Clinical trial · Interventional
Prevention and Screening Towards Elimination of Cervical Cancer
Prevention and Screening Intervention Project - Towards Elimination of Cervical Cancer
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
The research project applies the protocol of the World Health Organisation for screening of cervical cancer, with testing of hrHPV as first screening, followed by Visual Inspection of the cervix with Acetic Acid for hrHPV-positive women and for women with minor lesions thermo-ablation of affected areas. This procedure is applied in Uganda, India and Bangladesh. In Slovakia hrHPV-positive women are offered Pap-smear and for women with Pap IV lis excision.
Conditions
Conditions (3)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Cervical Dysplasia | Cervical Intraepithelial Neoplasia | ALIAS | 0.90 |
| Cervix Cancer | — | UNRESOLVED | — |
| HPV Infection | — | UNRESOLVED | — |
Interventions
Interventions (6)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| Community mobilisation for hrHPV self-testing | Behavioral | — | UNRESOLVED |
| Follow-up after testing | Behavioral | — | UNRESOLVED |
| hrHPV self-testing | Diagnostic Test | — | UNRESOLVED |
| Pap smear cytology | Diagnostic Test | — | UNRESOLVED |
| Thermo-ablation or cryotherapy for dysplasia | Procedure | — | UNRESOLVED |
| VIA | Diagnostic Test | — | UNRESOLVED |
Design
Arms and outcomes
Arms (2)
- type
- EXPERIMENTAL
- label
- Uganda, India, Bangladesh
- description
- hrHPV self-test, followed by VIA inspection for hrHPV-positive women.
- interventionNames
- Behavioral: Community mobilisation for hrHPV self-testing
- Diagnostic Test: hrHPV self-testing
- Behavioral: Follow-up after testing
- Diagnostic Test: VIA
- Procedure: Thermo-ablation or cryotherapy for dysplasia
- type
- EXPERIMENTAL
- label
- Slovakia
- description
- hrHPV self-test, followed by Pap-smear for cytology
- interventionNames
- Behavioral: Community mobilisation for hrHPV self-testing
- Diagnostic Test: hrHPV self-testing
- Behavioral: Follow-up after testing
- Procedure: Thermo-ablation or cryotherapy for dysplasia
- Diagnostic Test: Pap smear cytology
Eligibility
Eligibility (as posted)
- Sex
- Female
- Minimum age
- 30 Years
- Maximum age
- 60 Years
Show eligibility criteria text
Inclusion Criteria: * Female in eligible age group * Ability to give informed consent and participate in study Exclusion Criteria: * Clinical signs of cervical carcinoma * Menstruation or other vaginal blood loss
References
Publications (1)
- Source
- PubMed (NLM)
- Dataset
- PubMed E-utilities
- Retrieved
- Sep 10, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
Jaap Koot, Johnblack Kabukye, Guruvare Shyamala et al. · JMIR Form Res · Sep 3, 2026 · PMID 42691425 pubmed
- DERIVEDNazrul N, Rahman A, de Fouw M, Campbell C, Koot J, Kulsum MU, Ahmed MS, Haider SS, Hossain MA, Islam KM, Nessa A, Amrin M, Stekelenburg J, Beltman JJ. Cervical high-risk human papillomavirus infection and its associated risk factors: a community-based cross-sectional study in hard-to-reach areas in Bangladesh. BMJ Open. 2025 Dec 18;15(12):e103915. doi: 10.1136/bmjopen-2025-103915. PMID 41412622
- DERIVEDSultanov M, Zeeuw J, Koot J, der Schans JV, Beltman JJ, Fouw M, Majdan M, Rusnak M, Nazrul N, Rahman A, Nakisige C, Rao AP, Prasad K, Guruvare S, Biesma R, Versluis M, de Bock GH, Stekelenburg J. Investigating feasibility of 2021 WHO protocol for cervical cancer screening in underscreened populations: PREvention and SCReening Innovation Project Toward Elimination of Cervical Cancer (PRESCRIP-TEC). BMC Public Health. 2022 Jul 15;22(1):1356. doi: 10.1186/s12889-022-13488-z.