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Clinical trials · failure tracking
Oncology studies whose overall status is TERMINATED, WITHDRAWN or SUSPENDED on ClinicalTrials.gov, with the stop reason exactly as the registrant posted it. A category is attached only when an explicit keyword rule matches the text; CancerIndex never infers why a study stopped.
756 stopped studies mapped to Acute Leukemia and descendants · 89% state a reason
Over the 756 studies matching the cancer, status and year filters (the category filter does not change this chart). Each study is counted once, in the first matching category; greyed bars are studies whose text matched no rule or was empty.
Computedrules ci-stop-reasons-v1 · keyword matching only
A category is assigned when one of its keywords appears in the posted text (case-insensitive, whole words). Rules are tested in this order and the first match wins; every match is kept in the API (reasonMatches).
| NCT | Title | Phase | Status | First posted | Lead sponsor | Why stopped (as posted) | Category |
|---|---|---|---|---|---|---|---|
| NCT01207076 | AHN-12 Biodistribution in Advanced Leukemia | Phase 1 | terminated | Sep 22, 2010 | Masonic Cancer Center, University of Minnesota | Slow accrual | Enrollment / accrual |
| NCT01343368 | Preservation of Ovarian Function After Hematopoietic Cell Transplant | Phase 2 | terminated | Apr 28, 2011 | Masonic Cancer Center, University of Minnesota | not stated | Not stated |
| NCT02765997 | StemRegenin-1 Expanded vs Unexpanded UCB for High Risk Heme Malignancies | Phase 2 | withdrawn | May 9, 2016 | Masonic Cancer Center, University of Minnesota | IRB Disapproval | Other (stated, no rule matched) |
| NCT01163201 | T-Regulatory Cell and CD3 Depleted Double Umbilical Cord Blood Transplantation in… | Phase 1 / Phase 2 | withdrawn | Jul 15, 2010 | Masonic Cancer Center, University of Minnesota | Replaced by a new study | Other (stated, no rule matched) |
| NCT01639456 | CD3/CD19 Depleted or CD3 Depleted/CD56 Selected Haploid Donor Natural Killer Cell… | Phase 2 | withdrawn | Jul 12, 2012 | Masonic Cancer Center, University of Minnesota | study was abandoned and a new study was written to replace this one | Other (stated, no rule matched) |
| NCT01677949 | Clofarabine, Cyclophosphamide and Etoposide for Minimal Residual Disease Positive Acute… | Phase 2 | withdrawn | Sep 3, 2012 | Masonic Cancer Center, University of Minnesota | Slow accrual | Enrollment / accrual |
| NCT03108911 | Gluten Free Diet in Diminishing Side Effects Patients With Acute Myeloid Leukemia… | Phase 2 | terminated | Apr 11, 2017 | Rutgers, The State University of New Jersey | limited resources | Other (stated, no rule matched) |
| NCT02433483 | Microtransplantation to Treat Refractory or Relapsed Hematologic Malignancies in Younger… | Phase 2 | terminated | May 5, 2015 | St. Jude Children's Research Hospital | The study was closed due to poor accrual and because of competing protocols. | Enrollment / accrual |
| NCT00101140 | Donor Stem Cell Transplant in Treating Patients With Acute Myeloid Leukemia in Remission | Phase 2 | withdrawn | Jan 10, 2005 | Eastern Cooperative Oncology Group | not stated | Not stated |
| NCT03138395 | iCare3: Monitoring Circulating Cancer DNA After Chemotherapy in MDS and AML(iCare3) | — | withdrawn | May 3, 2017 | University of Florida | Study design modified to collect specimens from a bank requiring a separate IRB-approved protocol. | Other (stated, no rule matched) |
| NCT02255162 | Lenalidomide in Combination With Microtransplantation as Post-remission Therapy in AML | Phase 1 | terminated | Oct 2, 2014 | Massachusetts General Hospital | Slow Accrual | Enrollment / accrual |
| NCT01383447 | Entinostat And Imatinib Mesylate In Treating Patients With Relapsed or Refractory… | Phase 1 / Phase 2 | terminated | Jun 28, 2011 | National Cancer Institute (NCI) | This study was halted prematurely by the NCI for low accrual. | Enrollment / accrual |
| NCT01034592 | Pilot Lenalidomide in Adult Diamond-Blackfan Anemia Patients w/ RBC Transfusion-Dependent… | Phase 1 | terminated | Dec 17, 2009 | Jason Robert Gotlib | Poor accrual related to rarity of Diamond-Blackfan anemia (DBA) | Enrollment / accrual |
| NCT03141398 | Comparing CGM and OGTT in Relation to Iron Overload Detected by Pancreas T2* MRI in…(CGMs) | — | withdrawn | May 5, 2017 | Hamad Medical Corporation | Due to issues with study design | Other (stated, no rule matched) |
| NCT01342887 | Cyclosporine, Pravastatin Sodium, Etoposide, and Mitoxantrone Hydrochloride in Treating… | Phase 1 / Phase 2 | terminated | Apr 27, 2011 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT01076270 | Plerixafor and Filgrastim For Mobilization of Donor Peripheral Blood Stem Cells Before A… | N/A | terminated | Feb 26, 2010 | Fred Hutchinson Cancer Center | Funding withdrawal | Funding |
| NCT02276651 | Observational Trial of a Therapeutic Platelet Transfusion Regimen | — | terminated | Oct 28, 2014 | Klinikum Nürnberg | Insufficient recruitment | Enrollment / accrual |
| NCT02647190 | Intravenous Erwinia Chrysanthemi Asparaginase in Patients With Newly Diagnosed… | Phase 1 | withdrawn | Jan 6, 2016 | Memorial Sloan Kettering Cancer Center | not stated | Not stated |
| NCT00673153 | Vorinostat and Gemtuzumab Ozogamicin in Treating Older Patients With Previously Untreated… | Phase 2 | terminated | May 7, 2008 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT02259348 | Repeat Transplantation for Relapsed or Refractory Hematologic Malignancies Following… | Phase 2 | terminated | Oct 8, 2014 | St. Jude Children's Research Hospital | Investigator's decision. | Investigator |
| NCT00863434 | Clofarabine and Cytarabine in Treating Patients With Acute Myeloid Leukemia With Minimal… | Phase 2 | terminated | Mar 18, 2009 | University of Washington | not stated | Not stated |
| NCT01483274 | Decitabine and Vaccine Therapy for Patients With Relapsed AML Following Allogeneic Stem…(AML) | Phase 1 | withdrawn | Dec 1, 2011 | University of Louisville | Adult patient population barriers. | Other (stated, no rule matched) |
| NCT02791919 | Wee1 Kinase Inhibitor AZD1775 and Combination Chemotherapy in Treating Children,… | Phase 1 | withdrawn | Jun 7, 2016 | National Cancer Institute (NCI) | Other - Protocol moved to Disapproved | Other (stated, no rule matched) |
| NCT02520102 | Open Label Study of Sargramostim Among Patients Receiving Myelosuppressive Induction… | Phase 2 | withdrawn | Aug 11, 2015 | Sanofi | Company has fulfilled post-marketing requirements | Sponsor / business decision |
| NCT02973191 | A Study to Determine Safety, Feasibility and Efficacy of JCAR015 in Adult Subjects With…(ORBIT) | Phase 1 / Phase 2 | withdrawn | Nov 25, 2016 | Celgene | Development of JCAR015 has been discontinued. No subjects were enrolled/treated under protocol… | Enrollment / accrual |
| NCT02200380 | A Safety and Tolerability Study of CDX-301 With or Without Plerixafor for Stem Cell… | Phase 2 | terminated | Jul 25, 2014 | Celldex Therapeutics | not stated | Not stated |
| NCT02227108 | Study in Pediatrics With Relapsed or Refractory Pediatric Acute Lymphoblastic Leukemia… | Phase 2 | terminated | Aug 27, 2014 | MedImmune LLC | The study was terminated prior to a planned interim analysis based on lack of required efficacy in… | Efficacy / futility |
| NCT01465386 | Bortezomib in Treating Patients With High-Risk Acute Myeloid Leukemia in Remission | Phase 2 | terminated | Nov 4, 2011 | Fred Hutchinson Cancer Center | Closed early due to slow enrollment | Enrollment / accrual |
| NCT02257684 | A Dose Confirmation and Pharmacokinetic Study of Pegcrisantaspase Administered as… | Phase 2 | terminated | Oct 6, 2014 | Jazz Pharmaceuticals | Sponsor decision | Sponsor / business decision |
| NCT01607645 | Decitabine Followed by Idarubicin and Cytarabine in Treating Patients With Relapsed or… | Phase 2 | terminated | May 30, 2012 | Fred Hutchinson Cancer Center | The study was terminated early because there were other competing protocols. | Other (stated, no rule matched) |
| NCT00363467 | Busulfan Monotherapy as Conditioning for Autologous Hematopoietic Progenitor Cell… | N/A | terminated | Aug 15, 2006 | H. Lee Moffitt Cancer Center and Research Institute | Low accrual | Enrollment / accrual |
| NCT01749111 | Comparison Between Cyclophosphamide and Combination of Methotrexate + Calcineurin…(CICLODECH) | Phase 3 | terminated | Dec 13, 2012 | Hospital Israelita Albert Einstein | Lack of accrual | Enrollment / accrual |
| NCT01621477 | T-Cell Replete Haploidentical Donor Hematopoietic Stem Cell Plus Natural Killer (NK) Cell… | Phase 2 | terminated | Jun 18, 2012 | St. Jude Children's Research Hospital | Study was terminated in August 2016 due to replacement by a new study. | Other (stated, no rule matched) |
| NCT01843179 | Sulindac for Patients With AML | Phase 2 | withdrawn | Apr 30, 2013 | Massachusetts General Hospital | Lack of Funding | Funding |
| NCT00052598 | Therapeutic Allogeneic Lymphocytes and Aldesleukin in Treating Patients With High-Risk or… | Phase 1 / Phase 2 | terminated | Jan 27, 2003 | Fred Hutchinson Cancer Center | not stated | Not stated |
| NCT02167360 | Study of Efficacy and Safety of CTL019 in Adult ALL Patients | Phase 2 | withdrawn | Jun 19, 2014 | Abramson Cancer Center at Penn Medicine | Did not enroll | Enrollment / accrual |
| NCT02129062 | Ibrutinib in Treating Patients With Relapsed or Refractory B-cell Acute Lymphoblastic… | Phase 2 | terminated | May 2, 2014 | National Cancer Institute (NCI) | Slow accrual. | Enrollment / accrual |
| NCT01709396 | ED-TBI Followed By Allogeneic Stem Cell Transplantation For The Treatment Of Refractory…(ED-TBI) | Phase 2 | suspended | Oct 18, 2012 | Ottawa Hospital Research Institute | initial on hold due to space but now permanently suspended due to futility. | Efficacy / futility |
| NCT01176422 | Telomere and Telomerase | — | withdrawn | Aug 6, 2010 | University of Kansas Medical Center | lack of resources; no patient enrollment | Enrollment / accrual |
| NCT01520805 | Safety and Effectiveness Study of CPI-613 to Treat Refractory or Relapsed Leukemia and… | Phase 2 | withdrawn | Jan 30, 2012 | Cornerstone Pharmaceuticals | not stated | Not stated |
| NCT02861040 | Volasertib and Vincristine Sulfate Liposome in Treating Patients With Relapsed or… | Phase 1 | withdrawn | Aug 10, 2016 | Northwestern University | not stated | Not stated |
| NCT01401322 | Single Agent Lenalidomide in Adult Patients With Relapsed/Refractory Acute Lymphoblastic… | Phase 2 | terminated | Jul 25, 2011 | Stanford University | low accrual | Enrollment / accrual |
| NCT02528877 | Ruxolitinib Phosphate, Tacrolimus and Sirolimus in Preventing Acute Graft-versus-Host… | Phase 1 | withdrawn | Aug 19, 2015 | City of Hope Medical Center | The study design was revised so a new protocol will be opened. | Other (stated, no rule matched) |
| NCT02303782 | A Study Assessing tOTX015 in Combination With Azacitidine (AZA) or AZA Single Agent in… | Phase 1 / Phase 2 | withdrawn | Dec 1, 2014 | Oncoethix GmbH, a subsidiary of Merck & Co., Inc. (Rahway, New Jersey USA) | not stated | Not stated |
| NCT02281279 | Rituximab, Romidepsin, and Lenalidomide in Treating Patients With Recurrent or Refractory… | Phase 1 / Phase 2 | withdrawn | Nov 3, 2014 | Mayo Clinic | not stated | Not stated |
| NCT01960387 | Phase II Clofarabine and Cytarabine for Newly Diagnosed Acute Myeloid Leukemia(UPCI 13-066) | Phase 2 | terminated | Oct 10, 2013 | University of Pittsburgh | lack of accrual | Enrollment / accrual |
| NCT01652014 | Single or Double Donor Umbilical Cord Blood Transplant in Treating Patients With… | Phase 2 | withdrawn | Jul 27, 2012 | University of Medicine and Dentistry of New Jersey | Funding unavailable | Funding |
| NCT00185523 | Allogeneic Transplantation for Patients With Acute Leukemia or Chronic Myelogenous… | — | terminated | Sep 16, 2005 | Stanford University | not stated | Not stated |
| NCT00313053 | Study of mAb 216 With Chemotherapy for Treatment of Pediatric Relapsed or Refractory… | Phase 1 | terminated | Apr 11, 2006 | Clare Twist | not stated | Not stated |
| NCT02029417 | Omacetaxine Mepesuccinate, Cytarabine, and Decitabine in Treating Older Patients With… | Phase 2 | terminated | Jan 7, 2014 | Roswell Park Cancer Institute | Major revisions needed in study | Other (stated, no rule matched) |
Stop reasons are registrant-reported free text and are displayed verbatim (truncated; hover for the full text). Categories come from explicit keyword rules and are never inferred from the study design, sponsor or outcome; a study that stopped for several reasons is filed under the first rule that matched. A TERMINATED status does not imply a negative result.
Data updated 23 days agoSource updated Dec 5, 2017source: clinicaltrials