Rimegepant Plus Glofitamab and CD19 CAR-T Therapy in R/R LBCL

Inclusion Criteria:

* Able to understand and voluntarily sign the written informed consent form.
* Age 18 years or older.
* Histologically confirmed large B-cell lymphoma with CD19 and CD20 expression.
* Relapsed or refractory disease after at least one prior line of systemic therapy.
* Prior treatment must have included an anthracycline-containing chemotherapy regimen and an anti-CD20 monoclonal antibody.
* Considered suitable by the investigator to receive glofitamab and CD19 CAR-T cell therapy.
* Presence of at least one high-risk feature, including extranodal involvement, bulky disease, or TP53 abnormality.
* ECOG performance status of 0 to 2.
* Life expectancy of at least 12 weeks.
* Adequate bone marrow, hepatic, renal, pulmonary, and cardiac function as determined by the investigator.
* Participants of reproductive potential must agree to use effective contraception during the study period.
* Able and willing to comply with the study protocol, in the investigator's judgment.

Exclusion Criteria:

* History of hypersensitivity to any study treatment or related compounds.
* Active or uncontrolled infection requiring systemic treatment.
* History of allogeneic hematopoietic stem cell transplantation or organ transplantation.
* Uncontrolled or clinically significant viral infection as defined by the protocol.
* Known central nervous system involvement by lymphoma or clinically significant central nervous system disease that may interfere with study treatment or safety assessment.
* Severe or uncontrolled cardiovascular disease.
* Severe autoimmune disease or immune-mediated disease that may interfere with study treatment or safety assessment.
* Known or suspected history of hemophagocytic lymphohistiocytosis.
* Recent thromboembolic event before screening.
* History of another malignancy within 5 years before screening, except adequately treated carcinoma in situ or non-melanoma skin cancer.
* Receipt of prohibited anticancer therapy, immunosuppressive therapy, live attenuated vaccine, or other prohibited treatment within the protocol-specified period before enrollment.
* Pregnant or breastfeeding women, or participants planning pregnancy during the study period.
* Concurrent participation in another interventional clinical trial.
* Need for prohibited concomitant medications that cannot be discontinued or substituted.
* Any condition that, in the investigator's judgment, makes the participant unsuitable for study treatment or study participation.