breast Cancer Patient After Completing… | Phase 2 | withdrawn | Jul 10, 2008 | American Scitech International | Study is withdrawn due to unavailability of eligible subject population. We will request the… | Enrollment / accrual |
| NCT00494026 | Chemotherapy and Radiotherapy to Treat Patients With Limited Stage of Small Cell Lung… | Phase 2 | terminated | Jun 29, 2007 | Eli Lilly and Company | Study stopped early based on interim results of another trial, showing inferior activity of… | Other (stated, no rule matched) |
| NCT00447421 | A Study to Treat Small Cell Lung Cancer With a Combination of Cisplatin, Pemetrexed, and… | Phase 1 / Phase 2 | terminated | Mar 14, 2007 | Eli Lilly and Company | Interim results of another trial showed inferior activity of treatment | Other (stated, no rule matched) |
| NCT00313768 | Randomized Ph 2 Trial Of Paclitaxel/Carboplatin /Bevacizumab + PF-3512676 And P/C/B Alone… | Phase 2 | terminated | Apr 12, 2006 | Pfizer | See Termination Reason in Detailed Description. | Other (stated, no rule matched) |
| NCT00321308 | Trial of Pemetrexed With or Without PF-3512676 in Advanced Non-Small Cell Lung Cancer | Phase 2 | terminated | May 3, 2006 | Pfizer | See Termination Reason in Detailed Description. | Other (stated, no rule matched) |
| NCT00273507 | Neoadjuvant Chemotherapy in Non Small Cell Lung Cancer (NSCLC) Stages IB, IIA, IIB, and… | Phase 3 | terminated | Jan 9, 2006 | Rigshospitalet, Denmark | not stated | Not stated |
| NCT00461110 | A Study of BMS-663513 in Combination With Chemoradiation in Subjects With Non Small Cell… | Phase 1 | terminated | Apr 17, 2007 | Bristol-Myers Squibb | not stated | Not stated |
| NCT00434226 | A Study of Sunitinib in Combination With Bevacizumab, Carboplatin, and Paclitaxel in… | Phase 2 | terminated | Feb 13, 2007 | Genentech, Inc. | Based on data collected, the combination appeared to be poorly tolearated. | Other (stated, no rule matched) |
| NCT00307723 | Study of Bevacizumab in Combination With 5-FU, Oxaliplatin and External Beam Radiation… | Phase 1 / Phase 2 | terminated | Mar 28, 2006 | Massachusetts General Hospital | poor accrual | Enrollment / accrual |
| NCT00770354 | Phase II Study of AS1402 Combined With Letrozole to Treat Breast Cancer | Phase 2 | terminated | Oct 10, 2008 | Antisoma Research | not stated | Not stated |
| NCT00558922 | A Phase 1-2 XIAP Antisense AEG35156 With Carboplatin and Paclitaxel in Patients With… | Phase 1 / Phase 2 | terminated | Nov 15, 2007 | Aegera Therapeutics | Unacceptable Neurotoxicity (2 cases) | Other (stated, no rule matched) |
| NCT00532025 | Sorafenib in Resected Non-small Cell Lung Carcinoma(SIRN) | Phase 2 | terminated | Sep 19, 2007 | Johannes Gutenberg University Mainz | not stated | Not stated |
| NCT00234442 | Iressa in the Treatment of Brain Metastases From Non Small Cell Lung Cancer | Phase 2 | terminated | Oct 7, 2005 | AstraZeneca | Closed due to insufficient recruitment. | Enrollment / accrual |
| NCT00522639 | Predictive Value of FDG-PET-CT Scans for Patients With Lung Cancer Receiving Concurrent…(FDG-PET lung) | Phase 3 | terminated | Aug 30, 2007 | Maastricht Radiation Oncology | Poor accrual | Enrollment / accrual |
| NCT00383331 | Pemetrexed and Gemcitabine Every 14 Days Versus Every 21 Days in Advanced Non Small Cell… | Phase 2 | terminated | Oct 3, 2006 | Eli Lilly and Company | Trial was stopped early due to low enrollment | Enrollment / accrual |
| NCT00259285 | Pemetrexed and Cisplatin Treatment Before Surgery in Non Small Cell Lung Cancer | Phase 2 | terminated | Nov 29, 2005 | Eli Lilly and Company | Trial was stopped early due to low enrollment. | Enrollment / accrual |
| NCT00475657 | Pemetrexed and Cisplatin as Treatment in Small Cell Lung Cancer | Phase 2 | terminated | May 21, 2007 | Eli Lilly and Company | Terminated due to lack of efficacy | Efficacy / futility |
| NCT00435578 | Safety and Efficacy Study of Glufosfamide in Patients With Recurrent Sensitive Small Cell… | Phase 2 | terminated | Feb 15, 2007 | Threshold Pharmaceuticals | not stated | Not stated |
| NCT00491738 | A Study Evaluating the Efficacy and Safety of Sunitinib With or Without Bevacizumab in… | Phase 2 | terminated | Jun 26, 2007 | Genentech, Inc. | Based on the data collected, the combination of bevacizumab and sunitinib appeared to be poorly… | Other (stated, no rule matched) |
| NCT00174369 | MEK Inhibitor PD-325901 To Treat Advanced Non-Small Cell Lung Cancer | Phase 2 | terminated | Sep 15, 2005 | Pfizer | Terminated \[See Detailed Description for Termination Reason.\] | Other (stated, no rule matched) |
| NCT00585845 | Study of Safety and Tolerability of Intravenous CRS-207 in Adults With Selected Advanced… | Phase 1 | terminated | Jan 3, 2008 | Anza Therapeutics, Inc. | not stated | Not stated |
| NCT00637364 | High Intensity Focused Ultrasound Tumor Treatment for Pancreatic Cancer Pain(HIFU Pancreas) | Phase 1 / Phase 2 | suspended | Mar 18, 2008 | CMED HIFU Development Corporation | Sponsor is not proceeding with USA human trial at this time | Other (stated, no rule matched) |
| NCT00319683 | A Study of ADH300004 and 5-Fluorouracil in Locally Advanced, Recurrent, or Metastatic… | Phase 1 / Phase 2 | terminated | Apr 27, 2006 | Adherex Technologies, Inc. | Lack of funds | Funding |
| NCT00165633 | A Phase II/III Clinical Study on Inhibitory Effects of E0167 on Recurrence of… | Phase 2 / Phase 3 | terminated | Sep 14, 2005 | Eisai Limited | not stated | Not stated |
| NCT00172367 | Chemoprevention Trial for Uremia-Associated Urothelial Carcinoma | Phase 2 | withdrawn | Sep 15, 2005 | National Taiwan University Hospital | This study was for National Science Council project. The study was not funded, so the study was… | Funding |
| NCT00415155 | A Study of LY2181308 in Patients With Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | withdrawn | Dec 22, 2006 | Eli Lilly and Company | Trial cancelled | Other (stated, no rule matched) |
| NCT00351195 | Etoposide, Oxaliplatin and Capecitabine in Advanced Hepatocellular Carcinoma (HCC) | Phase 2 | terminated | Jul 12, 2006 | Rigshospitalet, Denmark | Did not meet the criteria for continuation to second stage | Other (stated, no rule matched) |
| NCT00161278 | Pilot Study for the Determination of Tumor Response to Chemotherapy in Advanced NSCLC… | Phase 2 | terminated | Sep 12, 2005 | University of Michigan Rogel Cancer Center | recruitment has ended | Enrollment / accrual |
| NCT00239200 | Lapatinib (GW572016) for Metastatic or Recurrent Squamous Cell Carcinoma Esophagus | Phase 2 | terminated | Oct 14, 2005 | University of Michigan Rogel Cancer Center | notification from sponsor | Other (stated, no rule matched) |
| NCT00535015 | Safety and Efficacy Study of Betamarc to Treat Loss of Weight and Appetite in Non-Small… | Phase 2 | terminated | Sep 26, 2007 | Anaborex | Objectives of study could not be met within a reasonable timeframe. | Other (stated, no rule matched) |
| NCT00607425 | Saliva mRNA Expression Profiling for Early Stage Non-Small Cell Lung Cancer Screening(SPIT-LC) | — | terminated | Feb 5, 2008 | Scottsdale Healthcare | Change in isolation method | Other (stated, no rule matched) |
| NCT00440934 | A Study of Electromagnetic Waves in the Treatment of the Advanced Hepatocarcinoma(THBC002) | Phase 2 | terminated | Feb 27, 2007 | Pasche, Boris, M.D. | Poor patient accrual | Enrollment / accrual |
| NCT00461344 | Docetaxel + Doxorubicin as Neoadjuvant Chemotherapy in Patients With Breast Cancer | Phase 2 | terminated | Apr 18, 2007 | Sanofi | due to slow recruitment of patients | Enrollment / accrual |
| NCT00263016 | Docetaxel in Non Small Cell Lung Cancer (NSCLC) | Phase 2 | terminated | Dec 7, 2005 | Sanofi | Slow recruitment | Enrollment / accrual |
| NCT00417677 | A Study Combining Treatment With Temsirolimus and Sunitinib for Subjects With Advanced… | Phase 1 / Phase 2 | terminated | Jan 4, 2007 | Wyeth is now a wholly owned subsidiary of Pfizer | Decision was made not to attempt a lower dose | Other (stated, no rule matched) |
| NCT00131651 | ATN-161 in Advanced Renal Cell Cancer | Phase 2 | terminated | Aug 19, 2005 | Attenuon | not stated | Not stated |
| NCT00559351 | RCT on the Combined Modality Treatment of Squamous Cell Carcinoma of the Esophagus | Phase 3 | terminated | Nov 16, 2007 | Ministry of Scientific Research and Information Technology, Poland | difficulty in recruitment | Enrollment / accrual |
| NCT00047632 | Safety and Efficacy of Interferon Gamma-1b Plus Chemotherapy for Ovarian and Peritoneal… | Phase 3 | terminated | Oct 11, 2002 | InterMune | futility | Efficacy / futility |
| NCT00061646 | Safety and Effectiveness of ABT-510 Plus Combination Chemotherapy in Subjects With… | Phase 2 | terminated | Jun 4, 2003 | Abbott | Enrollment suspended based upon interim analysis; subjects allowed to stay on study until disease… | Efficacy / futility |
| NCT00514332 | Comparison Between Colorectal Stents and Primary Surgery in Obstructive Colonic Cancer. A… | N/A | terminated | Aug 9, 2007 | University Hospital, Montpellier | enrolling participants stopped | Enrollment / accrual |
| NCT00116389 | Trial of Talabostat and Gemcitabine in Patients With Stage IV Adenocarcinoma of the… | Phase 2 | terminated | Jun 29, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00243204 | Study of Talabostat + Docetaxel Versus Docetaxel in Stage IIIB/IV Non-Small Cell Lung… | Phase 3 | terminated | Oct 21, 2005 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00290017 | Study of Talabostat and Pemetrexed vs. Pemetrexed in Stage IIIB/IV Non-Small Cell Lung… | Phase 3 | terminated | Feb 10, 2006 | Point Therapeutics | FDA Hold May 2007 | Other (stated, no rule matched) |
| NCT00316433 | Oxaliplatin/CPT-11 for Extensive Stage Small Cell Lung Cancer | Phase 2 | terminated | Apr 20, 2006 | Swedish Medical Center | not stated | Not stated |
| NCT00355212 | Comparison Between Radiofrequency Versus Ethanol Injection for the Treatment of… | Phase 3 | terminated | Jul 21, 2006 | Azienda Ospedaliera San Giovanni Battista | not stated | Not stated |
| NCT00151645 | Efficacy of Activated Lymphocytes in Renal Cell Carcinoma. | Phase 2 | terminated | Sep 9, 2005 | Rennes University Hospital | not stated | Not stated |
| NCT00179699 | Phase I Open-Label, Dose Escalation Study To Determine The Maximum Tolerated Dose And To… | Phase 1 | terminated | Sep 16, 2005 | Celgene Corporation | not stated | Not stated |
| NCT00211952 | Adjuvant Celecoxib in Completely Resected pN1-2 NSCLC Patients | Phase 3 | suspended | Sep 21, 2005 | Medical University of Gdansk | not stated | Not stated |
| NCT00189371 | Reinduction Chemotherapy Containing Carboplatin and Paclitaxel With or Without Epoetin… | Phase 3 | terminated | Sep 19, 2005 | AGO Study Group | not stated | Not stated |
| NCT00127595 | Oxaliplatin With Gemcitabine in Patients With Carcinoma of the Urothelial Tract | Phase 2 | terminated | Aug 8, 2005 | Gustave Roussy, Cancer Campus, Grand Paris | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Nov 24, 2009source: clinicaltrials