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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
1,232 stopped studies mapped to B-Cell Malignant Neoplasm and descendants · 88% state a reason
Over the 1,232 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT00216164 | Rituximab and Gemcitabine for Patients With Relapsed or Refractory Diffuse Large B-Cell… | Phase 2 | terminated | Sep 22, 2005 | Hoosier Cancer Research Network | Study terminated due to lack of response at the first efficacy analysis | Efficacy / futility |
| NCT01170052 | Bendamustine and Temsirolimus in Patients With Relapsed or Refractory Mantle Cell… | Phase 1 / Phase 2 | withdrawn | Jul 27, 2010 | Charite University, Berlin, Germany | insufficient enrollment | Enrollment / accrual |
| NCT00050687 | Safety and Pharmacokinetics of Orally Administered Gallium Maltolate in Various… | Phase 1 / Phase 2 | terminated | Dec 19, 2002 | Titan Pharmaceuticals | not stated | Not stated |
| NCT01116154 | Vorinostat and Lenalidomide in Treating Patients With Relapsed or Refractory Hodgkin… | Phase 1 | terminated | May 4, 2010 | City of Hope Medical Center | Sponsor withdrew support for the study | Other (stated, no rule matched) |
| NCT00386321 | Yt90 Zevalin and Combination Chemotherapy (Z-CHOP)in Treating Patients With Stage II,… | Phase 2 | terminated | Oct 11, 2006 | Chulalongkorn University | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00162500 | A Novel Vaccine for the Treatment of MUC1-expressing Tumor Malignancies | Phase 2 | withdrawn | Sep 13, 2005 | Hadassah Medical Organization | not stated | Not stated |
| NCT00136591 | A Phase 2 Study of Velcade™ in Subjects With Relapsed or Refractory Follicular B-Cell… | Phase 2 | terminated | Aug 29, 2005 | Lymphoma Study Association | An arm closed due to lack of efficacy | Efficacy / futility |
| NCT00210366 | Salvage Therapy With Idarubicin in Relapsing CNS Lymphoma | Phase 2 | terminated | Sep 21, 2005 | International Extranodal Lymphoma Study Group (IELSG) | due to slow accrual | Enrollment / accrual |
| NCT00275262 | A Study to Evaluate the Ability of Lupron Depot to Enhance Immune Function Following Bone… | Phase 2 | terminated | Jan 11, 2006 | Abbott | not stated | Not stated |
| NCT00646165 | Trial of Forodesine in Patients With Relapsed B-cell Chronic Lymphocytic Leukemia | Phase 1 | terminated | Mar 28, 2008 | Mundipharma Research Limited | Poor recruitment and change in development strategy | Enrollment / accrual |
| NCT00319930 | Phase 1, Dose-Escalation, Pharmacodynamic Study of IV CNF1010 in ZAP-70 Positive CLL | Phase 1 | terminated | Apr 27, 2006 | Biogen | Discontinuation of program | Other (stated, no rule matched) |
| NCT00918450 | Study Assessing the Safety and Efficacy of ABT-263 in Subjects With B-cell Chronic… | Phase 2 | withdrawn | Jun 11, 2009 | Abbott | Sponsor has decided to not proceed with this study. | Other (stated, no rule matched) |
| NCT00304590 | Study of XL999 in Patients With Multiple Myeloma | Phase 2 | terminated | Mar 20, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities in the subjects | Safety / toxicity |
| NCT00243763 | TKI258 in Subjects With Refractory or Relapsed Multiple Myeloma | Phase 1 | terminated | Oct 25, 2005 | Novartis | not stated | Not stated |
| NCT00474188 | A Study to Evaluate Lenalidomide Combined With Dexamethasone in Relapsed or Refractory… | Phase 2 | terminated | May 16, 2007 | Celgene Corporation | Business decision | Sponsor / business decision |
| NCT00344786 | Phase 1, Dose-Escalation Study of Oral CNF2024(BIIB021) in CLL | Phase 1 | terminated | Jun 27, 2006 | Biogen | Sponsor's decision | Sponsor / business decision |
| NCT00209014 | Phase II Trial of Thalidomide in Refractory/Relapsed Diffuse Large B-Cell Lymphoma and… | Phase 2 | terminated | Sep 21, 2005 | Emory University | Celgene unable to continue funds. | Funding |
| NCT00547404 | Phase I Study for Safety and Efficacy of P276-00 in Subjects With Myeloma | Phase 1 | withdrawn | Oct 22, 2007 | Piramal Enterprises Limited | Not to expose the patients to subtherapeutic dose | Other (stated, no rule matched) |
| NCT00083564 | Study Comparing STR (Skeletal Targeted Radiotherapy) Plus Melphalan to Melphalan Alone,… | Phase 3 | terminated | May 28, 2004 | Poniard Pharmaceuticals | For business reasons | Sponsor / business decision |
| NCT00039754 | A Trial of Skeletal Targeted Radiotherapy Using Holmium-166-DOTMP in Patients With… | Phase 1 / Phase 2 | terminated | Jun 11, 2002 | Poniard Pharmaceuticals | business reasons | Sponsor / business decision |
| NCT00485966 | Study Evaluating Effects of CX-3543 in Patients With Relapsed or Refractory B-Cell… | Phase 2 | withdrawn | Jun 13, 2007 | Cylene Pharmaceuticals | This study was withdrawn prior to patient enrollment | Enrollment / accrual |
| NCT00352742 | A Study of ATN-224 and Bortezomib in Patients With Multiple Myeloma | Phase 1 / Phase 2 | terminated | Jul 17, 2006 | Attenuon | not stated | Not stated |
| NCT00538096 | A Phase I Study to Evaluate Safety, Tolerability in Adults With Lymphoma | Phase 1 | withdrawn | Oct 2, 2007 | MedImmune LLC | Replacing this trial with a new trial. | Other (stated, no rule matched) |
| NCT00676871 | A Study to Evaluate the Safety, Tolerability, and Antitumor Activity of Continuous… | Phase 1 / Phase 2 | withdrawn | May 13, 2008 | MedImmune LLC | Replacing this trial with a new trial. | Other (stated, no rule matched) |
| NCT00200668 | Comparison Between FDG-PET and MRI for the Assessment of Response to Intensive… | N/A | terminated | Sep 20, 2005 | Nantes University Hospital | not stated | Not stated |
| NCT00234481 | Safety Study of XL844 in Subjects With Chronic Lymphocytic Leukemia | Phase 1 | terminated | Oct 7, 2005 | Exelixis | Study closed due to slow enrollment | Enrollment / accrual |
| NCT00644306 | Comparison of Melphalan-Prednisone (MP) to MP Plus Thalidomide in the Treatment of Newly…(IFM 01/01) | Phase 3 | terminated | Mar 26, 2008 | Central Hospital, Nancy, France | survival advantage demonstrated | Other (stated, no rule matched) |
| NCT00302861 | A Study to Evaluate the Treatment of Previously Untreated B-Cell Chronic Lymphocytic… | Phase 1 / Phase 2 | terminated | Mar 15, 2006 | Genitope Corporation | not stated | Not stated |
| NCT00143884 | Study of Low Intensity Conditioning and Immunotherapy for High-Risk Cancers of the Blood | Phase 2 | terminated | Sep 2, 2005 | University of Michigan Rogel Cancer Center | not stated | Not stated |
| NCT00180895 | Rituximab in Children and Adolescents With Relapsed and Refractory B-Cell NHL/L3ALL | Phase 2 | terminated | Sep 16, 2005 | Gustave Roussy, Cancer Campus, Grand Paris | not stated | Not stated |
| NCT00337506 | Velcade Combined With High-Dose Dexamethasone in Patients With Newly Diagnosed Multiple… | Phase 2 | terminated | Jun 16, 2006 | Nantes University Hospital | not stated | Not stated |
| NCT00083473 | A Pilot Study of Pivanex in Patients With Chronic Lymphocytic Leukemia | Phase 2 | terminated | May 26, 2004 | Titan Pharmaceuticals | not stated | Not stated |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated May 2, 2011source: clinicaltrials