Study to Evaluate How Patients Regard the Benefits and Risks of Low-dose Aspirin for the Prevention of Heart and Blood Vessels Disease and for the Prevention of Cancer of the Colon and Rectum

Patient Eligibility Criteria

Inclusion Criteria:

* Age and CVD characteristics

  * Primary prevention:

    * 50-70 years of age
    * Self-report clinical characteristics that result to 20% or higher, 10-year risk of CVD based on the Progetto Cuore scores
  * Secondary prevention:

    * 18 years or older
    * Having a self-reported history of CV event (e.g., myocardial infarction (MI), ischaemic stroke or Transient Ischaemic stroke, , and angina)
* Able to read and understand Italian
* No participation in an investigational program with interventions outside of routine clinical practice
* For qualitative interviews:

  * Willing and able to provide (electronic) informed consent to participate in the study
  * Willing and able to participate in a telephone interview, and to be audio-recorded
* For pilot/cognitive interviews :

  * Willing and able to complete an online survey
  * Willing and able to provide (electronic) informed consent to participate in the study
  * Willing and able to participate in an in-person interview, and to be audio-recorded
* For quantitative main survey:

  * Willing and able to complete an online survey
  * Willing and able to provide (electronic) informed consent to participate in the study

Exclusion Criteria:

* Have glucose-6-phosphate dehydrogenase (G6PD) deficiency (which commonly causes haemolytic anaemia, which is often triggered from eating fava beans, a condition called Favism)
* Have the following conditions (which are contraindications to low-dose aspirin)

  * Known hypersensitivity to salicylates
  * Known to have had asthma induced by salicylates
  * Having been diagnosed with acute gastroduodenal ulcers
  * Haemorrhagic diathesis
  * Renal failure
  * Hepatic failure
* Concomitant treatment with methotrexate
* Cognitive impairment, hearing difficulty, visual impairment, acute psychopathology, or insufficient knowledge of Italian that-in the opinion of the investigator/interviewer-could interfere with a patient's ability to provide written consent and complete an interview or survey
* To be currently pregnant
* Are pharmaceutical company employees or employed in a position where they have a direct role in treating patients with CVD

Physician Eligibility Criteria:

* A medically trained physician
* Able to read, speak, and understand Italian sufficiently to complete an interview
* Able to provide informed consent electronically
* Have at least five year experience prescribing low-dose aspirin for primary and secondary prevention of CVD
* Willing to be audio-recorded, including adherence to the interview instructions