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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
556 stopped studies mapped to Acute Myeloid Leukemia and descendants · 90% state a reason
Over the 556 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT05424562 | A Study to Assess Change in Disease State in Adult Participants With Acute Myeloid…(LIVEN) | — | terminated | Jun 21, 2022 | AbbVie | Strategic Considerations | Sponsor / business decision |
| NCT03494569 | Total Marrow and Lymphoid Irradiation, Fludarabine, and Melphalan Before Donor Stem Cell… | Phase 1 | suspended | Apr 11, 2018 | City of Hope Medical Center | Accrual goal | Enrollment / accrual |
| NCT06197672 | Chimeric Antigen Receptor T Cell Redirected to Target CD4 Positive Relapsed Refractory… | Phase 1 | suspended | Jan 9, 2024 | Huda Salman | Trial being transferred to new lead site | Other (stated, no rule matched) |
| NCT06714591 | Evaluate the Safety, Tolerability, Pharmacokinetic Profile, Efficacy of Bl-M11D1 | Phase 1 | terminated | Dec 3, 2024 | SystImmune Inc. | Sponsor prioritization of other development portfolio | Sponsor / business decision |
| NCT04021368 | RVU120 in Patients With Acute Myeloid Leukemia or High-risk Myelodysplastic Syndrome | Phase 1 | terminated | Jul 16, 2019 | Ryvu Therapeutics SA | RPD2 has been identified | Other (stated, no rule matched) |
| NCT06268574 | Safety and Efficacy of RVU120 for Treatment of Relapsed/Refractory AML(RIVER-52) | Phase 2 | terminated | Feb 20, 2024 | Ryvu Therapeutics SA | Sponsor decision | Sponsor / business decision |
| NCT06680661 | ABBA CORD: dCBT w/ Abatacept for aGVHD Prophylaxis | Phase 2 | suspended | Nov 8, 2024 | Leland Metheny | insufficient funding | Funding |
| NCT06704152 | BSB-1001 in Patients Undergoing HLA-Matched Allogenic Hematopoietic Stem Cell Transplant… | Phase 1 / Phase 2 | terminated | Nov 25, 2024 | BlueSphere Bio, Inc | Company Decision | Sponsor / business decision |
| NCT07566585 | Dose Finding Study to Evaluate the Safety of BSB-2002 in Relapsed or Refractory Acute… | Phase 1 | withdrawn | May 5, 2026 | BlueSphere Bio, Inc | Company Decision | Sponsor / business decision |
| NCT07338357 | Clinical Study of CLL-1 CAR-T in the Treatment of Children With R/R AML | Early Phase 1 | withdrawn | Jan 13, 2026 | First Affiliated Hospital of Guangxi Medical University | Strategic adjustment. | Sponsor / business decision |
| NCT06514261 | Testing the Combination of an Anti-Cancer Drug, Iadademstat, With Other Anti-Cancer Drugs… | Phase 1 | suspended | Jul 23, 2024 | National Cancer Institute (NCI) | Other - Pending amendment for study expansion. | Other (stated, no rule matched) |
| NCT04010877 | Multiple CAR-T Cell Therapy Targeting AML | Phase 1 / Phase 2 | terminated | Jul 8, 2019 | Shenzhen Geno-Immune Medical Institute | not stated | Not stated |
| NCT05780879 | A Proof of Concept Pilot Study of the Addition of Venetoclax to Standard Remission… | Phase 2 | terminated | Mar 23, 2023 | University of Michigan Rogel Cancer Center | Interim Analysis per Protocol | Efficacy / futility |
| NCT06802523 | Testing the Combination of Targeted Radiotherapy With Anti-Cancer Drugs, Venetoclax and… | Phase 1 | suspended | Jan 31, 2025 | National Cancer Institute (NCI) | Drug Supply Issues | Drug supply |
| NCT03728335 | Enasidenib (AG-221) Maintenance Post Allogeneic HCT in Patients With IDH2 Mutation | Phase 2 | suspended | Nov 2, 2018 | City of Hope Medical Center | Accrual goal met | Enrollment / accrual |
| NCT02392572 | ONC201 in Treating Patients With Relapsed or Refractory Acute Leukemia or High-Risk… | Phase 1 / Phase 2 | terminated | Mar 19, 2015 | M.D. Anderson Cancer Center | \<75% participants | Other (stated, no rule matched) |
| NCT06492707 | DR-18 to Prevent or Treat Acute Myeloid Leukemia or Myelodysplastic Syndrome Relapse… | Phase 1 | suspended | Jul 9, 2024 | Fred Hutchinson Cancer Center | Recruitment on hold with plans to open to accrual again soon. | Enrollment / accrual |
| NCT04994808 | Treosulfan-Based Versus Clofarabine-Based Conditioning Before Donor Hematopoietic Stem… | Phase 2 | terminated | Aug 6, 2021 | Fred Hutchinson Cancer Center | The study was closed due to the end of funding. | Funding |
| NCT06903702 | A Study of Azacitidine and Venetoclax Versus a Stem Cell Transplant in People 65 Years… | Phase 2 | withdrawn | Apr 1, 2025 | Memorial Sloan Kettering Cancer Center | Lack of funding | Funding |
| NCT06021600 | A Phase 1, Open-Label, Sequential Cross-over, Bioavailability/Bioequivalence Study to… | Phase 1 | terminated | Sep 1, 2023 | M.D. Anderson Cancer Center | Slow participant enrollment | Enrollment / accrual |
| NCT05377827 | Dose-Escalation and Dose-Expansion Study to Evaluate the Safety and Tolerability of… | Phase 1 | suspended | May 17, 2022 | Washington University School of Medicine | Drugs/Equipment Unavailable | Other (stated, no rule matched) |
| NCT03969446 | Pembrolizumab and Decitabine With or Without Venetoclax in Treating Patients With Acute… | Phase 1 | suspended | May 31, 2019 | City of Hope Medical Center | Accrual goal Met | Enrollment / accrual |
| NCT05400122 | Natural Killer (NK) Cells in Combination With Interleukin-2 (IL-2) and Transforming… | Phase 1 | suspended | Jun 1, 2022 | David Wald | Drugs unavailable | Other (stated, no rule matched) |
| NCT06158100 | Venetoclax in Combination With Azacitidine (VEN/AZA) Followed by Donor Lymphocyte… | Phase 1 | terminated | Dec 6, 2023 | Antonio M Jimenez Jimenez | Funding Sponsor decision due to review of efficacy data from other trials involving investigational… | Efficacy / futility |
| NCT03766126 | Lentivirally Redirected CD123 Autologous T Cells in AML | Phase 1 | terminated | Dec 6, 2018 | University of Pennsylvania | Administrative reasons. | Other (stated, no rule matched) |
| NCT07084584 | ENLIGHT-AML - An Open-label, Study of GB3226 in Patients With Relapsed/Refractory Acute… | Phase 1 | withdrawn | Jul 24, 2025 | Galecto Biotech AB | Study withdrawn due to business priority changes | Sponsor / business decision |
| NCT05716009 | Tagraxofusp-erzs, an IL-3 Diphtheria Fusion Protein, in Combination With Gemtuzumab…(GO-TAG) | Phase 1 | terminated | Feb 8, 2023 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Upon analysis of the first 7 participants accrued, it was determined that this combination… | Enrollment / accrual |
| NCT05744739 | Tomivosertib in Relapsed or Refractory Acute Myeloid Leukemia (AML) | Phase 1 | terminated | Feb 27, 2023 | Northwestern University | Premature withdrawal of investigational product per study sponsor. | Other (stated, no rule matched) |
| NCT03146871 | Recombinant EphB4-HSA Fusion Protein and Azacitidine or Decitabine for Relapsed or… | Phase 2 | terminated | May 10, 2017 | University of Southern California | Lack of funding | Funding |
| NCT04550442 | Venetoclax and Azacitidine for the Treatment of Relapsed or Refractory High-Risk… | Phase 1 / Phase 2 | terminated | Sep 16, 2020 | M.D. Anderson Cancer Center | \<75% participation | Other (stated, no rule matched) |
| NCT05712278 | A Study to Investigate Use of Off-the-shelf Natural Killer (NK) Cells (SAR445419) in… | Phase 1 | terminated | Feb 3, 2023 | Sanofi | Sponsor's decision | Sponsor / business decision |
| NCT04161885 | A Study Evaluating Safety and Efficacy of Venetoclax in Combination With Azacitidine…(VIALE-T) | Phase 3 | terminated | Nov 13, 2019 | AbbVie | Strategic considerations | Sponsor / business decision |
| NCT04250051 | Ivosidenib and Combination Chemotherapy for the Treatment of IDH1 Mutant Relapsed or… | Phase 1 | terminated | Jan 31, 2020 | Northwestern University | Low accrual | Enrollment / accrual |
| NCT05224661 | Molecular Evaluation of AML Patients After Stem Cell Transplant to Understand Relapse…(MEASURE) | — | terminated | Feb 4, 2022 | Center for International Blood and Marrow Transplant Research | The study was stopped due to exhaustion of funding. No additional financial support could be… | Funding |
| NCT01962636 | Umbilical Cord Blood Transplantation Using a Myeloablative Preparative Regimen for… | N/A | terminated | Oct 14, 2013 | Masonic Cancer Center, University of Minnesota | No longer a research question to answer. | Other (stated, no rule matched) |
| NCT04824794 | GEN3014 Trial in Relapsed or Refractory Hematologic Malignancies | Phase 1 / Phase 2 | terminated | Apr 1, 2021 | Genmab | The sponsor has decided to discontinue further development of GEN3014 after a comprehensive review… | Sponsor / business decision |
| NCT03246906 | Comparison of Triple GVHD Prophylaxis Regimens for Nonmyeloablative or Reduced Intensity… | Phase 2 | terminated | Aug 11, 2017 | Fred Hutchinson Cancer Center | Study was terminated prior to enrolling protocol target accrual goal due to declining accrual and… | Safety / toxicity |
| NCT07498465 | A Study to Find the Highest Dose of SNDX-5613 (Revumenib) as a Treatment Option After… | Phase 1 | withdrawn | Mar 27, 2026 | Children's Oncology Group | Other - Protocol moved to Withdrawn | Other (stated, no rule matched) |
| NCT04639024 | ADCT-301 in Patients With R/R AML, MDS, or MDS/MPN | Phase 2 | terminated | Nov 20, 2020 | Gwynn Long, M.D. | ADCT is reallocating all resources to the phase III program. | Other (stated, no rule matched) |
| NCT03878199 | Testing the Effect of Taking Ruxolitinib and CPX-351 in Combination for the Treatment of… | Phase 1 / Phase 2 | terminated | Mar 18, 2019 | Ohio State University Comprehensive Cancer Center | The study was originally planned to assess four escalating DLs of ruxolitinib (upto 40 mg twice… | Enrollment / accrual |
| NCT04435691 | Magrolimab, Azacitidine, and Venetoclax for the Treatment of Acute Myeloid Leukemia | Phase 1 / Phase 2 | terminated | Jun 17, 2020 | M.D. Anderson Cancer Center | 75% \> Participants | Other (stated, no rule matched) |
| NCT05607199 | A First in Human Study of AUR 103 Calcium to Evaluate Safety, Pharmacokinetics and…(BHARAT-1) | Phase 1 | terminated | Nov 7, 2022 | Aurigene Discovery Technologies Limited | Patient recruitment problems. | Enrollment / accrual |
| NCT05263271 | Gentulizumab in Relapsed/Refractory Acute Myelogenous Leukemia or Myelodysplastic Syndrome | Phase 1 | terminated | Mar 2, 2022 | Changchun GeneScience Pharmaceutical Co., Ltd. | Adjusted the product development strategy. | Sponsor / business decision |
| NCT01366612 | Fludarabine and Busulfan vs. Fludarabine, Busulfan and Total Body Irradiation(FLUBUTBI) | Phase 3 | terminated | Jun 6, 2011 | Hackensack Meridian Health | Lack of Accrual | Enrollment / accrual |
| NCT02333162 | Intensity Modulated Total Marrow Irradiation, Fludarabine Phosphate, and Melphalan in… | Phase 1 | suspended | Jan 7, 2015 | University of Chicago | Enrollment on hold pending amendment | Enrollment / accrual |
| NCT03150004 | Efficacy and Pharmacogenomics of Cladribine Based Salvage Chemotherapy in Patients With… | Phase 2 | terminated | May 11, 2017 | Medical College of Wisconsin | No longer have funding support to complete the pharmacogenetics component. | Funding |
| NCT05933070 | A Phase I Open-Label Dose Escalation Study of Intravenous INKmune In Patients With MDS or…(LAUREL) | Phase 1 | terminated | Jul 6, 2023 | Inmune Bio, Inc. | Slow/low Enrollment | Enrollment / accrual |
| NCT06563804 | A Study to Evaluate S227928 as a Single Agent and in Combination With Venetoclax in… | Phase 1 / Phase 2 | terminated | Aug 21, 2024 | Servier Bio-Innovation LLC | Sponsor decision | Sponsor / business decision |
| NCT04278768 | Dose Escalation/ Expansion Study of CA-4948 as Monotherapy in Patients With Acute… | Phase 1 / Phase 2 | suspended | Feb 20, 2020 | Curis, Inc. | Dosing completed in all cohorts. Planning underway for potential additional patient cohorts. | Other (stated, no rule matched) |
| NCT03922100 | Study of NMS-03592088 in Patients With Relapsed or Refractory AML or CMML | Phase 1 / Phase 2 | terminated | Apr 19, 2019 | Nerviano Medical Sciences | Study stopped due to strategic reasons. The decision is not based on specific safety findings as… | Safety / toxicity |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 10 hours agoSource updated Sep 29, 2026source: clinicaltrials