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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
3,705 stopped studies mapped to Carcinoma and descendants · 91% state a reason
Over the 3,705 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01379976 | Acetyl-L-carnitine in Combination With a Cisplatin-containing Chemotherapy as First Line… | Phase 3 | terminated | Jun 23, 2011 | Mario Negri Institute for Pharmacological Research | Recruitment was prematurely stopped due to difficulty of recruitment encountered by the… | Enrollment / accrual |
| NCT00469469 | Treatment Study Using Bevacizumab for Patients With Adrenocortical Carcinoma | Phase 2 | withdrawn | May 4, 2007 | Dartmouth-Hitchcock Medical Center | unable to enroll subjects into the study | Enrollment / accrual |
| NCT02156180 | Identification of Breath Biomarkers in Head and Neck Squamous Cell Carcinoma | — | suspended | Jun 5, 2014 | Queensland Centre of Excellence for Head and Neck Cancer | Awaiting funding to facilitate selected-ion flow-tube mass spectrometry (SIFT/MS) | Funding |
| NCT00073450 | Study of Lonafarnib in Patients With Recurrent Squamous Cell Carcinoma of the Head and… | Phase 2 | terminated | Nov 24, 2003 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT00707252 | Study of Polyphenon E in Addition to Erlotinib in Advanced Non Small Cell Lung Cancer | Phase 1 | terminated | Jun 30, 2008 | Louisiana State University Health Sciences Center Shreveport | Phase II not initiated due to cancellation of supply of Poly E by collaborator. | Drug supply |
| NCT01569321 | Diagosis of Breast Carcinoma: Characterization of Breast Lesions With CLEARPEMSONIC :… | N/A | terminated | Apr 3, 2012 | Assistance Publique Hopitaux De Marseille | not stated | Not stated |
| NCT01029418 | AZD6244 and Sorafenib in Advanced Hepatocellular Carcinoma | Phase 1 / Phase 2 | terminated | Dec 10, 2009 | National Cancer Centre, Singapore | The phase II portion was not conducted due to funding issue. | Funding |
| NCT01801163 | A Phase Ib Study of Stereotactic Body Radiotherapy (SBRT) Plus Sorafenib in Patients With… | Phase 1 | withdrawn | Feb 28, 2013 | Indiana University | Trial had no patients accrued while open | Enrollment / accrual |
| NCT01071564 | RO4929097 and Vismodegib in Treating Patients With Breast Cancer That is Metastatic or… | Phase 1 | terminated | Feb 19, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00081900 | A Safety and Efficacy Study of DENSPM in Patients With Liver Cancer Who Are Not Eligible… | Phase 1 / Phase 2 | terminated | Apr 28, 2004 | Genzyme, a Sanofi Company | This study was terminated early by Genzyme because there were insufficient data to support clinical… | Other (stated, no rule matched) |
| NCT01714037 | A Clinical Study on the Safety and Efficacy of Debio 0932 in Combination With Standard of…(HALO) | Phase 1 | terminated | Oct 25, 2012 | Debiopharm International SA | not stated | Not stated |
| NCT02023541 | Proton Beam Therapy to Treat Esophageal Cancer | Phase 1 | terminated | Dec 30, 2013 | Washington University School of Medicine | Lack of insurance coverage for proton beam treatment | Other (stated, no rule matched) |
| NCT02310971 | Cvac as Maintenance Treatment Patients With Resected Stage I or Stage II Adenocarcinoma… | Phase 2 | withdrawn | Dec 8, 2014 | Prima BioMed Ltd | The trial has been terminated per Sponsor direction due to longer than expected clinical and… | Other (stated, no rule matched) |
| NCT00940875 | A Study of Tarceva (Erlotinib) in Sequential Combination With Gemcitabine as First Line… | Phase 2 | terminated | Jul 16, 2009 | Hoffmann-La Roche | Study was stopped due to slower than expected recruitment. | Enrollment / accrual |
| NCT00930345 | Biological, Pathological and Imagery Markers in the First-line Treatment of Metastatic…(PREINSUT) | Phase 4 | terminated | Jun 30, 2009 | Assistance Publique - Hôpitaux de Paris | not stated | Not stated |
| NCT01732432 | Endometriosis and Frequency of Endometriosis-associated Ovarian Carcinomas (EAOC)(EAOC) | — | withdrawn | Nov 22, 2012 | University Hospital, Basel, Switzerland | not stated | Not stated |
| NCT00254891 | Trial of Paclitaxel/Carboplatin + PF-3512676 vs Paclitaxel/Carboplatin Alone in Patients… | Phase 3 | terminated | Nov 17, 2005 | Pfizer | See Termination Reason in Detailed Description | Other (stated, no rule matched) |
| NCT00254904 | Randomized Trial of Gemcitabine/Cisplatin + PF-3512676 vs Gemcitabine/Cisplatin Alone in… | Phase 3 | terminated | Nov 17, 2005 | Pfizer | See Termination Reason in Detailed Description | Other (stated, no rule matched) |
| NCT01547676 | Clamped or Unclamped Surgery in Treating Patients With Kidney Cancer | N/A | terminated | Mar 8, 2012 | University of Southern California | P.I. decided to terminate study due to multiple unresolved issues | Other (stated, no rule matched) |
| NCT00450879 | Pazopanib in Treating Patients With Newly Diagnosed or Locally and/or Regionally… | Phase 1 | terminated | Mar 22, 2007 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01953952 | Radiation Therapy and Cisplatin With or Without Surgery in Treating Patients With Stage… | Phase 2 | withdrawn | Oct 1, 2013 | Radiation Therapy Oncology Group | Slow accrual | Enrollment / accrual |
| NCT00132002 | Suberoylanilide Hydroxamic Acid in Treating Patients With Progressive Stage IV Breast… | Phase 2 | terminated | Aug 19, 2005 | National Cancer Institute (NCI) | Early termination for discouraging results | Other (stated, no rule matched) |
| NCT02059967 | Phase I IGART Study Using Active Breathing Control and Simultaneous Boost for Patients… | Phase 1 | withdrawn | Feb 11, 2014 | Virginia Commonwealth University | Due to no accrual. | Enrollment / accrual |
| NCT00659399 | Feasibility Study of Short Term Fondaparinux (Arixtra) in Chemotherapy-Pretreated Ovarian… | Phase 1 | withdrawn | Apr 16, 2008 | NYU Langone Health | Low accrual | Enrollment / accrual |
| NCT01486459 | A Feasibility Trial Using Lithium As A Neuroprotective Agent In Patients Undergoing…(TULIP) | N/A | terminated | Dec 6, 2011 | Barwon Health | Insufficient recruits | Enrollment / accrual |
| NCT01133262 | Effectiveness in Head and Neck Cancer Detection Using Positron Emission Tomography (PET)… | — | withdrawn | May 28, 2010 | Washington University School of Medicine | Feasibility/pilot study of 5 subjects registration not required | Other (stated, no rule matched) |
| NCT00251589 | A Phase I/II Clinical Trial of Vorinostat in Combination With Erlotinib for Patients With… | Phase 1 / Phase 2 | terminated | Nov 10, 2005 | Merck Sharp & Dohme LLC | This trial is being closed based on lack of substantive efficacy, slow accrual and overall… | Efficacy / futility |
| NCT01591512 | A Prospective Longitudinal Collection of Subjects Diagnosed With Small Cell Lung Cancer | — | terminated | May 4, 2012 | Fujirebio Diagnostics, Inc. | Decision was made by Sponsor to stop the trial. | Other (stated, no rule matched) |
| NCT01048983 | Reducing Symptom Burden - Non Small Cell Lung Cancer (NSCLC) | Phase 1 / Phase 2 | withdrawn | Jan 14, 2010 | M.D. Anderson Cancer Center | No accrual. | Enrollment / accrual |
| NCT02033538 | Neoadjuvant Chemotherapy of Nanoparticle Albumin-bound Paclitaxel in Squamous Cell… | Phase 2 | withdrawn | Jan 10, 2014 | Zhejiang University | This clinical trial was closed due to slow recruitment of patients. | Enrollment / accrual |
| NCT02034968 | Nimotuzumab Plus Nab-paclitaxel and Cisplatin in Treating Patients With Advanced… | Phase 2 | withdrawn | Jan 14, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT02041819 | Neoadjuvant Chemotherapy of Nimotuzumab Plus Nab-Paclitaxel in Squamous Cell Carcinoma of… | Phase 2 | withdrawn | Jan 22, 2014 | Zhejiang University | No recruitment | Enrollment / accrual |
| NCT00994240 | Cure Rates of Superficial Basal Cell Carcinoma (BCC) EDC | N/A | terminated | Oct 14, 2009 | University of Wisconsin, Madison | slow enrollment, lack of funding | Enrollment / accrual |
| NCT00803842 | Erlotinib Pharmacokinetics During Doxycycline Treatment for Erlotinib-induced Rash | N/A | withdrawn | Dec 8, 2008 | Northwestern University | Investigator left the institution and decided not to continue with the study. | Investigator |
| NCT00058214 | Perifosine in Treating Patients With Recurrent Prostate Cancer | Phase 2 | terminated | Apr 9, 2003 | National Cancer Institute (NCI) | Did not meet interim stopping criteria for continuation to the second stage. | Other (stated, no rule matched) |
| NCT00564876 | Phase II Study Evaluating The Safety And Response To Neoadjuvant Dasatinib In Early Stage…(TOP0706) | Phase 2 | terminated | Nov 28, 2007 | Duke University | Lack of accrual, study closed. | Enrollment / accrual |
| NCT01647334 | Shrinking Target Adaptive Radiotherapy for Locally Advanced Non-Small Cell Lung Cancer | N/A | terminated | Jul 23, 2012 | London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's | Poor accrual | Enrollment / accrual |
| NCT00535275 | NSCLC Relapse Therapy After Surgery and Peri-operative Chemotherapy | Phase 3 | terminated | Sep 26, 2007 | Intergroupe Francophone de Cancerologie Thoracique | Final analysis done, follow-up of patients no more necessary | Other (stated, no rule matched) |
| NCT00633568 | Randomised Study of Concomitant Radiochemotherapy in Non-small Cell Lung Cancer | Phase 3 | terminated | Mar 12, 2008 | European Lung Cancer Working Party | Slow recruitment | Enrollment / accrual |
| NCT00661011 | Lobectomy and Mediastinal Radiochemotherapy in Unresectable Stage III Non-Small Cell Lung… | Phase 2 | terminated | Apr 18, 2008 | European Lung Cancer Working Party | The study was terminated due to too slow recruitment | Enrollment / accrual |
| NCT02011594 | Phase II Study of Maintenance Treatment of Nimotuzumab for Advanced Esophageal Carcinoma | Phase 2 | withdrawn | Dec 13, 2013 | Zhejiang University | There was no participants enrolled in this clinical trial. | Enrollment / accrual |
| NCT01720693 | Novel Controlled Hypo-Perfusion Technique in Partial Nephrectomy | Phase 2 | terminated | Nov 2, 2012 | University Health Network, Toronto | Low accrual | Enrollment / accrual |
| NCT01166581 | Impact of Breast Magnetic Resonance Imaging (MRI) on Mastectomy Rates | — | terminated | Jul 21, 2010 | Summa Health System | Not enough data collected to work with | Other (stated, no rule matched) |
| NCT01353794 | Study to Observe Safety and Efficacy of Nexavar in Treatment of Kidney Cancer(POWER-NEXT) | — | withdrawn | May 16, 2011 | Bayer | not stated | Not stated |
| NCT01989858 | ITACA-S2 (Intergroup Trial in Adjuvant Chemotherapy for Adenocarcinoma of the Stomach)(ITACA-S2) | Phase 3 | terminated | Nov 21, 2013 | Mario Negri Institute for Pharmacological Research | lack of clinical cases | Other (stated, no rule matched) |
| NCT01333852 | Metformin Plus Paclitaxel for Metastatic or Recurrent Head and Neck Cancer(METTAX) | Phase 2 | terminated | Apr 12, 2011 | Lucas Vieira dos Santos | Low accrual | Enrollment / accrual |
| NCT00818675 | A Study of Ridaforolimus in Non-Small Cell Lung Cancer (NSCLC) Patients With Kirsten Rat… | Phase 2 | terminated | Jan 8, 2009 | Merck Sharp & Dohme LLC | not stated | Not stated |
| NCT01046383 | Effect of IMN1207 Versus Casein on Weight Loss, Survival and Quality of Life in Non-small… | Phase 3 | terminated | Jan 12, 2010 | Immunotec Inc. | Slower than anticipated recruitment | Enrollment / accrual |
| NCT00312650 | Doxil and Gemcitabine in Recurrent Ovarian Cancer | Phase 2 | terminated | Apr 10, 2006 | Women and Infants Hospital of Rhode Island | not stated | Not stated |
| NCT01886287 | P:II Above-Label Octreotide-LAR With Insufficiently Controlled Carcinoid Syndrome | Phase 2 | terminated | Jun 25, 2013 | H. Lee Moffitt Cancer Center and Research Institute | Slow accrual | Enrollment / accrual |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 24 days agoSource updated Apr 24, 2015source: clinicaltrials