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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
556 stopped studies mapped to Acute Myeloid Leukemia and descendants · 90% state a reason
Over the 556 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01065545 | The Role of Maintenance Oral Clofarabine in Older Adults With Acute Myeloid Leukemia | Phase 1 | withdrawn | Feb 9, 2010 | Northwestern University | Due to funding issues. | Funding |
| NCT01203228 | Dose-reduced Versus Standard Conditioning in MDS/sAML(RICMAC) | Phase 3 | terminated | Sep 16, 2010 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT01010373 | Safety and Efficacy Study of AS101 to Treat Elderly Acute Myeloid Leukemia (AML) and… | Phase 2 | suspended | Nov 10, 2009 | BioMAS Ltd | The sponsor is currently focusing on different indications | Other (stated, no rule matched) |
| NCT00907582 | ASCT for Relapsed APL After Molecular Remission | Phase 2 | terminated | May 22, 2009 | Shanghai Jiao Tong University School of Medicine | slow recruitment | Enrollment / accrual |
| NCT02238522 | Phase 1 Study Evaluating ZEN003365 in Relapsed/Refractory Lymphoproliferative… | Phase 1 | withdrawn | Sep 12, 2014 | Zenith Epigenetics | not stated | Not stated |
| NCT00594308 | In-Vivo Activated T-Cell Depletion to Prevent GVHD | N/A | terminated | Jan 15, 2008 | Indiana University | Treatment ineffective | Other (stated, no rule matched) |
| NCT00967512 | Aezea® (Cenersen) and Chemotherapy for AML Subjects ≥ 55 Years of Age With No Response to… | Phase 2 | withdrawn | Aug 28, 2009 | Eleos, Inc. | Study Was Terminated due to lack of Funding. | Funding |
| NCT00593645 | Clofarabine, Cytarabine, and Thymoglobulin for Allogeneic Transplantation | Phase 2 | terminated | Jan 15, 2008 | Washington University School of Medicine | toxicities were worse than expected | Safety / toxicity |
| NCT00184054 | Trial of Arsenic Trioxide With Ascorbic Acid in the Treatment of Adult Non-Acute… | Phase 2 | terminated | Sep 16, 2005 | University of Southern California | Competing studies | Other (stated, no rule matched) |
| NCT00387426 | Sunitinib in Treating Patients With Idiopathic Myelofibrosis | Phase 2 | terminated | Oct 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00933985 | Obatoclax Mesylate, Vincristine Sulfate, Doxorubicin Hydrochloride, and Dexrazoxane… | Phase 1 | terminated | Jul 8, 2009 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01193400 | Clofarabine and Low-dose Cytarabine Followed by Consolidation Therapy in AML Patients Age… | Phase 2 | terminated | Sep 1, 2010 | PETHEMA Foundation | not stated | Not stated |
| NCT01198054 | LENA-LMA-5:Lenalidomide in Acute Myeloid Leukemia (AML) | Phase 4 | terminated | Sep 9, 2010 | PETHEMA Foundation | not stated | Not stated |
| NCT01655875 | AMD3100 for Sensitizing in Allogeneic Blood or Marrow Transplant for Chemotherapy…(BMTAMD3100) | Phase 1 | terminated | Aug 2, 2012 | Emory University | lack of patient enrollment | Enrollment / accrual |
| NCT00396968 | AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant… | Phase 1 / Phase 2 | withdrawn | Nov 8, 2006 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT01478074 | ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia | Phase 1 | withdrawn | Nov 23, 2011 | Altor BioScience | The treatment planned was determined to be of low feasibility as no subject was found eligible and… | Enrollment / accrual |
| NCT00923234 | Combination of 5-azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute…(AZALE) | Phase 1 | terminated | Jun 18, 2009 | Technische Universität Dresden | The primary objective has already been answered with the number of recruited patients. | Enrollment / accrual |
| NCT00672152 | A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following…(WT-1) | Phase 1 | terminated | May 6, 2008 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT00967525 | Intraosseous Infusion of Unrelated Cord Blood Grafts | N/A | terminated | Aug 28, 2009 | Emory University | poor enrollment | Enrollment / accrual |
| NCT00814983 | Myeloablative Allogeneic Stem Cell Transplantation Using a Naive T-Cell Depleted… | Phase 1 / Phase 2 | terminated | Dec 29, 2008 | Duke University | IND approval for naive T-cell depletion not obtained | Other (stated, no rule matched) |
| NCT01500161 | Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing… | Phase 2 | terminated | Dec 28, 2011 | Texas Oncology Cancer Center | Insufficient accruals | Enrollment / accrual |
| NCT00297921 | A Phase 2 Study of Tandutinib in Patients With Newly Diagnosed Acute Myelogenous Leukemia… | Phase 1 / Phase 2 | withdrawn | Mar 1, 2006 | Millennium Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00985530 | Tamibarotene and Arsenic Trioxide for Relapsed Acute Promyelocytic Leukemia | Phase 1 | terminated | Sep 28, 2009 | Northwestern University | Supporting agency withdrew funding for study. | Funding |
| NCT00049582 | Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00301769 | SJG-136 in Treating Patients With Relapsed or Refractory Acute Leukemia, Myelodysplastic… | Phase 1 | terminated | Mar 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00720850 | Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or…(LENAMAINT) | Phase 2 | terminated | Jul 23, 2008 | Technische Universität Dresden | Low recruitment, scientific rationale not applicable anymore to all patients and possible induction… | Enrollment / accrual |
| NCT01159301 | Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid… | Phase 1 | terminated | Jul 9, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00514722 | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced… | N/A | terminated | Aug 10, 2007 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00513318 | Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients… | — | terminated | Aug 8, 2007 | University of California, San Francisco | Insufficient enrollment to justify keeping open. | Enrollment / accrual |
| NCT00150878 | Standard vs. Reduced-Intensity Conditioning in Patients With Acute Myeloid Leukemia in… | Phase 3 | terminated | Sep 8, 2005 | University Hospital Carl Gustav Carus | Insurance coverage reached | Other (stated, no rule matched) |
| NCT00101231 | Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia,… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00103272 | 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With… | Phase 1 | terminated | Feb 8, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01463410 | Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the… | — | terminated | Nov 1, 2011 | Skyline Diagnostics BV | The required number of banked samples could not be met due to limited availability. There is no… | Other (stated, no rule matched) |
| NCT00658411 | Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation | N/A | terminated | Apr 15, 2008 | Dana-Farber Cancer Institute | Closed due to slow patient accrual | Enrollment / accrual |
| NCT00089388 | Cilengitide in Treating Patients With Acute Myeloid Leukemia | Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00096148 | Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly… | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042796 | Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01265199 | Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Properties of… | Phase 1 | terminated | Dec 23, 2010 | Ascenta Therapeutics | Study was terminated before a MTD was determined for administrative reasons | Other (stated, no rule matched) |
| NCT00125606 | Phase 3 Trial for AML Patients in CR2 Comparing 8Gy TBI /Fludarabine to Conditioning With… | Phase 3 | terminated | Aug 1, 2005 | University Hospital Muenster | insufficient patient recruitement | Enrollment / accrual |
| NCT00790855 | Bendamustine in Acute Leukemia and MDS | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | M.D. Anderson Cancer Center | Lack of Response | Other (stated, no rule matched) |
| NCT00480987 | Oxaliplatin, Fludarabine, and Cytarabine in Acute Myeloid Leukemia (AML) or High-Risk… | Phase 1 / Phase 2 | terminated | Jun 1, 2007 | M.D. Anderson Cancer Center | Lack of support. | Other (stated, no rule matched) |
| NCT00443300 | Effectiveness of Protected Environment Rooms for AML and MDS | — | terminated | Mar 5, 2007 | M.D. Anderson Cancer Center | Terminated due to low accrual. | Enrollment / accrual |
| NCT00513305 | Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients… | Phase 3 | terminated | Aug 8, 2007 | Cephalon | Study has been stopped by sponsor decision | Sponsor / business decision |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00074750 | Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic… | Phase 1 | terminated | Dec 23, 2003 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00430443 | Liposomal Annamycin in Children and Young Adults With Refractory or Relapsed ALL or AML | Phase 1 | terminated | Feb 1, 2007 | Callisto Pharmaceuticals | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00839059 | Lenalidomide In Patients With Acute Myeloid Leukemia | Phase 1 | terminated | Feb 9, 2009 | University of Ulm | Results of an interim analysis and a hardly ongoing enrolment in the last 10 months in all six… | Efficacy / futility |
| NCT00226512 | To Determine the Role of Adding Campath-1H or ATG Given In-vivo in Addition to… | Phase 3 | withdrawn | Sep 27, 2005 | Hadassah Medical Organization | the PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT01034410 | A Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary… | Phase 2 | terminated | Dec 17, 2009 | Antisoma Research | not stated | Not stated |
| NCT00486265 | Phase I/II, Open-label, Multi-center, Two Part Dose-escalation, Safety, Pharmacokinetics… | Phase 1 | terminated | Jun 14, 2007 | AstraZeneca | AML assess. of response in Part B patients find treatment failure in all 8 evaluable for marrow… | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 22 days agoSource updated Apr 10, 2015source: clinicaltrials