TILs & Low-Dose IL-2 Therapy Following Cyclophosphamide and Fludarabine in Pleural Mesothelioma Patients

Inclusion Criteria:

* Able to sign and date the informed consent form.
* Must have measurable stage I-IV malignant pleural mesothelioma at the time of investigational treatment.
* May have 3 or fewer asymptomatic brain metastases.
* Patient age: ≥ 18 years.
* Clinical performance status of ECOG 0 or 1.
* Life expectancy \> 3 months from the date of consent.
* Laboratory analyses of tumor-infiltrating lymphocytes (TILs) from the patient must demonstrate that the TILs are suitable for use in protocol treatment
* More than 30 days has elapsed since any prior systemic therapy at the time of the cell infusion, or more than six weeks since prior nitrosurea therapy. All toxicities must have recovered to a grade 1 or less. Patients may have undergone minor surgical procedures with the past 3 weeks, as long as all toxicities have recovered to grade 1 or less
* Adequate organ function
* Women of child-bearing potential must have a negative pregnancy test. Patients of both genders must be willing to practice birth control during treatment and for 6 months post completion of IL-2 treatment.
* Patients must have adequate respiratory function in the opinion of the treating thoracic physician

Exclusion Criteria:

* Ongoing or prior use systemic steroid therapy within 4 weeks before the TILs infusion will be excluded.
* Known HIV positive patients will be excluded.
* Active hepatitis B or hepatitis C, syphilis, or HTLV will be excluded.
* Must not have any active systemic infections, coagulation disorders or other active major medical illnesses of the cardiovascular, respiratory or immune system, uncontrolled psychiatric disorders, or other conditions that may affect compliance with the trial.
* Must have no active underlying cardiac illnesses defined by positive stress test, LVEF \<40% or ongoing life threatening arrhythmias.