Clinical trial · Interventional
Thulium Laser En-bloc Resection of Primary Non-muscle Invasive Bladder Cancer
Evaluation of Thulium Laser Endoscopic En-bloc Resection Versus Conventional Trans-urethral En-bloc Resection of Primary Non-muscle Invasive Bladder Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The goal of this clinical trial is to know if thulium laser works to treat non-muscle invasive bladder cancer "NMIBC" efficiently in comparison to classical trans-urethral resection "TURBT". It will also learn about the safety of this technique. The main questions it aims to answer are: Does thulium laser lower the incidence of recurrence to participants with non- muscle invasive bladder cancer? What complications do participants have when using this technique? Investigators will compare thulium laser en-bloc resection to a classical trans-urethral en-bloc resection of bladder tumor Participants will: Do thulium laser en-bloc resection or trans-urethral en-bloc resection And will be classified to risk group according to European association of urology guidelines and followed up accordingly.
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Bladder Transitional Cell Carcinoma | Bladder Urothelial Carcinoma | ALIAS | 0.90 |
Interventions
Interventions (2)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Thulium laser en-bloc resection of bladder mass | Procedure | — | UNRESOLVED |
| Trans-urethral en-bloc resection of bladder mass | Procedure | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Thulium laser "TmLRBT"
- description
- Participants recieved thulium laser en-bloc resection of bladder mass
- interventionNames
- Procedure: Thulium laser en-bloc resection of bladder mass
- type
- ACTIVE_COMPARATOR
- label
- Trans-Urethral resection "TURBT"
- description
- Participants recieved trans-urethral en-bloc resection of bladder mass
- interventionNames
- Procedure: Trans-urethral en-bloc resection of bladder mass
Primary outcomes (2)
- measure
- Recurrence free survival rate
- timeFrame
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 50 Years
Show eligibility criteria text
Inclusion Criteria: * Age : adults and older adults * patients with bladder transitional cell carcinoma * Imaging examinations showed small bladder mass \< 3 cm and the bladder muscle has not been affected, no lymph node metastasis or distant metastasis; * Primary tumor Exclusion Criteria: * Large bladder mass \> 3 cm measured by CT urography * Recurrent tumor * Patients that confirmed post operative histopathology with muscle-invasive bladder transitional cell carcinoma * Received previous chemotherapy or radiotherapy * Other pathological types of bladder cancer
References
Publications (1)
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 29, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
Mohammed Mahmoud Zaza, Mohamed ElSayed ElAzab, Samuel Fayek Ebskharoun et al. · Int Urol Nephrol · Sep 22, 2026 · PMID 42771231 pubmed
- BACKGROUNDBadawy A, Sultan SM, Marzouk A, El-Sherif E. Thulium laser en bloc resection versus conventional transurethral resection of urinary bladder tumor: A comparative prospective study. Urol Ann. 2023 Jan-Mar;15(1):88-94. doi: 10.4103/ua.ua_59_22. Epub 2022 Nov 8. PMID 37006212