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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
754 stopped studies mapped to Acute Leukemia and descendants · 89% state a reason
Over the 754 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01001390 | The Effects of Ankle Foot Orthoses on Gait Efficiency in Children With Acute… | N/A | terminated | Oct 26, 2009 | St. Jude Children's Research Hospital | The study closed due to poor accrual and difficulty with participant compliance. | Enrollment / accrual |
| NCT00101205 | Oxaliplatin, Ifosfamide and Etoposide in Treating Young Patients With Recurrent or… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00396968 | AMD3100 With Busulfan, Fludarabine and Thymoglobulin for Allogeneic Stem Cell Transplant… | Phase 1 / Phase 2 | withdrawn | Nov 8, 2006 | Genzyme, a Sanofi Company | not stated | Not stated |
| NCT01478074 | ALT-801-activated Natural Killer Cells After FLAG Induction for Acute Myeloid Leukemia | Phase 1 | withdrawn | Nov 23, 2011 | Altor BioScience | The treatment planned was determined to be of low feasibility as no subject was found eligible and… | Enrollment / accrual |
| NCT00923234 | Combination of 5-azacitidine and Lenalidomide in Myelodysplastic Syndromes (MDS) or Acute…(AZALE) | Phase 1 | terminated | Jun 18, 2009 | Technische Universität Dresden | The primary objective has already been answered with the number of recruited patients. | Enrollment / accrual |
| NCT00672152 | A Phase I Study of WT1 Peptides to Induce Anti-Leukemia Immune Responses Following…(WT-1) | Phase 1 | terminated | May 6, 2008 | Michael Morse, MD | low accrual | Enrollment / accrual |
| NCT00957320 | Study of Sirolimus With PEG-Asparaginase in Acute Lymphoblastic Leukemia (ALL) | Phase 1 | withdrawn | Aug 12, 2009 | Emory University | no patients enrolled, decided not to pursue study | Enrollment / accrual |
| NCT00967525 | Intraosseous Infusion of Unrelated Cord Blood Grafts | N/A | terminated | Aug 28, 2009 | Emory University | poor enrollment | Enrollment / accrual |
| NCT00814983 | Myeloablative Allogeneic Stem Cell Transplantation Using a Naive T-Cell Depleted… | Phase 1 / Phase 2 | terminated | Dec 29, 2008 | Duke University | IND approval for naive T-cell depletion not obtained | Other (stated, no rule matched) |
| NCT01500161 | Pooled Unrelated Donor Umbilical Cord Blood Transplant For Hematologic Malignancy Needing… | Phase 2 | terminated | Dec 28, 2011 | Texas Oncology Cancer Center | Insufficient accruals | Enrollment / accrual |
| NCT00297921 | A Phase 2 Study of Tandutinib in Patients With Newly Diagnosed Acute Myelogenous Leukemia… | Phase 1 / Phase 2 | withdrawn | Mar 1, 2006 | Millennium Pharmaceuticals, Inc. | not stated | Not stated |
| NCT00985530 | Tamibarotene and Arsenic Trioxide for Relapsed Acute Promyelocytic Leukemia | Phase 1 | terminated | Sep 28, 2009 | Northwestern University | Supporting agency withdrew funding for study. | Funding |
| NCT00058461 | Combination Chemotherapy and Rituximab in Treating Young Patients With Recurrent or… | Phase 2 | terminated | Apr 9, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00049582 | Decitabine in Treating Patients With Myelodysplastic Syndromes or Acute Myeloid Leukemia | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00301769 | SJG-136 in Treating Patients With Relapsed or Refractory Acute Leukemia, Myelodysplastic… | Phase 1 | terminated | Mar 13, 2006 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00720850 | Lenalidomide Maintenance Therapy in Patients With Myelodysplastic Syndromes (MDS) or…(LENAMAINT) | Phase 2 | terminated | Jul 23, 2008 | Technische Universität Dresden | Low recruitment, scientific rationale not applicable anymore to all patients and possible induction… | Enrollment / accrual |
| NCT01159301 | Entinostat and Sorafenib Tosylate in Treating Patients With Advanced or Metastatic Solid… | Phase 1 | terminated | Jul 9, 2010 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01701375 | A Phase 1 Trial of TST of PD 0332991 Followed by Cytarabine and Mitoxantrone for Adults… | Phase 1 | terminated | Oct 5, 2012 | Sidney Kimmel Comprehensive Cancer Center at Johns Hopkins | Material sponsor withdrew support | Other (stated, no rule matched) |
| NCT00514722 | Pilot Study of Umbilical Cord Blood Transplantation in Adult Patient With Advanced… | N/A | terminated | Aug 10, 2007 | University of California, San Francisco | low accrual | Enrollment / accrual |
| NCT00513318 | Pilot Study of Reduced-Intensity Umbilical Cord Blood Transplantation in Adult Patients… | — | terminated | Aug 8, 2007 | University of California, San Francisco | Insufficient enrollment to justify keeping open. | Enrollment / accrual |
| NCT00150878 | Standard vs. Reduced-Intensity Conditioning in Patients With Acute Myeloid Leukemia in… | Phase 3 | terminated | Sep 8, 2005 | University Hospital Carl Gustav Carus | Insurance coverage reached | Other (stated, no rule matched) |
| NCT01492569 | Acupuncture Point Stimulation for Treatment of Chemotherapy Nausea and Vomiting | N/A | withdrawn | Dec 15, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT00101231 | Flavopiridol in Treating Patients With Relapsed or Refractory Acute Myeloid Leukemia,… | Phase 1 | terminated | Jan 10, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT00103272 | 17-N-Allylamino-17-Demethoxygeldanamycin and Bortezomib in Treating Patients With… | Phase 1 | terminated | Feb 8, 2005 | National Cancer Institute (NCI) | not stated | Not stated |
| NCT01463410 | Accuracy Testing of the Chromosomal Aberration and Gene Mutation Markers of the… | — | terminated | Nov 1, 2011 | Skyline Diagnostics BV | The required number of banked samples could not be met due to limited availability. There is no… | Other (stated, no rule matched) |
| NCT01251809 | Trial of Oncaspar® and Three Doses of Pegylated Recombinant Asparaginase in Adult… | Phase 1 / Phase 2 | terminated | Dec 2, 2010 | medac GmbH | not stated | Not stated |
| NCT00658411 | Deferoxamine for Iron Overload Before Allogeneic Stem Cell Transplantation | N/A | terminated | Apr 15, 2008 | Dana-Farber Cancer Institute | Closed due to slow patient accrual | Enrollment / accrual |
| NCT00089388 | Cilengitide in Treating Patients With Acute Myeloid Leukemia | Phase 2 | terminated | Aug 5, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00096148 | Idarubicin and Cytarabine With or Without Bevacizumab in Treating Patients With Newly… | Phase 2 | terminated | Nov 9, 2004 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT00042796 | Decitabine in Treating Children With Relapsed or Refractory Acute Myeloid Leukemia or… | Phase 1 | terminated | Jan 27, 2003 | National Cancer Institute (NCI) | Administratively complete. | Other (stated, no rule matched) |
| NCT01265199 | Study of the Safety, Tolerability, Pharmacokinetics and Pharmacodynamic Properties of… | Phase 1 | terminated | Dec 23, 2010 | Ascenta Therapeutics | Study was terminated before a MTD was determined for administrative reasons | Other (stated, no rule matched) |
| NCT01148134 | Pharmacokinetic Profile of Vincristine Administered With Imatinib for Bcr-Abl Positive… | — | terminated | Jun 22, 2010 | University Health Network, Toronto | Analysis of the first 10 patients did not show anyt trend toward differences in PK profiles between… | Other (stated, no rule matched) |
| NCT00125606 | Phase 3 Trial for AML Patients in CR2 Comparing 8Gy TBI /Fludarabine to Conditioning With… | Phase 3 | terminated | Aug 1, 2005 | University Hospital Muenster | insufficient patient recruitement | Enrollment / accrual |
| NCT00790855 | Bendamustine in Acute Leukemia and MDS | Phase 1 / Phase 2 | terminated | Nov 14, 2008 | M.D. Anderson Cancer Center | Lack of Response | Other (stated, no rule matched) |
| NCT00991744 | Liposomal Cytarabine for Central Nervous System (CNS)-Treatment in High-risk Acute… | Phase 3 | suspended | Oct 8, 2009 | Nordic Society for Pediatric Hematology and Oncology | Sterility problems in DepoCyte production | Other (stated, no rule matched) |
| NCT00480987 | Oxaliplatin, Fludarabine, and Cytarabine in Acute Myeloid Leukemia (AML) or High-Risk… | Phase 1 / Phase 2 | terminated | Jun 1, 2007 | M.D. Anderson Cancer Center | Lack of support. | Other (stated, no rule matched) |
| NCT00443300 | Effectiveness of Protected Environment Rooms for AML and MDS | — | terminated | Mar 5, 2007 | M.D. Anderson Cancer Center | Terminated due to low accrual. | Enrollment / accrual |
| NCT00513305 | Cytarabine in Combination With Arsenic Trioxide vs. Cytarabine Alone in Elderly Patients… | Phase 3 | terminated | Aug 8, 2007 | Cephalon | Study has been stopped by sponsor decision | Sponsor / business decision |
| NCT01558778 | Mechanical Stimulation in Preventing Bone Density Loss in Patients Undergoing Donor Stem… | N/A | withdrawn | Mar 20, 2012 | Roswell Park Cancer Institute | device not available | Other (stated, no rule matched) |
| NCT00570999 | Palifermin After Haploidentical PBSCT(KGF Haplo Allo) | Phase 2 | withdrawn | Dec 11, 2007 | European Society for Blood and Marrow Transplantation | not stated | Not stated |
| NCT00074750 | Study of DT388GMCSF Fusion Protein in Acute Myelogenous Leukemia (AML) and Chronic… | Phase 1 | terminated | Dec 23, 2003 | M.D. Anderson Cancer Center | Slow accrual. | Enrollment / accrual |
| NCT00430443 | Liposomal Annamycin in Children and Young Adults With Refractory or Relapsed ALL or AML | Phase 1 | terminated | Feb 1, 2007 | Callisto Pharmaceuticals | Participants are no longer being examined or treated. | Other (stated, no rule matched) |
| NCT00839059 | Lenalidomide In Patients With Acute Myeloid Leukemia | Phase 1 | terminated | Feb 9, 2009 | University of Ulm | Results of an interim analysis and a hardly ongoing enrolment in the last 10 months in all six… | Efficacy / futility |
| NCT00226512 | To Determine the Role of Adding Campath-1H or ATG Given In-vivo in Addition to… | Phase 3 | withdrawn | Sep 27, 2005 | Hadassah Medical Organization | the PI is no longer work at Hadassah | Other (stated, no rule matched) |
| NCT00187005 | Total Therapy Study XIV for Newly Diagnosed Patients With Acute Lymphoblastic Leukemia | Phase 3 | terminated | Sep 16, 2005 | St. Jude Children's Research Hospital | Toxicity | Safety / toxicity |
| NCT01034410 | A Study of AS1411 Combined With Cytarabine in the Treatment of Patients With Primary… | Phase 2 | terminated | Dec 17, 2009 | Antisoma Research | not stated | Not stated |
| NCT00486265 | Phase I/II, Open-label, Multi-center, Two Part Dose-escalation, Safety, Pharmacokinetics… | Phase 1 | terminated | Jun 14, 2007 | AstraZeneca | AML assess. of response in Part B patients find treatment failure in all 8 evaluable for marrow… | Other (stated, no rule matched) |
| NCT00279773 | Safety, Pharmacokinetics and Pharmacodynamics of TKI258 in Subjects With Acute Myeloid… | Phase 1 | terminated | Jan 20, 2006 | Novartis Pharmaceuticals | Study was stopped due to time dependent drug accumulation | Other (stated, no rule matched) |
| NCT00322673 | Study of XL999 in Patients With Acute Myeloid Leukemia (AML) | Phase 2 | terminated | May 8, 2006 | Symphony Evolution, Inc. | Study was terminated due to cardiac toxicities | Safety / toxicity |
| NCT00594555 | A Study Evaluating the Effects of CLAG With Gleevec in Refractory or Relapsed Acute… | Phase 2 | withdrawn | Jan 15, 2008 | University of Cincinnati | Principal Investigator resigned position with the University of Cincinnati, closing study at this… | Investigator |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Mar 27, 2014source: clinicaltrials