Neoantigen Reactive T Cells Combined With SHR-1210 for Chinese Patients With Advanced Refractory Solid Tumors

Inclusion Criteria:

* Adult patients aged 18 to 75 years old
* Histologic or cytologic confirmation of advanced refractory solid tumors with no available curative treatment options
* At least one measurable disease: diameter ≥20mm or spiral computed tomography(CT)≥10mm; and can providing with tumor specimen (for testing the expression of PD -L1 and the infiltrating lymphocytes)
* Must be human leukocyte antigen (HLA)-A2/A24/A11 positive
* Eastern Cooperative Oncology Group(ECOG)\<0-2 and expected survival time 3 months or more
* At least one new antigen can induce T cell secrete interferon - gamma (IFN - gamma) twice as normal controls during the new antigens screening
* Without anticancer treatment more than one month
* Hematology Index including: Neutrophile granulocyte greater than 1.5×10\^9/L; Hemoglobin greater than 10g/dL; Platelet greater than 100×10\^9/L
* Biochemical index including: Serum bilirubin not greater than 1.5x upper limit of reference range (ULN); glutamic-pyruvic transaminase（ALT） or glutamic-oxalacetic transaminase（AST） not greater than 2.5x ULN; Creatinine clearance no less than 60ml/min
* Peripheral venous channel open and no contraindications to separating lymphocytes
* Negative pregnancy test for women of childbearing potential, and patients must be willing to practice birth control during the regimen
* Provision of informed consent
* Be able to follow the research program and follow up process

Exclusion Criteria:

* Those who now are undergoing other antitumor drug therapy (including chemotherapy, systemic steroids therapy, surgery, target therapy or immune therapy);
* Prior treatment with PD-1 monoclonal antibody(mAb） or PD-L1 mAb;
* Prior malignancy active within the previous 5 years except for locally curable cancers that have been apparently cured, such as basal cell skin cancer or carcinoma in situ of the cervix;
* History with pulmonary tuberculosis, and positive tests for Acquired Immune Deficiency Syndrome(HIV),hepatitis C virus(HCV),hepatitis B virus(HBV);
* Patients with any active autoimmune disease or a documented history of autoimmune disease, or history of syndrome that required systemic steroids or immunosuppressive medications, such as hypophysitis, pneumonia, colitis, hepatitis, nephritis, hyperthyroidism or hypothyroidism; Severe, uncontrolled medical condition that would affect patients' compliance or obscure the interpretation of toxicity determination or adverse events, including active severe infection, uncontrolled diabetes, angiocardiopathy (heart failure \> class II New York Heart Association(NYHA), heart block \>II grade, myocardial infarction, unstable arrhythmia or unstable angina within past 6 months, cerebral infarction within past 3 months) or pulmonary disease ( interstitial pneumonia, obstructive pulmonary disease or symptomatic bronchospasm).
* Evidence with central nervous system(CNS) disease
* Pregnant or nursing
* Psychiatric medicines abuse without withdrawal, or history of psychiatric illness.
* Hypersensitivity to investigational drugs or its components.