Clinical trial · Interventional
Biomarker Guided Treatment in DLBCL
A Randomized, Phase 2 Study of Biomarker Guided Treatment in DLBCL
NCT04025593CI-TRIAL-00048366unknownPhase 2ClinicalTrials.gov clinicaltrialsProvenance
- Source
- ClinicalTrials.gov
- Retrieved
- Sep 8, 2026
- Layer
- normalized (units and labels harmonized; values unchanged)
- Run
- ING-CLINICALTRIALS-20260908-000001
Summary
Brief summary (as posted)
This study is to investigate the strategy of biomarker guided treatment in diffuse large B cell lymphoma
Conditions
Conditions (1)
Free-text conditions as registered, with the CancerIndex entity they were reconciled to and the match type.
| Condition (as posted) | Mapped entity | Match | Confidence |
|---|---|---|---|
| Diffuse Large B Cell Lymphoma | Diffuse Large B-Cell Lymphoma | CURATED_BROADER | 0.80 |
Interventions
Interventions (9)
| Intervention | Type | Mapped drug | Match |
|---|---|---|---|
| chidamide | Drug | — | UNRESOLVED |
| Cyclophosphamide | Drug | Cyclophosphamide | ALIAS |
| decitabine | Drug | Decitabine | ALIAS |
| Doxorubicin | Drug | Doxorubicin | ALIAS |
| Ibrutinib | Drug | Ibrutinib | ALIAS |
| Lenalidomide | Drug | Lenalidomide | ALIAS |
| Prednisone | Drug | Prednisone | ALIAS |
| Rituximab | Drug | Rituximab | ALIAS |
| Vincristine |
Design
Arms and outcomes
Arms (2)
- type
- ACTIVE_COMPARATOR
- label
- RCHOP
- interventionNames
- Drug: Cyclophosphamide
- Drug: Rituximab
- Drug: Doxorubicin
- Drug: Vincristine
- Drug: Prednisone
- type
- EXPERIMENTAL
- label
- RCHOPX
- interventionNames
- Drug: Cyclophosphamide
- Drug: Rituximab
- Drug: Doxorubicin
- Drug: Vincristine
- Drug: Prednisone
- Drug: Ibrutinib
- Drug: Lenalidomide
- Drug: chidamide
- Drug: decitabine
Primary outcomes (1)
- measure
- complete response rate
Eligibility
Eligibility (as posted)
- Sex
- All
- Minimum age
- 18 Years
- Maximum age
- 80 Years
Show eligibility criteria text
Inclusion Criteria: * Pathologically confirmed diffuse large B-cell lymphoma, CD20 positive * ECOG 0,1,2 * Life expectancy\>6 months * Informed consented * IPI\>1 Exclusion Criteria: * Chemotherapy before * Stem cell transplantation before * History of malignancy except for basal cell or squamous cell carcinoma of the skin or carcinoma in situ of the cervix * Uncontrollable cardio-cerebral vascular, coagulative, autoimmune, serious infectious disease * Primary CNS lymphoma * LVEF≤50% * Lab at enrollment (Unless caused by lymphoma) Neutrophile\<1.5\*10\^9/L Platelet\<75\*10\^9/L ALT or AST \>2\*ULN,AKP or bilirubin \>1.5\*ULN Creatinine\>1.5\*ULN Other uncontrollable medical condition that may that may interfere the participation of the study Not able to comply to the protocol for mental or other unknown reasons Pregnant or lactation HIV infection If HbsAg positive, should check HBV DNA, DNA positive patients cannot be enrolled. If HBsAg negative but HBcAb positive (whatever HBsAb status), should check HBV DNA,DNA positive patients cannot be enrolled.
References
Publications (0)
Data not yet available
No reference posted for this study.