A Phase III, Multicentre Study to Evaluate Consolidation Treatment With AZD0120 Compared With ASCT, in Participants With Newly Diagnosed Multiple Myeloma Who Are Transplant Eligible (DURGA-6).

Inclusion Criteria:

* ≥18 years of age.
* Documented diagnosis of NDMM according to IMWG diagnostic criteria.
* Documented measurable disease at diagnosis (serum M-protein ≥ 1.0 g/dL, urine M-protein 200 mg/24 hour, or serum Ig FLC 10 mg/dL (100 mg/L) and abnormal serum Ig kappa lambda FLC ratio)
* Must have completed 4 to 6 cycles of induction therapy with any of the following approved regimens: anti-CD38+VRd, DVTd, DRd or VRd
* Participant must have at least SD or better per IMWG response criteria (2016) after completion of induction, and prior to randomisation.
* ECOG performance status score of 0 or 1.
* Eligible for treatment with high-dose melphalan (200 mg/m²) followed by ASCT.
* Adequate organ and bone marrow function.

Exclusion Criteria:

* Known active, or prior history of CNS involvement or exhibits clinical signs of meningeal involvement of MM.
* Primary amyloidosis, active plasma cell leukaemia (at diagnosis and/or at time of screening), Waldenstrom macroglobulinemia or POEMS syndrome.
* Significant neurological or psychiatric condition
* Significant medical condition that places the participant at an unacceptable risk for treatment-related complications
* Participants who required the introduction of an additional agent therapy due to inadequate response.
* Prior T-cell engager therapy directed at any target.
* Prior CAR-T and/or CAR-NK cell therapy directed at any target for any indications
* Prior any therapy that is targeted to BCMA and CD19.